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Akcea Therapeutics
Akcea Therapeutics
(AKCA)
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Trade Name
Drug Name
Approved
Patent Expires
Indication
Tegsedi
Inotersen
2018-10-05
2025-2031
Amyloidosis
,
Familial amyloid neuropathies
Waylivra
Volanesorsen
2019-05-03
Hyperlipoproteinemia type i
Clinical Trials
Therapeutic Areas:
All
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All
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Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
Volanesorsen
therapeutic equivalency
,
urticaria
,
hypoxia
,
biliary tract neoplasms
,
schizophrenia
,
affect
,
gastric bypass
,
alveolar soft part sarcoma
,
neurofibrosarcoma
,
hypercapnia
,
peripheral vascular diseases
,
atherosclerosis
,
actinic keratosis
,
dental pulp necrosis
,
pruritus
,
psychological stress
,
leukemia myeloid chronic atypical bcr-abl negative
,
myelodysplastic-myeloproliferative diseases
,
myeloid leukemia accelerated phase
,
thrombocytosis
,
esophageal squamous cell carcinoma
,
arteriovenous fistula
,
prostatic hyperplasia
,
lower urinary tract symptoms
,
retinal detachment
,
acute pain
,
blastic plasmacytoid dendritic cell neoplasm
,
uveal neoplasms
,
liposarcoma
,
nerve sheath neoplasms
,
immune system diseases
,
biphenotypic leukemia acute
,
cardiovascular abnormalities
,
neuromyelitis optica
,
transverse myelitis
,
primary cutaneous anaplastic large cell lymphoma
,
hepatic insufficiency
,
juvenile arthritis
,
chronic progressive multiple sclerosis
,
cheilitis
,
vascular stiffness
,
vasodilation
,
intermittent claudication
,
oral surgery
,
carcinoid tumor
,
somatoform disorders
,
primary hyperoxaluria
,
aneurysm
,
osteosarcoma
,
germ cell and embryonal neoplasms
,
rhabdoid tumor
,
clear cell sarcoma
,
desmoplastic small round cell tumor
,
hepatoblastoma
,
wilms tumor
,
persian gulf syndrome
,
myelomonocytic leukemia acute
,
presbyopia
,
mycobacterium infections
,
addictive behavior
,
impulsive behavior
,
substance-related disorders
,
basal cell carcinoma
,
basal cell neoplasms
,
facial expression
,
stress fractures
,
physiological stress
,
volition
,
tympanic membrane perforation
,
melanoma
,
overweight
,
hypersensitivity
,
hematologic neoplasms
,
esophageal neoplasms
,
acute kidney injury
,
sarcopenia
,
myeloid leukemia
,
glioblastoma
,
human influenza
,
metabolic diseases
,
hidradenitis suppurativa
,
sleep
,
autistic disorder
,
milk hypersensitivity
,
primary myelofibrosis
,
myelomonocytic leukemia chronic
,
critical illness
,
fallopian tube neoplasms
,
neuroendocrine tumors
,
sepsis
,
brain neoplasms
,
mycosis fungoides
,
body weight
,
glioma
,
myelomonocytic leukemia juvenile
,
peritoneal neoplasms
,
transitional cell carcinoma
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
neuroblastoma
,
polycystic ovary syndrome
,
bile duct neoplasms
,
hematologic diseases
,
cutaneous malignant melanoma
,
adrenocortical carcinoma
,
t-cell lymphoma cutaneous
,
autoimmune diseases
,
ketosis
,
glucose metabolism disorders
,
tuberculosis
,
disease
,
oropharyngeal neoplasms
,
precancerous conditions
,
pelvic organ prolapse
,
rhabdomyosarcoma
,
meningeal carcinomatosis
,
promyelocytic leukemia acute
,
myeloid leukemia chronic-phase
,
cytokine release syndrome
,
ependymoma
,
gastrointestinal neoplasms
,
sclerosis
,
essential tremor
,
hidradenitis
,
exanthema
,
uveal melanoma
,
nasopharyngeal carcinoma
,
stomatitis
,
sezary syndrome
,
large-cell lymphoma immunoblastic
,
bone marrow failure disorders
,
primary graft dysfunction
,
polycythemia vera
,
dwarfism
,
smoking cessation
,
dental pulp diseases
,
cerebrospinal fluid leak
,
endometrial neoplasms
,
islet cell adenoma
,
laron syndrome
,
exocrine pancreatic insufficiency
,
major depressive disorder
,
autism spectrum disorder
,
adrenal cortex neoplasms
,
pulmonary tuberculosis
,
t-cell lymphoma peripheral
,
tuberous sclerosis
,
medulloblastoma
,
gliosarcoma
,
astrocytoma
,
large granular lymphocytic leukemia
,
t-cell leukemia
,
neuralgia
,
paresis
,
paraplegia
,
penile induration
,
snoring
,
atrophic rhinitis
,
urologic neoplasms
,
tongue neoplasms
,
cerebrotendinous xanthomatosis
,
xanthomatosis
,
hairy cell leukemia
,
poems syndrome
,
kidney neoplasms
,
paraganglioma
,
immunoglobulin light-chain amyloidosis
,
nasal polyps
,
stem cell transplantation
,
large-cell lymphoma anaplastic
,
dyskeratosis congenita
,
respiratory syncytial virus infections
,
positron emission tomography computed tomography
,
pemphigus
,
tetanus
,
pulmonary arterial hypertension
,
viral pneumonia
,
keratoconjunctivitis
,
tic disorders
,
altitude sickness
,
polycythemia
,
pancytopenia
,
malignant pleural effusion
,
diverticulitis
,
rosacea
,
stomatognathic diseases
,
substance withdrawal syndrome
,
alagille syndrome
,
out-of-hospital cardiac arrest
,
typhoid fever
,
cholera
,
cross infection
,
intracranial hypotension
,
amyotrophic lateral sclerosis
,
iron overload
,
alopecia areata
,
severe acute respiratory syndrome
,
mastocytosis
,
