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Therapeutic Areas:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Arikayce	Amikacin	2018-09-28	2024-2035	Respiratory tract infections , Urinary tract infections , Bacterial infections , Intraabdominal infections , Pseudomonas infections , Infectious skin diseases , Escherichia coli infections , Soft tissue infections , Surgical wound infection , Staphylococcal infections , Burns , Endocarditis , Central nervous system infections , Proteus infections , Infectious bone diseases , Acinetobacter infections , Klebsiella infections , Mycobacterium infections , Serratia infections
Iplex	Mecasermin rinfabate	2005-12-12		—

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

respiratory aspiration

,

,

,

nontuberculous mycobacteria

,

,

cystic fibrosis

,

,

nontuberculous mycobacterium infections

,

mycobacterium infections

,

persistent infection

,

mycobacterium avium-intracellulare infection

,

communicable diseases

,

pseudomonas infections

Mecasermin rinfabate

myotonic dystrophy

,

,

healthy volunteers/patients

,

renal insufficiency

,

,

hepatic insufficiency

,

,

cystic fibrosis

,

,

hidradenitis suppurativa

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

healthy volunteers/patients

,

stomach diseases

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

non-hodgkin lymphoma

,

,

b-cell lymphoma

,

phenylketonurias

,

,

,

carpal tunnel syndrome

,

autonomic nervous system diseases

,

,

,

primary dysautonomias

,

pancreas transplantation

,

,

,

brain neoplasms

,

hyperparathyroidism

,

,

,

,

insulin infusion systems

,

aortic aneurysm

,

pregnancy-induced hypertension

,

,

multiple myeloma

,

nesidioblastosis

,

out-of-hospital cardiac arrest

,

gastric emptying

,

,

,

intraoperative complications

,

postoperative cognitive complications

,

uterine cervical neoplasms

,

stem cell transplantation

,

,

heart valve diseases

,

intracranial aneurysm

,

plasma cell neoplasms

,

gastrointestinal endoscopy

,

physiological phenomena

,

urogenital neoplasms

,

female genital neoplasms

,

thoracic neoplasms

,

,

brain stem neoplasms

,

,

lecithin cholesterol acyltransferase deficiency

,

mucopolysaccharidosis ii

,

,

open-angle glaucoma

,

uveal neoplasms

,

,

kallmann syndrome

,

,

germ cell and embryonal neoplasms

,

,

alpha 1-antitrypsin deficiency

,

intradermal injections

,

behcet syndrome

,

,

retinal vasculitis

,

,

graft pancreatitis

,

renal cell carcinoma

,

keratoconjunctivitis sicca

,

yang deficiency

,

taste disorders

,

,

vasoconstriction

,

loss of function mutation

,

,

spinal cord injuries

,

hyperandrogenism

,

feeding behavior

,

,

endometrial neoplasms

,

,

parkinson disease

,

nutritional and metabolic diseases

,

muscular atrophy

,

lipid metabolism disorders

,

hepatocellular carcinoma

,

liver neoplasms

,

unconsciousness

,

mucopolysaccharidoses

,

chronic pancreatitis

,

,

,

ovarian neoplasms

,

,

multiple sclerosis

,

energy metabolism

,

,

neoplasm metastasis

,

exocrine pancreatic insufficiency

,

duchenne muscular dystrophy

,

latent autoimmune diabetes in adults

,

cognition disorders

,

,

,

,

alcohol drinking

,

,

squamous cell carcinoma of head and neck

,

pulmonary arterial hypertension

,

,

triple negative breast neoplasms

,

neurocognitive disorders

,

mucopolysaccharidosis i

,

,

congenital adrenal hyperplasia

,

carcinoid tumor

,

rectal neoplasms

,

head and neck neoplasms

,

,

hyperlactatemia

,

congenital hyperinsulinism

,

emergence delirium

,

islets of langerhans transplantation

,

wolfram syndrome

,

,

,

kidney neoplasms

,

,

immunologic deficiency syndromes

,

ovarian epithelial carcinoma

,

pulmonary hypertension

,

hyperpigmentation

,

