Tradename | Company | Number | Date | Products |
---|---|---|---|---|
PROGRAF | Astellas Pharma | N-050708 RX | 1994-04-08 | 3 products, RLD, RS |
PROGRAF | Astellas Pharma | N-050709 RX | 1994-04-08 | 1 products, RLD, RS |
ASTAGRAF XL | Astellas Pharma | N-204096 RX | 2013-07-19 | 3 products, RLD, RS |
PROGRAF | Astellas Pharma | N-210115 RX | 2018-05-24 | 2 products, RLD, RS |
PROTOPIC | LEO Pharma | N-050777 RX | 2000-12-08 | 2 products, RLD, RS |
ENVARSUS XR | Veloxis Pharmaceuticals | N-206406 RX | 2015-07-10 | 3 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
hyaluronic acid sodium salt 1% / niacinamide 4% / tacrolimus 0.1% | unapproved drug other | 2019-04-24 |
hyaluronic acid sodium salt 1% / tacrolimus 0.1% / urea 20% | unapproved drug other | 2019-05-16 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
atopic dermatitis | EFO_0000274 | D003876 | L20 |
graft vs host disease | — | D006086 | D89.81 |
Expiration | Code | ||
---|---|---|---|
TACROLIMUS, PROGRAF, ASTELLAS | |||
2028-07-16 | ODE-360 | ||
2025-05-24 | ODE-269, ODE-294 | ||
TACROLIMUS, ASTAGRAF XL, ASTELLAS | |||
2025-05-24 | ODE* |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Tacrolimus, Envarsus Xr, Veloxis Pharms Inc | |||
8664239 | 2028-08-30 | U-1752, U-2677, U-2678 | |
8685998 | 2028-08-30 | DP | U-1752, U-2677, U-2678 |
9549918 | 2028-05-30 | DP | |
10166190 | 2028-05-30 | DP | |
10864199 | 2028-05-30 | U-2677, U-2678 | |
11110081 | 2028-05-30 | U-2678 | |
11123331 | 2028-05-30 | U-2677 | |
11419823 | 2028-05-30 | DP | |
7994214 | 2024-08-30 | DP | |
8486993 | 2024-08-30 | DP | U-1752 |
8586084 | 2024-08-30 | U-1752 | |
8591946 | 2024-08-30 | DP | |
8617599 | 2024-08-30 | DP | |
8623410 | 2024-08-30 | DP | |
8623411 | 2024-08-30 | U-1752 | |
8889185 | 2024-08-30 | U-1752 | |
8889186 | 2024-08-30 | U-1752 | |
9161907 | 2024-08-30 | DP | U-1752 |
9757362 | 2024-08-30 | DP | |
9763920 | 2024-08-30 | DP | |
10548880 | 2024-08-30 | U-2677, U-2678 | |
11077096 | 2024-08-30 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Kidney transplantation | D016030 | — | — | 11 | 42 | 33 | 91 | 32 | 198 |
Liver transplantation | D016031 | EFO_0010682 | — | 4 | 19 | 22 | 31 | 20 | 92 |
Graft vs host disease | D006086 | — | D89.81 | 19 | 59 | 8 | 3 | 5 | 79 |
Renal insufficiency | D051437 | HP_0000083 | N19 | 7 | 9 | 12 | 16 | 7 | 47 |
Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 9 | 12 | 8 | 20 | 6 | 46 |
Immunosuppression therapy | D007165 | — | — | 4 | 4 | 3 | 16 | 20 | 45 |
Atopic dermatitis | D003876 | EFO_0000274 | L20 | 2 | 6 | 14 | 16 | 5 | 43 |
Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 7 | 19 | 4 | 1 | 8 | 32 |
Lupus nephritis | D008181 | EFO_0005761 | — | 1 | 1 | 8 | 7 | 7 | 24 |
Kidney diseases | D007674 | EFO_0003086 | N08 | 4 | 6 | 4 | 5 | 2 | 18 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | — | D46 | 37 | 100 | 9 | — | 8 | 137 |
Myeloid leukemia acute | D015470 | — | C92.0 | 20 | 64 | 12 | — | 4 | 90 |
Leukemia | D007938 | — | C95 | 26 | 65 | 2 | — | 5 | 85 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 14 | 54 | 10 | — | 3 | 75 |
Lymphoma | D008223 | — | C85.9 | 17 | 55 | 2 | — | 7 | 74 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 12 | 41 | 4 | — | 1 | 52 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 9 | 40 | 6 | — | 1 | 50 |
Multiple myeloma | D009101 | — | C90.0 | 17 | 38 | 1 | — | 2 | 50 |
Hodgkin disease | D006689 | — | C81 | 11 | 35 | 4 | — | 1 | 45 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 7 | 32 | 2 | — | 1 | 40 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hematologic neoplasms | D019337 | — | — | 15 | 28 | — | — | 3 | 38 |
Plasma cell neoplasms | D054219 | — | — | 8 | 26 | — | — | 4 | 36 |
Aplastic anemia | D000741 | HP_0001915 | D61.9 | 2 | 15 | — | — | 1 | 18 |
Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 3 | 16 | — | — | — | 17 |
Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 4 | 14 | — | — | — | 16 |
Myeloid leukemia chronic-phase | D015466 | — | — | 4 | 13 | — | — | — | 15 |
Sickle cell anemia | D000755 | EFO_0000697 | D57 | 5 | 10 | — | — | — | 13 |
Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 1 | 13 | — | — | — | 13 |
Myeloid leukemia accelerated phase | D015465 | — | — | 1 | 11 | — | — | — | 11 |
Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 3 | 8 | — | — | — | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 17 | — | — | — | 4 | 21 |
Immune tolerance | D007108 | — | — | 1 | — | — | — | 2 | 3 |
Hepacivirus | D016174 | — | — | 1 | — | — | — | 1 | 2 |
Organ transplantation | D016377 | — | — | 2 | — | — | — | — | 2 |
Venous thromboembolism | D054556 | EFO_0004286 | I74 | 1 | — | — | — | — | 1 |
Peripheral blood stem cell transplantation | D036102 | — | — | 1 | — | — | — | — | 1 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Islets of langerhans transplantation | D016381 | — | — | — | — | — | — | 2 | 2 |
Heart disease risk factors | D000082742 | — | — | — | — | — | — | 1 | 1 |
Bone diseases | D001847 | — | M89.9 | — | — | — | — | 1 | 1 |
Death | D003643 | PATO_0001422 | — | — | — | — | — | 1 | 1 |
Antibody formation | D000917 | — | — | — | — | — | — | 1 | 1 |
Delirium | D003693 | — | R41.0 | — | — | — | — | 1 | 1 |
Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 1 | 1 |
Corneal transplantation | D016039 | EFO_0010676 | — | — | — | — | — | 1 | 1 |
Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | — | 1 | 1 |
Mucositis | D052016 | EFO_1001898 | — | — | — | — | — | 1 | 1 |
Drug common name | Tacrolimus |
INN | tacrolimus |
Description | Tacrolimus (anhydrous) is a macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It has a role as an immunosuppressive agent and a bacterial metabolite. |
Classification | Small molecule |
Drug class | immunosuppressives |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC.O |
PDB | — |
CAS-ID | 109581-93-3 |
RxCUI | — |
ChEMBL ID | CHEMBL3989887 |
ChEBI ID | — |
PubChem CID | 445643 |
DrugBank | DB00864 |
UNII ID | Y5L2157C4J (ChemIDplus, GSRS) |