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Company ReportsMelinta Therapeutics

Melinta Therapeutics(MLNT)

Melinta Therapeutics, founded in 2000 as Rib-X Pharmaceuticals, is an American publicly traded biopharmaceutical firm that focuses on the design and development of novel broad-spectrum antibiotics for the treatment of antibiotic-resistant infections in hospital and community settings. The company is located in New Haven, Connecticut.

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Kimyrsa	Oritavancin diphosphate	2021-03-12	2029-2035	Bacterial infections , Infectious skin diseases , Bacterial skin diseases , Soft tissue infections , Streptococcal infections , Staphylococcal infections
Orbactiv	Oritavancin diphosphate	2014-08-06	2029-2035	Bacterial infections , Infectious skin diseases , Bacterial skin diseases , Soft tissue infections , Streptococcal infections , Staphylococcal infections

Clinical Trials

Therapeutic Areas:

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Classification:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

bacterial infections

,

gram-positive bacterial infections

,

bacterial skin diseases

,

,

communicable diseases

,

,

wound infection

,

,

,

bacterial infections

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

non-alcoholic fatty liver disease

,

,

,

community-acquired infections

,

bacterial pneumonia

,

,

ocular hypertension

,

,

open-angle glaucoma

,

bacterial skin diseases

Sodium chloride

bacterial infections

,

gram-negative bacterial infections

,

hypertriglyceridemia

,

allergic rhinitis

,

,

,

migraine disorders

,

systemic lupus erythematosus

,

cutaneous lupus erythematosus

,

staphylococcal infections

,

,

,

respiratory syncytial viruses

,

sickle cell anemia

,

type 2 diabetes mellitus

,

diabetes mellitus

,

streptococcal infections

,

alzheimer disease

,

respiratory tract infections

,

borrelia infections

,

,

meningococcal infections

,

cerebral amyloid angiopathy

,

,

familial cerebral amyloid angiopathy

,

,

pulmonary sarcoidosis

,

serogroup b neisseria meningitidis

,

esophageal neoplasms

,

ventilator-associated pneumonia

,

healthy volunteers/patients

,

,

pneumococcal infections

,

,

clostridium infections

,

,

clostridioides difficile

,

meningococcal meningitis

,

human influenza

,

essential hypertension

,

,

,

hepatocellular carcinoma

,

liver neoplasms

,

community-acquired infections

,

bacterial pneumonia

,

,

headache disorders

,

,

renal cell carcinoma

,

,

gastrointestinal stromal tumors

,

,

,

,

postoperative pain

,

,

pneumococcal pneumonia

,

streptococcus pneumoniae

,

,

hyperlipidemias

,

,

cardiovascular diseases

,

health risk behaviors

,

vascular stiffness

hepatic insufficiency

,

renal insufficiency

,

castration-resistant prostatic neoplasms

,

,

,

,

,

unknown primary neoplasms

,

immunomodulation

,

gram-positive bacterial infections

,

t-cell lymphoma peripheral

,

,

merkel cell carcinoma

,

mycosis fungoides

,

clear cell sarcoma

,

myelodysplastic syndromes

,

,

,

pulmonary sarcoidosis

,

lyme neuroborreliosis

,

hypertriglyceridemia

,

,

granuloma annulare

,

mycobacterium avium complex

,

thoracic neoplasms

,

pelvic neoplasms

,

,

,

brain neoplasms

,

stomach neoplasms

,

,

triple negative breast neoplasms

,

head and neck neoplasms

,

urinary bladder neoplasms

,

multiple myeloma

,

neoplasm metastasis

,

ovarian neoplasms

,

thyroid neoplasms

,

,

plasma cell neoplasms

,

small cell lung carcinoma

,

ovarian epithelial carcinoma

,

esophageal neoplasms

,

borrelia infections

,

endometrial neoplasms

,

thyroid diseases

,

keratoconjunctivitis sicca

,

dry eye syndromes

,

uveal neoplasms

,

respiratory syncytial viruses

,

,

,

transitional cell carcinoma

,

kidney diseases

,

small cell carcinoma

,

adenocarcinoma of lung

,

large-cell lymphoma anaplastic

,

,

,

pheochromocytoma

,

,

healthcare-associated pneumonia

,

systemic lupus erythematosus

,

alopecia areata

,

,

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

oligodendroglioma

,

,

hemangioblastoma

,

urogenital neoplasms

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

,

neurofibromatosis 1

,

neurofibromatoses

,

,

germ cell and embryonal neoplasms

