Code | Description |
---|---|
S0179 | Megestrol acetate, oral, 20 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Anorexia | D000855 | HP_0002039 | R63.0 | 1 | 7 | 8 | 1 | — | 16 |
Cachexia | D002100 | HP_0004326 | R64 | 2 | 4 | 6 | 2 | — | 14 |
Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 3 | 1 | 1 | 2 | 8 |
Second primary neoplasms | D016609 | — | — | — | — | — | 1 | — | 1 |
Feeding behavior | D005247 | — | — | — | — | — | 1 | — | 1 |
Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Endometrial neoplasms | D016889 | EFO_0004230 | — | 3 | 16 | 4 | — | 1 | 20 |
Endometrial hyperplasia | D004714 | — | N85.0 | — | 11 | 7 | — | — | 12 |
Neoplasms | D009369 | — | C80 | — | 4 | 2 | — | 1 | 7 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 5 | 2 | — | — | 7 |
Head and neck neoplasms | D006258 | — | — | — | 1 | 1 | — | — | 2 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | 1 | — | 1 | 2 |
Body weight changes | D001836 | — | — | — | 1 | 1 | — | — | 2 |
Weight loss | D015431 | HP_0001824 | — | — | — | 2 | — | — | 2 |
Overweight | D050177 | — | E66.3 | — | 2 | 2 | — | — | 2 |
Esophageal squamous cell carcinoma | D000077277 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hiv wasting syndrome | D019247 | EFO_0007312 | — | 1 | 2 | — | — | 1 | 4 |
Endometrioid carcinoma | D018269 | — | — | 1 | 3 | — | — | — | 3 |
Vomiting | D014839 | HP_0002013 | R11.1 | — | 1 | — | — | — | 1 |
Triple negative breast neoplasms | D064726 | — | — | — | 1 | — | — | — | 1 |
Phenylketonurias | D010661 | — | E70.0 | — | 1 | — | — | — | 1 |
Uterine neoplasms | D014594 | EFO_0003859 | C55 | — | 1 | — | — | — | 1 |
Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | — | 1 |
Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
Absorption | D000042 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Adrenal insufficiency | D000309 | — | — | — | — | — | — | 1 | 1 |
Colorectal neoplasms | D015179 | — | — | — | — | — | — | 1 | 1 |
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
Fertility preservation | D059247 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Megestrol acetate |
INN | megestrol |
Description | Megestrol acetate is a steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. It has a role as an antineoplastic agent, an appetite enhancer, a contraceptive drug, a progestin and a synthetic oral contraceptive. It is a steroid ester, an acetate ester, a 20-oxo steroid and a 3-oxo-Delta(4) steroid. It is functionally related to a megestrol. |
Classification | Small molecule |
Drug class | estrogens; progestins |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C |
PDB | — |
CAS-ID | 595-33-5 |
RxCUI | — |
ChEMBL ID | CHEMBL1201139 |
ChEBI ID | — |
PubChem CID | 11683 |
DrugBank | DB00351 |
UNII ID | EA6LD1M70M (ChemIDplus, GSRS) |