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Company ReportsThe Medicines Company

The Medicines Company

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Clinical Trials

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Angiox	Bivalirudin	2004-09-20	2028-2039	Acute coronary syndrome , Unstable angina
Ionsys	Fentanyl	2006-05-22	2024-2033	Neoplasms , Pain , Postoperative pain , Psychotic disorders

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

opioid-related disorders

,

morphine dependence

,

opiate substitution treatment

venous thrombosis

,

healthy volunteers/patients

,

carotid artery diseases

,

coronary artery bypass

,

,

,

cardiovascular diseases

,

,

subarachnoid hemorrhage

,

,

intracranial aneurysm

,

endovascular procedures

,

aortic valve stenosis

,

transcatheter aortic valve replacement

,

hematologic diseases

,

cardiac surgical procedures

,

,

,

myocardial infarction

,

,

coronary artery disease

,

st elevation myocardial infarction

,

acute coronary syndrome

,

coronary disease

,

myocardial ischemia

,

percutaneous coronary intervention

,

,

inferior wall myocardial infarction

,

,

,

,

unstable angina

,

thrombocytopenia

,

non-st elevated myocardial infarction

,

,

,

balloon angioplasty coronary

,

respiratory distress syndrome

,

blood coagulation disorders

,

hemostatic disorders

,

angina pectoris

,

,

atherosclerosis

,

carotid stenosis

,

microvascular angina

,

respiratory insufficiency

large b-cell lymphoma diffuse

,

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

,

,

,

hodgkin disease

,

mantle-cell lymphoma

,

b-cell lymphoma

,

triple negative breast neoplasms

,

renal cell carcinoma

,

,

,

,

chronic hepatitis b

,

communicable diseases

,

,

parkinson disease

,

parkinsonian disorders

,

movement disorders

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

chronic renal insufficiency

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

graft vs host disease

,

type 1 diabetes mellitus

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

brain neoplasms

,

,

oligodendroglioma

,

pancreatic neoplasms

,

,

neuroendocrine tumors

,

islet cell carcinoma

,

,

,

somatostatinoma

,

,

,

breast neoplasms

,

myelodysplastic syndromes

,

thrombocytopenia

,

,

,

,

retinal vein occlusion

,

vision disorders

,

,

macular degeneration

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

juvenile arthritis

,

,

kidney diseases

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

organ transplantation

,

wet macular degeneration

,

neoplasm metastasis

,

graft rejection

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

non-alcoholic fatty liver disease

,

,

postoperative pain

,

,

choroidal neovascularization

,

pathologic neovascularization

,

chronic kidney failure

,

renal insufficiency

,

liver transplantation

,

kidney transplantation

,

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

liver cirrhosis

,

,

atrial fibrillation

Antithrombin iii

streptococcal infections

,

rectal neoplasms

,

,

atrial fibrillation

,

mantle-cell lymphoma

,

multiple myeloma

,

plasma cell neoplasms

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

colonic neoplasms

,

streptococcus agalactiae

,

breast neoplasms

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

non-small-cell lung carcinoma

,

,

prostatic neoplasms

,

psoriatic arthritis

,

meningococcal infections

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

,

sickle cell anemia

,

,

renal cell carcinoma

,

,

,

vision disorders

,

,

,

meningococcal meningitis

,

,

thrombocytopenia

,

,

neuroendocrine tumors

,

,

myeloid leukemia

,

ovarian neoplasms

,

human influenza

,

myelodysplastic syndromes

,

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

hepatocellular carcinoma

,

carcinoid tumor

,

malignant carcinoid syndrome

,

serotonin syndrome

,

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

homozygous familial hypercholesterolemia

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

gastrointestinal stromal tumors

,

philadelphia chromosome

,

ovarian epithelial carcinoma

,

axial spondyloarthritis

