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Company ReportsThe Medicines Company

The Medicines Company

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Clinical Trials

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Angiox	Bivalirudin	2004-09-20	2028-2039	Acute coronary syndrome , Unstable angina
Ionsys	Fentanyl	2006-05-22	2024-2033	Neoplasms , Pain , Postoperative pain , Psychotic disorders

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

,

,

,

breakthrough pain

venous thrombosis

,

healthy volunteers/patients

,

carotid artery diseases

,

coronary artery bypass

,

cardiovascular diseases

,

,

,

,

subarachnoid hemorrhage

,

,

intracranial aneurysm

,

endovascular procedures

,

aortic valve stenosis

,

transcatheter aortic valve replacement

,

hematologic diseases

,

cardiac surgical procedures

,

,

,

myocardial infarction

,

,

coronary artery disease

,

st elevation myocardial infarction

,

acute coronary syndrome

,

coronary disease

,

myocardial ischemia

,

percutaneous coronary intervention

,

,

,

inferior wall myocardial infarction

,

,

,

non-st elevated myocardial infarction

,

unstable angina

,

thrombocytopenia

,

,

,

balloon angioplasty coronary

,

respiratory distress syndrome

,

blood coagulation disorders

,

hemostatic disorders

,

angina pectoris

,

,

atherosclerosis

,

carotid stenosis

,

microvascular angina

,

respiratory insufficiency

anxiety disorders

,

healthy volunteers/patients

,

huntington disease

,

non-alcoholic fatty liver disease

,

,

,

,

,

breast neoplasms

,

,

chronic hepatitis b

,

chronic hepatitis

,

parkinson disease

,

eosinophilic esophagitis

,

,

biliary liver cirrhosis

,

,

,

pulmonary hypertension

,

pulmonary arterial hypertension

,

diffuse scleroderma

,

,

,

,

short bowel syndrome

,

myocardial infarction

,

drug resistance

,

heat stress disorders

,

,

combat disorders

,

traumatic stress disorders

,

gastrointestinal diseases

,

,

intestinal diseases

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

depressive disorder

,

,

,

major depressive disorder

,

,

,

,

kidney diseases

,

,

cardiovascular diseases

,

chronic renal insufficiency

,

chronic hepatitis c

,

papillomavirus infections

,

,

,

pulmonary embolism

,

,

thromboembolism

,

,

venous thrombosis

,

,

papillomavirus vaccines

,

,

meningococcal infections

,

,

glucose metabolism disorders

,

metabolic diseases

,

vascular diseases

,

,

metabolic syndrome

,

endocrine system diseases

,

hypertriglyceridemia

,

rheumatoid arthritis

,

atrial fibrillation

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

systemic scleroderma

,

juvenile arthritis

,

behcet syndrome

,

dermatomyositis

,

ankylosing spondylitis

,

sjogren's syndrome

,

systemic lupus erythematosus

,

,

spondylarthritis

,

systemic vasculitis

,

diabetic neuropathies

,

hypercholesterolemia

,

,

facial nerve diseases

,

,

wasting syndrome

,

,

keratoconjunctivitis sicca

,

dry eye syndromes

healthy volunteers/patients

,

alzheimer disease

,

female genital neoplasms

,

,

chronic hepatitis b

,

,

major depressive disorder

,

depressive disorder

,

triple negative breast neoplasms

,

pancreatic neoplasms

,

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

,

sickle cell anemia

,

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

parkinson disease

,

autistic disorder

,

autism spectrum disorder

,

pervasive child development disorders

,

chronic hepatitis

,

rectal neoplasms

,

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

stomach neoplasms

,

esophageal neoplasms

,

,

neoplasm metastasis

,

antiphospholipid syndrome

,

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

lupus nephritis

,

human influenza

,

breast neoplasms

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

non-hodgkin lymphoma

,

myeloid leukemia acute

,

multiple sclerosis

,

,

,

hepatocellular carcinoma

,

colonic neoplasms

,

thrombocytopenic purpura idiopathic

,

liver cirrhosis

,

neuromyelitis optica

,

membranous glomerulonephritis

,

chronic progressive multiple sclerosis

,

,

nephrotic syndrome

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

,

hemolytic anemia autoimmune

,