mast cell activation disorders
,
kernicterus
,
otitis media
,
bronchogenic carcinoma
,
bronchial neoplasms
,
solitary pulmonary nodule
,
prolapse
,
scoliosis
,
progression-free survival
,
autonomic nervous system diseases
,
menkes kinky hair syndrome
,
small cell carcinoma
,
essential thrombocythemia
,
adult t-cell leukemia-lymphoma
,
eyelid neoplasms
,
sunburn
,
adrenal gland neoplasms
,
patent ductus arteriosus
,
hand-foot syndrome
,
congenital abnormalities
,
hepatorenal syndrome
,
drug therapy
,
pseudomyxoma peritonei
,
postherpetic neuralgia
,
peripheral nerve injuries
,
retinal perforations
,
residual neoplasm
,
keratitis
,
lymphoproliferative disorders
,
nontuberculous mycobacterium infections
,
mycobacterium avium-intracellulare infection
,
immunotherapy
,
biological therapy
,
skin neoplasms
,
myeloid leukemia acute
,
leukemia
,
prostatic neoplasms
,
stomach neoplasms
,
pancreatic neoplasms
,
liver neoplasms
,
myelodysplastic syndromes
,
acquired immunodeficiency syndrome
,
hepatocellular carcinoma
,
precursor cell lymphoblastic leukemia-lymphoma
,
hodgkin disease
,
ovarian neoplasms
,
chronic hepatitis b
,
b-cell chronic lymphocytic leukemia
,
lung neoplasms
,
gingival recession
,
carcinoma
,
communicable diseases
,
pregnancy
,
adenocarcinoma
,
fibrosis
,
triple negative breast neoplasms
,
osteoarthritis
,
graft vs host disease
,
hypoglycemia
,
malnutrition
,
motor activity
,
cerebral palsy
,
renal cell carcinoma
,
multiple sclerosis
,
depression
,
gastroesophageal reflux
,
vision disorders
,
sarcoma
,
squamous cell carcinoma of head and neck
,
gastrointestinal stromal tumors
,
retinal diseases
,
oxidative stress
,
mantle-cell lymphoma
,
immunologic deficiency syndromes
,
colonic neoplasms
,
rectal neoplasms
,
cholangiocarcinoma
,
lymphoid leukemia
,
iron-deficiency anemia
,
hypertriglyceridemia
,
traumatic brain injuries
,
ovarian epithelial carcinoma
,
gallbladder neoplasms
,
iron deficiencies
,
pre-eclampsia
,
retinal vein occlusion
,
choroidal neovascularization
,
parkinson disease
,
chronic hepatitis
,
relapsing-remitting multiple sclerosis
,
ewing sarcoma
,
geographic atrophy
,
spontaneous abortion
,
b-cell lymphoma marginal zone
,
bacterial infections
,
hyperlipidemias
,
contraception
,
non-alcoholic fatty liver disease
,
fatty liver
,
urinary bladder neoplasms
,
thyroid diseases
,
digestive system diseases
,
preleukemia
,
pathologic complete response
,
sialorrhea
,
squamous cell carcinoma
,
general anesthesia
,
respiratory insufficiency
,
nasopharyngeal neoplasms
,
cachexia
,
hepatitis
,
hepatitis a
,
osteoporosis
,
dyspnea
,
anxiety disorders
,
dysmenorrhea
,
myocardial ischemia
,
cystic fibrosis
,
alopecia
,
duodenal ulcer
,
neoadjuvant therapy
,
pneumonia
,
castration-resistant prostatic neoplasms
,
hepatitis b
,
thrombocytopenia
,
organ transplantation
,
end stage liver disease
,
blepharospasm
,
sleep apnea syndromes
,
edema
,
adjuvant chemotherapy
,
depressive disorder
,
sickle cell anemia
,
lipodystrophy
,
generalized anxiety disorder
,
hyperlipoproteinemia type i
,
peptic esophagitis
,
gingival hemorrhage
,
amyloid plaque
,
respiratory distress syndrome
,
postmenopausal osteoporosis
,
adenomatous polyposis coli
,
severe acute respiratory syndrome-related coronavirus
,
tooth erosion
,
severe acute malnutrition
,
tobacco use cessation
,
pancreatic ductal carcinoma
,
male breast neoplasms
,
cardiac surgical procedures
,
hiv-1
,
retinal degeneration
,
sports nutritional physiological phenomena
,
alcoholism
,
erectile dysfunction
,
fluid therapy
,
disease progression
,
intellectual disability
,
urinary bladder diseases
,
lacrimal apparatus diseases
,
langerhans-cell histiocytosis
,
laparoscopy
,
waldenstrom macroglobulinemia
,
obstructive sleep apnea
,
tonsillectomy
,
oximetry
,
pathologic processes
,
delayed graft function
,
plasmacytoma
,
blood coagulation disorders
,
degenerative myopia
,
bone fractures
,
bacterial skin diseases
,
hyperlipoproteinemia type v
,
hyperlipoproteinemias
,
familial partial lipodystrophy
,
drug overdose
,
breast diseases
,
lung transplantation
,
bronchiolitis obliterans
,
bronchiolitis obliterans syndrome
,
arthralgia
,
neuroectodermal tumors
,
stomach ulcer
,
systolic heart failure
,
endocrine system diseases
,
corneal injuries
,
gallstones
,
cholelithiasis
,
cholecystolithiasis
,
cytomegalovirus infections
,
dental calculus
,
bites and stings
,
thyrotoxicosis
,
hyperthyroxinemia
,
polyps
,
hyperplasia
,
neuronal ceroid-lipofuscinoses
,
muscle weakness
,
diabetic foot
,
pulpitis
,
partial denture removable
,
squamous cell neoplasms
,
philadelphia chromosome
,
invasive hydatidiform mole
,
habitual abortion
,
essential hypertension
,
retinal neovascularization
,
ventilator-associated pneumonia
,
delayed emergence from anesthesia
,
euthyroid sick syndromes
,
tobacco use
,
agammaglobulinemia
,
primary immunodeficiency diseases
,
st elevation myocardial infarction
,
non-st elevated myocardial infarction
,
tooth bleaching
,
healthy volunteers/patients
,
breast neoplasms
,
diabetes mellitus
,