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

graft vs host disease

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

rheumatoid arthritis

,

,

,

,

,

,

haemophilus influenzae

,

non-hodgkin lymphoma

,

b-cell lymphoma

,

,

hodgkin disease

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

follicular lymphoma

,

pancreatic neoplasms

,

,

myeloid leukemia chronic-phase

,

neuroendocrine carcinoma

,

,

,

essential hypertension

,

systolic murmurs

,

multiple sclerosis

,

neoplasm metastasis

,

chronic progressive multiple sclerosis

,

,

small cell lung carcinoma

,

healthy volunteers/patients

,

,

,

,

neuroendocrine tumors

,

neoplasm metastasis

,

,

b-cell chronic lymphocytic leukemia

,

multiple hamartoma syndrome

,

carcinoid tumor

,

aplastic anemia

,

,

oligodendroglioma

,

,

,

,

cerebellar neoplasms

,

brain neoplasms

,

hepatocellular carcinoma

,

endometrial neoplasms

,

pancreatic neoplasms

,

neuroendocrine carcinoma

,

islet cell carcinoma

,

atopic dermatitis

,

,

,

hodgkin disease

,

,

rheumatoid arthritis

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

neurofibromatosis 2

,

neurofibromatosis 1

,

neurofibromatoses

,

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

t-cell lymphoma cutaneous

,

tuberous sclerosis

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

,

,

myeloproliferative disorders

,

essential thrombocythemia

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

non-hodgkin lymphoma

,

mantle-cell lymphoma

,

colorectal neoplasms

,

kidney neoplasms

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

,

psoriatic arthritis

,

renal cell carcinoma

,

,

,

,

,

,

,

meningococcal meningitis

,

prostatic neoplasms

,

organ transplantation

,

graft rejection

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

paroxysmal hemoglobinuria

,

,

chronic urticaria

,

,

hypersensitivity

,

food hypersensitivity

,

peanut hypersensitivity

,

juvenile arthritis

,

,

hereditary autoinflammatory diseases

,

,

familial mediterranean fever

,

,

,

,

,

,

attention deficit disorder with hyperactivity

,

,

,

major depressive disorder

,

depressive disorder

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

heart transplantation

,

bone resorption

,

,

,

myeloid leukemia

,

kidney transplantation

,

breast neoplasms

,

,

bcr-abl positive chronic myelogenous leukemia

,

meningococcal infections

,

,

sickle cell anemia

,

liver transplantation

,

multiple sclerosis

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

gastrointestinal stromal tumors

,

myeloid leukemia acute

,

human influenza

,

macular degeneration

,

lymphoid leukemia

,

,

,

alzheimer disease

,

choroidal neovascularization

,

pathologic neovascularization

,

,

beta-thalassemia

,

,

parkinson disease

,

relapsing-remitting multiple sclerosis

,

dry eye syndromes

,

type 2 diabetes mellitus

,

diabetes mellitus

,

polycythemia vera

,

primary myelofibrosis

,

graft vs host disease

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

myeloid leukemia chronic-phase

,

,

myelodysplastic syndromes

,

,

,

wet macular degeneration

,

,

,

cystic fibrosis

,

allergic bronchopulmonary aspergillosis

,

pulmonary aspergillosis

,

retinal detachment

,

vascular diseases

,

dissociative disorders

,

polypoidal choroidal vasculopathy

,

diabetic retinopathy

,

pneumococcal infections

,

hemochromatosis

,

,

philadelphia chromosome

,

,

stomach neoplasms

,

,

ankylosing spondylitis

,

spondylarthritis

,

healthy volunteers/patients

,

renal insufficiency

,

pharmacokinetics

,

biological availability

,

,

,

,

chronic kidney failure

,

kidney diseases

,

therapeutic equivalency

,

cardiovascular diseases

,

bariatric surgery

,

thromboembolism

,

venous thromboembolism

,

,

acute coronary syndrome

,

,

,

myocardial infarction

,

myocardial ischemia

,

,

,

transcatheter aortic valve replacement

,

,

percutaneous coronary intervention

,

unstable angina

,

knee osteoarthritis

,

hip osteoarthritis

,

,

,

,

coronavirus infections

,

,

respiratory insufficiency

,

communicable diseases