,

chronic hepatitis c

,

,

,

rheumatoid arthritis

,

,

,

juvenile arthritis

,

,

follicular lymphoma

,

,

,

myelodysplastic syndromes

,

,

,

acquired immunodeficiency syndrome

,

kidney transplantation

,

drug-related side effects and adverse reactions

,

heart disease risk factors

,

cognitive dysfunction

complex regional pain syndromes

,

,

,

,

,

,

stress urinary incontinence

,

,

prostatic hyperplasia

,

choroidal neovascularization

,

,

diabetes mellitus

,

magnetic resonance imaging

,

,

,

hypertrophic cicatrix

,

,

major depressive disorder

,

carpal tunnel syndrome

,

premature ejaculation

,

,

rectal neoplasms

,

low anterior resection syndrome

,

,

penile induration

,

thoracic outlet syndrome

,

postherpetic neuralgia

,

motor neuron disease

,

thyroid diseases

,

,

ovarian neoplasms

,

stomach neoplasms

,

head and neck neoplasms

,

esophageal neoplasms

,

,

urinary bladder neoplasms

,

small cell lung carcinoma

,

endophthalmitis

,

lacrimal apparatus diseases

,

,

radiation injuries

,

uveal neoplasms

,

,

pancreatic neoplasms

,

macular degeneration

,

,

breast neoplasms

,

myofascial pain syndromes

,

neurogenic urinary bladder

,

,

,

,

,

non-small-cell lung carcinoma

,

dystonic disorders

,

temporomandibular joint disorders

,

,

,

somatoform disorders

,

systemic scleroderma

,

raynaud disease

,

diffuse scleroderma

,

urinary bladder diseases

,

multiple sclerosis

,

,

postoperative pain

,

breast diseases

,

hereditary breast and ovarian cancer syndrome

,

,

,

,

patellofemoral pain syndrome

,

allergic conjunctivitis

,

,

muscle spasticity

,

overactive urinary bladder

,

urinary incontinence

,

migraine disorders

,

,

,

,

healthy volunteers/patients

,

,

,

dry eye syndromes

,

,

prostatic neoplasms

,

diabetic retinopathy

,

parkinson disease

,

,

,

,

,

chronic kidney failure

,

renal insufficiency

,

iron-deficiency anemia

,

iron deficiencies

,

,

interstitial cystitis

,

graves ophthalmopathy

,

,

,

spinal cord injuries

,

developmental disabilities

,

,

,

left ventricular hypertrophy

,

,

sjogren's syndrome

,

retinal vein occlusion

,

herpes labialis

,

traumatic brain injuries

,

,

,

,

keratoconjunctivitis sicca

,

,

,

muscle strength

,

clostridium botulinum type a

colorectal neoplasms

,

,

rectal neoplasms

,

squamous cell carcinoma of head and neck

,

chronic obstructive pulmonary disease

,

,

multiple myeloma

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

breast neoplasms

,

,

non-small-cell lung carcinoma

,

,

vision disorders

,

bcr-abl positive chronic myelogenous leukemia

,

neoplasm metastasis

,

,

,

,

myeloid leukemia

,

spondylarthritis

,

,

,

,

psoriatic arthritis

,

ankylosing spondylitis

,

retinal vein occlusion

,

,

chronic urticaria

,

,

cystic fibrosis

,

,

choroidal neovascularization

,

osteitis deformans

,

,

renal cell carcinoma

,

philadelphia chromosome

,

ovarian neoplasms

,

pituitary acth hypersecretion

,

,

,

myelodysplastic syndromes

,

,

thrombocytopenia

,

diabetic retinopathy

,

macular degeneration

,

,

hematologic diseases

,

sickle cell anemia

,

sickle cell trait

,

vaso-occlusive crises

,

,

,

,

,

neuroendocrine tumors

,

,

gastrointestinal stromal tumors

,

triple negative breast neoplasms

,

myeloid leukemia acute

,

acth-secreting pituitary adenoma

,

,

pseudomonas aeruginosa

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

respiratory aspiration

,

prostatic neoplasms

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

retinal diseases

,

wet macular degeneration

,

pathologic neovascularization

,

adenocarcinoma of lung

,

brain neoplasms

,

,

hepatocellular carcinoma

,

stomach neoplasms

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

carcinoid tumor

,

malignant carcinoid syndrome

,

serotonin syndrome

,

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

homozygous familial hypercholesterolemia

,

,

lupus nephritis

,

,

axial spondyloarthritis

,

endometrioid carcinoma

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

allergic rhinitis seasonal

,

graft vs host disease

,

primary myelofibrosis

,

,

inclusion body myositis

,

juvenile arthritis

,

hereditary autoinflammatory diseases

,

,

familial mediterranean fever

,

diabetes mellitus

,

retinal neovascularization

,

rheumatoid arthritis

,

hereditary sensory and autonomic neuropathies

,

,

hyperlipoproteinemia type i

,

hyperpituitarism

,

degenerative myopia

,

,

non-hodgkin lymphoma

,

,

pulmonary infarction

,

hodgkin disease

,

behcet syndrome

,

,

,

,

giant cell arteritis

,

,

hypersensitivity

,

food hypersensitivity

,

polymyalgia rheumatica

,

male breast neoplasms

,

follicular lymphoma

,

polycythemia vera

,

,

,

myeloid leukemia chronic-phase

,

,

left ventricular hypertrophy

,

pathologic dilatation

,

,

essential hypertension

,

systolic murmurs

,

disease progression

ischemic stroke

,

,

carotid stenosis

,

pathologic constriction

,

,

intracranial hemorrhages

,

,

,

myocardial infarction

,

,

cardiogenic shock

,

coronary artery disease

ebola hemorrhagic fever

,

marburg virus disease

knee prosthesis

,

,

tendon injuries

,

,

tissue adhesions

,

hip osteoarthritis

,

,

,

,

high-risk pregnancy

,

intervertebral disc degeneration

,

multiple trauma

,

vascular diseases

,

,

neoplasm metastasis

,

operative surgical procedures

,

urinary retention

,

,

,

physician-nurse relations

,

,

,

traumatic intracranial hemorrhage

,

cardiovascular diseases

,

cerebrovascular disorders

,

central nervous system diseases

,

,

nervous system diseases

,

,

,

,

pulmonary emphysema

,

,

spinal curvatures

,

critical illness

,

pituitary neoplasms

,

pituitary diseases

,

hereditary breast and ovarian cancer syndrome

,

spinal cord neoplasms

,

spinal neoplasms

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

squamous cell carcinoma

,

traumatic brain injuries

,

,

,

,

von willebrand diseases

,

,

,

hematologic neoplasms

,

,

thrombocytopenia

,

,

hereditary hemorrhagic telangiectasia

,

,

hemorrhagic shock

,

transfusion reaction

,

coronary artery bypass

,

,

chronic renal insufficiency

,

,

urinary bladder neoplasms

,

,

traumatic brain hemorrhage

,

hyperpigmentation

,

pulmonary hypertension

,

lung transplantation

,

spinal dysraphism

,

,

intraoperative complications

,

aortic dissection

,

brain neoplasms

,

,

,

head and neck neoplasms

,

acute kidney injury

,

,

transcatheter aortic valve replacement

,

hereditary angioedemas

,

female genital neoplasms

,

,

,

,

obstetric labor

,

,

hematopoietic stem cell transplantation

,

,

subarachnoid hemorrhage

,

carotid artery diseases

,

spinal injuries

,

abdominal aortic aneurysm

,

,

aortic aneurysm

,

pathologic processes

,

,

,

pancreatic neoplasms

,

,

femoracetabular impingement

,

,

surgical wound infection

,

,

,

,

agranulocytosis

,

feeding behavior

,

replacement arthroplasty shoulder

,

,

postpartum hemorrhage

,

surgical blood loss

,

postoperative hemorrhage

,

knee osteoarthritis

,

,

,

,

,

,

obstetric labor complications

,

,

replacement arthroplasty knee

,

postoperative pain

,

wounds and injuries

,

blood coagulation disorders

,

,

hemostatic disorders

,

placenta previa

,

gastrointestinal hemorrhage

,

uterine hemorrhage

,

blood transfusion

,

replacement arthroplasty hip

,

cerebral hemorrhage

,

,

drug-related side effects and adverse reactions

,

,

,

subdural hematoma

,

,

cardiac surgical procedures

,

,

,

,

subdural hematoma chronic

,

venous thrombosis

,

,

,

,

postoperative complications

,

,

,

rotator cuff injuries

,

breast neoplasms

,

cardiopulmonary bypass

,

coronary artery disease

,

,

,

,

femoral fractures

,

,

,

thromboembolism

,

,

,

congenital abnormalities

,

congenital heart defects

,

anterior cruciate ligament injuries

,

,

,

liver cirrhosis

,

ovarian neoplasms

,

uterine myomectomy

,

anterior cruciate ligament reconstruction

,

,

cesarean section

,

craniosynostoses

,

,

,

,

communicable diseases

,

musculoskeletal diseases

,

healthy volunteers/patients

,

,

venous thromboembolism

,

paranasal sinus diseases

,

shoulder impingement syndrome

,

prostatic neoplasms

,

,

nephrolithiasis

,

,

,

placenta accreta

,

spinal stenosis

,

,

femoral neck fractures

,

intracranial hemorrhages

,

prostatic hyperplasia

,

hypersensitivity

,

bariatric surgery

,

,

,

pathologic dilatation

,

urologic diseases

,

patient satisfaction

,

,

,

orthognathic surgery

,

tooth extraction

,

pregnancy complications

,

pelvic organ prolapse

,

hemorrhagic stroke

,

,

,

stomach neoplasms

,

liver neoplasms

,

colonic neoplasms

,

ovarian epithelial carcinoma

,

radius fractures

,

wrist fractures

,

,

humeral fractures

,

,

opioid-related disorders

,

deficiency diseases

,

chronic urticaria

,

,

nasal obstruction

,

,

injection site reaction

,

,

cross infection

,

wound infection

,

,

,

,

colorectal neoplasms

,

uterine inertia

,

staghorn calculi

,

myocardial infarction

,

pulmonary embolism

,

,

hemiarthroplasty

,

arteriovenous fistula

,

,

pathologic constriction

,

gynecologic surgical procedures

,

rheumatic diseases

,

,

,

,

,

pancreaticoduodenectomy

,

,

biliary tract surgical procedures

,

,

,

dupuytren contracture

,

,

,

,

esophageal neoplasms

,

duodenal neoplasms

,

heart valve diseases

,

prospective studies

,

randomized controlled trials as topic

,

eyelid diseases

,

,

shoulder fractures

,

shoulder injuries

,

contraceptive devices

,

,

autoimmune diseases

,

intravenous administration

,

,

,

,

,

,

hyperaldosteronism

,

pulmonary arterial hypertension

,

urinary tract infections

,

,

sleep initiation and maintenance disorders

,

cardiac arrhythmias

,

,

,

liver transplantation

,

blood platelet disorders

,

,

pigmentation disorders

,

heterotopic ossification

,

coronavirus infections

,

,

mucocutaneous lymph node syndrome

,

hyperphosphatemia

,

bronchopulmonary dysplasia

,

adrenal insufficiency

,

,

,

coagulation protein disorders

,

attention deficit disorder with hyperactivity

,

,

rheumatoid arthritis

,

replacement arthroplasty

,

kidney diseases

,

respiratory tract infections

,

,

migraine disorders

,

,

,

bacterial infections

,

intraabdominal infections

,

healthcare-associated pneumonia

,

methicillin-resistant staphylococcus aureus

,

,

staphylococcal infections

,

,

,

general anesthesia

,

,

,

gram-negative bacterial infections

,

,

bacterial meningitis

,

,

central nervous system infections

,

neuromuscular blockade

,

,

,

cytomegalovirus retinitis

,

,

adenoviridae infections

,

port-wine stain

,

,

,

capillary hemangioma

,

,

bipolar disorder

,

autistic disorder

,

,

treatment-resistant schizophrenia

,

potassium deficiency

,

,

iron-deficiency anemia

,

iron deficiencies

,

diabetes insipidus

,

cytoreduction surgical procedures

,

primary graft dysfunction

,

intervertebral disc displacement

,

,

congenital hip dislocation

,

femur head necrosis

,

,

acute lung injury

,

retinal diseases

,

factor xi deficiency

,

closed fractures

,

orthopedic procedures

,

erythrocyte transfusion

,

neurosurgical procedures

,

lacrimal duct obstruction

,

off-pump coronary artery bypass

,

spinal cord diseases

,

spinal cord compression

,

hematologic diseases

,

recreational drug use

,

,

peptic ulcer hemorrhage

,

osteogenesis imperfecta

,

skin pigmentation

,

obstetric delivery

,

,

,

obstetrical anesthesia

,

abruptio placentae

,

prolonged pregnancy

,

,

transurethral resection of prostate

,

,

vaginal hysterectomy

,

percutaneous nephrolithotomy

,

,

cardiovascular surgical procedures

,

lens subluxation

,

joint dislocations

,

fracture dislocation

,

elbow fractures

,

dermatofibrosarcoma

,

spontaneous fractures

,

thoracic surgical procedures

,

autologous blood transfusion

,

,

,

retinal detachment

,

diabetic retinopathy

,

renal insufficiency

,

,

spinal anesthesia

,

,

ear acupuncture

,

acupuncture analgesia

,

acupuncture therapy

,

,

end stage liver disease

Antineoplaston a10

healthy volunteers/patients

P2y purinoceptor 12

acute coronary syndrome

,

percutaneous coronary intervention

,

atherosclerosis

,

myocardial infarction

,

st elevation myocardial infarction

,

non-st elevated myocardial infarction

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

healthy volunteers/patients

Fluoroquinolone

healthy volunteers/patients

,

,

cardiovascular diseases

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