artificial pancreas

,

retinopathy of prematurity

,

,

systemic lupus erythematosus

,

,

,

,

cerebrovascular disorders

,

acanthosis nigricans

,

cutaneous leishmaniasis

,

percutaneous coronary intervention

,

respiratory distress syndrome

,

atrial fibrillation

,

,

rhabdomyosarcoma

,

,

,

myelodysplastic syndromes

,

hypoparathyroidism

,

,

thymus neoplasms

,

femoral fractures

,

,

multiple system atrophy

,

post-traumatic stress disorders

,

autistic disorder

,

beta-thalassemia

,

smoking cessation

,

mucopolysaccharidosis iii

,

cardiopulmonary bypass

,

graft rejection

,

bronchopulmonary dysplasia

,

hemoglobinopathies

,

relapsing-remitting multiple sclerosis

,

,

noonan syndrome

,

,

myotonic dystrophy

,

hodgkin disease

,

aplastic anemia

,

pituitary neoplasms

,

,

,

,

laryngeal diseases

,

alveolar rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

,

pure autonomic failure

,

,

immunosenescence

,

microsatellite instability

,

myelomonocytic leukemia chronic

,

,

refractory anemia with excess of blasts

,

refractory anemia

,

fragile x syndrome

,

familial primary pulmonary hypertension

,

cutaneous malignant melanoma

,

sexual infantilism

,

,

,

,

,

small cell lung carcinoma

,

severe combined immunodeficiency

,

x-linked combined immunodeficiency diseases

,

pick disease of the brain

,

psychotic affective disorders

,

,

cerebral intraventricular hemorrhage

,

aids dementia complex

,

chronic progressive multiple sclerosis

,

,

,

chronic limb-threatening ischemia

,

potassium deficiency

,

,

,

tobacco use disorder

,

alcohol-related disorders

,

22q11 deletion syndrome

,

enterovirus infections

,

,

regional blood flow

,

islet cell carcinoma

,

acute lung injury

,

newborn respiratory distress syndrome

,

delayed puberty

,

,

desmoplastic small round cell tumor

,

primitive neuroectodermal tumors peripheral

,

neuroectodermal tumors

,

,

tardive dyskinesia

,

,

patient compliance

,

executive function

,

polyneuropathies

,

physical endurance

,

,

cigarette smoking

,

tibial fractures

,

papillomaviridae

,

thrombocytopenia

,

,

paroxysmal hemoglobinuria

,

pure red-cell aplasia

,

bone marrow failure disorders

,

,

endometrioid carcinoma

,

hereditary sensory and autonomic neuropathies

,

genital diseases

,

,

,

,

sickle cell anemia

,

gingival hyperplasia

,

breast neoplasms

,

alzheimer disease

,

,

diabetes complications

,

prostatic neoplasms

,

,

,

autoimmune diseases

,

cardiac surgical procedures

,

,

chronic obstructive pulmonary disease

,

,

,

,

,

pregnancy complications

,

,

postoperative complications

,

non-small-cell lung carcinoma

,

rheumatoid arthritis

,

nutrition disorders

,

pancreatic neoplasms

,

graves ophthalmopathy

,

,

female infertility

,

adrenal insufficiency

,

chronic periodontitis

,

microvascular angina

,

immune system diseases

,

,

anorexia nervosa

,

mental disorders

,

,

,

growth disorders

,

,

,

menstruation disturbances

,

hypopituitarism

,

,

body weight changes

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

periodontal diseases

,

addison disease

,

,

congenital generalized lipodystrophy

,

gestational weight gain

,

,

familial partial lipodystrophy

,

,

diastolic heart failure

,

severe acute respiratory syndrome

,

,

pathologic processes

,

memory disorders

,

chronic disease

,

,

malabsorption syndromes

,

adrenocortical carcinoma

,

,

primitive neuroectodermal tumors

,

,

lymphoid leukemia

,

,

st elevation myocardial infarction

,

vascular dementia

,

androgen-insensitivity syndrome

,

pharmacokinetics

,

periodontal pocket

,

,

colonic diseases

,

,

,

olfaction disorders

,

hyperthyroidism

,

temporomandibular joint disorders

,

,

,

,

,