,

carcinoid tumor

,

urethral neoplasms

,

ureteral neoplasms

,

alveolar soft part sarcoma

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

cholangiocarcinoma

,

gene rearrangement

,

lobular carcinoma

,

plasma cell leukemia

,

medulloblastoma

,

,

rhabdomyosarcoma

,

diffuse intrinsic pontine glioma

,

intraductal carcinoma noninfiltrating

,

b-cell lymphoma

,

cutaneous lupus erythematosus

,

keratoconjunctivitis

,

,

respiratory tract infections

,

,

,

,

hidradenitis suppurativa

,

,

meningococcal infections

,

neoadjuvant therapy

,

diabetes mellitus

,

type 1 diabetes mellitus

,

,

multidrug-resistant tuberculosis

,

von hippel-lindau disease

,

,

,

neurodermatitis

,

,

urologic neoplasms

,

urologic diseases

,

neoplasms by site

,

glandular and epithelial neoplasms

,

,

,

benign fibrous histiocytoma

,

,

malignant fibrous histiocytoma

,

myeloid leukemia accelerated phase

,

,

malignant mesothelioma

,

,

urinary bladder diseases

,

adrenal cortex neoplasms

,

adrenocortical carcinoma

,

second primary neoplasms

,

pulmonary tuberculosis

,

hematologic neoplasms

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

mouth neoplasms

,

,

penile neoplasms

,

plexiform neurofibroma

,

,

testicular neoplasms

,

solitary fibrous tumors

,

,

hemangiopericytoma

,

male urogenital diseases

,

urogenital diseases

,

adenoid cystic carcinoma

,

,

hemangiosarcoma

,

systemic scleroderma

,

diffuse scleroderma

,

,

,

post-acute covid-19 syndrome

,

,

colorectal neoplasms

,

,

atopic dermatitis

,

,

,

,

kidney neoplasms

,

prostatic neoplasms

,

squamous cell carcinoma

,

liver neoplasms

,

pancreatic neoplasms

,

hepatocellular carcinoma

,

,

psoriatic arthritis

,

squamous cell neoplasms

,

squamous cell carcinoma of head and neck

,

,

male breast neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

myeloid leukemia chronic-phase

,

juvenile arthritis

,

,

,

bacterial pneumonia

,

,

mycobacterium avium-intracellulare infection

,

immune system diseases

,

inborn genetic diseases

,

genetic skin diseases

,

eczematous skin diseases

,

hypersensitivity

,

immediate hypersensitivity

,

islet cell carcinoma

,

ankylosing spondylitis

,

bacterial infections

,

pancreatic ductal carcinoma

,

,

,

febrile neutropenia

,

,

mycobacterium infections

,

adenosquamous carcinoma

,

large cell carcinoma

,

nervous system diseases

,

optic nerve diseases

,

disease progression

,

cardiovascular diseases

,

immunologic deficiency syndromes

,

breast neoplasms

,

healthy volunteers/patients

,

,

renal cell carcinoma

,

non-small-cell lung carcinoma

,

,

,

rheumatoid arthritis

,

,

,

,

,

acquired immunodeficiency syndrome

,

communicable diseases

,

bcr-abl positive chronic myelogenous leukemia

,

,

ulcerative colitis

,

,

,

myeloid leukemia

,

neuroendocrine tumors

,

gastrointestinal stromal tumors

,

non-hodgkin lymphoma

,

kidney transplantation

,

philadelphia chromosome

,

islet cell adenoma

,

intraabdominal infections

,

mantle-cell lymphoma

,

,

spondylarthritis

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

,

,

,

,

,

ventilator-associated pneumonia

,

chronic hepatitis c

,

,

axial spondyloarthritis

,

,

premature birth

,

bacterial vaginosis

,

vaginal diseases

,

,

infectious skin diseases

,

soft tissue infections

,

,

,

community-acquired infections

,

staphylococcal infections

,

,

hypercholesterolemia

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

bacterial skin diseases

,

,

asymptomatic infections

,

,

,

respiratory tract diseases

,

communicable diseases

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

streptococcal infections

,

,

,

healthy volunteers/patients

,

chemical and drug induced liver injury

,

,

therapeutic equivalency

,

prosthesis-related infections

,

,

brain neoplasms

,

,

,

erectile dysfunction

,

pulmonary tuberculosis

,

,

colorectal neoplasms

,

,

,

,

colonic neoplasms

,

,

pleural effusion

,

,

,

pancreatic fistula

,

bacterial pneumonia

,

intraabdominal infections

,

,

,

,

,

,

acalculous cholecystitis

,

,

community-acquired infections

,

,

,

,

chronic obstructive pulmonary disease

,

obstructive lung diseases

,

,