,

rheumatic diseases

,

collagen diseases

,

coronary disease

,

,

intracranial arteriosclerosis

,

arteriosclerosis

,

atrial fibrillation

,

,

,

venous thrombosis

,

pulmonary embolism

,

coronary artery disease

,

peripheral arterial disease

,

,

peripheral vascular diseases

,

,

disease progression

,

,

,

replacement arthroplasty knee

,

replacement arthroplasty hip

,

congenital heart defects

,

,

fontan procedure

Sodium chloride

,

,

,

,

,

,

depressive disorder

,

,

streptococcal infections

,

streptococcus agalactiae

,

,

acute kidney injury

,

wounds and injuries

,

,

,

aplastic anemia

,

,

hematologic neoplasms

,

,

cutaneous malignant melanoma

,

major depressive disorder

,

suicidal ideation

,

stomach neoplasms

,

bacterial infections

,

gram-positive bacterial infections

,

diabetic nephropathies

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

,

parkinson disease

,

healthy volunteers/patients

,

peritoneal neoplasms

,

intestinal obstruction

,

triple negative breast neoplasms

,

complex regional pain syndromes

,

reflex sympathetic dystrophy

,

somatoform disorders

,

,

,

congenital hyperinsulinism

,

nesidioblastosis

,

hyperinsulinism

,

,

eosinophilic esophagitis

,

,

sickle cell anemia

,

treatment-resistant depressive disorder

,

meningococcal infections

,

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

,

non-small-cell lung carcinoma

,

,

homozygous familial hypercholesterolemia

,

,

meningococcal meningitis

,

cardiovascular diseases

,

,

kidney diseases

,

renal cell carcinoma

,

,

cystic fibrosis

,

prostatic neoplasms

,

,

,

pancreatic neoplasms

,

chronic renal insufficiency

,

kidney transplantation

,

graft rejection

,

,

,

,

,

japanese encephalitis

,

respiratory tract infections

,

,

,

metabolic bone diseases

,

,

,

pulmonary eosinophilia

,

hepatocellular carcinoma

,

liver neoplasms

,

gastrointestinal stromal tumors

,

atherosclerosis

,

,

,

diabetes complications

,

vitreous hemorrhage

,

,

essential hypertension

,

metabolic syndrome

,

,

,

systolic murmurs

,

isolated systolic hypertension

,

neoplasm metastasis

,

,

human influenza

,

diabetes mellitus

,

multiple myeloma

,

plasma cell neoplasms

,

breast neoplasms

,

hypersensitivity

,

left ventricular hypertrophy

,

,

,

,

communicable diseases

,

,

diabetic retinopathy

,

,

insulin resistance

,

prehypertension

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

type 2 diabetes mellitus

,

,

,

retinal diseases

,

hip osteoarthritis

,

,

food hypersensitivity

,

abdominal obesity

,

retinal neovascularization

,

pathologic neovascularization

,

migraine disorders

,

migraine without aura

,

angina pectoris

,

microvascular angina

,

,

migraine with aura

,

health risk behaviors

,

vascular stiffness

hyperlipidemias

,

gastrointestinal stromal tumors

,

,

iron-deficiency anemia

,

iron deficiencies

,

,

,

,

small cell lung carcinoma

,

healthy volunteers/patients

,

,

primary myelofibrosis

,

myeloid leukemia acute

,

myeloid leukemia

,

,

hepatocellular carcinoma

,

,

plexiform neurofibroma

,

neurofibromatoses

,

,

,

,

chronic obstructive pulmonary disease

,

,

triple negative breast neoplasms

,

,

,

essential thrombocythemia

,

polycythemia vera

,

,

,

lupus nephritis

,

,

inflammatory breast neoplasms

,

prostatic neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

wiskott-aldrich syndrome

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

hyperlipoproteinemia type ii

,

organ transplantation

,

homozygous familial hypercholesterolemia

,

cryopyrin-associated periodic syndromes

,

myelodysplastic syndromes

,

,

liver transplantation

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

parkinson disease

,

,

,

juvenile arthritis

,

,

,

,

hepatitis b virus

,

,

,

,

vision disorders

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

,

acute coronary syndrome

,

,

,

pulmonary eosinophilia

,

pancreatic neoplasms

,

,

,

kidney transplantation

,

,

hypercholesterolemia

,

cardiovascular diseases

,

atherosclerosis

,

chronic kidney failure

,

kidney diseases

,

thrombocytopenia

,

,

breast neoplasms

,

,

renal insufficiency

,

,

,

,

chronic renal insufficiency

,

,

renal replacement therapy

,

drug-related side effects and adverse reactions

,

heart transplantation

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

,

cystic fibrosis

,

pseudomonas infections

,

type 2 diabetes mellitus

,

diabetes mellitus

,

multiple myeloma

,

plasma cell neoplasms

,

transplantation

,

cytomegalovirus infections

,

communicable diseases

,

,

postoperative complications

,

,

,

,

blood coagulation disorders

,

hemostatic disorders

,

urinary retention

,

urinary bladder neoplasms

,

,

patient satisfaction

,

,

physician-nurse relations

,

intervertebral disc degeneration

,

traumatic intracranial hemorrhage

,

multiple trauma

,

traumatic brain hemorrhage

,

hereditary breast and ovarian cancer syndrome

,

thromboembolism

,

,

traumatic brain injuries

,

subdural hematoma

,

,

obstetric labor complications

,

subdural hematoma chronic

,

,

hemorrhagic shock

,

thrombocytopenia

,

,

,

,

,

,

congenital abnormalities

,

spinal stenosis

,

spinal dysraphism

,

transfusion reaction

,

,

gastrointestinal hemorrhage

,

,

,

uterine hemorrhage

,

,

,

pregnancy complications

,

obstetric labor

,

hematologic neoplasms

,

hematopoietic stem cell transplantation

,

subarachnoid hemorrhage

,

spinal injuries

,

intraoperative complications

,

intracranial hemorrhages

,

,

femoracetabular impingement

,

,

,

,

brain neoplasms

,

,

,

postpartum hemorrhage

,

surgical blood loss

,

,

knee osteoarthritis

,

,

,

postoperative pain

,

wounds and injuries

,

postoperative hemorrhage

,

,

,

replacement arthroplasty hip

,

rotator cuff injuries

,

,

breast neoplasms

,

,

femoral fractures

,

replacement arthroplasty knee

,

,

,

uterine myomectomy

,

blood transfusion

,

anterior cruciate ligament reconstruction

,

,

,

,

,

venous thrombosis

,

,

drug-related side effects and adverse reactions

,

,

,

,

healthy volunteers/patients

,

,

,

prostatic neoplasms

,

urologic diseases

,

placenta previa

,

,

,

,

cesarean section

,

placenta accreta

,

cardiopulmonary bypass

,

craniosynostoses

,

radius fractures

,

wrist fractures

,

humeral fractures

,

opioid-related disorders

,

,

deficiency diseases

,

shoulder impingement syndrome

,

,

injection site reaction

,

,

anterior cruciate ligament injuries

,

,

,

orthognathic surgery

,

uterine inertia

,

,

myocardial infarction

,

pulmonary embolism

,

,

,

cardiac surgical procedures

,

,

dupuytren contracture

,

,

,

prostatic hyperplasia

,

nephrolithiasis

,

,

,

,

,

colonic neoplasms

,

stomach neoplasms

,

esophageal neoplasms

,

duodenal neoplasms

,

,

shoulder fractures

,

shoulder injuries

,

,

hypersensitivity

,

liver neoplasms

,

,

contraceptive devices

,

pelvic organ prolapse

,

,

,

,

,

,

,

congenital heart defects

,

musculoskeletal diseases

,

acupuncture therapy

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

hyperpigmentation

,

pulmonary hypertension

,

intervertebral disc displacement

,

congenital hip dislocation

,

developmental dysplasia of the hip

,

osteogenesis imperfecta

,

,

,

obstetrical anesthesia

,

vascular diseases

,

bariatric surgery

,

cardiovascular surgical procedures

,

,

neoplasm metastasis

,

spontaneous fractures

,

femoral neck fractures

,

spinal diseases

,

migraine disorders

,

healthy volunteers/patients

,

,

,

chronic obstructive pulmonary disease

,

pulmonary hypertension

,

peripheral arterial disease

,

pulmonary arterial hypertension

,

obstructive lung diseases

,

pure autonomic failure

,

colorectal neoplasms

,

,

adenomatous polyps

,

liver transplantation

,

nasal surgical procedures

,

rectal neoplasms

,

genetic polymorphism

,

,

pathologic dilatation

,

obstructive sleep apnea

,

sleep apnea syndromes

,

non-small-cell lung carcinoma

,

,

,

,

,

coronary stenosis

,

,

cerebral hemorrhage

,

variant angina pectoris

,

aortic valve stenosis

,

,

brain neoplasms

,

prostatic neoplasms

,

placental site trophoblastic tumor

,

choriocarcinoma

,

,

acute liver failure

,

,

aortic coarctation

,

,

sickle cell anemia

,

,

localized scleroderma

,

,

hemorrhagic shock

,

phase ii as topic clinical trials

,

,

,

connective tissue diseases

,

,

communicable diseases

,

catheter-related infections

,

,

,

cholecystolithiasis

,

,

biliary tract diseases

,

,

peripheral nervous system diseases

,

diabetic neuropathies

,

vasovagal syncope

,

spinal cord injuries

,

autonomic dysreflexia

,

gestational trophoblastic disease

,

,

raynaud disease

,

neoplasm metastasis

,

,

,

,

acute coronary syndrome

,

erectile dysfunction

,

systemic scleroderma

,

,

autoimmune diseases

,

trophoblastic neoplasms

,

,

,

ischemic stroke

,

diffuse scleroderma

,

hyperlipidemias

,

pulmonary edema

,

cardiac catheterization

,

drug-related side effects and adverse reactions

,

endoscopic retrograde cholangiopancreatography

,

,

rheumatoid arthritis

,

,

,

metabolic bone diseases

,

,

reperfusion injury

,

myocardial reperfusion injury

,

,

ventricular remodeling

,

anterior wall myocardial infarction

,

,

coronary artery disease

,

myocardial ischemia

,

coronary disease

,

,

myocardial infarction

,

,

angina pectoris

,

,

,

,

,

st elevation myocardial infarction

,

,

cardiovascular diseases

,

diabetes mellitus

,

kidney diseases

,

coronary artery bypass

,

type 2 diabetes mellitus

,

chronic renal insufficiency

,

unstable angina

,

type 1 diabetes mellitus

,

hydatidiform mole

,

percutaneous coronary intervention

,

no-reflow phenomenon

,

,

renal insufficiency

,

peripheral vascular diseases

,

arteriovenous fistula

,

,

hypercholesterolemia

,

pregnancy complications

,

,

retained placenta

,

,

regional blood flow

,

,

microcirculation

,

,

chinese traditional medicine

,

heart transplantation

,

cardiopulmonary bypass

,

,

diastolic heart failure

,

intracranial vasospasm

,

inferior wall myocardial infarction

,

escherichia coli infections

,

,

,

premature obstetric labor

,

premature birth

,

,

gender dysphoria

,

atherosclerosis

,

,

acute kidney injury

,

microvascular angina

,

coronary circulation

,

chronic kidney failure

,

pathologic constriction

,

migraine with aura

,

,

cognitive dysfunction

,

,

wounds and injuries

,

,

migraine without aura

,

controlled hypotension

,

vascular access devices

,

breech presentation

,

tympanic membrane perforation

,

breast neoplasms

,

,

,

lactic acidosis

,

,

,

coronary angiography

,

postoperative complications

,

,

multiple chronic conditions

,

,

coronary vasospasm

,

intracranial hemorrhages

,

vascular diseases

,

retinal diseases

,

,

essential hypertension

,

myocardial bridging

,

postpartum hemorrhage

,

,

,

middle cerebral artery infarction

,

magnetic resonance angiography

,

vascular remodeling

,

cardiomyopathies

,

dilated cardiomyopathy

,

coronavirus infections

,

,

,

systemic lupus erythematosus

,

headache disorders

,

central nervous system diseases

,

,

nervous system diseases

,

primary headache disorders

,

blood coagulation disorders

,

hemostatic disorders

,

hemorrhagic disorders

,

polycystic ovary syndrome

,

,

female infertility

,

arteriosclerosis

,

,

psychotic disorders

,

hypersensitivity

,

arterial occlusive diseases

,

myofascial pain syndromes

,

,

replacement arthroplasty knee

,

postoperative pain

,

esophageal neoplasms

,

cardiogenic shock

,

lacrimal duct obstruction

,

dacryocystorhinostomy

,

maxillofacial injuries

,

,

,

respiratory tract diseases

,

respiration disorders

,

persistent fetal circulation syndrome

,

echocardiography

,

,

,

kidney transplantation

,

,

drug-eluting stents

,

coronary occlusion

,

,

vascular graft occlusion

,

,

central venous pressure

,

urinary bladder neoplasms

,

cardiovascular diseases

,

coronary artery disease

,

,

venous thrombosis

,

pulmonary embolism

,

acute coronary syndrome

,

percutaneous coronary intervention

,

atherosclerosis

,

myocardial infarction

,

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

1

2

>

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