LEO Pharma - PharmaKB

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Company ReportsLEO Pharma

LEO Pharma

LEO Pharma A/S is a multinational Danish pharmaceutical company, founded in 1908, with a presence in about 100 countries. Its headquarters are in Ballerup, near Copenhagen The company is 100% integrated into a private foundation owned by the LEO Foundation. Leo Pharma develops and markets products for dermatology, bone remodeling thrombosis and coagulation. In 1945 it was the first producer of penicillin outside the US and UK.

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Therapeutic Areas:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Adbry	Tralokinumab	2021-12-27		Atopic dermatitis
Adtralza	Tralokinumab	2021-06-17		Atopic dermatitis
Desonate	Desonide	2006-10-20	2025-2027	Inflammation , Facial dermatoses , Foot dermatoses , Hand dermatoses , Scalp dermatoses , Leg dermatoses
Dovonex	Calcipotriene	1993-12-29	2026-2039	Psoriasis, Atopic dermatitis, Pruritus ani, Inflammation, Facial dermatoses, Seborrheic dermatitis, Foot dermatoses, Hand dermatoses, Scalp dermatoses, Leg dermatoses
Enstilar	Betamethasone, Calcipotriene	2015-10-16	2027-2039	Psoriasis, Atopic dermatitis, Pruritus ani, Inflammation, Facial dermatoses, Seborrheic dermatitis, Foot dermatoses, Hand dermatoses, Scalp dermatoses, Leg dermatoses, Mycoses, Oral candidiasis, Vulvovaginal candidiasis, Tinea pedis, Cutaneous candidiasis
Finacea	Azelaic acid	2002-12-24	2024-2029	Acne vulgaris, Rosacea
Innohep	Tinzaparin	2000-07-14		Venous thrombosis, Pulmonary embolism, Thromboembolism
Kyntheum	Brodalumab	2017-07-17		Psoriasis
Picato	Ingenol mebutate	2012-01-23	2026-2033	Actinic keratosis
Pindac	Pinacidil	1989-12-28		Hypertension
Protopic	Tacrolimus	2000-12-08	2024-2028	Atopic dermatitis, Kidney transplantation, Graft vs host disease, Liver transplantation, Graft rejection

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Clinical Trials

Therapeutic Areas:

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Classification:

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Approval:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

