Pinacidil
Pindac (pinacidil) is a small molecule pharmaceutical. Pinacidil was first approved as Pindac on 1989-12-28. It is used to treat hypertension in the USA. It is known to target ATP-sensitive inward rectifier potassium channel 11 and ATP-sensitive inward rectifier potassium channel 8.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pinacidil
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PINDAC | LEO Pharma | N-019456 DISCN | 1989-12-28 | 2 products |
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypertension | EFO_0000537 | D006973 | I10 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02D: Arteriolar smooth muscle, agents acting on
— C02DG: Guanine derivatives acting on arteriolar smooth muscle
— C02DG01: Pinacidil
— C02L: Antihypertensives and diuretics in combination
— C02LX: Other antihypertensives and diuretics in atc
— C02LX01: Pinacidil and diuretics
HCPCS
No data
Clinical
No data
Drug
General
| Drug common name | Pinacidil |
| INN | pinacidil |
| Description | 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine is a member of pyridines. |
| Classification | Small molecule |
| Drug class | vasodilators (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(N/C(=N\C#N)Nc1ccncc1)C(C)(C)C.O |
Identifiers
| PDB | — |
| CAS-ID | 60560-33-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200338 |
| ChEBI ID | 34923 |
| PubChem CID | 4826 |
| DrugBank | — |
| UNII ID | BB4UGO5K0D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNJ11
KCNJ11
KCNJ8
KCNJ8
Organism
Homo sapiens
Gene name
KCNJ11
Gene synonyms
NCBI Gene ID
Protein name
ATP-sensitive inward rectifier potassium channel 11
Protein synonyms
beta-cell inward rectifier subunit, IKATP, Inward rectifier K(+) channel Kir6.2, inwardly rectifing potassium channel subfamily J member 11, inwardly rectifying potassium channel KIR6.2, inwardly-rectifying potassium channel subfamily J member 11, potassium channel inwardly rectifing subfamily J member 11, Potassium channel, inwardly rectifying subfamily J member 11, potassium voltage-gated channel subfamily J member 11
Uniprot ID
Mouse ortholog
Kcnj11 (16514)
ATP-sensitive inward rectifier potassium channel 11 (Q9QX21)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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