Brensocatib
Brensocatib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against dipeptidyl peptidase 1.
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Commercial
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | — | 2 | 1 | — | 1 | 4 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | 1 | 1 | — | 1 | 3 |
| Covid-19 | D000086382 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | — | — | — | 1 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | — | — | — | 1 |
| Nasal polyps | D009298 | HP_0100582 | J33 | — | 1 | — | — | — | 1 |
| Polyps | D011127 | EFO_0000662 | — | — | 1 | — | — | — | 1 |
| Rhinosinusitis | D000096825 | — | — | — | 1 | — | — | — | 1 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | — | 1 | — | — | — | 1 |
| Hidradenitis | D016575 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brensocatib |
| INN | brensocatib |
| Description | Brensocatib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against dipeptidyl peptidase 1. |
| Classification | Small molecule |
| Drug class | cathespin inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)cc3)cc21 |
Identifiers
| PDB | — |
| CAS-ID | 1802148-05-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3900409 |
| ChEBI ID | — |
| PubChem CID | 118253852 |
| DrugBank | DB15638 |
| UNII ID | 25CG88L0BB (ChemIDplus, GSRS) |
Target
Agency Approved
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Trends
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Safety
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Adverse Events
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