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Company ReportsAkcea Therapeutics

Akcea Therapeutics(AKCA)

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Therapeutic Areas:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Tegsedi	Inotersen	2018-10-05	2025-2031	Amyloidosis , Familial amyloid neuropathies
Waylivra	Volanesorsen	2019-05-03		Hyperlipoproteinemia type i

Clinical Trials

Therapeutic Areas:

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Classification:

All

Approval:

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Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

therapeutic equivalency

,

myelomonocytic leukemia chronic

,

,

,

biliary tract neoplasms

,

,

,

,

alveolar soft part sarcoma

,

neurofibrosarcoma

,

peripheral vascular diseases

,

actinic keratosis

,

dental pulp necrosis

,

,

psychological stress

,

leukemia myeloid chronic atypical bcr-abl negative

,

myelodysplastic-myeloproliferative diseases

,

myeloid leukemia accelerated phase

,

,

esophageal squamous cell carcinoma

,

arteriovenous fistula

,

prostatic hyperplasia

,

lower urinary tract symptoms

,

retinal detachment

,

,

blastic plasmacytoid dendritic cell neoplasm

,

uveal neoplasms

,

,

nerve sheath neoplasms

,

immune system diseases

,

biphenotypic leukemia acute

,

cardiovascular abnormalities

,

neuromyelitis optica

,

transverse myelitis

,

primary cutaneous anaplastic large cell lymphoma

,

hepatic insufficiency

,

juvenile arthritis

,

chronic progressive multiple sclerosis

,

,

vascular stiffness

,

,

,

intermittent claudication

,

,

carcinoid tumor

,

islet cell adenoma

,

somatoform disorders

,

atherosclerosis

,

primary hyperoxaluria

,

,

tobacco use cessation

,

,

germ cell and embryonal neoplasms

,

,

clear cell sarcoma

,

adrenal cortex neoplasms

,

desmoplastic small round cell tumor

,

,

,

persian gulf syndrome

,

myelomonocytic leukemia acute

,

,

mycobacterium infections

,

wet macular degeneration

,

addictive behavior

,

impulsive behavior

,

basal cell carcinoma

,

basal cell neoplasms

,

facial expression

,

stress fractures

,

physiological stress

,

,

,

,

hypersensitivity

,

hematologic neoplasms

,

esophageal neoplasms

,

renal cell carcinoma

,

myeloid leukemia

,

,

acute kidney injury

,

metabolic diseases

,

,

hidradenitis suppurativa

,

human influenza

,

,

autistic disorder

,

,

critical illness

,

fallopian tube neoplasms

,

neuroendocrine tumors

,

,

brain neoplasms

,

mycosis fungoides

,

milk hypersensitivity

,

primary myelofibrosis

,

,

myelomonocytic leukemia juvenile

,

transitional cell carcinoma

,

,

polycystic ovary syndrome

,

bile duct neoplasms

,

cutaneous malignant melanoma

,

t-cell lymphoma cutaneous

,

,

glucose metabolism disorders

,

,

,

oropharyngeal neoplasms

,

pelvic organ prolapse

,

neoadjuvant therapy

,

meningeal carcinomatosis

,

promyelocytic leukemia acute

,

myeloid leukemia chronic-phase

,

cytokine release syndrome

,

,

gastrointestinal neoplasms

,

,

essential tremor

,

,

peritoneal neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

squamous cell carcinoma

,

,

,

nasopharyngeal carcinoma

,

,

hematologic diseases

,

sezary syndrome

,

large-cell lymphoma immunoblastic

,

bone marrow failure disorders

,

adrenocortical carcinoma

,

primary graft dysfunction

,

autoimmune diseases

,

,

smoking cessation

,

dental pulp diseases

,

cerebrospinal fluid leak

,

endometrial neoplasms

,

,

,

exocrine pancreatic insufficiency

,

precancerous conditions

,

major depressive disorder

,

autism spectrum disorder

,

rhabdomyosarcoma

,

pulmonary tuberculosis

,

t-cell lymphoma peripheral

,

tuberous sclerosis

,

medulloblastoma

,

,

,

large granular lymphocytic leukemia

,

t-cell leukemia

,

,

,

,

penile induration

,

,

atrophic rhinitis

,

urologic neoplasms

,

tongue neoplasms

,

cerebrotendinous xanthomatosis

,

,

hairy cell leukemia

,

,

kidney neoplasms

,

,

immunoglobulin light-chain amyloidosis

,

,

stem cell transplantation

,

large-cell lymphoma anaplastic

,

dyskeratosis congenita

,

respiratory syncytial virus infections

,

positron emission tomography computed tomography

,

,

,

pulmonary arterial hypertension

,

viral pneumonia

,

keratoconjunctivitis

,

polycythemia vera

,

,

altitude sickness

,

,

,

malignant pleural effusion

,

,

,

stomatognathic diseases

,

substance withdrawal syndrome

,

alagille syndrome

,

out-of-hospital cardiac arrest

,

,

,

cross infection

,

respiratory distress syndrome

,

intracranial hypotension

,

amyotrophic lateral sclerosis

,

,

alopecia areata

,

severe acute respiratory syndrome

,

,

mast cell activation disorders

,

neurotoxicity syndromes

,

,

,

bronchogenic carcinoma

,

bronchial neoplasms

,

solitary pulmonary nodule

,

,

,

progression-free survival

,

autonomic nervous system diseases

,

menkes kinky hair syndrome

,

small cell carcinoma

,

,

patent ductus arteriosus

,

hand-foot syndrome

,

congenital abnormalities

,

hepatorenal syndrome

,

,

pseudomyxoma peritonei

,

postherpetic neuralgia

,

peripheral nerve injuries

,

retinal perforations

,

residual neoplasm

,

,

lymphoproliferative disorders

,

nontuberculous mycobacterium infections

,

mycobacterium avium-intracellulare infection

,

colorectal neoplasms

,

myeloid leukemia acute

,

,

prostatic neoplasms

,

stomach neoplasms

,

pancreatic neoplasms

,

liver neoplasms

,

myelodysplastic syndromes

,

acquired immunodeficiency syndrome

,

communicable diseases

,

ovarian neoplasms

,

hepatocellular carcinoma

,

chronic hepatitis b

,

hodgkin disease

,

gingival recession

,

precursor cell lymphoblastic leukemia-lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

