Tinzaparin sodium
Innohep (tinzaparin sodium) is an oligosaccharide pharmaceutical. Tinzaparin sodium was first approved as Innohep on 2000-07-14. It is used to treat pulmonary embolism, thromboembolism, and venous thrombosis in the USA. The pharmaceutical is active against antithrombin-III.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| respiratory tract diseases | D012140 |
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tinzaparin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INNOHEP | LEO Pharma | N-020484 DISCN | 2000-07-14 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| innohep | 2008-04-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| venous thrombosis | — | D020246 | I82.40 |
| pulmonary embolism | EFO_0003827 | D011655 | I26 |
| thromboembolism | — | D013923 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1655 | Injection, tinzaparin sodium, 1000 iu |
Clinical
Clinical Trials
792 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thromboembolism | D013923 | — | — | 6 | 37 | 69 | 35 | 61 | 198 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | 6 | 33 | 68 | 29 | 58 | 185 |
| Thrombosis | D013927 | — | — | 8 | 29 | 49 | 36 | 66 | 177 |
| Venous thrombosis | D020246 | — | I82.40 | 5 | 27 | 43 | 36 | 46 | 149 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 6 | 9 | 29 | 20 | 25 | 84 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 14 | 22 | 12 | 28 | 74 |
| Embolism | D004617 | — | — | 5 | 8 | 21 | 16 | 19 | 64 |
| Neoplasms | D009369 | — | C80 | 1 | 6 | 12 | 3 | 21 | 41 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 3 | 4 | 6 | 14 | 27 |
| Syndrome | D013577 | — | — | 4 | 7 | 5 | 4 | 5 | 23 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 2 | 4 | 2 | — | 5 | 12 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 3 | 1 | — | 4 | 9 |
| Replacement arthroplasty knee | D019645 | — | — | — | 5 | 3 | — | — | 8 |
| Colorectal neoplasms | D015179 | — | — | — | 2 | 4 | — | 2 | 8 |
| Lymphoma | D008223 | — | C85.9 | 1 | 3 | 1 | — | 3 | 7 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | 1 | 4 | — | 2 | 6 |
| Intracranial thrombosis | D020767 | — | — | — | 2 | 3 | — | 1 | 5 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | 1 | 2 | — | 2 | 5 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | 1 | — | 1 | 4 |
| Female genital neoplasms | D005833 | — | — | — | 1 | 2 | — | 1 | 4 |
Show 72 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | 2 | — | — | 1 | 11 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 4 | — | — | 1 | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 2 | — | — | 1 | 3 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | 3 | — | — | — | 3 |
| Pregnancy rate | D018873 | — | — | 1 | 1 | — | — | 1 | 3 |
| B-cell lymphoma | D016393 | — | — | 1 | 2 | — | — | — | 2 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | 1 | — | — | 1 | 2 |
| Staphylococcal infections | D013203 | — | A49.01 | — | 1 | — | — | 1 | 2 |
| Catheter-related infections | D055499 | — | — | — | 1 | — | — | 1 | 2 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | 1 | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | 1 | — | — | — | — | 1 |
| Balloon angioplasty coronary | D015906 | EFO_0003951 | — | 1 | — | — | — | — | 1 |
| Cesarean section | D002585 | — | — | 1 | — | — | — | — | 1 |
| Stillbirth | D050497 | — | P95 | 1 | — | — | — | — | 1 |
| Clear cell sarcoma | D018227 | — | — | 1 | — | — | — | — | 1 |
| Pseudotumor cerebri | D011559 | EFO_1001132 | G93.2 | 1 | — | — | — | — | 1 |
| Intracranial hypertension | D019586 | EFO_1000992 | — | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 7 | 7 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 6 | 6 |
| Ecchymosis | D004438 | — | — | — | — | — | — | 3 | 3 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 2 | 2 |
| Length of stay | D007902 | — | — | — | — | — | — | 2 | 2 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | — | — | — | 2 | 2 |
| Non-st elevated myocardial infarction | D000072658 | — | — | — | — | — | — | 2 | 2 |
| Artificial respiration | D012121 | — | — | — | — | — | — | 2 | 2 |
| Traumatic intracranial hemorrhage | D020198 | — | — | — | — | — | — | 2 | 2 |
| Blood coagulation | D001777 | GO_0007596 | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tinzaparin sodium |
| INN | tinzaparin sodium |
| Description | Tinzaparin is an antithrombotic drug in the heparin group. It is a low molecular weight heparin (LMWH) marketed as Innohep worldwide. It has been approved by the U.S. Food and Drug Administration (FDA) for once daily treatment and prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE).
|
| Classification | Peptide |
| Drug class | heparin derivatives and low molecular weight (or depolymerized) heparins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201414 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3S182ET3UA (ChemIDplus, GSRS) |
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
Black-box warning for: Innohep
Adverse Events
Top Adverse Reactions
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3,486 adverse events reported
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