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Company ReportsThe Medicines Company

The Medicines Company

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Angiox	Bivalirudin	2004-09-20	2028-2039	Acute coronary syndrome , Unstable angina
Ionsys	Fentanyl	2006-05-22	2024-2033	Neoplasms , Pain , Postoperative pain , Psychotic disorders

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

opiate overdose

,

,

,

shoulder impingement syndrome

,

biological availability

,

,

tympanic membrane perforation

,

respiration disorders

,

pharmacokinetics

,

tissue adhesions

,

supratentorial neoplasms

,

respiratory tract diseases

,

spinal fractures

,

catastrophization

,

threatened abortion

,

,

interventional radiography

,

postural drainage

,

substance-related disorders

,

,

,

,

,

narcotic-related disorders

,

,

stress urinary incontinence

,

ventricular heart septal defects

,

,

obstructive lung diseases

,

subdural hematoma chronic

,

neonatal intensive care

,

heroin dependence

,

,

radical mastectomy

,

irritable bowel syndrome

,

,

,

,

chronic limb-threatening ischemia

,

prenatal diagnosis

,

craniocerebral trauma

,

biliary tract neoplasms

,

avulsion fractures

,

intracranial vasospasm

,

tetralogy of fallot

,

endocardial cushion defects

,

carpal tunnel syndrome

,

paroxysmal dyspnea

,

ventilator weaning

,

,

,

radiation injuries

,

papillomavirus infections

,

vulvar diseases

,

cervical intraepithelial neoplasia

,

vulvar neoplasms

,

uterine cervical dysplasia

,

traumatic stress disorders acute

,

,

chemically-induced disorders

,

,

retinopathy of prematurity

,

intranasal administration

,

post-traumatic headache

,

inguinal hernia

,

,

,

respiratory aspiration

,

pain management

,

obstetrical anesthesia

,

,

,

anxiety disorders

,

intervertebral disc degeneration

,

obstetric labor

,

vascular diseases

,

obstetrical analgesia

,

,

,

arterial occlusive diseases

,

abdominal neoplasms

,

,

,

heart septal defects

,

,

atrial heart septal defects

,

neoplasm metastasis

,

subarachnoid hemorrhage

,

infratentorial neoplasms

,

chronic kidney failure

,

,

,

peripheral arterial disease

,

peripheral vascular diseases

,

cerebral infarction

,

,

postherpetic neuralgia

,

complex regional pain syndromes

,

reflex sympathetic dystrophy

,

neurosurgical procedures

,

aortic coarctation

,

intrahepatic cholestasis

,

congenital cystic adenomatoid malformation of lung

,

,

pathologic processes

,

,

pelvic floor disorders

,

,

,

radiation-induced abnormalities

,

bone marrow diseases

,

coronavirus infections

,

,

suppurative otitis media

,

multiple trauma

,

opiate substitution treatment

,

,

pathologic neovascularization

,

interstitial lung diseases

,

bronchial spasm

,

fracture fixation

,

somatoform disorders

,

palliative care

,

premature infant diseases

,

diabetic neuropathies

,

respiratory signs and symptoms

,

digestive system surgical procedures

,

spinal cord neoplasms

,

spinal neoplasms

,

,

endotracheal anesthesia

,

,

,

postoperative pain

,

,

,

,

,

,

,

,

,

,

emergence delirium

,

general anesthesia

,

breakthrough pain

,

cesarean section

,

,

postoperative nausea and vomiting

,

,

opioid-related disorders

,

spinal anesthesia

,

,

,

,

respiratory insufficiency

,

postoperative complications

,

healthy volunteers/patients

,

anesthesia and analgesia

,

,

breast neoplasms

,

epidural anesthesia

,

,

drug-related side effects and adverse reactions

,

wounds and injuries

,

epidural analgesia

,

,

,

local anesthesia

,

critical illness

,

,

artificial respiration

,

,

coronary artery disease

,

,

,

,

replacement arthroplasty knee

,

,

laparoscopic cholecystectomy

,

,

obstructive sleep apnea

,

psychomotor agitation

,

,

,

conscious sedation

,

patient satisfaction

,

pancreatic neoplasms

,

patient-controlled analgesia

,