,

,

triple negative breast neoplasms

,

,

graft vs host disease

,

,

,

,

,

vision disorders

,

,

squamous cell carcinoma of head and neck

,

lymphoid leukemia

,

multiple sclerosis

,

gastrointestinal stromal tumors

,

,

retinal diseases

,

gastroesophageal reflux

,

oxidative stress

,

,

mantle-cell lymphoma

,

immunologic deficiency syndromes

,

colonic neoplasms

,

rectal neoplasms

,

cholangiocarcinoma

,

iron-deficiency anemia

,

hypertriglyceridemia

,

wounds and injuries

,

traumatic brain injuries

,

ovarian epithelial carcinoma

,

gallbladder neoplasms

,

iron deficiencies

,

,

,

retinal vein occlusion

,

choroidal neovascularization

,

parkinson disease

,

chronic hepatitis

,

,

geographic atrophy

,

spontaneous abortion

,

bacterial infections

,

hyperlipidemias

,

,

non-alcoholic fatty liver disease

,

urinary bladder neoplasms

,

thyroid diseases

,

digestive system diseases

,

,

pathologic complete response

,

,

relapsing-remitting multiple sclerosis

,

respiratory insufficiency

,

nasopharyngeal neoplasms

,

,

,

,

b-cell lymphoma marginal zone

,

,

,

anxiety disorders

,

hyperlipoproteinemia type i

,

,

myocardial ischemia

,

cystic fibrosis

,

,

castration-resistant prostatic neoplasms

,

,

thrombocytopenia

,

organ transplantation

,

end stage liver disease

,

,

sleep apnea syndromes

,

,

adjuvant chemotherapy

,

general anesthesia

,

depressive disorder

,

sickle cell anemia

,

,

generalized anxiety disorder

,

peptic esophagitis

,

,

gingival hemorrhage

,

,

postmenopausal osteoporosis

,

adenomatous polyposis coli

,

alcohol drinking

,

wasting syndrome

,

severe acute respiratory syndrome-related coronavirus

,

,

severe acute malnutrition

,

pancreatic ductal carcinoma

,

male breast neoplasms

,

cardiac surgical procedures

,

,

retinal degeneration

,

sports nutritional physiological phenomena

,

,

,

,

disease progression

,

intellectual disability

,

urinary bladder diseases

,

lacrimal apparatus diseases

,

,

langerhans-cell histiocytosis

,

,

waldenstrom macroglobulinemia

,

obstructive sleep apnea

,

,

,

pathologic processes

,

delayed graft function

,

,

blood coagulation disorders

,

degenerative myopia

,

,

bacterial skin diseases

,

hyperlipoproteinemia type v

,

hyperlipoproteinemias

,

familial partial lipodystrophy

,

,

breast diseases

,

lung transplantation

,

bronchiolitis obliterans

,

bronchiolitis obliterans syndrome

,

,

neuroectodermal tumors

,

,

systolic heart failure

,

endocrine system diseases

,

corneal injuries

,

,

,

cholecystolithiasis

,

cytomegalovirus infections

,

dental calculus

,

bites and stings

,

,

hyperthyroxinemia

,

,

,

neuronal ceroid-lipofuscinoses

,

muscle weakness

,

,

,

partial denture removable

,

philadelphia chromosome

,

invasive hydatidiform mole

,

habitual abortion

,

essential hypertension

,

retinal neovascularization

,

ventilator-associated pneumonia

,

delayed emergence from anesthesia

,

euthyroid sick syndromes

,

,

agammaglobulinemia

,

primary immunodeficiency diseases

,

healthy volunteers/patients

,

breast neoplasms

,

diabetes mellitus

,

,

,

type 2 diabetes mellitus

,

,

chronic hepatitis c

,

insulin resistance

,

non-small-cell lung carcinoma

,

multiple myeloma

,

,

kidney transplantation

,

,

,

,

,

dry eye syndromes

,

,

postoperative pain

,

neoplasm metastasis

,

non-hodgkin lymphoma

,

,

type 1 diabetes mellitus

,

,

,

metabolic syndrome

,

,

kidney diseases

,