colorectal neoplasms
,
obesity
,
hepatitis c
,
type 2 diabetes mellitus
,
hiv infections
,
non-small-cell lung carcinoma
,
chronic hepatitis c
,
insulin resistance
,
multiple myeloma
,
kidney transplantation
,
covid-19
,
hypertension
,
lymphoma
,
neoplasms
,
dry eye syndromes
,
infections
,
postoperative pain
,
hemophilia a
,
non-hodgkin lymphoma
,
neoplasm metastasis
,
inflammation
,
type 1 diabetes mellitus
,
macular edema
,
glaucoma
,
metabolic syndrome
,
dental caries
,
knee osteoarthritis
,
celiac disease
,
kidney diseases
,
renal insufficiency
,
chronic renal insufficiency
,
pain
,
ocular hypertension
,
syndrome
,
chronic kidney failure
,
keratoconjunctivitis sicca
,
anemia
,
diabetic retinopathy
,
ulcer
,
ulcerative colitis
,
eye diseases
,
bcr-abl positive chronic myelogenous leukemia
,
cardiovascular diseases
,
asthma
,
recurrence
,
head and neck neoplasms
,
open-angle glaucoma
,
liver cirrhosis
,
plasma cell neoplasms
,
heart failure
,
dyslipidemias
,
liver transplantation
,
rheumatoid arthritis
,
hepacivirus
,
weight loss
,
chronic obstructive pulmonary disease
,
anesthesia
,
cognitive dysfunction
,
large b-cell lymphoma diffuse
,
colitis
,
macular degeneration
,
liver diseases
,
malaria
,
hiv
,
epilepsy
,
aplastic anemia
,
postoperative nausea and vomiting
,
psoriasis
,
crohn disease
,
follicular lymphoma
,
hemorrhage
,
b-cell lymphoma
,
aging
,
hyperglycemia
,
stroke
,
infertility
,
coronavirus infections
,
hypothyroidism
,
periodontitis
,
myeloproliferative disorders
,
muscle spasticity
,
analgesia
,
migraine disorders
,
agnosia
,
diarrhea
,
postoperative complications
,
prediabetic state
,
hypercholesterolemia
,
premature birth
,
chronic pain
,
uterine cervical neoplasms
,
sars-cov-2
,
reperfusion injury
,
urinary incontinence
,
uveitis
,
glucose intolerance
,
respiratory tract infections
,
coronary artery disease
,
gingivitis
,
attention deficit disorder with hyperactivity
,
skin aging
,
dentin sensitivity
,
skin diseases
,
heart diseases
,
falciparum malaria
,
amyloidosis
,
overactive urinary bladder
,
peptic ulcer
,
pterygium
,
arthritis
,
headache
,
replacement arthroplasty knee
,
anterior cruciate ligament injuries
,
cesarean section
,
hyperlipoproteinemia type ii
,
circulating neoplastic cells
,
burkitt lymphoma
,
virus diseases
,
cardiomyopathies
,
post-traumatic stress disorders
,
muscular atrophy
,
diabetic neuropathies
,
periodontal pocket
,
periodontal attachment loss
,
alzheimer disease
,
blast crisis
,
opioid-related disorders
,
diabetic nephropathies
,
diabetes complications
,
vascular diseases
,
immunosuppression therapy
,
graft rejection
,
urge urinary incontinence
,
peripheral arterial disease
,
vomiting
,
patient compliance
,
necrosis
,
drug-related side effects and adverse reactions
,
uterine cervical incompetence
,
pain management
,
acne vulgaris
,
heart transplantation
,
angioedema
,
systemic scleroderma
,
hematopoietic stem cell transplantation
,
atopic dermatitis
,
blood pressure
,
lipid metabolism disorders
,
delirium
,
menorrhagia
,
leiomyoma
,
myofibroma
,
surgical wound infection
,
post-dural puncture headache
,
cytokinesis
,
cutis laxa
,
cardiac arrhythmias
,
kidney calculi
,
ileus
,
neurodegenerative diseases
,
dental enamel hypoplasia
,
myocardial infarction
,
shoulder pain
,
papillomavirus infections
,
squamous intraepithelial lesions
,
hip osteoarthritis
,
cataract
,
surgical blood loss
,
diastolic heart failure
,
acute coronary syndrome
,
nocturia
,
stroke rehabilitation
,
interstitial cystitis
,
morphine dependence
,
brain injuries
,
nausea
,
rotator cuff injuries
,
osteonecrosis
,
knee injuries
,
rupture
,
intervertebral disc displacement
,
spinal anesthesia
,
left ventricular hypertrophy
,
diffuse scleroderma
,
nephrotic syndrome
,
allergic rhinitis
,
lung diseases
,
bronchiectasis
,
pseudomonas infections
,
pseudomonas aeruginosa
,
intraocular pressure
,
low tension glaucoma
,
carpal tunnel syndrome
,
trigger finger disorder
,
de quervain disease
,
ganglion cysts
,
intermediate uveitis
,
cholecystitis
,
peptic ulcer hemorrhage
,
hypoalbuminemia
,
parenteral nutrition
,
mitochondrial diseases
,
seizures
,
open fractures
,
schistosomiasis
,
helminthiasis
,
postpartum depression
,
melanosis
,
spirometry
,
barrett esophagus
,
arterial occlusive diseases
,
coronavirus
,
viral load
,
polymerase chain reaction
,
salivation
,
colonoscopy
,
pulmonary hypertension
,
impacted tooth
,
herpes zoster
,
hemiarthroplasty
,
tooth abrasion
,
bacterial eye infections
,
child nutrition disorders
,
yin deficiency
,
infarction
,
minoca
,
vascular dementia
,
dementia
,
mixed dementias
,
papilloma
,
ichthyosis
,
drug interactions
,
drug resistance
,
physiological sexual dysfunction
,
developmental defects of enamel
,
trigeminal neuralgia
,
xerophthalmia
,
emergence delirium
,
takayasu arteritis
,
vivax malaria
,
exercise
,
phenylketonurias
,
wounds and injuries
,
wound healing
,
irritable bowel syndrome
,
myopia
,
fatigue
,
biological availability
,
gastrointestinal diseases
,
female genital diseases
,
