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Drug ReportsOritavancin
Orbactiv, Tenkasi (previously orbactiv)(oritavancin)
Kimyrsa, Orbactiv, Tenkasi (oritavancin) is an unknown pharmaceutical. Oritavancin was first approved as Orbactiv on 2014-08-06. It is used to treat bacterial infections, infectious skin diseases, staphylococcal infections, and streptococcal infections in the USA. It has been approved in Europe to treat bacterial skin diseases and soft tissue infections.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Kimyrsa, Orbactiv
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oritavancin diphosphate
Tradename
Company
Number
Date
Products
KIMYRSAMelinta TherapeuticsN-214155 RX2021-03-12
1 products, RLD, RS
ORBACTIVMelinta TherapeuticsN-206334 RX2014-08-06
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
kimyrsaNew Drug Application2021-07-30
orbactivNew Drug Application2022-02-25
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infections—D001424A49
infectious skin diseases—D012874—
streptococcal infectionsEFO_1001476D013290—
staphylococcal infections—D013203A49.01
Agency Specific
FDA
EMA
Expiration
Code
ORITAVANCIN DIPHOSPHATE, KIMYRSA, MELINTA THERAP
2024-08-06GAIN
2024-03-12NP
2019-08-06NCE
ORITAVANCIN DIPHOSPHATE, ORBACTIV, MELINTA THERAP
2024-08-06GAIN
2019-08-06NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Oritavancin Diphosphate, Kimyrsa, Melinta Therap
96493522035-07-16DP
96820612030-04-26U-1569, U-3101
84205922029-08-29U-1570, U-3101
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XA: Glycopeptide antibacterials
— J01XA05: Oritavancin
HCPCS
Code
Description
J2406
Injection, oritavancin (kimyrsa), 10 mg
J2407
Injection, oritavancin (orbactiv), 10 mg
Clinical
No data
Drug
General
Drug common nameOritavancin
INNoritavancin
Description
Oritavancin, sold under the brand name Orbactiv among others, is a semisynthetic glycopeptide antibiotic medication for the treatment of serious Gram-positive bacterial infections. Its chemical structure as a lipoglycopeptide is similar to vancomycin.
Classification
Small molecule
Drug classvancomycin-related compounds
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O[C@H]3C[C@](C)(N)[C@@H](O)[C@H](C)O3)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(NCc3ccc(-c4ccc(Cl)cc4)cc3)[C@@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O
Identifiers
PDB—
CAS-ID171099-57-3
RxCUI—
ChEMBL IDCHEMBL1688530
ChEBI ID82699
PubChem CID16131319
DrugBankDB04911
UNII IDPUG62FRZ2E (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Orbactiv – The Medicines Company
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Orbactiv – Melinta Therapeutics /new/
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Estimated US medical usage
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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