islet cell adenoma

,

,

,

systemic scleroderma

,

raynaud disease

,

diffuse scleroderma

,

spinal anesthesia

,

cesarean section

,

puerperal disorders

,

health education

,

squamous cell carcinoma

,

squamous cell neoplasms

,

adenosquamous carcinoma

,

large cell carcinoma

,

,

systolic heart failure

,

severe acute respiratory syndrome-related coronavirus

,

,

respiratory tract diseases

,

,

condylomata acuminata

,

iga glomerulonephritis

,

alveolar bone loss

,

retinal vein occlusion

,

neovascular glaucoma

,

,

,

reperfusion injury

,

parenteral nutrition

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

pharmacological phenomena

,

pancreatic fistula

,

,

,

corneal diseases

,

invasive hydatidiform mole

,

sjogren's syndrome

,

stem cell research

,

,

,

diabetes mellitus

,

type 2 diabetes mellitus

,

type 1 diabetes mellitus

,

insulin resistance

,

,

metabolic syndrome

,

,

,

healthy volunteers/patients

,

,

prediabetic state

,

,

glucose intolerance

,

polycystic ovary syndrome

,

gestational diabetes

,

hypersensitivity

,

,

non-alcoholic fatty liver disease

,

cardiovascular diseases

,

,

,

metabolic diseases

,

glucose metabolism disorders

,

,

,

,

,

cognitive dysfunction

,

pediatric obesity

,

hyperinsulinism

,

critical illness

,

kidney diseases

,

coronary artery disease

,

endocrine system diseases

,

vitamin d deficiency

,

,

,

atherosclerosis

,

,

,

abdominal obesity

,

cystic fibrosis

,

pregnancy in diabetics

,

diabetic nephropathies

,

,

diabetic ketoacidosis

,

sedentary behavior

,

,

,

chronic kidney failure

,

coronary disease

,

chronic renal insufficiency

,

,

obstructive sleep apnea

,

myocardial ischemia

,

sleep apnea syndromes

,

hypercholesterolemia

,

,

,

,

,

hyperlipidemias

,

,

,

hypertriglyceridemia

,

bariatric surgery

,

,

,

wounds and injuries

,

,

myocardial infarction

,

chronic hepatitis c

,

,

pituitary dwarfism

,

,

,

,

renal insufficiency

,

,

,

,

mitochondrial diseases

,

,

diabetic retinopathy

,

diabetic neuropathies

,

premature birth

,

bipolar disorder

,

,

,

oxidative stress

,

heart disease risk factors

,

liver cirrhosis

,

depressive disorder

,

drug delivery systems

,

,

glycemic control

,

major depressive disorder

,

insulin secretion

,

,

,

retinal diseases

,

acquired immunodeficiency syndrome

,

psychotic disorders

,

,

colorectal neoplasms

,

kidney transplantation

,

colonic neoplasms

,

peripheral arterial disease

,

,

high-risk pregnancy

,

,

acute kidney injury

,

respiratory aspiration

,

liver transplantation

,

,

sleep initiation and maintenance disorders

,

vascular stiffness

,

,

vascular diseases

,

,

ischemic stroke

,

,

,

dry eye syndromes

,

essential hypertension

,

prehypertension

,

disease progression

,

,

hyperlipoproteinemias

,

lipoatrophic diabetes mellitus

,

peripheral vascular diseases

,

cardiomyopathies

,

,

acute coronary syndrome

,

coronary artery bypass

,

traumatic brain injuries

,

,

,

,

peripheral nervous system diseases

,

,

neuroendocrine tumors

,

thyroid diseases

,

,

,

autism spectrum disorder

,

,

,

,

obstructive lung diseases

,

,

,

,

,

ventricular dysfunction

,

pituitary acth hypersecretion

,

chronic hepatitis

,

,

,

failure to thrive

,

,

atopic dermatitis

,

,

,

,

alopecia areata

,

pancreatic diseases

,

left ventricular dysfunction

,

,

respiratory insufficiency

,

erectile dysfunction

,

coronavirus infections

,

gastrointestinal neoplasms

,

coronary restenosis

,

,

arteriosclerosis

,

,

hospitalization

,

inferior wall myocardial infarction

,

chronic hepatitis b

,

postoperative pain

,

hiv-associated lipodystrophy syndrome

,

,

,

,

,

,

,

subarachnoid hemorrhage