head and neck neoplasms

,

,

enterobacteriaceae infections

,

helicobacter infections

,

,

maxillary sinusitis

,

,

alcoholic liver diseases

,

,

,

alcoholic hepatitis

,

chronic renal insufficiency

,

kidney diseases

,

congenital abnormalities

,

vesico-ureteral reflux

,

,

,

intestinal obstruction

,

peptic ulcer perforation

,

cross infection

,

,

,

abdominal abscess

,

,

intestinal perforation

,

,

,

,

,

catheter-related infections

,

,

induced hypothermia

,

suppurative otitis media

,

cholecystectomy

,

central nervous system neoplasms

,

intestinal neoplasms

,

nervous system neoplasms

,

bites and stings

,

hematologic neoplasms

,

agammaglobulinemia

,

urinary bladder neoplasms

,

,

incisional hernia

,

osteoradionecrosis

,

,

,

communicable diseases

,

,

,

,

,

,

,

,

urinary tract infections

,

surgical wound infection

,

wound infection

,

bacterial infections

,

respiratory tract infections

,

,

wounds and injuries

,

,

,

,

,

,

,

,

,

febrile neutropenia

,

,

chronic bronchitis

,

ventilator-associated pneumonia

,

,

mandibular fractures

,

,

postoperative complications

,

,

,

multidrug-resistant tuberculosis

,

infectious arthritis

,

postoperative pain

,

staphylococcal infections

,

,

bacterial skin diseases

,

,

,

,

,

,

antibiotic prophylaxis

,

aspiration pneumonia

,

soft tissue infections

,

liver cirrhosis

,

,

overactive urinary bladder

,

,

dental pulp necrosis

,

,

,

,

streptococcal infections

,

dental focal infection

,

focal infection

,

surgical amputation

,

temporomandibular joint disorders

,

temporomandibular joint dysfunction syndrome

,

obstructive sleep apnea

,

sleep apnea syndromes

,

,

,

,

prostatic neoplasms

,

neurogenic urinary bladder

,

tooth extraction

,

neonatal sepsis

,

out-of-hospital cardiac arrest

,

,

,

atrial fibrillation

,

,

venous thrombosis

,

pulmonary embolism

,

,

infectious skin diseases

,

respiratory aspiration

,

surgical wound dehiscence

,

,

,

,

,

pulmonary infarction

,

gastroenteritis

,

pharmacokinetics

,

bisphosphonate-associated osteonecrosis of the jaw

,

acute cholecystitis

,

,

,

,

,

,

,

periapical periodontitis

,

alveolar bone loss

,

,

,

subcutaneous injections

,

,

critical illness

,

spontaneous abortion

,

incomplete abortion

,

peritonsillar abscess

,

ulcerative colitis

,

,

,

chronic kidney failure

,

renal insufficiency

,

continuous renal replacement therapy

,

penicillin resistance

,

capillary leak syndrome

,

electric impedance

,

,

myelodysplastic syndromes

,

myeloproliferative disorders

,

multiple myeloma

,

precancerous conditions

,

myelodysplastic-myeloproliferative diseases

,

plasma cell neoplasms

,

,

,

,

,

,

,

,

bone resorption

,

esophageal motility disorders

,

esophageal achalasia

,

diffuse esophageal spasm

,

esophageal diseases

,

motor disorders

,

,

abdominal hernia

,

internal hernia

,

,

,

,

asymptomatic diseases

,

,

,

,

orbital fractures

,

orbital cellulitis

,

methicillin-resistant staphylococcus aureus

,

,

human influenza

,

respiratory syncytial viruses

,

,

,

,

anastomotic leak

,

laparoscopic cholecystectomy

,

,

,

supernumerary tooth

,

dental implants

,

pharmacokinetics

,

healthy volunteers/patients

,

renal cell carcinoma

,

,

kidney neoplasms

,

,

,

diabetes mellitus

,

type 1 diabetes mellitus

,

type 2 diabetes mellitus

,

airway obstruction

,

,

respiratory hypersensitivity

,

periapical periodontitis

,

myelodysplastic-myeloproliferative diseases

,

,

gene rearrangement

,

,

,

neoplasm metastasis

,

hematologic neoplasms

,

acquired immunodeficiency syndrome

,

endometrioid carcinoma

,

serous cystadenocarcinoma

,

vulvar neoplasms

,

,

sezary syndrome

,

t-cell lymphoma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

large-cell lymphoma anaplastic

,

immunoblastic lymphadenopathy

,

mycosis fungoides

,

adult t-cell leukemia-lymphoma

,

intraocular lymphoma

,

t-cell lymphoma cutaneous

,

burkitt lymphoma

,

plasmablastic lymphoma

,

large-cell lymphoma immunoblastic

,

t-cell leukemia

,

,

,

non-small-cell lung carcinoma

,

,

,

myeloproliferative disorders

,

precursor cell lymphoblastic leukemia-lymphoma

,

myelodysplastic syndromes