prostatic neoplasms

,

sleep apnea syndromes

,

,

,

intravenous anesthesia

,

procedural pain

,

cardiac surgical procedures

,

intervertebral disc displacement

,

neuromuscular blockade

,

,

,

,

conduction anesthesia

,

bariatric surgery

,

knee osteoarthritis

,

,

colorectal neoplasms

,

,

traumatic brain injuries

,

congenital heart defects

,

,

postoperative period

,

,

atrial fibrillation

,

intratracheal intubation

,

liver neoplasms

,

respiratory distress syndrome

,

muscle hypotonia

,

,

colonic neoplasms

,

thoracic surgical procedures

,

obstetric labor complications

,

depressive disorder

,

,

cognitive dysfunction

,

stomach neoplasms

,

,

morphine dependence

,

,

orthopedic procedures

,

,

urinary retention

,

brain neoplasms

,

personal satisfaction

,

muscle relaxation

,

postoperative cognitive complications

,

head and neck neoplasms

,

,

newborn respiratory distress syndrome

,

,

,

,

hepatocellular carcinoma

,

male breast neoplasms

,

,

,

,

,

urinary bladder neoplasms

,

cardiovascular diseases

,

,

,

liver cirrhosis

,

,

,

,

chronic obstructive pulmonary disease

,

,

gastrointestinal endoscopy

,

myocardial infarction

,

,

,

,

,

,

,

,

,

,

,

myocardial ischemia

,

sickle cell anemia

,

,

coronary artery bypass

,

,

,

,

acute lung injury

,

replacement arthroplasty hip

,

spinal stenosis

,

pain measurement

,

,

postpartum depression

,

cardiac arrhythmias

,

rectal neoplasms

,

femoral neck fractures

,

malignant pleural effusion

,

,

,

intraoperative awareness

,

,

migraine disorders

,

,

heart valve diseases

,

,

anesthesia recovery period

,

,

premature birth

,

,

endoscopic retrograde cholangiopancreatography

,

electroencephalography

,

newborn infant diseases

,

,

,

muscle weakness

,

esophageal neoplasms

,

immunosuppression therapy

,

obstetric delivery

,

kidney neoplasms

,

,

,

intractable pain

,

,

video-assisted thoracic surgery

,

prostatic hyperplasia

,

,

,

,

,

carcinoma in situ

,

delayed emergence from anesthesia

,

solitary pulmonary nodule

,

pathologic dilatation

,

,

,

aortic valve stenosis

,

aortic aneurysm

,

,

,

,

,

pancreatic diseases

,

sleep wake disorders

,

elective surgical procedures

,

pleural effusion

,

pleural diseases

,

diabetes mellitus

,

,

ultrasonography

,

,

,

,

intraoperative complications

,

low cardiac output

,

hypoventilation

,

near-infrared spectroscopy

,

,

laryngeal masks

,

oxidative stress

,

st elevation myocardial infarction

,

,

post-traumatic stress disorders

,

,

uterine cervical incompetence

,

vitreous detachment

,

failed back surgery syndrome

,

renal cell carcinoma

,

colonic diverticulosis

,

intestinal pseudo-obstruction

,

,

postoperative care

,

closed fractures

,

,

,

,

female genital neoplasms

,

,

,

urologic surgical procedures

,

,

,

,

,

oocyte retrieval

,

,

,

biliary tract diseases

,

surgical blood loss

,

catheter ablation

,

insulin resistance

,

,

intracranial hemorrhages

,

,

,

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

intraocular pressure

,

,

hematologic neoplasms

,

,

,

pulmonary atelectasis

,

non-small-cell lung carcinoma

,

,

stress fractures

,

,

research peer review

,

,

systemic inflammatory response syndrome

,

gastrointestinal diseases

,

digestive system diseases

,

,

inflammatory bowel diseases

,

vaso-occlusive crises

,

lymphadenopathy

,

,

liver transplantation

,

forearm injuries

,

,

gynecologic surgical procedures

,

tooth extraction

,

,

pituitary neoplasms

,

pituitary diseases

,

retinal detachment

,

,

vitreous hemorrhage

,

lens subluxation

,

epiretinal membrane

,

retinal perforations

,

dissociative disorders

,

,

compression fractures

,

,

,

colonic diverticulitis

,

myocardial revascularization

,

,

spinal injuries

,

,

,

,

ductal carcinoma

,