,

drug-related side effects and adverse reactions

,

cerebral infarction

,

,

clostridium botulinum type a

,

gonadal disorders

,

gonadal dysgenesis

,

prader-willi syndrome

,

hyperglycemic hyperosmolar nonketotic coma

,

peritoneal dialysis

,

,

carotid stenosis

,

arterial occlusive diseases

,

intermittent claudication

,

,

pervasive child development disorders

,

,

,

environmental biomarkers

,

,

,

unstable angina

,

male infertility

,

attention deficit disorder with hyperactivity

,

attention deficit and disruptive behavior disorders

,

oppositional defiant disorder

,

,

ataxia telangiectasia

,

,

mesial movement of teeth

,

,

acth-secreting pituitary adenoma

,

,

psychological sexual dysfunctions

,

intracranial hemorrhages

,

angina pectoris

,

,

myocardial revascularization

,

,

water-electrolyte imbalance

,

right ventricular dysfunction

,

patient preference

,

blood glucose self-monitoring

,

communicable diseases

,

,

feeding and eating disorders

,

,

body composition

,

,

satiety response

,

surgical wound infection

,

lipid metabolism

,

gastrointestinal microbiome

,

intermittent fasting

,

sleep deprivation

,

adolescent development

,

anxiety disorders

,

congenital abnormalities

,

,

patient satisfaction

,

,

medication adherence

,

,

injection site reaction

,

fetal growth retardation

,

iron metabolism disorders

,

cushing syndrome

,

,

,

,

,

cardiac arrhythmias

,

alcoholic fatty liver

,

appetite regulation

,

fetal macrosomia

,

sleep wake disorders

,

,

patient participation

,

knee osteoarthritis

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

microcirculation

,

metabolically benign obesity

,

diabetes insipidus

,

dumping syndrome

,

stomach neoplasms

,

aortic valve stenosis

,

circadian rhythm sleep disorders

,

,

noncommunicable diseases

,

,

,

therapeutic equivalency

,

,

dilated cardiomyopathy

,

cerebrovascular circulation

,

attitudes health knowledge practice

,

pregnancy in obesity

,

carbohydrate metabolism

,

,

exercise therapy

,

,

cardiometabolic risk factors

,

atrophic muscular disorders

,

glucose tolerance test

,

psychological stress

,

appetitive behavior

,

menstrual cycle

,

nutrition therapy

,

gender dysphoria

,

caloric restriction

,

patient reported outcome measures

,

,

,

orthostatic hypotension

,

pituitary diseases

,

nerve degeneration

,

diabetic cardiomyopathies

,

endoplasmic reticulum stress

,

,

,

,

esophageal neoplasms

,

hypertrophic cicatrix

,

high-intensity interval training

,

,

hip osteoarthritis

,

,

,

hematopoietic stem cell transplantation

,

child development

,

magnetic resonance imaging

,

transcranial direct current stimulation

,

,

,

elective surgical procedures

,

infectious encephalitis

,

hypertrophic cardiomyopathy

,

,

iron-deficiency anemia

,

iron deficiencies

,

,

behavioral symptoms

,

,

premature obstetric labor

,

addictive behavior

,

left ventricular hypertrophy

,

habitual abortion

,

,

body fat distribution

,

pathologic dilatation

,

hyperprolactinemia

,

myofascial pain syndromes

,

respiratory tract infections

,

klinefelter syndrome

,

non-hodgkin lymphoma

,

,

abdominal aortic aneurysm

,

hyperaldosteronism

,

nutritional status

,

epidermolysis bullosa

,

epidermolysis bullosa dystrophica

,

,

post-acute covid-19 syndrome

,

,

maternal-fetal relations

,

resistance training

,

,

,

carbohydrate loading diet

,

,

mitochondrial myopathies

,

,

genetic polymorphism

,

,

,

cardiorespiratory fitness

,

food diet and nutrition

,

,

,

,

dystonic disorders

,

acute cholecystitis

,

,

acalculous cholecystitis

,

urinary bladder neoplasms

,

shoulder injuries

,

,

,

postpartum depression

,