micronutrients
,
emergencies
,
coronary disease
,
microbiota
,
periapical periodontitis
,
inflammatory bowel diseases
,
periodontal diseases
,
acidosis
,
torticollis
,
postoperative period
,
astigmatism
,
adenocarcinoma of lung
,
hemolysis
,
acromegaly
,
protein deficiency
,
sensitivity training groups
,
bariatric surgery
,
failure to thrive
,
malabsorption syndromes
,
lipid metabolism
,
obstructive lung diseases
,
sleep deprivation
,
asymptomatic diseases
,
craniofacial abnormalities
,
arthrogryposis
,
common cold
,
probiotics
,
pregnancy rate
,
renal dialysis
,
inborn errors metabolism
,
food hypersensitivity
,
environmental biomarkers
,
dehydration
,
personal satisfaction
,
mobility limitation
,
uterine prolapse
,
hypotension
,
inguinal hernia
,
inborn genetic diseases
,
abdominal pain
,
pediatric obesity
,
temporomandibular joint disorders
,
bone resorption
,
dietary proteins
,
orthodontic retainers
,
hiatal hernia
,
eczema
,
laparoscopic cholecystectomy
,
cardiometabolic risk factors
,
homocystinuria
,
menstrual cycle
,
orthodontics
,
low back pain
,
alveolar ridge augmentation
,
frailty
,
myofascial pain syndromes
,
fibromyalgia
,
islets of langerhans transplantation
,
papilledema
,
obstetric delivery
,
caloric restriction
,
sexually transmitted diseases
,
contraception behavior
,
homosexuality
,
lacerations
,
bronchiolo-alveolar adenocarcinoma
,
iritis
,
anterior uveitis
,
iridocyclitis
,
hemolytic anemia
,
glycogen storage disease type iii
,
glycogen storage disease
,
hypogonadism
,
hyperinsulinism
,
hyperandrogenism
,
glomerular filtration rate
,
renal circulation
,
renal plasma flow
,
sjogren's syndrome
,
ankle fractures
,
bunion
,
hammer toe syndrome
,
tailor's bunion
,
retinoblastoma
,
treatment-resistant depressive disorder
,
nutritional status
,
infant nutritional physiological phenomena
,
avitaminosis
,
noncommunicable diseases
,
kwashiorkor
,
blood glucose self-monitoring
,
solanum tuberosum
,
resistant starch
,
toxemia
,
gout
,
dilated cardiomyopathy
,
hiv-associated lipodystrophy syndrome
,
local anesthesia
,
dental care for children
,
dental anxiety
,
staphylococcal infections
,
exercise-induced asthma
,
lymphedema
,
magnetic resonance imaging
,
therapeutics
,
surgical flaps
,
gluten-free diet
,
growth disorders
,
female infertility
,
brain diseases
,
hepatic encephalopathy
,
aphthous stomatitis
,
multidrug-resistant tuberculosis
,
psychological burnout
,
second primary neoplasms
,
diet therapy
,
multiple trauma
,
missed abortion
,
pathologic constriction
,
congenital heart defects
,
liver failure
,
inclusion body myositis
,
hypopituitarism
,
keratoconus
,
osteomyelitis
,
metabolic bone diseases
,
bacterial vaginosis
,
vaginal diseases
,
alcohol drinking
,
growth and development
,
metabolism
,
wasting syndrome
,
fuchs' endothelial dystrophy
,
ischemic stroke
,
retinopathy of prematurity
,
short bowel syndrome
,
cartilage diseases
,
systemic inflammatory response syndrome
,
ageusia
,
carcinogenesis
,
neoplastic cell transformation
,
dental plaque
,
surgical wound
,
turner syndrome
,
anxiety
,
emotional regulation
,
hyperuricemia
,
hyperoxaluria
,
dna damage
,
free tissue flaps
,
radius fractures
,
wrist fractures
,
hernia
,
intestinal diseases
,
psychotic disorders
,
respiratory aspiration
,
sedentary behavior
,
constipation
,
digestive signs and symptoms
,
self-injurious behavior
,
infant nutrition disorders
,
hyperphagia
,
total parenteral nutrition
,
emission-computed tomography single-photon
,
radioisotope diagnostic techniques
,
siderosis
,
molar hypomineralization
,
nutritional and metabolic diseases
,
alveolar bone loss
,
injection site reaction
,
gastroenteritis
,
atrial fibrillation
,
cerebrovascular disorders
,
hyperthyroidism
,
nurse's role
,
uterine hemorrhage
,
metrorrhagia
,
multiple abnormalities
,
pityriasis rubra pilaris
,
darier disease
,
keratosis
,
fever
,
immunity
,
trained immunity
,
myoclonus
,
sinus floor augmentation
,
electroacupuncture
,
psoriatic arthritis
,
ankylosing spondylitis
,
corneal ulcer
,
joint diseases
,
temporomandibular joint dysfunction syndrome
,
arthrocentesis
,
paralysis
,
dystonic disorders
,
only child
,
induced abortion
,
tissue adhesions
,
afibrinogenemia
,
nephrolithiasis
,
urolithiasis
,
urinary calculi
,
calculi
,
high-throughput nucleotide sequencing
,
heat stress disorders
,
hypernatremia
,
heat-shock response
,
mycoses
,
onychomycosis
,
thoracic neoplasms
,
fluorescence
,
healthy aging
,
body weight changes
,
deglutition disorders
,
liquid biopsy
,
dengue
,
positron-emission tomography
,
obstructive jaundice
,
jaundice
,
bile duct diseases
,
meibomian gland dysfunction
,
blepharitis
,
therapeutic chemoembolization
,
spinal cord injuries
,
autoimmunity
,
ostomy
,
male circumcision
,
dermatitis
,
tyrosinemias
,
alkaptonuria
,
maple syrup urine disease
,
autoimmune thyroiditis
,
breast feeding
,
lactation
,
lewy body disease
,
musculoskeletal diseases
,
tendinopathy
,
tennis elbow
,
pulpotomy
,
tooth loss
,
malocclusion
,
anodontia
,
vulvar neoplasms
,
thyroid neoplasms