intraductal carcinoma noninfiltrating

,

trigeminal neuralgia

,

arteriovenous malformations

,

percutaneous coronary intervention

,

esophageal achalasia

,

unwanted pregnancy

,

first pregnancy trimester

,

glucose intolerance

,

persistent vegetative state

,

,

cervical cerclage

,

major depressive disorder

,

,

,

multiple organ failure

,

migraine without aura

,

migraine with aura

,

enzyme induction

,

intestinal diseases

,

ambulatory surgical procedures

,

thyroid neoplasms

,

,

retained placenta

,

rheumatoid arthritis

,

electroconvulsive therapy

,

,

abdominal aortic aneurysm

,

immunomodulation

,

vascular surgical procedures

,

breast cancer lymphedema

,

,

thrombophlebitis

,

,

therapeutic chemoembolization

,

,

affective symptoms

,

minor surgical procedures

,

,

transcatheter aortic valve replacement

,

,

pleural empyema

,

,

,

pericardial effusion

,

pleural neoplasms

,

,

sigmoid neoplasms

,

motion sickness

,

,

,

hypertensive intracranial hemorrhage

,

intracranial hypertension

,

postoperative hemorrhage

,

free tissue flaps

,

thyroid diseases

,

,

femoral neuropathy

,

perioperative care

,

enhanced recovery after surgery

,

,

pulmonary tuberculosis

,

pulmonary infarction

,

,

,

female genital diseases

,

aortic dissection

,

nociceptive pain

,

femoral fractures

,

renal insufficiency

,

inhalation anesthesia

,

rotator cuff injuries

,

spinal diseases

,

hip osteoarthritis

,

transurethral resection of prostate

,

,

cholecystectomy

,

,

breast diseases

,

kidney transplantation

,

,

sleep deprivation

,

coronary disease

,

unconsciousness

,

operative surgical procedures

,

,

acute kidney injury

,

hypersensitivity

,

percutaneous nephrolithotomy

,

,

,

arterial pressure

,

,

,

,

,

chronic renal insufficiency

,

,

,

,

deglutition disorders

,

hemiarthroplasty

,

bites and stings

,

,

,

mental disorders

,

multiple pulmonary nodules

,

kidney diseases

,

,

,

sleep initiation and maintenance disorders

,

communicable diseases

,

healthcare-associated pneumonia

,

staphylococcal infections

,

,

potassium deficiency

,

endometrial neoplasms

,

uterine cervical neoplasms

,

uterine hemorrhage

,

,

portal hypertension

,

physiologic monitoring

,

cardiopulmonary bypass

,

neurologic manifestations

,

,

drug interactions

,

,

intracranial aneurysm

,

airway management

,

intraoperative monitoring

,

gastroesophageal reflux

,

,

,

,

,

,

,

thoracic neoplasms

,

personality disorders

,

shoulder injuries

,

,

ischemic stroke

,

,

musculoskeletal pain

,

,

endoscopic mucosal resection

,

inferior wall myocardial infarction

,

systolic murmurs

,

,

traumatic stress disorders

,

congenital abnormalities

,

acquired joint deformities

,

carotid stenosis

,

maxillofacial injuries

,

maxillofacial abnormalities

,

mandibulofacial dysostosis

,

,

,

,

anterograde amnesia

,

musculoskeletal diseases

,

pregnancy-induced hypertension

,

solitary kidney

,

,

,

,

spine osteoarthritis

,

,

hypertrophic pyloric stenosis

,

pyloric stenosis

,

gastric outlet obstruction

,

vitreoretinal surgery

,

cutaneous fistula

,

female infertility

,

anterior cruciate ligament injuries

,

uterine prolapse

,

,

alzheimer disease

,

,

tibial fractures

,

urinary incontinence

,

,

,

,

breech presentation

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

predictive value of tests

,

fertilization in vitro

,

,

,

pregnancy outcome

,

mobility limitation

,

,

,

peritoneal dialysis

,

,

balanced anesthesia

,

respiratory tract infections

,

,

,

,

hyperaldosteronism

,

pulmonary arterial hypertension

,

urinary tract infections

,

bacterial infections

,

intraabdominal infections

,

methicillin-resistant staphylococcus aureus

,

,

,

,

gram-negative bacterial infections

,

,

bacterial meningitis

,

,

central nervous system infections

,

,

,

cytomegalovirus retinitis