,

,

myeloid leukemia accelerated phase

,

,

,

,

head and neck neoplasms

,

lymphoid leukemia

,

neuroendocrine tumors

,

multiple myeloma

,

myeloid leukemia acute

,

non-hodgkin lymphoma

,

b-cell chronic lymphocytic leukemia

,

hodgkin disease

,

ovarian epithelial carcinoma

,

female genital diseases

,

,

genital diseases

,

nasopharyngeal carcinoma

,

oropharyngeal neoplasms

,

squamous cell neoplasms

,

laryngeal neoplasms

,

verrucous carcinoma

,

laryngeal diseases

,

obstructive sleep apnea

,

multiple sclerosis

,

,

adenocarcinoma of lung

,

,

kidney transplantation

,

t-cell lymphoma peripheral

,

combination drug therapy

,

,

,

small cell lung carcinoma

,

essential thrombocythemia

,

polycythemia vera

,

primary myelofibrosis

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

leukemia myeloid chronic atypical bcr-abl negative

,

myelomonocytic leukemia juvenile

,

hypereosinophilic syndrome

,

eosinophilic leukemia acute

,

philadelphia chromosome

,

,

,

second primary neoplasms

,

breast neoplasms

,

male breast neoplasms

,

pancreatic ductal carcinoma

,

acinar cell carcinoma

,

esophageal neoplasms

,

renal cell carcinoma

,

kidney neoplasms

,

gallbladder neoplasms

,

hypopharyngeal neoplasms

,

,

anticholinergic syndrome

,

,

type 1 diabetes mellitus

,

,

bcr-abl positive chronic myelogenous leukemia

,

myeloid leukemia

,

,

diabetes mellitus

,

,

urinary tract infections

,

,

,

communicable diseases

,

pancreatic neoplasms

,

squamous cell carcinoma

,

myeloid leukemia chronic-phase

,

prostatic neoplasms

,

uterine cervical neoplasms

,

vaginal neoplasms

,

,

,

wounds and injuries

,

chronic disease

,

type 2 diabetes mellitus

,

,

,

,

adenosquamous carcinoma

,

,

human influenza

,

,

haemophilus infections

,

,

,

ventilator-associated pneumonia

,

bacterial pneumonia

,

spinal cord injuries

,

peripheral nerve injuries

,

,

,

hypertriglyceridemia

,

chronic pancreatitis

,

alcoholic pancreatitis

,

intracranial hemorrhages

,

,

traumatic intracranial hemorrhage

,

connective and soft tissue neoplasms

,

connective tissue neoplasms

,

,

,

,

squamous cell carcinoma of head and neck

,

,

parkinson disease

,

,

,

,

,

,

chronic renal insufficiency

,

kidney diseases

,

falciparum malaria

,

,

femoral fractures

,

,

psychotic disorders

,

mental disorders

,

,

metabolic bone diseases

,

osteoporotic fractures

,

chronic kidney failure

,

,

renal replacement therapy

,

,

knee osteoarthritis

,

anxiety disorders

,

healthy volunteers/patients

,

,

intervertebral disc degeneration

,

plantar fasciitis

,

,

sprains and strains

,

,

,

femoral neck fractures

,

,

,

,

,

intervertebral disc displacement

,

,

humeral fractures

,

respiratory aspiration

,

,

,

postherpetic neuralgia

,

spinal stenosis

,

retinal diseases

,

,

,

,

,

,

,

,

,

major depressive disorder

,

depressive disorder

,

professional-patient relations

,

replacement arthroplasty hip

,

,

,

dental restoration failure

,

tooth attrition

,

dental restoration wear

,

hepatocellular carcinoma

,

liver neoplasms

,

cesarean section

,

alzheimer disease

,

musculoskeletal manipulations

,

patellofemoral pain syndrome

,

somatoform disorders

,

hemiarthroplasty

,

heterotopic ossification

,

pelvic floor disorders

,

,

sick sinus syndrome

,

artificial pacemaker

,

,

hiv seropositivity

,

,

neurologic gait disorders

,

myofascial pain syndromes

,

,

plastic surgery procedures

,

parkinsonian disorders

,

,

neuromuscular blockade

,

,

,

,

,

chronic periodontitis

,

,

,

gestational diabetes

,

postoperative complications

,

pancreatic fistula

,

pancreaticoduodenectomy

,

,

atopic dermatitis

,

,

,

high-intensity interval training

,

plyometric exercise

,

somatosensory disorders

,

,

,

angle class i malocclusion

,

patient participation

,

,

hyperamylasemia

,

distal humeral fractures

,

radial head and neck fractures

,

elbow fractures

,

,

,

,

,

,

bone resorption

,

,

rheumatoid arthritis

,

vascular stiffness

,

traumatic brain injuries

,

,

post-traumatic stress disorders

,

traumatic stress disorders

healthy volunteers/patients

,

,

,

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