,
enhanced recovery after surgery
,
joint dislocations
,
whey proteins
,
urinary tract infections
,
heart disease risk factors
,
gingival overgrowth
,
atrophy
,
thalassemia
,
behavior
,
uterine neoplasms
,
urogenital neoplasms
,
female genital neoplasms
,
neoplasms by site
,
uterine diseases
,
alphapapillomavirus
,
uterine cervical diseases
,
uterine cervical dysplasia
,
female urogenital diseases and pregnancy complications
,
urogenital diseases
,
genital diseases
,
postmenopause
,
pregnancy-induced hypertension
,
pregnancy complications
,
prenatal care
,
patient participation
,
psychological distress
,
psychological resilience
,
muscle fatigue
,
bone density
,
oral hygiene
,
sleep initiation and maintenance disorders
,
neuroinflammatory diseases
,
morbid obesity
,
abscess
,
chronic urticaria
,
photosensitivity disorders
,
erythema
,
anesthesia and analgesia
,
gastrectomy
,
periapical diseases
,
thrombosis
,
tissue transplantation
,
smoking
,
exercise tolerance
,
adolescent development
,
atrophic muscular disorders
,
energy metabolism
,
peri-implantitis
,
aortic valve stenosis
,
transcatheter aortic valve replacement
,
conduct disorder
,
shoulder injuries
,
regeneration
,
dental implants
,
hypertrophic cicatrix
,
pilonidal sinus
,
enteral nutrition
,
tooth extraction
,
eating
,
vegetarian diet
,
gyrate atrophy
,
conversion disorder
,
low cardiac output
,
aortic coarctation
,
facial pain
,
myalgia
,
musculoskeletal pain
,
facial neuralgia
Inotersen
amyloidosis
,
familial amyloid neuropathies
,
pregnancy
Pelacarsen
renal insufficiency
,
healthy volunteers/patients
,
cardiovascular diseases
,
hyperlipidemias
,
hyperlipoproteinemias
VUPANORSEN
hypertriglyceridemia
,
hypercholesterolemia
,
hyperlipoproteinemia type ii
,
lipodystrophy
,
familial partial lipodystrophy
,
liver diseases
,
type 2 diabetes mellitus
,
diabetes mellitus
,
non-alcoholic fatty liver disease
,
fatty liver
,
hyperlipidemias
,
hyperlipoproteinemia type v
,
syndrome
,
hyperlipoproteinemia type i
,
hyperlipoproteinemias
,
homozygous familial hypercholesterolemia
Endocrine
cystic fibrosis
,
pain
,
graves disease
,
hereditary breast and ovarian cancer syndrome
,
dyslipidemias
,
congenital adrenal hyperplasia
,
adrenal gland diseases
,
endocrine bone diseases
,
alopecia
,
hyperthyroidism
,
fatigue
,
lymphoma
,
adrenocortical hyperfunction
,
bone neoplasms
,
stem cell transplantation
,
adrenogenital syndrome
,
narcolepsy
,
cataplexy
,
postmenopausal osteoporosis
,
alopecia areata
,
porokeratosis
,
pachyonychia congenita
,
urologic neoplasms
,
non-hodgkin lymphoma
,
hematologic neoplasms
,
b-cell chronic lymphocytic leukemia
,
prolymphocytic leukemia t-cell
,
prolymphocytic leukemia
,
pathologic processes
,
aneurysm
,
osteosarcoma
,
kidney neoplasms
,
malformed nails
,
palmoplantar keratoderma
,
tuberous sclerosis
,
cancer pain
,
non-alcoholic fatty liver disease
,
multiple endocrine neoplasia
,
pheochromocytoma
,
papillary thyroid cancer
,
brain neoplasms
,
cognitive dysfunction
,
liver diseases
,
castration-resistant prostatic neoplasms
,
covid-19
,
bariatric surgery
,
diabetic foot
,
medullary carcinoma
,
arthralgia
,
colorectal neoplasms
,
bone diseases
,
chronic disease
,
neuroendocrine carcinoma
,
post-traumatic stress disorders
,
hyperinsulinism
,
adrenocortical carcinoma
,
head and neck neoplasms
,
lung diseases
,
foot ulcer
,
stomach neoplasms
,
colonic neoplasms
,
gastrointestinal neoplasms
,
spinal cord injuries
,
lung neoplasms
,
hypersensitivity
,
musculoskeletal diseases
,
sarcoma
,
hyperandrogenism
,
gastrointestinal diseases
,
chronic pancreatitis
,
ulcer
,
renal cell carcinoma
,
paraganglioma
,
ductal carcinoma
,
malignant carcinoid syndrome
,
uterine cervical neoplasms
,
sleep wake disorders
,
hepatocellular carcinoma
,
melanoma
,
kidney transplantation
,
osteoarthritis
,
hypercholesterolemia
,
second primary neoplasms
,
liposarcoma
,
hereditary sensory and autonomic neuropathies
,
islet cell carcinoma
,
urogenital neoplasms
,
respiratory tract diseases
,
central nervous system neoplasms
,
respiratory tract neoplasms
,
bronchogenic carcinoma
,
thoracic neoplasms
,
bronchial neoplasms
,
hypertrophic cardiomyopathy
,
cardiomyopathies
,
islets of langerhans transplantation
,
diabetic nephropathies
,
suicide
,
intestinal neoplasms
,
intestinal diseases
,
therapeutics
,
diabetes complications
,
mesothelioma
,
anaplastic thyroid carcinoma
,
arthritis
,
menopause
,
ataxia
,
atrophy
,
optic atrophy
,
paraneoplastic syndromes
,
female genital neoplasms
,
peritoneal diseases
,
multiple endocrine neoplasia type 2a
,
multiple endocrine neoplasia type 2b
,
skin diseases
,
carcinoma in situ
,
dyspepsia
,
renal insufficiency
,
dental caries
,
cachexia
,
neutropenia
,
metabolism
,
energy metabolism
,
contraception
,
joint diseases
,
hemangiosarcoma
,
pathologic complete response
,
radiosurgery
,
stomatitis
,
vomiting
,
adenocarcinoma of lung
,
oligospermia
,
azoospermia
,
nephritis
,
wolfram syndrome
,
animal mammary neoplasms
,
combination drug therapy
,