,

adenoviridae infections

,

port-wine stain

,

,

,

capillary hemangioma

,

,

bipolar disorder

,

autistic disorder

,

,

treatment-resistant schizophrenia

,

,

,

alpha 1-antitrypsin deficiency

,

argininosuccinic aciduria

,

unplanned pregnancy

,

,

retinal neoplasms

,

,

endovascular procedures

,

laryngeal neoplasms

,

mitochondrial diseases

,

,

long qt syndrome

,

caudal anesthesia

,

psychomotor performance

,

,

urologic diseases

,

neurotoxicity syndromes

,

colonic diseases

,

functional colonic diseases

,

neurodevelopmental disorders

,

circadian rhythm sleep disorders

,

,

pharmacological phenomena

,

cholecystolithiasis

,

,

atherosclerosis

,

,

diaphragmatic hernias congenital

,

diaphragmatic hernia

,

,

asphyxia neonatorum

,

,

,

inert gas narcosis

,

immunologic cytotoxicity

,

cerebrovascular disorders

,

central nervous system diseases

,

,

nervous system diseases

,

acute coronary syndrome

,

ventricular tachycardia

,

peritoneal neoplasms

,

pathologic constriction

,

noninvasive ventilation

,

first labor stage

,

horner syndrome

,

,

,

gastrointestinal neoplasms

,

,

diverticular diseases

,

,

mediastinal neoplasms

,

barrett esophagus

,

spinal puncture

,

,

,

,

,

myelodysplastic syndromes

,

myeloproliferative disorders

,

multiple myeloma

,

precancerous conditions

,

myelodysplastic-myeloproliferative diseases

,

central nervous system neoplasms

,

lymphoproliferative disorders

,

plasma cell neoplasms

,

,

,

nervous system neoplasms

,

,

adrenal insufficiency

,

ovarian neoplasms

,

fallopian tube neoplasms

,

peripheral nervous system diseases

,

,

nephrolithiasis

,

cytokine release syndrome

,

mechanical ventilators

,

,

,

lacrimal duct obstruction

,

dacryocystorhinostomy

,

echocardiography

,

cognition disorders

,

neurocognitive disorders

,

modified radical mastectomy

,

congenital hip dislocation

,

hip dislocation

,

developmental dysplasia of the hip

,

overactive urinary bladder

,

,

moyamoya disease

,

rapid sequence induction and intubation

,

,

substance withdrawal syndrome

,

sprains and strains

,

separation anxiety

,

,

,

,

,

,

multiple fractures

,

ankle fractures

,

radius fractures

,

wrist fractures

,

,

respiratory function tests

,

,

,

intravenous infusions

,

,

adenomatous polyps

,

recreational drug use

,

,

tubal sterilization

,

mouth neoplasms

,

cardiac procedures anesthesia

,

carbon monoxide poisoning

,

focal nodular hyperplasia

,

idiopathic noncirrhotic portal hypertension

,

,

,

marijuana abuse

,

brachial plexus block

,

cigarette smoking

,

abdominal hernia

,

,

pharmacogenomic testing

,

,

immediate hypersensitivity

,

drug hypersensitivity

,

ambulatory care

,

,

mitral valve insufficiency

,

early ambulation

,

motor evoked potentials

,

somatosensory evoked potentials

,

,

one-lung ventilation

,

craniosynostoses

,

,

,

,

nutrition disorders

,

,

thoracic diseases

,

pregnancy complications

,

muscle rigidity

,

umbilical hernia

,

type 2 diabetes mellitus

,

post-dural puncture headache

,

,

,

,

virtual reality exposure therapy

,

male circumcision

,

acupuncture analgesia

,

,

muscular diseases

,

neuromuscular monitoring

,

abdominal obesity

,

pancreaticoduodenectomy

,

,

uterine neoplasms

,

uterine diseases

,

cervical plexus block

,

vision disorders

,

,

gastric dilatation

,

artificial pacemaker

,

,

pulmonary ventilation

,

body mass index

,

,

subdural hematoma

,

,

,

left ventricular dysfunction

,

,

headache disorders

,

positive-pressure respiration

,

,

proximal femoral fractures

,

acoustic neuroma

,

microvascular decompression surgery

,

spondylolisthesis

venous thrombosis

,

healthy volunteers/patients

,

carotid artery diseases

,

cardiogenic shock

,

congenital heart defects

,

cardiomyopathies

,

,

coronary artery bypass

,