renal insufficiency

,

,

knee osteoarthritis

,

ocular hypertension

,

,

chronic kidney failure

,

chronic renal insufficiency

,

,

keratoconjunctivitis sicca

,

plasma cell neoplasms

,

diabetic retinopathy

,

,

,

,

cardiovascular diseases

,

,

,

head and neck neoplasms

,

ulcerative colitis

,

open-angle glaucoma

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

,

liver cirrhosis

,

liver transplantation

,

rheumatoid arthritis

,

,

chronic obstructive pulmonary disease

,

,

,

cognitive dysfunction

,

large b-cell lymphoma diffuse

,

,

macular degeneration

,

,

,

,

,

,

,

,

hypercholesterolemia

,

follicular lymphoma

,

b-cell lymphoma

,

,

,

,

aplastic anemia

,

postoperative nausea and vomiting

,

coronavirus infections

,

,

,

,

muscle spasticity

,

,

migraine disorders

,

,

postoperative complications

,

prediabetic state

,

uterine cervical neoplasms

,

,

myeloproliferative disorders

,

reperfusion injury

,

urinary incontinence

,

,

,

glucose intolerance

,

premature birth

,

coronary artery disease

,

,

attention deficit disorder with hyperactivity

,

,

,

,

,

,

,

,

,

,

replacement arthroplasty knee

,

anterior cruciate ligament injuries

,

cesarean section

,

adenocarcinoma of lung

,

hyperlipoproteinemia type ii

,

circulating neoplastic cells

,

burkitt lymphoma

,

,

cardiomyopathies

,

respiratory tract infections

,

post-traumatic stress disorders

,

diabetic neuropathies

,

periodontal pocket

,

periodontal attachment loss

,

dentin sensitivity

,

alzheimer disease

,

hip osteoarthritis

,

,

opioid-related disorders

,

diabetic nephropathies

,

diabetes complications

,

vascular diseases

,

falciparum malaria

,

immunosuppression therapy

,

graft rejection

,

overactive urinary bladder

,

urge urinary incontinence

,

peripheral arterial disease

,

,

,

patient compliance

,

,

drug-related side effects and adverse reactions

,

uterine cervical incompetence

,

pain management

,

,

heart transplantation

,

,

systemic scleroderma

,

hematopoietic stem cell transplantation

,

atopic dermatitis

,

,

lipid metabolism disorders

,

,

,

,

,

surgical wound infection

,

post-dural puncture headache

,

,

,

cardiac arrhythmias

,

,

,

neurodegenerative diseases

,

,

papillomavirus infections

,

squamous intraepithelial lesions

,

,

surgical blood loss

,

diastolic heart failure

,

acute coronary syndrome

,

,

stroke rehabilitation

,

interstitial cystitis

,

morphine dependence

,

,

rotator cuff injuries

,

,

,

,

intervertebral disc displacement

,

spinal anesthesia

,

left ventricular hypertrophy

,

diffuse scleroderma

,

nephrotic syndrome

,

allergic rhinitis

,

,

,

pseudomonas infections

,

pseudomonas aeruginosa

,

intraocular pressure

,

low tension glaucoma

,

carpal tunnel syndrome

,

trigger finger disorder

,

de quervain disease

,

,

intermediate uveitis

,

,

peptic ulcer hemorrhage

,

hypoalbuminemia

,

parenteral nutrition

,

mitochondrial diseases

,

,

,

schistosomiasis

,

,

postpartum depression

,

,

,

barrett esophagus

,

arterial occlusive diseases

,

,

,

polymerase chain reaction

,

,

,

pulmonary hypertension

,

,

,

hemiarthroplasty

,

,

bacterial eye infections

,

child nutrition disorders

,

,

myocardial infarction

,

,

,

vascular dementia

,

,

mixed dementias

,

,

,

drug interactions

,

drug resistance

,

physiological sexual dysfunction

,

trigeminal neuralgia

,

,

emergence delirium

,

takayasu arteritis

,

,

,

phenylketonurias

