Jetrea(ocriplasmin)
Jetrea (ocriplasmin) is a protein pharmaceutical. Ocriplasmin was first approved as Jetrea on 2012-10-17. It is used to treat retinal diseases in the USA. It has been approved in Europe to treat retinal diseases.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| retinal diseases | — | D012164 | H35.9 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J7316 | Injection, ocriplasmin, 0.125 mg |
Clinical
Clinical Trials
434 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 16 | 50 | 41 | 12 | 61 | 168 |
| Ischemic stroke | D000083242 | — | — | 13 | 41 | 35 | 14 | 41 | 134 |
| Ischemia | D007511 | EFO_0000556 | — | 5 | 20 | 18 | 4 | 22 | 65 |
| Cerebral infarction | D002544 | — | I63 | 2 | 15 | 11 | 2 | 14 | 40 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 3 | 7 | 5 | 6 | 10 | 29 |
| Infarction | D007238 | EFO_0009463 | — | — | 3 | 12 | 8 | 5 | 28 |
| Embolism | D004617 | — | — | 1 | 3 | 7 | 7 | 6 | 24 |
| Thrombosis | D013927 | — | — | 3 | 3 | 5 | 7 | 6 | 24 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | 3 | 7 | 7 | 4 | 21 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 11 | 4 | 2 | 18 |
Show 45 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | 4 | 5 | — | 3 | 11 |
| Cerebral hemorrhage | D002543 | — | — | 1 | 4 | 2 | — | 1 | 8 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 3 | 1 | — | 3 | 7 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 1 | 2 | 2 | — | 2 | 6 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | 1 | — | 5 | 6 |
| Hemostatic disorders | D020141 | — | — | — | — | 1 | — | 5 | 6 |
| Coronary disease | D003327 | — | — | 1 | — | 3 | — | 2 | 6 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | 3 | — | 2 | 6 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | — | 1 | — | 1 | 5 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 4 | 2 | — | — | 5 |
Show 31 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | 1 | — | — | 7 | 8 |
| Neoplasms | D009369 | — | C80 | 3 | 3 | — | — | — | 5 |
| Macular edema | D008269 | — | — | 1 | 2 | — | — | 1 | 3 |
| Vitrectomy | D014821 | — | — | — | 3 | — | — | — | 3 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 2 | 3 |
| Edema | D004487 | — | R60.9 | — | 1 | — | — | 1 | 2 |
| Malignant pleural effusion | D016066 | — | J91.0 | 1 | 1 | — | — | — | 2 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | 2 | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 1 | 1 | — | — | — | 2 |
| Hypertensive intracranial hemorrhage | D020299 | — | — | — | 1 | — | — | 1 | 2 |
Show 31 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 2 | — | — | — | 1 | 3 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 3 | — | — | — | — | 3 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | — | — | — | 1 | 3 |
| Flushing | D005483 | — | R23.2 | 1 | — | — | — | 1 | 2 |
| Thrombophlebitis | D013924 | — | — | 1 | — | — | — | — | 1 |
| Adjuvant chemotherapy | D017024 | — | — | 1 | — | — | — | — | 1 |
| Gallstones | D042882 | EFO_0004210 | — | 1 | — | — | — | — | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | 1 | — | — | — | — | 1 |
| Cholelithiasis | D002769 | EFO_0004799 | K80 | 1 | — | — | — | — | 1 |
| Cholecystolithiasis | D041761 | EFO_1000864 | — | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Toxemia | D014115 | — | — | — | — | — | — | 7 | 7 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 6 | 6 |
| Fibrinolysis | D005342 | — | — | — | — | — | — | 3 | 3 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 3 | 3 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 3 | 3 |
| Rupture | D012421 | — | — | — | — | — | — | 2 | 2 |
| Mortality | D009026 | EFO_0004352 | — | — | — | — | — | 2 | 2 |
| Thrombotic stroke | D000083244 | — | — | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 2 | 2 |
Show 79 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ocriplasmin |
| INN | ocriplasmin |
| Description | Ocriplasmin, sold under the brand name Jetrea, is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface. It is used for treatment of symptomatic vitreomacular adhesion, for which it received FDA approval on 17 October 2012. It works by dissolving the proteins that link the vitreous to the macula, resulting in posterior detachment of the vitreous from the retina.
|
| Classification | Enzyme |
| Drug class | plasmin proteins and derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2095222 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08888 |
| UNII ID | 7V6HE3DM5A (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Additional graphs summarizing 652 documents
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Safety
Black-box Warning
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Adverse Events
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691 adverse events reported
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