Tezacitabine
Tezacitabine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 28tak gum care tooth | unapproved drug other | 2018-07-17 |
| akten | New Drug Application | 2024-04-19 |
| alka seltzer | OTC monograph final | 2012-11-09 |
| alka seltzer original | OTC monograph not final | 2023-03-01 |
| alka seltzer originial 1s blister pack | C200263 | 2023-11-05 |
| alka-seltzer | C200263 | 2023-12-15 |
| alka-seltzer extra strength | C200263 | 2023-12-04 |
| alka-seltzer hangover relief | OTC monograph final | 2023-05-18 |
| alka-seltzer heartburn | C200263 | 2023-12-04 |
| alka-seltzer heartburn relief extra strength | C200263 | 2024-07-30 |
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Clinical
Clinical Trials
199 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | — | — | 1 | 1 | 1 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 2 | — | 1 | — | 3 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | 1 | 1 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 1 | — | 2 | — | 3 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 2 | 1 | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 2 | 1 | 3 |
| Infections | D007239 | EFO_0000544 | — | 1 | — | 1 | 1 | — | 3 |
| Colonoscopy | D003113 | — | — | — | — | — | 2 | 1 | 3 |
| Colonic neoplasms | D003110 | — | C18 | — | 1 | — | 1 | — | 2 |
| Headache | D006261 | HP_0002315 | R51 | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 2 | 5 | 4 | — | — | 11 |
| Syndrome | D013577 | — | — | 2 | 2 | 6 | — | 1 | 10 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 3 | 2 | — | — | 7 |
| Seizures | D012640 | HP_0002069 | G40.4 | 2 | — | 4 | — | — | 6 |
| Myoclonic epilepsies | D004831 | HP_0002123 | G40.4 | — | 1 | 2 | — | — | 3 |
| Abdominal pain | D015746 | HP_0002027 | R10.9 | — | — | 1 | — | 2 | 3 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | 2 | — | 1 | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 2 | 1 | — | — | 2 |
| Spasm | D013035 | — | M62.83 | — | — | 2 | — | — | 2 |
| Infantile spasms | D013036 | HP_0011097 | G40.82 | — | — | 2 | — | — | 2 |
Show 35 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 4 | 5 | — | — | 2 | 9 |
| Healthy volunteers/patients | — | — | — | 3 | 1 | — | — | 5 | 9 |
| Neoplasms | D009369 | — | C80 | 4 | 4 | — | — | 1 | 8 |
| Colorectal neoplasms | D015179 | — | — | 2 | 5 | — | — | 2 | 7 |
| Adenocarcinoma | D000230 | — | — | 3 | 4 | — | — | — | 5 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | 4 | 5 |
| Recurrence | D012008 | — | — | 2 | 2 | — | — | — | 4 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 2 | — | — | 2 | 4 |
| Leukemia | D007938 | — | C95 | 3 | 1 | — | — | — | 3 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 1 | — | — | 2 | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | 2 | 3 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | — | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 2 | — | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | — | 2 |
| Anemia | D000740 | HP_0001903 | D64.9 | 1 | — | — | — | 1 | 2 |
| Myeloid leukemia | D007951 | — | C92 | 2 | — | — | — | — | 2 |
| Preleukemia | D011289 | — | — | 2 | — | — | — | — | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | 1 | 2 |
Show 43 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperglycemia | D006943 | HP_0003074 | R73.9 | — | — | — | — | 3 | 3 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | — | 3 | 3 |
| Food diet and nutrition | D000066888 | — | — | — | — | — | — | 2 | 2 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | — | — | — | 2 | 2 |
| Skin aging | D015595 | EFO_0005422 | — | — | — | — | — | 2 | 2 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 2 | 2 |
| Postmenopause | D017698 | — | — | — | — | — | — | 1 | 1 |
| Respiratory signs and symptoms | D012818 | — | — | — | — | — | — | 1 | 1 |
| Bacterial infections | D001424 | — | A49 | — | — | — | — | 1 | 1 |
| Metabolism | D008660 | GO_0008152 | — | — | — | — | — | 1 | 1 |
Show 36 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tezacitabine |
| INN | tezacitabine |
| Description | Tezacitabine is a ribonucleotide reductase inhibitor. It is a synthetic purine nucleoside analogue with potential antineoplastic activity. It is used in synthetic DNA.
|
| Classification | Small molecule |
| Drug class | nucleoside antiviral or antineoplastic agents, cytarabine or azarabine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)/C2=C\F)c(=O)n1.O |
Identifiers
| PDB | — |
| CAS-ID | 130306-02-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989496 |
| ChEBI ID | — |
| PubChem CID | 6435808 |
| DrugBank | — |
| UNII ID | 7607Y95N9S (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Cidofovir, Docetaxel, Docetaxel anhydrous, Endrate, Levothyroxine sodium, Methylene blue inj, Osmoprep, Paroxetine hydrochloride anhydrous, Pnv prenatal vitamin
Adverse Events
Top Adverse Reactions
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15,432 adverse events reported
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