Volanesorsen
Waylivra (volanesorsen) is an oligonucleotide pharmaceutical. Volanesorsen was first approved as Waylivra on 2019-05-03. It has been approved in Europe to treat hyperlipoproteinemia type i.
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Brand Name | Status | Last Update |
|---|---|---|
| acne free blackhead removing scrub 2 salicylic acid with charcoal | C200263 | 2024-06-19 |
| aha glycolic acid foam cleanser (sulfate-free)- 7.5 oz | unapproved drug other | 2024-10-21 |
| clear days ahead | OTC monograph final | 2023-01-24 |
| lactic acid free for sportswoman synergy | OTC monograph not final | 2017-01-01 |
| lactic acid free m synergy | OTC monograph not final | 2016-10-24 |
| oil free acne scrub | OTC monograph final | 2010-07-08 |
| peach slices 3 step acne starter kit | C200263 | 2024-08-14 |
| premasol - sulfite-free (amino acid) | ANDA | 2022-08-04 |
| walgreens oil-free acne wash | C200263 | 2024-06-03 |
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969 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 29 | — | — | 2 | 18 | 49 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 3 | 7 | 2 | 7 | 24 | 41 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 6 | 5 | 17 | 3 | 9 | 40 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 3 | 5 | 4 | 27 | 38 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 9 | 2 | 7 | 19 | 37 |
| Syndrome | D013577 | — | — | 4 | 9 | 6 | 1 | 8 | 27 |
| Insulin resistance | D007333 | HP_0000855 | — | 1 | 3 | — | 2 | 21 | 26 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 4 | 2 | 3 | 4 | 9 | 21 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 3 | 2 | 3 | 8 | 20 |
| Lymphoma | D008223 | — | C85.9 | 5 | 11 | 3 | 1 | 1 | 20 |
Show 141 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 8 | 11 | 4 | — | 3 | 25 |
| Infections | D007239 | EFO_0000544 | — | 2 | 3 | 9 | — | 7 | 20 |
| Colorectal neoplasms | D015179 | — | — | 3 | 10 | 6 | — | 2 | 19 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | 2 | 8 | — | 4 | 16 |
| Myelodysplastic syndromes | D009190 | — | D46 | 5 | 5 | 3 | — | 1 | 14 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 4 | 7 | 2 | — | 2 | 14 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 7 | 5 | — | 2 | 14 |
| Communicable diseases | D003141 | — | — | — | 2 | 6 | — | 6 | 13 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 5 | 1 | — | 1 | 11 |
| Preleukemia | D011289 | — | — | 4 | 4 | 3 | — | — | 11 |
Show 111 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | 1 | — | — | 5 | 7 |
| Hematologic neoplasms | D019337 | — | — | 2 | 5 | — | — | — | 6 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | 3 | — | — | — | 5 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | 3 | — | — | — | 5 |
| Anemia | D000740 | HP_0001903 | D64.9 | 1 | 3 | — | — | 1 | 5 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | — | — | 3 | 5 |
| Melanoma | D008545 | — | — | 2 | 3 | — | — | — | 5 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 2 | — | — | 2 | 5 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | 2 | — | — | 3 | 5 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 3 | 1 | — | — | — | 4 |
Show 97 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 4 | 5 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | — | — | — | 4 | 5 |
| Acute pain | D059787 | — | R52 | 1 | — | — | — | 3 | 4 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 3 | — | — | — | — | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 3 | — | — | — | — | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | 2 | 3 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | — | — | — | 1 | 3 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 2 | — | — | — | — | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Peptic ulcer | D010437 | HP_0004398 | K27 | 2 | — | — | — | — | 2 |
Show 63 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Phenylketonurias | D010661 | — | E70.0 | — | — | — | — | 7 | 7 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 6 | 6 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 5 | 5 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 4 | 4 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 3 | 3 |
| Micronutrients | D018977 | — | — | — | — | — | — | 3 | 3 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 3 | 3 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | — | 3 | 3 |
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 3 | 3 |
| Microbiota | D064307 | — | — | — | — | — | — | 3 | 3 |
Show 197 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Volanesorsen |
| INN | volanesorsen |
| Description | Volanesorsen, sold under the brand name Waylivra, is a triglyceride-reducing drug. It is a second-generation 2'-O-methoxyethyl (2'-MOE) chimeric antisense therapeutic oligonucleotide (ASO) that targets the messenger RNA for apolipoprotein C3 (apo-CIII).
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| Classification | Oligonucleotide |
| Drug class | antisense oligonucleotides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3544994 |
| ChEBI ID | — |
| PubChem CID | 122409770 |
| DrugBank | DB15067 |
| UNII ID | 2O4BE0K238 (ChemIDplus, GSRS) |
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Waylivra – Ionis Pharmaceuticals
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Safety
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26 adverse events reported
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