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Drug ReportsPrucalopride
Motegrity, Resolor(prucalopride)
Motegrity, Prucalopride, Resolor (prucalopride) is a small molecule pharmaceutical. Prucalopride was first approved as Resolor on 2009-10-14. It is used to treat constipation in the USA. It has been approved in Europe to treat constipation. It is known to target 5-hydroxytryptamine receptor 4.
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Target
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Motegrity, Prucalopride
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Prucalopride succinate
Tradename
Company
Number
Date
Products
MOTEGRITYTakedaN-210166 RX2018-12-14
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
motegrityNew Drug Application2025-03-03
prucaloprideANDA2023-11-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
constipation—D003248K59.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A06: Drugs for constipation
— A06A: Drugs for constipation
— A06AX: Other drugs for constipation in atc
— A06AX05: Prucalopride
HCPCS
No data
Clinical
Clinical Trials
72 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ConstipationD003248—K59.0——1—34
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePrucalopride
INNprucalopride
Description
Prucalopride is a member of benzamides.
Classification
Small molecule
Drug classsulpride derivatives and analogs
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1
Identifiers
PDB—
CAS-ID179474-81-8
RxCUI—
ChEMBL IDCHEMBL117287
ChEBI ID—
PubChem CID3052762
DrugBankDB06480
UNII ID0A09IUW5TP (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR4
HTR4
Organism
Homo sapiens
Gene name
HTR4
Gene synonyms
NCBI Gene ID
3360
Protein name
5-hydroxytryptamine receptor 4
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled, cardiac 5-HT4 receptor, Serotonin receptor 4
Uniprot ID
Q9UQR6
Mouse ortholog
Htr4 (15562)
5-hydroxytryptamine receptor 4 (Q9R2A4)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Resolor – Shire
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,306 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,358 adverse events reported
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