Brand Name | Status | Last Update |
---|---|---|
herceptin hylecta | Biologic Licensing Application | 2019-05-13 |
phesgo | Biologic Licensing Application | 2020-06-29 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
breast neoplasms | EFO_0003869 | D001943 | C50 |
gastrointestinal neoplasms | — | D005770 | C26.9 |
Expiration | Code | ||
---|---|---|---|
trastuzumab, Herceptin, Genentech, Inc. | |||
2117-10-20 | Orphan excl. |
Code | Description |
---|---|
J9316 | Injection, pertuzumab, trastuzumab, and hyaluronidase-zzxf, per 10 mg |
J9354 | Injection, ado-trastuzumab emtansine, 1 mg |
J9355 | Injection, trastuzumab, excludes biosimilar, 10 mg |
J9356 | Injection, trastuzumab, 10 mg and hyaluronidase-oysk |
J9358 | Injection, fam-trastuzumab deruxtecan-nxki, 1 mg |
Q5112 | Injection, trastuzumab-dttb, biosimilar, (ontruzant), 10 mg |
Q5113 | Injection, trastuzumab-pkrb, biosimilar, (herzuma), 10 mg |
Q5114 | Injection, trastuzumab-dkst, biosimilar, (ogivri), 10 mg |
Q5116 | Injection, trastuzumab-qyyp, biosimilar, (trazimera), 10 mg |
Q5117 | Injection, trastuzumab-anns, biosimilar, (kanjinti), 10 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 212 | 493 | 161 | 15 | 114 | 896 |
Neoplasms | D009369 | — | C80 | 51 | 42 | 6 | 2 | 15 | 105 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 20 | 47 | 12 | 1 | 11 | 80 |
Male breast neoplasms | D018567 | — | — | 11 | 17 | 2 | 1 | 1 | 28 |
Cardiotoxicity | D066126 | EFO_1001482 | — | 1 | 3 | 3 | 1 | 12 | 20 |
Heart failure | D006333 | HP_0001635 | I50 | 3 | 4 | — | 1 | 3 | 10 |
Breast diseases | D001941 | — | N60-N65 | 1 | 5 | 2 | 1 | 1 | 8 |
Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | — | — | 1 | 1 | 3 |
Second primary neoplasms | D016609 | — | — | — | — | — | 1 | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colorectal neoplasms | D015179 | — | — | 9 | 21 | 4 | — | 2 | 30 |
Non-small-cell lung carcinoma | D002289 | — | — | 11 | 18 | 1 | — | 2 | 28 |
Adenocarcinoma | D000230 | — | — | 5 | 21 | 3 | — | 4 | 27 |
Esophageal neoplasms | D004938 | — | C15 | 8 | 12 | 2 | — | 1 | 20 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | 7 | 16 | 1 | — | — | 20 |
Triple negative breast neoplasms | D064726 | — | — | 8 | 14 | 1 | — | — | 19 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 6 | 9 | 2 | — | 3 | 18 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 10 | 10 | 1 | — | 1 | 18 |
Inflammatory breast neoplasms | D058922 | — | — | 3 | 6 | 4 | — | — | 11 |
Invasive hydatidiform mole | D002820 | — | D39.2 | 3 | 6 | 1 | — | — | 9 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 10 | 9 | — | — | — | 16 |
Endometrial neoplasms | D016889 | EFO_0004230 | — | 9 | 7 | — | — | — | 12 |
Urinary bladder neoplasms | D001749 | — | C67 | 5 | 10 | — | — | — | 12 |
Lung neoplasms | D008175 | HP_0100526 | C34.90 | 6 | 8 | — | — | 1 | 12 |
Prostatic neoplasms | D011471 | — | C61 | 5 | 5 | — | — | 1 | 10 |
Urologic neoplasms | D014571 | — | C64-C68 | 1 | 9 | — | — | — | 10 |
Multiple myeloma | D009101 | — | C90.0 | 3 | 5 | — | — | — | 7 |
Colonic neoplasms | D003110 | — | C18 | 3 | 4 | — | — | — | 7 |
Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 2 | 4 | — | — | — | 6 |
Rectal neoplasms | D012004 | — | — | 1 | 5 | — | — | — | 6 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 15 | — | — | — | — | 15 |
Hodgkin disease | D006689 | — | C81 | 2 | — | — | — | — | 2 |
Ovarian epithelial carcinoma | D000077216 | — | — | 2 | — | — | — | — | 2 |
Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | — | 1 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 2 | 2 |
Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 2 | 2 |
Observation | D019370 | — | — | — | — | — | — | 1 | 1 |
Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | — | 1 | 1 |
Digestive system neoplasms | D004067 | — | — | — | — | — | — | 1 | 1 |
Cardiac rehabilitation | D000072038 | — | — | — | — | — | — | 1 | 1 |
Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | — | — | 1 | 1 |
Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Trastuzumab |
INN | trastuzumab |
Description | Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.
|
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | >5U6A:A|Light Chain
DIQMTQSPILLSASVGDRVTITCRASQDVNTAVAWYQQRTNGSPRLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQP
EDEADYYCQQHYTTPPTFGAGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>5U6A:B|Heavy Chain
EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQSPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAIYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |