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Company ReportsThe Medicines Company

The Medicines Company

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Clinical Trials

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Angiox	Bivalirudin	2004-09-20	2028-2039	Acute coronary syndrome , Unstable angina
Ionsys	Fentanyl	2006-05-22	2024-2033	Neoplasms , Pain , Postoperative pain , Psychotic disorders

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

,

,

paroxysmal dyspnea

venous thrombosis

,

healthy volunteers/patients

,

carotid artery diseases

,

coronary artery bypass

,

,

,

cardiovascular diseases

,

,

subarachnoid hemorrhage

,

,

intracranial aneurysm

,

endovascular procedures

,

aortic valve stenosis

,

transcatheter aortic valve replacement

,

hematologic diseases

,

cardiac surgical procedures

,

,

,

myocardial infarction

,

,

coronary artery disease

,

st elevation myocardial infarction

,

acute coronary syndrome

,

coronary disease

,

myocardial ischemia

,

percutaneous coronary intervention

,

,

inferior wall myocardial infarction

,

,

,

,

unstable angina

,

thrombocytopenia

,

non-st elevated myocardial infarction

,

,

,

balloon angioplasty coronary

,

respiratory distress syndrome

,

blood coagulation disorders

,

hemostatic disorders

,

angina pectoris

,

,

atherosclerosis

,

carotid stenosis

,

microvascular angina

,

respiratory insufficiency

healthy volunteers/patients

,

non-alcoholic fatty liver disease

,

,

,

,

,

,

chronic hepatitis b

,

chronic hepatitis

,

parkinson disease

,

eosinophilic esophagitis

,

,

,

biliary liver cirrhosis

,

,

,

,

pulmonary hypertension

,

pulmonary arterial hypertension

,

diffuse scleroderma

,

,

,

,

short bowel syndrome

,

drug resistance

,

heat stress disorders

,

,

combat disorders

,

traumatic stress disorders

,

gastrointestinal diseases

,

,

intestinal diseases

,

,

,

,

kidney diseases

,

,

chronic renal insufficiency

,

chronic hepatitis c

,

,

papillomavirus infections

,

,

cardiovascular diseases

,

pulmonary embolism

,

,

thromboembolism

,

,

venous thrombosis

,

major depressive disorder

,

depressive disorder

,

,

papillomavirus vaccines

,

meningococcal infections

,

,

glucose metabolism disorders

,

metabolic diseases

,

vascular diseases

,

,

metabolic syndrome

,

endocrine system diseases

,

hypertriglyceridemia

,

rheumatoid arthritis

,

,

atrial fibrillation

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

systemic scleroderma

,

juvenile arthritis

,

behcet syndrome

,

dermatomyositis

,

ankylosing spondylitis

,

,

sjogren's syndrome

,

systemic lupus erythematosus

,

rheumatic diseases

,

,

spondylarthritis

,

,

systemic vasculitis

,

collagen diseases

,

diabetic neuropathies

,

hypercholesterolemia

,

,

facial nerve diseases

,

,

wasting syndrome

,

,

keratoconjunctivitis sicca

,

dry eye syndromes

Sodium chloride

dental anesthesia

,

hemoglobinopathies

,

bone marrow failure disorders

,

inborn errors metabolism

,

primary immunodeficiency diseases

neoplasm metastasis

,

postoperative nausea and vomiting

,

,

viral hepatitis human

,

,

brain neoplasms

,

,

,

,

large cell carcinoma

,

chronic obstructive pulmonary disease

,

,

,

follicular lymphoma

,

mouth neoplasms

,

oropharyngeal neoplasms

,

laryngeal neoplasms

,

hypopharyngeal neoplasms

,

non-hodgkin lymphoma

,

type 2 diabetes mellitus

,

diabetes mellitus

,

non-small-cell lung carcinoma

,

,

,

,

,

breast neoplasms

,

,

communicable diseases

,

,

chronic hepatitis c

,

esophageal neoplasms

,

,

,

,

,

,

colorectal neoplasms

,

triple negative breast neoplasms

,

head and neck neoplasms

,

squamous cell carcinoma

,

,

,

chronic hepatitis

,

,

stomach neoplasms

,

squamous cell carcinoma of head and neck

,

ovarian neoplasms

,

sleep initiation and maintenance disorders

,

clostridium infections

,

multiple myeloma

,

plasma cell neoplasms

,

chronic renal insufficiency

,

kidney diseases

,

hodgkin disease

,

ovarian epithelial carcinoma

,

malignant mesothelioma

,

,

migraine disorders

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

,

essential hypertension

,

microsatellite instability

,

nasopharyngeal neoplasms

,

squamous cell neoplasms

,

acquired immunodeficiency syndrome

,

,

,

general anesthesia

,

neuromuscular blockade

,

intraabdominal infections

,

urinary tract infections

,

postmenopausal osteoporosis

,

hypercholesterolemia

,

alzheimer disease

,

pancreatic neoplasms

,

,

erectile dysfunction

,

renal cell carcinoma

,

nasopharyngeal carcinoma

,

surgical wound infection

,

bacterial skin diseases

,

bacterial infections

,

staphylococcal infections

,

,

immunologic deficiency syndromes

,

,

type 1 diabetes mellitus

,

renal insufficiency

,

cytomegalovirus infections

,

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

transitional cell carcinoma

,

hepatocellular carcinoma

,

liver neoplasms

,

fallopian tube neoplasms

,

,

,

bacterial pneumonia

,

,

,

,

,

hepatic insufficiency

,

,

prostatic hyperplasia

,

,

,

,

cognitive dysfunction

,

,

,

plexiform neurofibroma

,

neurofibromatosis 1

,

neurofibromatoses

,

,

hereditary breast and ovarian cancer syndrome

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

rheumatoid arthritis

,

,

hip osteoarthritis

,

surgical blood loss

,

replacement arthroplasty hip

acute coronary syndrome

,

knee prosthesis

,

,

tendon injuries

,

,

tissue adhesions

,

hip osteoarthritis

,

,

,

high-risk pregnancy

,

intervertebral disc degeneration

,

,

multiple trauma

,

,

neoplasm metastasis

,

operative surgical procedures

,

urinary retention

,

,

patient satisfaction

,

,

physician-nurse relations

,

,

traumatic intracranial hemorrhage

,

,

,

,

pulmonary emphysema

,

,

spinal curvatures

,

critical illness

,

pituitary neoplasms

,

pituitary diseases

,

hereditary breast and ovarian cancer syndrome

,

spinal cord neoplasms

,

spinal neoplasms

,

squamous cell carcinoma

,

,

traumatic brain injuries

,

,

,

von willebrand diseases

,

,

,

hematologic neoplasms

,

,

hereditary hemorrhagic telangiectasia

,

,

,

hyperpigmentation

,

hemorrhagic shock

,

thrombocytopenia

,

transfusion reaction

,

coronary artery bypass

,

,

chronic renal insufficiency

,

kidney diseases

,

,

urinary bladder neoplasms

,

,

,

,

traumatic brain hemorrhage

,

pulmonary hypertension

,

lung transplantation

,

spinal dysraphism

,

,

intraoperative complications

,

brain neoplasms

,

head and neck neoplasms

,

,

transcatheter aortic valve replacement

,

hereditary angioedemas

,

female genital neoplasms

,

,

,

obstetric labor

,

,

hematopoietic stem cell transplantation

,

,

subarachnoid hemorrhage

,

carotid artery diseases

,

spinal injuries

,

abdominal aortic aneurysm

,

,

aortic aneurysm

,

,

,

pancreatic neoplasms

,

hepatocellular carcinoma

,

,

,

femoracetabular impingement

,

,

surgical wound infection

,

,

,

,

,

acute kidney injury

,

,

agranulocytosis

,

feeding behavior

,

replacement arthroplasty shoulder

,

,

surgical blood loss

,

postpartum hemorrhage

,

postoperative hemorrhage

,

,

knee osteoarthritis

,

,

,

,

,

,

obstetric labor complications

,

wounds and injuries

,

postoperative pain

,

replacement arthroplasty knee

,

blood coagulation disorders

,

hemostatic disorders

,

placenta previa

,

,

uterine hemorrhage

,

gastrointestinal hemorrhage

,

replacement arthroplasty hip

,

blood transfusion

,

cerebral hemorrhage

,

,

,

,

,

subdural hematoma

,

,

,

drug-related side effects and adverse reactions

,

cardiac surgical procedures

,

subdural hematoma chronic

,

femoral fractures

,

,

,

,

,

,

rotator cuff injuries

,

,

breast neoplasms

,

cardiopulmonary bypass

,

coronary artery disease

,

,

,

postoperative complications

,

venous thrombosis

,

,

,

,

,

congenital abnormalities

,

congenital heart defects

,

,

,

,

liver cirrhosis

,

ovarian neoplasms

,

uterine myomectomy

,

anterior cruciate ligament reconstruction

,

thromboembolism

,

craniosynostoses

,

,

,

communicable diseases

,

healthy volunteers/patients

,

anterior cruciate ligament injuries

,

,

paranasal sinus diseases

,

shoulder impingement syndrome

,

prostatic neoplasms

,

,

,

nephrolithiasis

,

,

ovarian epithelial carcinoma

,

,

,

placenta accreta

,

spinal stenosis

,

,

,

cesarean section

,

femoral neck fractures

,

,

prostatic hyperplasia

,

hypersensitivity

,

,

,

pathologic dilatation

,

urologic diseases

,

,

orthognathic surgery

,

tooth extraction

,

pregnancy complications

,

pelvic organ prolapse

,

,

hemorrhagic stroke

,

,

,

stomach neoplasms

,

liver neoplasms

,

colonic neoplasms

,

intracranial hemorrhages

,

radius fractures

,

wrist fractures

,

venous thromboembolism

,

humeral fractures

,

,

,

opioid-related disorders

,

deficiency diseases

,

chronic urticaria

,

,

nasal obstruction

,

,

injection site reaction

,

,

cross infection

,

wound infection

,

,

,

,

,

colorectal neoplasms

,

uterine inertia

,

staghorn calculi

,

myocardial infarction

,

pulmonary embolism

,

,

,

,

hemiarthroplasty

,

arteriovenous fistula

,

,

pathologic constriction

,

gynecologic surgical procedures

,

,

,

,

,

pancreaticoduodenectomy

,

,

biliary tract surgical procedures

,

,

,

dupuytren contracture

,

,

,

,

,

esophageal neoplasms

,

duodenal neoplasms

,

heart valve diseases

,

prospective studies

,

randomized controlled trials as topic

,

eyelid diseases

,

,

shoulder fractures

,

shoulder injuries

,

contraceptive devices

,

autoimmune diseases

,

intravenous administration

,

,

,

,

,

,

hyperaldosteronism

,

pulmonary arterial hypertension

,

urinary tract infections

,

,

sleep initiation and maintenance disorders

,

cardiac arrhythmias

,

,

,

,

,

blood platelet disorders

,

,

heterotopic ossification

,

coronary disease

,

myocardial ischemia

,

coronavirus infections

,

,

mucocutaneous lymph node syndrome

,

hyperphosphatemia

,

bronchopulmonary dysplasia

,

adrenal insufficiency

,

,

coagulation protein disorders

,

attention deficit disorder with hyperactivity

,

musculoskeletal diseases

,

,

rheumatoid arthritis

,

replacement arthroplasty

,

respiratory tract infections

,

,

migraine disorders

,

,

,

bacterial infections

,

intraabdominal infections

,

healthcare-associated pneumonia

,

methicillin-resistant staphylococcus aureus

,

,

staphylococcal infections

,

,

,

general anesthesia

,

,

,

gram-negative bacterial infections

,

,

bacterial meningitis

,

,

central nervous system infections

,

neuromuscular blockade

,

,

,

cytomegalovirus retinitis

,

adenoviridae infections

,

port-wine stain

,

,

,

capillary hemangioma

,

,

bipolar disorder

,

autistic disorder

,

,

treatment-resistant schizophrenia

,

potassium deficiency

,

,

iron-deficiency anemia

,

iron deficiencies

,

cytoreduction surgical procedures

