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Drug ReportsMannitol
Mannitol 25%, Bronchitol(mannitol)
Aridol, Bronchitol, Mannitol, Osmitrol (mannitol) is a small molecule pharmaceutical. Mannitol was first approved as Mannitol 20% on 1982-01-01. It is used to treat anuria, brain edema, ocular hypertension, and oliguria in the USA. It has been approved in Europe to treat cystic fibrosis.
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Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
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2Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
respiratory tract diseasesD012140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Aridol, Bronchitol, Mannitol, Osmitrol (discontinued: Mannitol, Resectisol)
Combinations
Sorbitol-mannitol (discontinued: Sorbitol-mannitol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mannitol
Tradename
Company
Number
Date
Products
MANNITOL 5% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
MANNITOL 10% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
MANNITOL 15% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
MANNITOL 20% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
OSMITROL 5% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 10% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 20% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 15% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 5% IN WATER IN PLASTIC CONTAINERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 10% IN WATER IN PLASTIC CONTAINERBaxterN-013684 RX1982-01-01
1 products
Show 6 marketed
Show 22 discontinued
Mannitol
+
Sorbitol
Tradename
Company
Number
Date
Products
SORBITOL-MANNITOL IN PLASTIC CONTAINEROtsukaN-018316 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
aridol bronchial challenge test kitNew Drug Application2025-02-13
bronchitolNew Drug Application2024-09-03
curestem cell healer c10 programunapproved drug other2020-06-08
curestem cell healer c20unapproved drug other2020-06-05
curestem cell healer c5 programunapproved drug other2020-06-05
gd11 rx scm c5unapproved drug other2017-08-24
imuflex wb-rp blood bag system with integral whole blood leukocyte reduction filter (saving platelets) with diversion blood sampling arm anticoagul...New Drug Application2024-10-21
imuflex wb-sp blood bag system with integral whole blood leukocyte reduction filter (saving platelets) with diversion blood sampling arm anticoagul...New Drug Application2024-12-17
leuprolide acetate depotNew Drug Application2024-08-27
lutrate depotNew Drug Application2025-06-03
Show 7 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ocular hypertensionEFO_1001069D009798H40.0
brain edemaEFO_1000845D001929G93.6
anuriaEFO_0009530D001002R34
oliguria—D009846—
constipation—D003248K59.0
poisoningEFO_0008546D011041T65.91
Agency Specific
FDA
EMA
Expiration
Code
MANNITOL, BRONCHITOL, CHIESI
2027-10-30ODE-327
2023-10-30NP
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A06: Drugs for constipation
— A06A: Drugs for constipation
— A06AD: Osmotically acting laxatives
— A06AD16: Mannitol
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05B: Iv solutions used in parenteral administration of fluids, electrolytes and nutrients
— B05BC: Solutions producing osmotic diuresis
— B05BC01: Mannitol
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CX: Other irrigating solutions in atc
— B05CX04: Mannitol
R: Respiratory system drugs
— R05: Cough and cold preparations
— R05C: Expectorants, excl. combinations with cough suppressants
— R05CB: Mucolytics
— R05CB16: Mannitol
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CX: Other diagnostic agents in atc
— V04CX04: Mannitol
HCPCS
Code
Description
J2150
Injection, mannitol, 25% in 50 ml
J7665
Mannitol, administered through an inhaler, 5 mg
Clinical
Clinical Trials
494 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial conjunctivitisD003234EFO_1000829H10.0——1——1
ConjunctivitisD003231—H10——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C801————1
Non-small-cell lung carcinomaD002289——1————1
Lung neoplasmsD008175—C34.901————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMannitol
INN—
Description
D-mannitol is the D-enantiomer of mannitol. It has a role as an osmotic diuretic, a sweetening agent, an antiglaucoma drug, a metabolite, an allergen, a hapten, a food bulking agent, a food anticaking agent, a food humectant, a food stabiliser, a food thickening agent, an Escherichia coli metabolite and a member of compatible osmolytes.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Identifiers
PDB—
CAS-ID69-65-8
RxCUI—
ChEMBL IDCHEMBL689
ChEBI ID16899
PubChem CID6251
DrugBankDB00742
UNII ID—
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Mannitol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 92,698 documents
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Safety
Black-box Warning
Black-box warning for: Aridol bronchial challenge test kit
Adverse Events
Top Adverse Reactions
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3,698 adverse events reported
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