female genital diseases
,
ovarian diseases
,
uterine diseases
,
uterine cervical diseases
,
fallopian tube diseases
,
myofibromatosis
,
malignant mesothelioma
,
nervous system neoplasms
,
postpartum depression
,
acanthosis nigricans
,
germ cell and embryonal neoplasms
,
colonic diseases
,
neuroectodermal tumors
,
sars-cov-2
,
pseudohypoaldosteronism
,
biliary tract diseases
,
shock
,
hemorrhagic shock
,
urologic diseases
,
urinary retention
,
neurogenic urinary bladder
,
inborn genetic diseases
,
squamous cell carcinoma of head and neck
,
molecular targeted therapy
,
combat disorders
,
myxoid liposarcoma
,
leukopenia
,
endocrine gland neoplasms
,
osteoporosis
,
carcinoma
,
hyperaldosteronism
,
cushing syndrome
,
ovarian neoplasms
,
recurrence
,
body weight
,
pituitary diseases
,
adenocarcinoma
,
chronic renal insufficiency
,
pituitary acth hypersecretion
,
sleep initiation and maintenance disorders
,
rare diseases
,
ductal carcinoma breast
,
adrenal gland neoplasms
,
non-small-cell lung carcinoma
,
thyroidectomy
,
metabolic bone diseases
,
intraductal carcinoma noninfiltrating
,
lobular carcinoma
,
breast diseases
,
kidney diseases
,
autoimmune diseases
,
hot flashes
,
ovarian epithelial carcinoma
,
disease
,
inflammatory bowel diseases
,
liver neoplasms
,
circulating neoplastic cells
,
pregnancy
,
ectopic acth syndrome
,
neoplasms by site
,
turner syndrome
,
disease progression
,
hiv infections
,
pancreatic diseases
,
adrenal cortex neoplasms
,
nutritional and metabolic diseases
,
drug-related side effects and adverse reactions
,
craniopharyngioma
,
adamantinoma
,
digestive system neoplasms
,
addison disease
,
amenorrhea
,
nutrition disorders
,
hirsutism
,
choristoma
,
neoadjuvant therapy
,
diabetic retinopathy
,
menstruation disturbances
,
drug therapy
,
digestive system diseases
,
fallopian tube neoplasms
,
noonan syndrome
,
musculoskeletal pain
,
graves ophthalmopathy
,
hormone-dependent neoplasms
,
thyrotoxicosis
,
dwarfism
,
ulcerative colitis
,
crohn disease
,
unilateral breast neoplasms
,
overnutrition
,
male infertility
,
pancreatic ductal carcinoma
,
neoplasms by histologic type
,
glandular and epithelial neoplasms
,
peritoneal neoplasms
,
inflammatory breast neoplasms
,
eunuchism
,
adrenocortical adenoma
,
meningioma
,
chromosome disorders
,
signs and symptoms
,
sex chromosome disorders of sex development
,
mucinous adenocarcinoma
,
restless legs syndrome
,
psychomotor agitation
,
bites and stings
,
psychological distress
,
colitis
,
patient acceptance of health care
,
ependymoma
,
sex chromosome disorders
,
failure to thrive
,
signs and symptoms pathological conditions
,
adjuvant chemotherapy
,
breast neoplasms
,
diabetes mellitus
,
type 2 diabetes mellitus
,
type 1 diabetes mellitus
,
obesity
,
neoplasms
,
endocrine system diseases
,
insulin resistance
,
hypoglycemia
,
prostatic neoplasms
,
syndrome
,
triple negative breast neoplasms
,
male breast neoplasms
,
gestational diabetes
,
polycystic ovary syndrome
,
thyroid diseases
,
metabolic diseases
,
neoplasm metastasis
,
neuroendocrine tumors
,
metabolic syndrome
,
glucose metabolism disorders
,
healthy volunteers/patients
,
hyperglycemia
,
overweight
,
thyroid neoplasms
,
hypertension
,
infertility
,
glucose intolerance
,
pancreatic neoplasms
,
weight loss
,
cardiovascular diseases
,
hyperparathyroidism
,
acromegaly
,
vitamin d deficiency
,
hypogonadism
,
blood glucose self-monitoring
,
pituitary neoplasms
,
invasive hydatidiform mole
,
primary hyperparathyroidism
,
inflammation
,
thyroid nodule
,
laron syndrome
,
endometrial neoplasms
,
heart failure
,
adenoma
,
islet cell adenoma
,
fatty liver
,
coronary artery disease
,
parathyroid neoplasms
,
goiter
,
pancreatitis
,
pituitary dwarfism
,
carcinoid tumor
,
multiple endocrine neoplasia type 1
,
thalassemia
,
hypopituitarism
,
diabetic ketoacidosis
,
female infertility
,
hypercalcemia
,
postoperative pain
,
wounds and injuries
,
myocardial ischemia
,
parathyroid diseases
,
traumatic brain injuries
,
acute coronary syndrome
,
hypoparathyroidism
,
postmenopause
,
coronary disease
,
hyperplasia
,
atrial fibrillation
,
ketosis
,
serotonin syndrome
,
hyperlipidemias
,
brain injuries
,
secondary hyperparathyroidism
,
postoperative nausea and vomiting
,
hypocalcemia
,
transgenes
,
spontaneous abortion
,
leukemia
,
anemia
,
sickle cell anemia
,
intraoperative complications
,
breast carcinoma in situ
,
alzheimer disease
,
pre-eclampsia
,
knee osteoarthritis
,
macular edema
,
postoperative complications
,
hoarseness
,
hormone replacement therapy
,
hypertriglyceridemia
,
precursor cell lymphoblastic leukemia-lymphoma
,
atrophic vaginitis
,
eclampsia
,
diastolic heart failure
,
embryo transfer
,
osteogenesis imperfecta
,
t-cell lymphoma cutaneous
,
myelodysplastic syndromes
,
myeloid leukemia acute
,
blood coagulation disorders
,
aplastic anemia
,
lymphoid leukemia
,
prolactinoma
,
hypoalphalipoproteinemias
,
optic nerve hypoplasia
,
septo-optic dysplasia
,
patient preference
,
endometrial hyperplasia
,
prediabetic state
,
motor activity
