Jetrea(ocriplasmin)
Jetrea (ocriplasmin) is a protein pharmaceutical. Ocriplasmin was first approved as Jetrea on 2012-10-17. It is used to treat retinal diseases in the USA. It has been approved in Europe to treat retinal diseases.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| retinal diseases | — | D012164 | H35.9 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J7316 | Injection, ocriplasmin, 0.125 mg |
Clinical
Clinical Trials
523 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 16 | 44 | 48 | 13 | 50 | 159 |
| Ischemic stroke | D000083242 | — | — | 12 | 47 | 53 | 18 | 33 | 149 |
| Ischemia | D007511 | EFO_0000556 | — | 7 | 14 | 11 | 5 | 14 | 48 |
| Thrombosis | D013927 | — | — | 3 | 4 | 11 | 6 | 8 | 31 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 3 | 15 | 7 | 6 | 30 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | 4 | 9 | 10 | 6 | 29 |
| Cerebral infarction | D002544 | — | I63 | 3 | 11 | 7 | 3 | 6 | 26 |
| Infarction | D007238 | EFO_0009463 | — | — | 3 | 8 | 6 | 7 | 23 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 2 | 1 | 3 | 5 | 11 | 22 |
| Embolism | D004617 | — | — | 1 | 1 | 2 | 4 | 4 | 12 |
Show 49 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tissue adhesions | D000267 | — | — | — | 3 | 4 | — | 4 | 11 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | 3 | 5 | — | 2 | 10 |
| Cerebral hemorrhage | D002543 | — | — | 1 | 4 | 2 | — | 2 | 9 |
| Neoplasms | D009369 | — | C80 | 2 | 3 | 2 | — | 2 | 7 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 6 | — | — | 7 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 6 | — | 1 | 7 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | 1 | — | 5 | 6 |
| Hemostatic disorders | D020141 | — | — | — | — | 1 | — | 5 | 6 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | 2 | 3 | — | 1 | 6 |
| Coronary disease | D003327 | — | — | — | — | 5 | — | 1 | 6 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | 2 | 2 | — | — | 1 | 4 |
| Brain infarction | D020520 | EFO_0004277 | I63 | — | 3 | — | — | 1 | 4 |
| Vitreous detachment | D020255 | EFO_1001238 | H43.81 | — | 1 | — | — | 2 | 3 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | 3 | — | — | — | 3 |
| Vitrectomy | D014821 | — | — | — | 3 | — | — | — | 3 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 1 | 1 | — | — | — | 2 |
| Hypertensive intracranial hemorrhage | D020299 | — | — | — | 1 | — | — | 1 | 2 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | 1 | 2 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | 1 | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 2 | — | — | — | 1 | 3 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 3 | — | — | — | — | 3 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | — | — | — | 1 | 3 |
| Malignant pleural effusion | D016066 | — | J91.0 | 1 | — | — | — | — | 1 |
| Thrombophlebitis | D013924 | — | — | 1 | — | — | — | — | 1 |
| Adjuvant chemotherapy | D017024 | — | — | 1 | — | — | — | — | 1 |
| Gallstones | D042882 | EFO_0004210 | — | 1 | — | — | — | — | 1 |
| Cholelithiasis | D002769 | EFO_0004799 | K80 | 1 | — | — | — | — | 1 |
| Cholecystolithiasis | D041761 | EFO_1000864 | — | 1 | — | — | — | — | 1 |
| Vision disorders | D014786 | — | H53.11 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 7 | 7 |
| Toxemia | D014115 | — | — | — | — | — | — | 7 | 7 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 6 | 6 |
| Fibrinolysis | D005342 | — | — | — | — | — | — | 3 | 3 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 3 | 3 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 3 | 3 |
| Rupture | D012421 | — | — | — | — | — | — | 2 | 2 |
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 2 | 2 |
| Mortality | D009026 | EFO_0004352 | — | — | — | — | — | 2 | 2 |
| Thrombotic stroke | D000083244 | — | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ocriplasmin |
| INN | ocriplasmin |
| Description | Ocriplasmin, sold under the brand name Jetrea, is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface. It is used for treatment of symptomatic vitreomacular adhesion, for which it received FDA approval on 17 October 2012. It works by dissolving the proteins that link the vitreous to the macula, resulting in posterior detachment of the vitreous from the retina.
|
| Classification | Enzyme |
| Drug class | plasmin proteins and derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2095222 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08888 |
| UNII ID | 7V6HE3DM5A (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
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691 adverse events reported
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