in vitro oocyte maturation techniques

,

hematologic diseases

,

perioperative period

,

body-weight trajectory

,

,

pancreatic intraductal neoplasms

,

polyostotic fibrous dysplasia

,

fibrous dysplasia of bone

,

gastrointestinal diseases

,

digestive system diseases

,

dietary proteins

,

newborn infant diseases

,

,

,

patient discharge

,

,

truncal vagotomy

,

,

,

multiple acyl coenzyme a dehydrogenase deficiency

,

pathologic constriction

,

glomerular filtration rate

,

renal circulation

,

renal plasma flow

,

adolescent behavior

,

spinal dysraphism

,

neuromuscular diseases

,

,

wiskott-aldrich syndrome

,

acupuncture therapy

,

pulmonary fibrosis

,

empty sella syndrome

,

congenital microtia

,

periapical periodontitis

,

corneal perforation

,

subcutaneous injections

,

,

osteoporotic fractures

,

long qt syndrome

,

romano-ward syndrome

,

compulsive behavior

,

peripheral nerve injuries

,

mandibular nerve injuries

,

,

,

facial paralysis

,

,

inappropriate prescribing

,

deprescriptions

,

,

shy-drager syndrome

,

,

central serous chorioretinopathy

,

portal hypertension

,

,

,

marijuana abuse

,

,

cardiovascular surgical procedures

,

testicular neoplasms

,

,

healthy lifestyle

,

postprandial period

,

protein deficiency

,

cell proliferation

,

ectopic pregnancy

,

muscle spasticity

,

macular degeneration

,

,

,

,

,

,

intestinal diseases

,

,

solanum tuberosum

,

resistant starch

,

muscle weakness

,

,

predictive value of tests

,

alpha-thalassemia

,

,

restless legs syndrome

,

psychomotor agitation

,

common variable immunodeficiency

,

endomyocardial fibrosis

,

autoimmune thyroiditis

,

,

hashimoto disease

,

,

multiple trauma

,

hemorrhagic shock

,

wound infection

,

,

,

,

,

dietary supplements

,

obstetric labor

,

,

oral lichen planus

,

,

,

diffuse idiopathic skeletal hyperostosis

,

,

,

digestive system surgical procedures

,

,

attitude to health

,

inflammatory bowel diseases

,

nerve compression syndromes

,

charcot-marie-tooth disease

,

hereditary sensory and motor neuropathy

,

overactive urinary bladder

,

,

spontaneous abortion

,

,

laparoscopic cholecystectomy

,

,

metabolic brain diseases

,

replacement arthroplasty knee

,

,

,

premature cardiac complexes

,

cardiovascular diagnostic techniques

,

,

circadian rhythm

,

,

basal metabolism

,

parkinsonian disorders

,

synucleinopathies

,

,

weights and measures

,

physical fitness

,

fallopian tube diseases

,

,

muscular dystrophies

,

dental prosthesis

,

,

,

capsule opacification

,

adenomatous polyps

,

immediate hypersensitivity

,

postmenopausal osteoporosis

,

stress fractures

,

physiological stress

,

acute-phase reaction

,

cross infection

,

transcatheter aortic valve replacement

,

,

,

exercise tolerance

,

atherosclerotic plaque

,

fetal development

,

,

,

hyperphosphatemia

,

adrenal cortex neoplasms

,

adrenocortical adenoma

,

rectal diseases

,

lactose intolerance

,

,

,

,

diabetic angiopathies

,

,

,

,

langerhans-cell histiocytosis

,

,

artificial respiration

,

systemic inflammatory response syndrome

,

cocaine-related disorders

,

ventilator-associated pneumonia

,

congenital heart defects

,

breast cancer lymphedema

,

,

,

schizophrenia spectrum and other psychotic disorders

,

genetic variation

,

turner syndrome

,

bardet-biedl syndrome

,

laurence-moon syndrome

,

,

werner syndrome

,

adrenocortical hyperfunction

,

persistent infection

,

skin manifestations

,

emotional eating

,

thrombelastography

,

psychological dependency

,

palliative care

,

,

,

,

,

hematologic neoplasms

,

spinal diseases

,

epidermolysis bullosa simplex

,

disorders of sex development

,

junctional epidermolysis bullosa

,