,

,

,

,

irritable bowel syndrome

,

biological availability

,

gastrointestinal diseases

,

,

,

coronary disease

,

,

inflammatory bowel diseases

,

,

,

postoperative period

,

,

,

,

muscular atrophy

,

protein deficiency

,

sensitivity training groups

,

female genital diseases

,

bariatric surgery

,

failure to thrive

,

malabsorption syndromes

,

lipid metabolism

,

,

obstructive lung diseases

,

sleep deprivation

,

asymptomatic diseases

,

craniofacial abnormalities

,

,

,

periapical periodontitis

,

,

,

periodontal diseases

,

inborn errors metabolism

,

food hypersensitivity

,

environmental biomarkers

,

,

personal satisfaction

,

mobility limitation

,

uterine prolapse

,

,

inguinal hernia

,

inborn genetic diseases

,

,

pediatric obesity

,

temporomandibular joint disorders

,

dietary proteins

,

orthodontic retainers

,

cardiometabolic risk factors

,

,

,

,

islets of langerhans transplantation

,

,

obstetric delivery

,

caloric restriction

,

sexually transmitted diseases

,

contraception behavior

,

,

,

bronchiolo-alveolar adenocarcinoma

,

,

anterior uveitis

,

,

hemolytic anemia

,

glycogen storage disease type iii

,

glycogen storage disease

,

,

hyperinsulinism

,

hyperandrogenism

,

glomerular filtration rate

,

renal circulation

,

renal plasma flow

,

sjogren's syndrome

,

ankle fractures

,

,

hammer toe syndrome

,

tailor's bunion

,

,

treatment-resistant depressive disorder

,

nutritional status

,

infant nutritional physiological phenomena

,

,

noncommunicable diseases

,

,

blood glucose self-monitoring

,

solanum tuberosum

,

resistant starch

,

,

dilated cardiomyopathy

,

hiv-associated lipodystrophy syndrome

,

local anesthesia

,

dental care for children

,

,

staphylococcal infections

,

exercise-induced asthma

,

,

magnetic resonance imaging

,

,

,

gluten-free diet

,

growth disorders

,

female infertility

,

hepatic encephalopathy

,

aphthous stomatitis

,

multidrug-resistant tuberculosis

,

psychological burnout

,

,

second primary neoplasms

,

,

multiple trauma

,

missed abortion

,

pathologic constriction

,

congenital heart defects

,

,

inclusion body myositis

,

hypopituitarism

,

,

,

metabolic bone diseases

,

bacterial vaginosis

,

vaginal diseases

,

growth and development

,

,

fuchs' endothelial dystrophy

,

ischemic stroke

,

retinopathy of prematurity

,

short bowel syndrome

,

cartilage diseases

,

systemic inflammatory response syndrome

,

,

,

neoplastic cell transformation

,

,

,

turner syndrome

,

,

emotional regulation

,

,

,

,

free tissue flaps

,

radius fractures

,

wrist fractures

,

,

intestinal diseases

,

psychotic disorders

,

respiratory aspiration

,

sedentary behavior

,

,

digestive signs and symptoms

,

self-injurious behavior

,

infant nutrition disorders

,

,

total parenteral nutrition

,

emission-computed tomography single-photon

,

radioisotope diagnostic techniques

,

,

dental enamel hypoplasia

,

molar hypomineralization

,

nutritional and metabolic diseases

,

alveolar bone loss

,

injection site reaction

,

gastroenteritis

,

atrial fibrillation

,

cerebrovascular disorders

,

hyperthyroidism

,

,

uterine hemorrhage

,

,

multiple abnormalities

,

pityriasis rubra pilaris

,

,

,

,

,

trained immunity

,

,

sinus floor augmentation

,

electroacupuncture

,

psoriatic arthritis

,

ankylosing spondylitis

,

,

,

temporomandibular joint dysfunction syndrome

,

,

,

dystonic disorders

,

,

