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Drug ReportsIsoniazid
Isoniazid
Isoniazid, Rifamate, Rifater (isoniazid) is a small molecule pharmaceutical. Isoniazid was first approved as Nydrazid on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
Isoniazid (discontinued: Dow-isoniazid, Hyzyd, Inh, Isoniazid, Laniazid, Nydrazid, Rimifon, Stanozide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Isoniazid
Tradename
Company
Number
Date
Products
NYDRAZIDBristol Myers SquibbN-008392 DISCN1982-01-01
1 products
ISONIAZIDEpic PharmaN-008678 DISCN1982-01-01
2 products, RLD
ISONIAZIDEli LillyN-008499 DISCN1982-01-01
2 products
ISONIAZIDPanray CorporationN-008428 DISCN1982-01-01
3 products
RIMIFONRocheN-008420 DISCN1982-01-01
3 products
NYDRAZIDSandozN-008662 DISCN1982-01-01
1 products
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Isoniazid
+
Pyrazinamide
+
Rifampin
Tradename
Company
Number
Date
Products
RIFATERSanofiN-050705 DISCN1994-05-31
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
albuterol sulfate inhalation solutionANDA2024-12-17
albuterol sulfate inhalation solution, 0.5%ANDA2025-03-24
ammoniaunapproved drug other2021-09-02
ammonia inhalantunapproved drug other2020-04-27
ammonia inhalantsunapproved drug other2024-10-28
amoray premium vaporizing inhalerOTC monograph final2016-03-31
arformoterol tartrate inhalationANDA2023-01-24
arformoterol tartrate inhalation solutionANDA2025-02-11
bardown smelling saltsunapproved drug other2025-04-16
berinertBiologic Licensing Application2009-11-10
Show 42 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AC: Hydrazides for tuberculosis treatment
— J04AC01: Isoniazid
— J04AC51: Isoniazid, combinations
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM01: Streptomycin and isoniazid
— J04AM02: Rifampicin and isoniazid
— J04AM03: Ethambutol and isoniazid
— J04AM04: Thioacetazone and isoniazid
— J04AM05: Rifampicin, pyrazinamide and isoniazid
— J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
— J04AM07: Rifampicin, ethambutol and isoniazid
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
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Clinical
Clinical Trials
380 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TuberculosisD014376EFO_0000774A15-A19141——5
Pulmonary tuberculosisD014397EFO_1000049A15—21——3
Hemophilia aD006467EFO_0007267D66——1——1
Hemophilia bD002836—D67——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Latent tuberculosisD055985—Z22.711———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameIsoniazid
INNisoniazid
Description
Isoniazide is a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. It has a role as an antitubercular agent and a drug allergen. It is functionally related to an isonicotinic acid.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
NNC(=O)c1ccncc1
Identifiers
PDB—
CAS-ID54-85-3
RxCUI—
ChEMBL IDCHEMBL64
ChEBI ID6030
PubChem CID3767
DrugBankDB00951
UNII IDV83O1VOZ8L (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Isoniazid
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 58,305 documents
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Safety
Black-box Warning
Black-box warning for: Feiba, Isoniazid, Provocholine, Provocholine provocholine inhalation solution
Adverse Events
Top Adverse Reactions
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46,962 adverse events reported
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