,
pediatric obesity
,
sedentary behavior
,
depression
,
morbid obesity
,
medication adherence
,
pregnancy complications
,
infections
,
malnutrition
,
critical illness
,
hypothyroidism
,
exercise
,
chronic kidney failure
,
precocious puberty
,
congenital abnormalities
,
adrenal insufficiency
,
mental disorders
,
treatment adherence and compliance
,
anxiety disorders
,
iron overload
,
klinefelter syndrome
,
schizophrenia
,
aging
,
life style
,
sarcopenia
,
communicable diseases
,
adiposity
,
peripheral nervous system diseases
,
stroke
,
hemorrhage
,
growth disorders
,
gastric bypass
,
psychological stress
,
exocrine pancreatic insufficiency
,
sepsis
,
feeding behavior
,
primary ovarian insufficiency
,
multiple sclerosis
,
bipolar disorder
,
psychotic disorders
,
heart diseases
,
health behavior
,
diabetes insipidus
,
major depressive disorder
,
hashimoto disease
,
hypospadias
,
acupuncture therapy
,
anxiety
,
endometriosis
,
disorders of sex development
,
abdominal obesity
,
muscle weakness
,
dysmenorrhea
,
pregnancy rate
,
weight gain
,
prader-willi syndrome
,
dysphonia
,
fibrosis
,
tic disorders
,
congenital heart defects
,
gastroparesis
,
epilepsy
,
dementia
,
hemophilia b
,
craniofacial abnormalities
,
arthrogryposis
,
patient compliance
,
adrenal rest tumor
,
pregnancy in diabetics
,
left ventricular dysfunction
,
premature birth
,
burns
,
neuralgia
,
fibromyalgia
,
feeding and eating disorders
,
depressive disorder
,
diabetic neuropathies
,
fasting
,
microbiota
,
irritable bowel syndrome
,
attention deficit disorder with hyperactivity
,
frailty
,
chronic pain
,
cognition
,
psychological burnout
,
gastrointestinal microbiome
,
survivorship
,
psoriasis
,
anesthesia
,
paresis
,
analgesia
,
deglutition disorders
,
pancreatic intraductal neoplasms
,
polyostotic fibrous dysplasia
,
fibrous dysplasia of bone
,
esophageal neoplasms
,
alcoholic fatty liver
,
liver cirrhosis
,
liver transplantation
,
obstructive sleep apnea
,
sleep apnea syndromes
,
hereditary neoplastic syndromes
,
lactation
,
pseudopseudohypoparathyroidism
,
pseudohypoparathyroidism
,
rheumatoid arthritis
,
acquired immunodeficiency syndrome
,
hearing loss
,
connective tissue diseases
,
craniocerebral trauma
,
retinal diseases
,
mitochondrial diseases
,
eosinophilic esophagitis
,
sjogren's syndrome
,
dilated cardiomyopathy
,
intellectual disability
,
retinitis pigmentosa
,
deafness
,
hirschsprung disease
,
neurodevelopmental disorders
,
anorexia
,
body weight changes
,
anorexia nervosa
,
hiv
,
bone marrow diseases
,
bone fractures
,
sarcoidosis
,
breast feeding
,
menstruation
,
glucose tolerance test
,
immunosuppression therapy
,
subarachnoid hemorrhage
,
alcoholism
,
fetal growth retardation
,
dialysis
,
cardiorespiratory fitness
,
fetal macrosomia
,
testicular neoplasms
,
migraine disorders
,
parkinson disease
,
chronic obstructive pulmonary disease
,
arterial occlusive diseases
,
mood disorders
,
somatoform disorders
,
bone density
,
anovulation
,
hyperphagia
,
autoimmune polyendocrinopathies
,
eye diseases
,
keratoconus
,
oral pathology
,
toxemia
,
gonadal dysgenesis
,
parasomnias
,
thyroiditis
,
gender dysphoria
,
beta-thalassemia
,
psychotherapy
,
pregnancy-induced hypertension
,
cardiac surgical procedures
,
emergence delirium
,
lower urinary tract symptoms
,
autonomic nervous system diseases
,
radiation injuries
,
adrenalectomy
,
fertilization in vitro
,
motivation
,
diet therapy
,
ventricular dysfunction
,
asthma
,
physiological sexual dysfunction
,
nasopharyngeal carcinoma
,
nasopharyngeal neoplasms
,
and serous mucinous cystic neoplasms
,
myocardial infarction
,
sleep deprivation
,
hyperprolactinemia
,
ovarian reserve
,
disease susceptibility
,
mental health
,
inborn errors metabolism
,
lipodystrophy
,
nutritional status
,
bacterial vaginosis
,
multiple chronic conditions
,
self efficacy
,
post-acute covid-19 syndrome
,
hip osteoarthritis
,
professional burnout
,
ectopic pregnancy
,
premature menopause
,
metabolome
,
lymphatic metastasis
,
patient participation
,
essential hypertension
,
perimenopause
,
segmental mastectomy
,
motivational interviewing
,
hepatolenticular degeneration
,
autoimmune thyroiditis
,
rheumatic diseases
,
psychological well-being
,
metabolic brain diseases
,
local anesthesia
,
asthenia
,
agnosia
,
calcium metabolism disorders
,
neck pain
,
back pain
,
myocarditis
,
pelvic exenteration
,
traumatic stress disorders
,
lead poisoning
,
poisoning
,
congenital hyperinsulinism
,
nesidioblastosis
,
driving under the influence
,
enteral nutrition
,
metabolically benign obesity
,
postural orthostatic tachycardia syndrome
,
cardiac arrhythmias
,
ideal body weight
,
physiological phenomena
,
appetite regulation
,
minor planets
,
glucagonoma
,
birth weight
,
peutz-jeghers syndrome
,
carney complex
,
dermatofibrosarcoma
,
neurotoxicity syndromes
,
gestational weight gain
,
opioid-related disorders
,
endocrine surgical procedures
,
respiratory aspiration
,
thymus neoplasms
,
adrenarche
,
neuroblastoma
,
tetralogy of fallot
,
pulmonary atresia