immune tolerance

,

islets of langerhans transplantation

,

,

,

venous thromboembolism

,

thromboembolism

,

peripheral blood stem cell transplantation

,

brain neoplasms

,

,

germ cell and embryonal neoplasms

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

,

invasive pulmonary aspergillosis

,

neuroepithelial neoplasms

,

basal cell carcinoma

,

,

merkel cell carcinoma

,

squamous cell neoplasms

,

basal cell neoplasms

,

therapeutic equivalency

,

epidermolysis bullosa dystrophica

,

,

respiratory syncytial virus infections

,

hypercholesterolemia

,

localized scleroderma

,

male genital diseases

,

urologic surgical procedures

,

,

alopecia areata

,

muscular dystrophies

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma marginal zone

,

myeloid leukemia chronic-phase

,

myeloid leukemia accelerated phase

,

aplastic anemia

,

,

,

waldenstrom macroglobulinemia

,

large-cell lymphoma immunoblastic

,

refractory anemia with excess of blasts

,

sezary syndrome

,

mycosis fungoides

,

t-cell lymphoma cutaneous

,

,

sickle cell anemia

,

b-cell lymphoma

,

t-cell lymphoma

,

hematologic diseases

,

bone marrow failure disorders

,

prolymphocytic leukemia

,

extranodal nk-t-cell lymphoma

,

large-cell lymphoma anaplastic

,

leukemia myeloid chronic atypical bcr-abl negative

,

lymphoproliferative disorders

,

hemoglobinopathies

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

polycythemia vera

,

hairy cell leukemia

,

essential thrombocythemia

,

lymphomatoid granulomatosis

,

interdigitating dendritic cell sarcoma

,

neutrophilic leukemia chronic

,

myelomonocytic leukemia acute

,

precancerous conditions

,

immunoblastic lymphadenopathy

,

adult t-cell leukemia-lymphoma

,

immune system diseases

,

monocytic leukemia acute

,

plasma cell leukemia

,

,

,

metabolic diseases

,

refractory anemia

,

kidney neoplasms

,

erythroblastic leukemia acute

,

t-cell lymphoma peripheral

,

plasmablastic lymphoma

,

,

primary immunodeficiency diseases

,

renal cell carcinoma

,

intraocular lymphoma

,

focal segmental glomerulosclerosis

,

megakaryoblastic leukemia acute

,

paroxysmal hemoglobinuria

,

large granular lymphocytic leukemia

,

t-cell leukemia

,

,

autoimmune diseases

,

,

systemic scleroderma

,

myeloid sarcoma

,

,

diamond-blackfan anemia

,

shwachman-diamond syndrome

,

bone marrow diseases

,

promyelocytic leukemia acute

,

,

macular degeneration

,

,

,

cord blood stem cell transplantation

,

,

homologous transplantation

,

,

primitive neuroectodermal tumors

,

neurofibrosarcoma

,

phenylketonurias

,

residual neoplasm

,

intestinal neoplasms

,

wiskott-aldrich syndrome

,

thrombocytopenic purpura idiopathic

,

hypereosinophilic syndrome

,

eosinophilic leukemia acute

,

pulmonary fibrosis

,

metabolic brain diseases

,

blastic plasmacytoid dendritic cell neoplasm

,

inborn errors metabolism

,

,

inborn genetic diseases

,

common variable immunodeficiency

,

autoimmune lymphoproliferative syndrome

,

dyskeratosis congenita

,

epidermolysis bullosa

,

,

paraproteinemias

,

diffuse scleroderma

,

breast neoplasms

,

hereditary hemorrhagic telangiectasia

,

,

,

geographic atrophy

,

patient compliance

,

duchenne muscular dystrophy

,

neoplasms by histologic type

,

b-cell leukemia

,

immunoproliferative disorders

,

connective tissue diseases

,

mesenchymal stem cell transplantation

,

acute kidney tubular necrosis

,

neuromuscular diseases

,

rhabdomyosarcoma

,

desmoplastic small round cell tumor

,

primitive neuroectodermal tumors peripheral

,

langerhans-cell histiocytosis

,

metabolic brain diseases inborn

,

,

severe combined immunodeficiency

,

prolymphocytic leukemia t-cell

,

,

prolymphocytic leukemia b-cell

,

autologous transplantation

,

chronic obstructive pulmonary disease

,

,

idiopathic pulmonary fibrosis

,

hermanski-pudlak syndrome

,

,

drug evaluation

,

,

alzheimer disease

,

cognitive dysfunction

,

multiple sclerosis

,

deficiency diseases

,

,

gata2 deficiency

,

mast-cell leukemia

,

,

reactive arthritis

,

,

opportunistic infections

,

,

hemophagocytic lymphohistiocytosis

,

,

,

acute liver failure

,

,

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

digeorge syndrome

,

,

hypoparathyroidism

,

acquired immunodeficiency syndrome

,

,

nerve sheath neoplasms

,

facial transplantation

,

,

facial injuries

,

dentofacial deformities

,

craniofacial abnormalities

,

,

,

ovarian neoplasms

,

gestational trophoblastic disease

,

testicular neoplasms

,

ovarian epithelial carcinoma

,

trophoblastic neoplasms

,

vascular diseases

,

hemoglobin sc disease

,

vulvar lichen sclerosus

,

lichen sclerosus et atrophicus

,

,

,

allergic rhinitis

,

,

,

,

kasabach-merritt syndrome

,

hemangioendothelioma

,

,

hemorrhagic cystitis

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

iga glomerulonephritis

,

peripheral nerve injuries

,

cutaneous lupus erythematosus

,

lymphatic diseases

,

hypochromic anemia

,

sideroblastic anemia

,

corneal neovascularization

,

pathologic neovascularization

,

eyelid neoplasms

,

,

respiratory aspiration

,

pseudomyxoma peritonei

,

non-small-cell lung carcinoma

,

,

,

vision disorders

,

rheumatic diseases

,

collagen diseases

,

neoplasms by site

,

disease attributes

,

pathologic processes

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

multiple myeloma

,

myeloproliferative disorders

,

,

non-hodgkin lymphoma

,

hematologic neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

myeloid leukemia

,

b-cell chronic lymphocytic leukemia

,

plasma cell neoplasms

,

primary myelofibrosis

,

follicular lymphoma

,

mantle-cell lymphoma

,

lymphoid leukemia

,

myelomonocytic leukemia chronic

,

myelodysplastic-myeloproliferative diseases

,

burkitt lymphoma