,

primary graft dysfunction

,

intervertebral disc displacement

,

,

liver transplantation

,

congenital hip dislocation

,

developmental dysplasia of the hip

,

femur head necrosis

,

,

aortic dissection

,

acute lung injury

,

retinal diseases

,

factor xi deficiency

,

closed fractures

,

orthopedic procedures

,

erythrocyte transfusion

,

neurosurgical procedures

,

lacrimal duct obstruction

,

off-pump coronary artery bypass

,

spinal cord diseases

,

spinal cord compression

,

hematologic diseases

,

recreational drug use

,

,

peptic ulcer hemorrhage

,

osteogenesis imperfecta

,

skin pigmentation

,

,

obstetric delivery

,

,

obstetrical anesthesia

,

abruptio placentae

,

prolonged pregnancy

,

,

transurethral resection of prostate

,

vaginal hysterectomy

,

percutaneous nephrolithotomy

,

pigmentation disorders

,

vascular diseases

,

,

bariatric surgery

,

cardiovascular surgical procedures

,

lens subluxation

,

joint dislocations

,

fracture dislocation

,

elbow fractures

,

dermatofibrosarcoma

,

spontaneous fractures

,

thoracic surgical procedures

,

autologous blood transfusion

,

,

spinal diseases

,

,

,

,

retinal detachment

,

diabetic retinopathy

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

myeloid leukemia

,

blood flow velocity

,

coronary circulation

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

ischemic stroke

,

,

sickle cell anemia

,

,

pancreatic ductal carcinoma

,

pancreatic neoplasms

,

,

graft rejection

,

cerebral infarction

,

coronary artery disease

,

myocardial infarction

,

,

acute coronary syndrome

,

coronary disease

,

myocardial ischemia

,

,

,

percutaneous coronary intervention

,

st elevation myocardial infarction

,

platelet aggregation

,

,

atrial fibrillation

,

,

cardiovascular diseases

,

,

inferior wall myocardial infarction

,

atherosclerosis

,

peripheral arterial disease

,

unstable angina

,

,

dual anti-platelet therapy

,

,

intracranial aneurysm

,

,

coronary stenosis

,

chronic renal insufficiency

,

kidney diseases

,

drug-eluting stents

,

peripheral vascular diseases

,

non-st elevated myocardial infarction

,

,

healthy volunteers/patients

,

,

endovascular procedures

,

,

arteriosclerosis

,

,

,

cardiogenic shock

,

vascular diseases

,

ventricular remodeling

,

,

,

aortic valve stenosis

,

,

angina pectoris

,

platelet activation

,

platelet function tests

,

drug interactions

,

,

induced hypothermia

,

stomatognathic diseases

,

,

bronchial hyperreactivity

,

out-of-hospital cardiac arrest

,

migraine disorders

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

thrombocytopenia

,

renal insufficiency

,

hematologic diseases

,

,

blood coagulation disorders

,

hemorrhagic stroke

,

hemostatic disorders

,

coagulation protein disorders

,

heart valve prosthesis

,

cerebral hemorrhage

,

subarachnoid hemorrhage

,

nervous system diseases

,

coronary thrombosis

,

drug resistance

,

,

disseminated intravascular coagulation

,

heart disease risk factors

,

blood platelet disorders

,

,

pathologic processes

,

systemic inflammatory response syndrome

,

,

postoperative hemorrhage

,

surgical blood loss

,

,

,

,

,

endomyocardial fibrosis

,

cerebrovascular disorders

,

stomach neoplasms

,

blood transfusion

,

extracorporeal membrane oxygenation

,

drug-related side effects and adverse reactions

,

pharmacogenomic testing

,

,

cardiomyopathies

,

,

intracranial arteriosclerosis

,

,

,

,

,

,

bacterial conjunctivitis

,

,

,

cataract extraction

,

intravitreal injections

acute coronary syndrome

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