wasting syndrome

,

,

endoscopic retrograde cholangiopancreatography

,

,

stomach diseases

,

pneumoperitoneum

,

autoimmune polyendocrinopathies

,

obstetric labor complications

,

recreational drug use

,

hypopigmentation

,

lens subluxation

,

marfan syndrome

,

blood coagulation disorders

,

blood platelet disorders

,

hemostatic disorders

,

coagulation protein disorders

,

b-cell lymphoma

,

,

,

thromboembolism

,

refeeding syndrome

,

child nutrition disorders

,

severe acute malnutrition

,

local anesthesia

,

spinal cord stimulation

,

,

somatoform disorders

,

,

,

urologic diseases

,

health behavior

,

hypoalphalipoproteinemias

,

food preferences

,

,

,

sensorineural hearing loss

,

gingival recession

,

blood transfusion

,

,

muscle strength

,

mitochondrial dynamics

,

sentinel lymph node biopsy

,

orthopedic procedures

,

perioperative care

,

artificial intelligence

,

,

health status indicators

,

positron-emission tomography

,

,

systolic murmurs

,

liver regeneration

,

primary ovarian insufficiency

,

premature menopause

,

,

,

motivational interviewing

,

,

,

,

leriche syndrome

,

,

,

,

brain hypoxia-ischemia

,

striae distensae

,

,

,

metabolic bone diseases

,

musculoskeletal diseases

,

blood flow velocity

,

blood flow restriction therapy

,

thyroid neoplasms

,

gallbladder neoplasms

,

,

,

uterine cervical incompetence

,

,

psychological distress

,

psychological resilience

,

,

precancerous conditions

,

intraductal carcinoma noninfiltrating

,

,

torsades de pointes

,

,

,

,

migraine disorders

,

treatment adherence and compliance

,

neurodegenerative diseases

,

taste perception

,

cognitive behavioral therapy

,

,

sexual behavior

,

pain management

,

postpartum period

,

ectopic acth syndrome

,

fecal microbiota transplantation

,

,

chronobiology disorders

,

non-small-cell lung carcinoma

,

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

squamous cell carcinoma

,

squamous cell neoplasms

,

adenosquamous carcinoma

,

large cell carcinoma

,

cardiovascular diseases

,

atherosclerosis

,

vascular diseases

,

diabetes mellitus

,

type 2 diabetes mellitus

,

type 1 diabetes mellitus

,

insulin resistance

,

,

metabolic syndrome

,

,

coronary artery bypass

,

unstable angina

,

myocardial revascularization

,

,

prediabetic state

,

,

hypersensitivity

,

glucose intolerance

,

,

,

pituitary dwarfism

,

left ventricular hypertrophy

,

left ventricular dysfunction

,

diabetic angiopathies

,

diabetic nephropathies

,

kidney diseases

,

diabetes complications

,

retinal diseases

,

diabetic neuropathies

,

diabetic retinopathy

,

psychotic disorders

,

bipolar disorder

,

hyperlipidemias

,

hematologic diseases

,

,

t-cell lymphoma

,

t-cell lymphoma peripheral

healthy volunteers/patients

Fluoroquinolone

healthy volunteers/patients

,

kidney diseases

,

retinal diseases

,

,

insulin resistance

,

,

,

urinary tract infections

,

,

respiratory tract infections

,

,

bacterial infections

,

,

chronic bronchitis

,

respiratory tract diseases

,

infectious skin diseases

,

bacterial skin diseases

,

bacterial pneumonia

,

community-acquired pneumonia

,

,

,

bronchial diseases

,

urologic diseases

,

,

,

maxillary sinusitis

,

,

,

healthcare-associated pneumonia

,

congenital abnormalities

,

nervous system diseases

,

hereditary congenital and neonatal diseases and abnormalities

,

neural tube defects

,

nervous system malformations

,

spinal dysraphism

,

neurogenic urinary bladder

,

,

paranasal sinus diseases

,

,

,

,

,

,

,

critical illness

,

,

retinal detachment

,

aortic dissection

,

dissociative disorders

,

musculoskeletal diseases

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