Siliq, Kyntheum(brodalumab)
Kyntheum, Siliq (brodalumab) is an antibody pharmaceutical. Brodalumab was first approved as Siliq on 2017-02-15. It is used to treat psoriasis in the USA. It has been approved in Europe to treat psoriasis.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Siliq
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Brodalumab
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Siliq | brodalumab | Bausch Health Companies | N-761032 RX | 2017-02-15 | 1 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| siliq | Biologic Licensing Application | 2024-11-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| psoriasis | EFO_0000676 | D011565 | L40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 4 | 3 | 10 | 10 | 12 | 39 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | 3 | 3 | 1 | 2 | 9 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | 1 | 3 | 1 | 3 | 8 |
| Skin diseases | D012871 | — | L00-L99 | — | — | — | 1 | 1 | 2 |
| Exfoliative dermatitis | D003873 | — | L26 | — | — | 1 | 1 | — | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | 1 | 2 |
| Papulosquamous skin diseases | D017444 | — | L40-L45 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | 1 | — | 1 | — | — | 2 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | 1 | — | 1 | — | — | 2 |
| Sclerosis | D012598 | — | — | 1 | — | 1 | — | — | 2 |
| Spondylarthritis | D025241 | — | — | — | 1 | 1 | — | — | 2 |
| Spondylitis | D013166 | — | M46.9 | — | 1 | 1 | — | — | 2 |
| Axial spondyloarthritis | D000089183 | — | — | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hidradenitis suppurativa | D017497 | — | L73.2 | 3 | 1 | — | — | 1 | 5 |
| Hidradenitis | D016575 | — | — | 3 | 1 | — | — | — | 4 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 3 | — | — | — | 3 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 2 | — | — | — | 3 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | 2 | — | — | — | 2 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | 1 | — | — | — | 1 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | — | 1 | — | — | — | 1 |
| Rheumatic diseases | D012216 | — | M79.0 | — | 1 | — | — | — | 1 |
| Joint diseases | D007592 | — | M12.9 | — | 1 | — | — | — | 1 |
| Musculoskeletal diseases | D009140 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | 1 | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | — | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | — | 2 | 2 |
| Dermatitis | D003872 | — | L30.9 | — | — | — | — | 1 | 1 |
| Eczema | D004485 | — | L30.9 | — | — | — | — | 1 | 1 |
| Pruritus | D011537 | — | L29 | — | — | — | — | 1 | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | — | — | — | — | 1 | 1 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | — | — | — | — | 1 | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | — | — | — | 1 | 1 |
| Chronic urticaria | D000080223 | — | L50.8 | — | — | — | — | 1 | 1 |
| Exanthema | D005076 | — | — | — | — | — | — | 1 | 1 |
| Urticaria | D014581 | EFO_0005531 | L50 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brodalumab |
| INN | brodalumab |
| Description | Brodalumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742996 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11776 |
| UNII ID | 6ZA31Y954Z (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
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Brodalumab – AstraZeneca
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,169 documents
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Safety
Black-box Warning
Black-box warning for: Siliq
Adverse Events
Top Adverse Reactions
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2,196 adverse events reported
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