,

myelomonocytic leukemia juvenile

,

hematopoietic stem cell transplantation

,

healthy volunteers/patients

,

congenital abnormalities

,

biphenotypic leukemia acute

,

thrombocytopenia

,

,

myasthenia gravis

,

,

wounds and injuries

,

muscle weakness

,

neoplasm metastasis

,

,

,

bronchiolitis obliterans

,

pathologic complete response

,

,

,

,

,

,

,

amyotrophic lateral sclerosis

,

female infertility

,

transplantation immunology

,

host vs graft reaction

,

traumatic amputation

,

,

breast cancer lymphedema

,

surgical amputation

,

,

diabetic retinopathy

,

,

caregiver burden

,

carotid artery diseases

,

atherosclerosis

,

,

penetrating keratoplasty

,

,

,

motor neuron disease

,

male urologic surgical procedures

,

pigmentation disorders

,

,

,

induction chemotherapy

,

spontaneous remission

,

kidney transplantation

,

graft vs host disease

,

liver transplantation

,

,

renal insufficiency

,

graft rejection

,

immunosuppression therapy

,

chronic kidney failure

,

kidney diseases

,

atopic dermatitis

,

,

type 1 diabetes mellitus

,

,

lupus nephritis

,

psychology rejection

,

heart transplantation

,

bronchiolitis obliterans syndrome

,

diabetes mellitus

,

,

,

,

,

,

chronic renal insufficiency

,

membranous glomerulonephritis

,

nephrotic syndrome

,

,

lung transplantation

,

delayed graft function

,

allergic conjunctivitis

,

systemic lupus erythematosus

,

transplantation

,

,

,

,

communicable diseases

,

immunologic deficiency syndromes

,

rheumatoid arthritis

,

cytomegalovirus infections

,

keratoconjunctivitis

,

,

pharmacokinetics

,

beta-thalassemia

,

liver neoplasms

,

organ transplantation

,

stem cell transplantation

,

,

,

,

medication adherence

,

,

end stage liver disease

,

ulcerative colitis

,

,

oral lichen planus

,

interstitial lung diseases

,

reperfusion injury

,

hepatocellular carcinoma

,

liver cirrhosis

,

bone marrow transplantation

,

,

chronic hepatitis c

,

,

,

,

neurotoxicity syndromes

,

retinal diseases

,

drug-related side effects and adverse reactions

,

dermatomyositis

,

,

epstein-barr virus infections

,

dry eye syndromes

,

sjogren's syndrome

,

prostatic neoplasms

,

glomerulonephritis

,

,

herpesviridae infections

,

drug interactions

,

cardiovascular diseases

,

x-linked combined immunodeficiency diseases

,

pancreas transplantation

,

lipoid nephrosis

,

renal replacement therapy

,

type 2 diabetes mellitus

,

polyomavirus infections

,

,

,

keratoconjunctivitis sicca

,

pure red-cell aplasia

,

,

,

insulin resistance

,

,

,

,

coronary disease

,

left ventricular hypertrophy

,

primary graft dysfunction

,

,

diabetic nephropathies

,

metabolic syndrome

,

autoimmune hepatitis

,

contact dermatitis

,

seborrheic dermatitis

,

,

hereditary sensory and autonomic neuropathies

,

cytomegalovirus

,

muscle strength

,

,

arteriosclerosis

,

cross-sectional studies

,

immune reconstitution

,

chronic hepatitis b

,

chronic hepatitis

,

,

glomerular filtration rate

,

,

,

occupational dermatitis

,

,

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

kearns-sayre syndrome

,

,

,

allergic contact dermatitis

,

erectile dysfunction

,

,

,

acute kidney injury

,

heart disease risk factors

,

,

antibody formation

,

long qt syndrome

,

,

torsades de pointes

,

postoperative complications

,

coronary artery disease

,

,

corneal transplantation

,

,

inflammatory bowel diseases

,

intestinal diseases

,

hemolytic-uremic syndrome

,

thrombotic thrombocytopenic purpura

,

,

autosomal dominant polycystic kidney

,

,

secondary hyperparathyroidism

,

immunoglobulin light-chain amyloidosis

,

monoclonal gammopathy of undetermined significance

,

,

castration-resistant prostatic neoplasms

,

,

intralesional injections

,

food-drug interactions

,

paraneoplastic syndromes

,

bites and stings

,

,

,

genetic predisposition to disease

,

,

corneal diseases

,

hemochromatosis

,

,

penetrating eye injuries

,

dried blood spot testing

,

adaptive immunity

,

,

,

glucose intolerance

,

behcet syndrome

,

,

,

hyperspectral imaging

,

treatment adherence and compliance

,

area under curve

,

glucose metabolism disorders

,

disease progression

,

hospitalization

,

,

psoriatic arthritis

,

healthy volunteers/patients

,

,

seborrheic dermatitis

,

perioral dermatitis

,

,

healthy volunteers/patients

Ingenol mebutate

molluscum contagiosum

,

healthy volunteers/patients

,

,

,

basal cell carcinoma

,

basal cell neoplasms

,

condylomata acuminata

,

actinic keratosis

,

,

healthy volunteers/patients

,

atopic dermatitis

,

,

healthy volunteers/patients

,

alopecia areata

,

,

atopic dermatitis

,

,

,

discoid lupus erythematosus

,

systemic lupus erythematosus

,

,

Betamethasone dipropionate

healthy volunteers/patients

drug-related side effects and adverse reactions

,

healthy volunteers/patients

,

sleep initiation and maintenance disorders

,

,

lennox gastaut syndrome

,

,

treatment-resistant schizophrenia

,

myoclonic epilepsies

,

,

generalized epilepsy

,

epilepsia partialis continua

,

psychotic disorders

,

schizophrenia spectrum and other psychotic disorders

,

,

partial epilepsies

,

drug resistant epilepsy

,

status epilepticus

sickle cell anemia

,

brain neoplasms

,

,

,

retinal vein occlusion

,

,

myocardial infarction

,

hypersensitivity

,

,

transcatheter aortic valve replacement

,

percutaneous coronary intervention

,

macular degeneration

,

disseminated intravascular coagulation

,

venous thromboembolism

,

thromboembolism

,

,

pathologic processes

,

,

,

cerebrospinal fluid leak

,

,

breast neoplasms

,

segmental mastectomy

,

cardiopulmonary bypass

,

,

wounds and injuries

,

,

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