induced abortion

,

tissue adhesions

,

afibrinogenemia

,

bone resorption

,

nephrolithiasis

,

,

urinary calculi

,

,

high-throughput nucleotide sequencing

,

heat stress disorders

,

,

heat-shock response

,

,

,

thoracic neoplasms

,

,

,

body weight changes

,

deglutition disorders

,

,

,

,

positron-emission tomography

,

obstructive jaundice

,

,

bile duct diseases

,

meibomian gland dysfunction

,

,

therapeutic chemoembolization

,

erectile dysfunction

,

spinal cord injuries

,

,

,

male circumcision

,

,

,

maple syrup urine disease

,

autoimmune thyroiditis

,

laparoscopic cholecystectomy

,

,

,

menstrual cycle

,

lewy body disease

,

musculoskeletal diseases

,

,

,

,

,

,

,

vulvar neoplasms

,

thyroid neoplasms

,

enhanced recovery after surgery

,

joint dislocations

,

,

urinary tract infections

,

heart disease risk factors

,

gingival overgrowth

,

immediate dental implant loading

,

,

,

,

alphapapillomavirus

,

uterine cervical dysplasia

,

,

pregnancy-induced hypertension

,

pregnancy complications

,

,

patient participation

,

psychological distress

,

psychological resilience

,

,

,

,

sleep initiation and maintenance disorders

,

,

neuroinflammatory diseases

,

,

,

,

chronic urticaria

,

photosensitivity disorders

,

,

anesthesia and analgesia

,

,

periapical diseases

,

alveolar ridge augmentation

,

,

tissue transplantation

,

,

,

exercise tolerance

,

adolescent development

,

atrophic muscular disorders

,

energy metabolism

,

peri-implantitis

,

aortic valve stenosis

,

transcatheter aortic valve replacement

,

conduct disorder

,

familial amyloid neuropathies

,

renal insufficiency

,

cardiovascular diseases

,

hyperlipidemias

,

hyperlipoproteinemias

hypertriglyceridemia

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

familial partial lipodystrophy

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

non-alcoholic fatty liver disease

,

,

hyperlipidemias

,

hyperlipoproteinemia type v

,

,

hyperlipoproteinemia type i

,

hyperlipoproteinemias

,

homozygous familial hypercholesterolemia

,

,

,

,

,

,

,

bacterial conjunctivitis

,

,

,

corneal diseases

,

cataract extraction

,

macular degeneration

,

intravitreal injections

,

endophthalmitis

Fluoroquinolone

healthy volunteers/patients

,

kidney diseases

,

retinal diseases

,

,

insulin resistance

,

,

,

urinary tract infections

,

,

respiratory tract infections

,

,

bacterial infections

,

,

chronic bronchitis

,

respiratory tract diseases

,

infectious skin diseases

,

bacterial skin diseases

,

bacterial pneumonia

,

community-acquired pneumonia

,

,

,

bronchial diseases

,

urologic diseases

,

,

,

maxillary sinusitis

,

,

,

healthcare-associated pneumonia

,

congenital abnormalities

,

nervous system diseases

,

hereditary congenital and neonatal diseases and abnormalities

,

neural tube defects

,

nervous system malformations

,

spinal dysraphism

,

neurogenic urinary bladder

,

,

paranasal sinus diseases

,

,

,

,

,

,

,

critical illness

,

,

retinal detachment

,

aortic dissection

,

dissociative disorders

,

musculoskeletal diseases

cardiovascular diseases

,

hepatic insufficiency

,

healthy volunteers/patients

,

aortic valve stenosis

,

pathologic constriction

,

cardiovascular diseases

,

hyperlipidemias

,

hyperlipoproteinemias

,

atherosclerosis

,

myocardial infarction

,

acute coronary syndrome

,

,

,

,

genetic polymorphism

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