,
pulmonary valve stenosis
,
macular degeneration
,
immunity
,
multiple trauma
,
transsexualism
,
vascular stiffness
,
torsades de pointes
,
thrombocytopenic purpura idiopathic
,
systemic lupus erythematosus
,
hiv seropositivity
,
systemic scleroderma
,
behcet syndrome
,
short bowel syndrome
,
cataract
,
retinal detachment
,
mucocutaneous lymph node syndrome
,
large-cell lymphoma anaplastic
,
leiomyosarcoma
,
shy-drager syndrome
,
marfan syndrome
,
muscular diseases
,
walker-warburg syndrome
,
osteomyelitis
,
multiple system atrophy
,
biliary liver cirrhosis
,
hemolytic-uremic syndrome
,
hemolysis
,
digeorge syndrome
,
lyme disease
,
muscle spasticity
,
myasthenia gravis
,
ataxia telangiectasia
,
multiple abnormalities
,
esophageal achalasia
,
beckwith-wiedemann syndrome
,
leukoencephalopathies
,
polyneuropathies
,
blindness
,
hereditary eye diseases
,
fragile x syndrome
,
meningitis
,
myoclonus
,
muscular atrophy
,
rectal fistula
,
telangiectasis
,
metachromatic leukodystrophy
,
intestinal pseudo-obstruction
,
eye abnormalities
,
hemophagocytic lymphohistiocytosis
,
neonatal myasthenia gravis
,
spinocerebellar degenerations
,
fanconi syndrome
,
sensorineural hearing loss
,
vitamin b 12 deficiency
,
frontotemporal dementia
,
williams syndrome
,
spinocerebellar ataxias
,
machado-joseph disease
,
oculocerebrorenal syndrome
,
friedreich ataxia
,
scheuermann disease
,
mucolipidoses
,
phenylketonurias
,
autosomal dominant optic atrophy
,
hypertrophy
,
cerebellar ataxia
,
wagr syndrome
,
dysarthria
,
cystinosis
,
x-linked bulbo-spinal atrophy
,
halitosis
,
idiopathic hypersomnia
,
disorders of excessive somnolence
,
hypophosphatasia
,
gastroenteritis
,
silver-russell syndrome
,
de lange syndrome
,
vitamin e deficiency
,
atypical hemolytic uremic syndrome
,
nerve degeneration
,
nijmegen breakage syndrome
,
alstrom syndrome
,
leigh disease
,
retinitis
,
glycogen storage disease
,
leber congenital amaurosis
,
aniridia
,
mannosidase deficiency diseases
,
osteochondrodysplasias
,
amnesia
,
meningocele
,
hyperargininemia
,
papilloma
,
biliary atresia
,
primary progressive aphasia
,
pick disease of the brain
,
undiagnosed diseases
,
kleine-levin syndrome
,
klippel-feil syndrome
,
frasier syndrome
,
denys-drash syndrome
,
wolf-hirschhorn syndrome
,
alagille syndrome
,
cockayne syndrome
,
viral meningitis
,
channelopathies
,
transient global amnesia
,
refsum disease
,
cauda equina syndrome
,
corneal opacity
,
hyperacusis
,
hereditary corneal dystrophies
,
nervous system lead poisoning adult
,
ectodermal dysplasia
,
pathologic nystagmus
,
apraxias
,
beta-mannosidosis
,
cogan syndrome
,
olivopontocerebellar atrophies
,
nonketotic hyperglycinemia
,
coffin-lowry syndrome
,
olivary degeneration
,
uniparental disomy
,
brachydactyly
,
cryotherapy
,
shwachman-diamond syndrome
,
lipomatosis
,
glycemic control
,
neurologic manifestations
,
cerebrovascular disorders
,
hemoglobinopathies
,
left ventricular hypertrophy
,
lipid metabolism disorders
,
sudden death cardiac
,
electrocardiography
,
atherosclerosis
,
familial combined hyperlipidemia
,
oxidative stress
,
organ transplantation
,
transplantation
,
musculoskeletal manipulations
,
exercise test
,
clinical deterioration
,
vocal cord paralysis
,
recurrent laryngeal nerve injuries
,
substance-related disorders
,
vision disorders
,
diverticular diseases
,
prostatic diseases
,
gout
,
hearing disorders
,
gastritis
,
diverticulum
,
trauma and stressor related disorders
,
hemochromatosis
,
hemosiderosis
,
hypoxia
,
nervous system diseases
,
bradycardia
,
artificial pacemaker
,
oropharyngeal neoplasms
,
alcohol drinking in college
,
keratitis
,
autoimmune hepatitis
,
neurogenic diabetes insipidus
,
nephrogenic diabetes insipidus
,
delusions
,
stress fractures
,
social adjustment
,
ventricular flutter
,
ventricular tachycardia
,
heart arrest
,
ventricular fibrillation
,
molecular typing
,
body image
,
venous thromboembolism
,
thromboembolism
,
survival analysis
,
conduct disorder
,
attention deficit and disruptive behavior disorders
,
oppositional defiant disorder
,
hemophilia a
,
obstructive lung diseases
,
psychophysiologic disorders
,
gynecomastia
,
acute kidney injury
,
postural balance
,
pharmacogenomic testing
,
dna damage
,
hypotension
,
intractable pain
,
acrodynia
,
humans
,
fetal development
,
urinary bladder neoplasms
,
ultrasonography
,
elasticity imaging techniques
,
dent disease
,
cryptorchidism
,
tobacco use
,
urinary incontinence
,
enuresis
,
thyroid dysgenesis
,
androgen-insensitivity syndrome
,
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rickets
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family relations
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coitus
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spinal stenosis
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Trinessa
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Thienopyridine
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Tqj230
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