Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ASTAGRAF XL | Astellas Pharma | N-204096 RX | 2013-07-19 | 3 products, RLD, RS |
PROGRAF | Astellas Pharma | N-050708 RX | 1994-04-08 | 3 products, RLD, RS |
PROGRAF | Astellas Pharma | N-050709 RX | 1994-04-08 | 1 products, RLD, RS |
PROGRAF | Astellas Pharma | N-210115 RX | 2018-05-24 | 2 products, RLD, RS |
PROTOPIC | LEO Pharma | N-050777 RX | 2000-12-08 | 2 products, RLD, RS |
ENVARSUS XR | Veloxis Pharmaceuticals | N-206406 RX | 2015-07-10 | 3 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
astagraf xl | New Drug Application | 2023-08-25 |
envarsus | New Drug Application | 2025-02-26 |
hyaluronic acid sodium salt 1% / niacinamide 4% / tacrolimus 0.1% | unapproved drug other | 2019-04-24 |
hyaluronic acid sodium salt 1% / tacrolimus 0.1% / urea 20% | unapproved drug other | 2019-05-16 |
niacinamide 4% / tacrolimus 0.03% | unapproved drug other | 2019-05-16 |
niacinamide 4% / tacrolimus 0.1% | unapproved drug other | 2019-04-24 |
prograf | New Drug Application | 2023-08-25 |
protopic | New Drug Application | 2010-05-24 |
tacrolimus | ANDA | 2025-03-05 |
tacrolimus 0.1% | unapproved drug other | 2019-05-09 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
atopic dermatitis | EFO_0000274 | D003876 | L20 |
graft vs host disease | — | D006086 | D89.81 |
Expiration | Code | ||
---|---|---|---|
TACROLIMUS, PROGRAF, ASTELLAS | |||
2028-07-16 | ODE-360 | ||
2025-05-24 | ODE-269, ODE-294 | ||
TACROLIMUS, ASTAGRAF XL, ASTELLAS | |||
2025-05-24 | ODE* |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Tacrolimus, Envarsus Xr, Veloxis Pharms Inc | |||
8664239 | 2028-08-30 | U-1752, U-2677, U-2678 | |
8685998 | 2028-08-30 | DP | U-1752, U-2677, U-2678 |
9549918 | 2028-05-30 | DP | |
10166190 | 2028-05-30 | DP | |
10864199 | 2028-05-30 | U-2677, U-2678 | |
11110081 | 2028-05-30 | U-2678 | |
11123331 | 2028-05-30 | U-2677 | |
11419823 | 2028-05-30 | DP | |
7994214 | 2024-08-30 | DP | |
8486993 | 2024-08-30 | DP | U-1752 |
8586084 | 2024-08-30 | U-1752 | |
8591946 | 2024-08-30 | DP | |
8617599 | 2024-08-30 | DP | |
8623410 | 2024-08-30 | DP | |
8623411 | 2024-08-30 | U-1752 | |
8889185 | 2024-08-30 | U-1752 | |
8889186 | 2024-08-30 | U-1752 | |
9161907 | 2024-08-30 | DP | U-1752 |
9757362 | 2024-08-30 | DP | |
9763920 | 2024-08-30 | DP | |
10548880 | 2024-08-30 | U-2677, U-2678 | |
11077096 | 2024-08-30 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Drug common name | Tacrolimus |
INN | tacrolimus |
Description | Tacrolimus (anhydrous) is a macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It has a role as an immunosuppressive agent and a bacterial metabolite. |
Classification | Small molecule |
Drug class | immunosuppressives |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC.O |
PDB | — |
CAS-ID | 109581-93-3 |
RxCUI | — |
ChEMBL ID | CHEMBL3989887 |
ChEBI ID | — |
PubChem CID | 445643 |
DrugBank | DB00864 |
UNII ID | Y5L2157C4J (ChemIDplus, GSRS) |