Isoniazid
Isoniazid, Rifamate, Rifater (isoniazid) is a small molecule pharmaceutical. Isoniazid was first approved as Nydrazid on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Isoniazid (discontinued: Dow-isoniazid, Hyzyd, Inh, Isoniazid, Laniazid, Nydrazid, Rimifon, Stanozide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Isoniazid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NYDRAZID | Bristol Myers Squibb | N-008392 DISCN | 1982-01-01 | 1 products |
| ISONIAZID | Epic Pharma | N-008678 DISCN | 1982-01-01 | 2 products, RLD |
| ISONIAZID | Eli Lilly | N-008499 DISCN | 1982-01-01 | 2 products |
| ISONIAZID | Panray Corporation | N-008428 DISCN | 1982-01-01 | 3 products |
| RIMIFON | Roche | N-008420 DISCN | 1982-01-01 | 3 products |
| NYDRAZID | Sandoz | N-008662 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| albuterol sulfate inhalation | ANDA | 2024-12-20 |
| albuterol sulfate inhalation solution | ANDA | 2025-12-10 |
| albuterol sulfate inhalation solution, 0.5% | ANDA | 2025-12-10 |
| ammonia | unapproved drug other | 2021-09-02 |
| ammonia inhalant | unapproved drug other | 2020-04-27 |
| ammonia inhalants | C200263 | 2025-11-27 |
| amoray premium vaporizing inhaler | OTC monograph final | 2016-03-31 |
| arformoterol tartrate inhalation | ANDA | 2025-07-15 |
| arformoterol tartrate inhalation solution | ANDA | 2025-12-10 |
| bardown smelling salts | unapproved drug other | 2025-04-16 |
Show 43 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AC: Hydrazides for tuberculosis treatment
— J04AC01: Isoniazid
— J04AC51: Isoniazid, combinations
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM01: Streptomycin and isoniazid
— J04AM02: Rifampicin and isoniazid
— J04AM03: Ethambutol and isoniazid
— J04AM04: Thioacetazone and isoniazid
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
— J04AM07: Rifampicin, ethambutol and isoniazid
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
No data
Clinical
Clinical Trials
396 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 32 | 79 | 63 | 32 | 70 | 252 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 6 | 44 | 26 | 7 | 12 | 85 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 5 | 14 | 17 | 10 | 16 | 57 |
| Latent tuberculosis | D055985 | — | Z22.7 | 11 | 6 | 15 | 11 | 9 | 47 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 3 | 3 | 9 | 5 | 10 | 28 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | 1 | 7 | 10 | 2 | 8 | 25 |
| Hereditary angioedemas | D054179 | EFO_0004131 | — | 1 | 7 | 7 | 3 | 5 | 20 |
| Hiv | D006678 | — | O98.7 | 3 | 3 | 6 | 1 | 5 | 17 |
| Infections | D007239 | EFO_0000544 | — | 2 | 3 | 7 | 3 | 3 | 17 |
| Angioedema | D000799 | EFO_0005532 | T78.3 | 1 | 4 | 7 | 1 | 3 | 14 |
Show 37 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningeal tuberculosis | D014390 | — | A17.0 | 1 | 8 | 3 | — | 2 | 12 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 2 | 6 | — | — | 9 |
| Aids-related opportunistic infections | D017088 | — | — | 1 | — | 1 | — | 5 | 7 |
| Meningitis | D008581 | EFO_0000584 | G03 | — | 2 | 1 | — | 2 | 5 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | 1 | 1 | — | 1 | 3 |
| Respiratory tract infections | D012141 | — | J06.9 | 1 | 1 | 1 | — | 1 | 3 |
| Extensively drug-resistant tuberculosis | D054908 | — | — | — | 1 | 2 | — | 1 | 3 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 3 | 1 | — | — | 3 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | — | 1 | — | 1 | 3 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | 1 | — | 1 | 2 |
Show 23 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aids-related complex | D000386 | EFO_0007137 | B20 | — | 1 | — | — | 2 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | 1 | 2 |
| Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | — | 2 | — | — | — | 2 |
| Hemoglobinuria | D006456 | — | R82.3 | — | 2 | — | — | — | 2 |
| Gram-positive bacterial infections | D016908 | — | — | 1 | 1 | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | — | — | — | 1 |
| Malaria | D008288 | EFO_0001068 | B54 | — | 1 | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 1 | — | — | — | 1 |
| Craniocerebral trauma | D006259 | — | S00 | — | 1 | — | — | — | 1 |
| Brain injuries | D001930 | — | S06.9 | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | 1 | 7 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 1 | — | — | — | 2 | 3 |
| Breast feeding | D001942 | — | — | 1 | — | — | — | 1 | 2 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | — | — | — | — | 3 | 3 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 2 | 2 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | — | 1 | 1 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | — | — | — | 1 | 1 |
| Birth weight | D001724 | EFO_0004344 | — | — | — | — | — | 1 | 1 |
| Acute cholecystitis | D041881 | EFO_1001289 | K81.0 | — | — | — | — | 1 | 1 |
| Cholecystitis | D002764 | — | K81 | — | — | — | — | 1 | 1 |
| Acalculous cholecystitis | D042101 | EFO_1000790 | — | — | — | — | — | 1 | 1 |
Show 32 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Isoniazid |
| INN | isoniazid |
| Description | Isoniazide is a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. It has a role as an antitubercular agent and a drug allergen. It is functionally related to an isonicotinic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NNC(=O)c1ccncc1 |
Identifiers
| PDB | — |
| CAS-ID | 54-85-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL64 |
| ChEBI ID | 6030 |
| PubChem CID | 3767 |
| DrugBank | DB00951 |
| UNII ID | V83O1VOZ8L (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Feiba – Takeda
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Ruconest – Pharming
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Cinryze – Shire
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Cinryze – Takeda
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
Isoniazid
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 61,589 documents
View more details
Safety
Black-box Warning
Black-box warning for: Feiba, Isoniazid, Provocholine, Provocholine provocholine inhalation solution
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
51,349 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use