cardiovascular diseases

,

,

,

subarachnoid hemorrhage

,

,

intracranial aneurysm

,

endovascular procedures

,

aortic valve stenosis

,

transcatheter aortic valve replacement

,

hematologic diseases

,

cardiac surgical procedures

,

,

,

myocardial infarction

,

,

coronary artery disease

,

st elevation myocardial infarction

,

acute coronary syndrome

,

coronary disease

,

myocardial ischemia

,

percutaneous coronary intervention

,

,

,

inferior wall myocardial infarction

,

,

,

,

non-st elevated myocardial infarction

,

unstable angina

,

thrombocytopenia

,

hemostatic disorders

,

,

balloon angioplasty coronary

,

respiratory distress syndrome

,

blood coagulation disorders

,

angina pectoris

,

,

,

coronavirus infections

,

,

,

,

,

,

mucocutaneous lymph node syndrome

,

hyperaldosteronism

,

pulmonary arterial hypertension

,

urinary tract infections

,

hyperphosphatemia

,

,

,

sleep initiation and maintenance disorders

,

,

cardiac arrhythmias

,

bronchopulmonary dysplasia

,

adrenal insufficiency

,

,

,

coagulation protein disorders

,

attention deficit disorder with hyperactivity

,

atherosclerosis

,

carotid stenosis

,

microvascular angina

,

respiratory insufficiency

primary myelofibrosis

,

,

small cell lung carcinoma

,

migraine disorders

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

burkitt lymphoma

,

,

myeloid leukemia acute

,

deficiency diseases

,

paraproteinemias

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

breast neoplasms

,

immune system diseases

,

hematologic neoplasms

,

type 2 diabetes mellitus

,

,

metabolic diseases

,

,

glycogen storage disease

,

,

immunoglobulin g4-related disease

,

,

myeloid leukemia

,

,

falciparum malaria

,

,

,

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

,

renal insufficiency

,

hematologic diseases

,

blood protein disorders

,

neoplasms by histologic type

,

prostatic neoplasms

,

circulating neoplastic cells

,

x-linked bulbo-spinal atrophy

,

heart transplantation

,

non-small-cell lung carcinoma

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

esophageal neoplasms

,

,

neoplasm metastasis

,

aplastic anemia

,

multiple myeloma

,

hypercholesterolemia

,

meningococcal infections

,

plasma cell neoplasms

,

hemolytic anemia autoimmune

,

,

meningococcal meningitis

,

stomach neoplasms

,

,

kidney diseases

,

gaucher disease

,

,

chronic renal insufficiency

,

hyperphosphatemia

,

multiple sclerosis

,

,

homozygous familial hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

,

healthy volunteers/patients

,

,

glycogen storage disease type ii

,

atopic dermatitis

,

diabetes mellitus

,

insulin resistance

,

,

glycogen storage disease type iii

,

,

non-hodgkin lymphoma

,

,

postmenopausal osteoporosis

,

,

lymphoproliferative disorders

postherpetic neuralgia

diabetic retinopathy

,

vitreous hemorrhage

,

dry eye syndromes

,

,

,

Antineoplaston a10

healthy volunteers/patients

,

,

,

allergic rhinitis perennial

P2y purinoceptor 12

myocardial infarction

,

st elevation myocardial infarction

,

dual anti-platelet therapy

,

,

coronary artery disease

,

renal insufficiency

,

ischemic stroke

,

,

coronary disease

,

myocardial ischemia

,

hematologic diseases

,

,

blood coagulation disorders

,

hemorrhagic stroke

,

thrombocytopenia

,

hemostatic disorders

,

coagulation protein disorders

Fluoroquinolone

healthy volunteers/patients

,

,

communicable diseases

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

,

community-acquired infections

,

bacterial pneumonia

,

urinary tract infections

,

atrial fibrillation

,

dual anti-platelet therapy

,

coronary artery disease

,

myocardial ischemia

,

coronary disease

,

vascular diseases

,

coronary stenosis

,

coronary restenosis

,

myocardial infarction

,

acute coronary syndrome

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