Hydroxyamphetamine
Paredrine, Paremyd (hydroxyamphetamine) is a small molecule pharmaceutical. Hydroxyamphetamine was first approved as Paredrine on 1982-01-01.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydroxyamphetamine hydrobromide
+
Tropicamide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PAREMYD | Epic Pharma | N-019261 DISCN | 1992-01-30 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| paremyd | New Drug Application | 2022-09-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| keratitis | — | D007634 | H16 |
| iritis | EFO_1000997 | D007500 | — |
| iridocyclitis | — | D015863 | H20 |
Agency Specific
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EMA
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Clinical
Clinical Trials
385 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 6 | 3 | 3 | 15 | 47 | 72 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | 1 | 9 | 5 | 4 | 2 | 20 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | 9 | 5 | 4 | 2 | 20 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 9 | 5 | 2 | 3 | 19 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 7 | 4 | 3 | 3 | 17 |
| Chronic renal insufficiency | D051436 | — | N18 | 2 | 1 | — | 2 | 7 | 12 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | 1 | — | 2 | 7 | 12 |
| Covid-19 | D000086382 | — | U07.1 | 2 | 2 | 1 | 1 | 6 | 10 |
| Healthy volunteers/patients | — | — | — | 4 | 1 | 1 | 1 | 3 | 10 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | 2 | 3 | 2 | 3 | 10 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 2 | 2 | — | 2 | 8 |
| Syndrome | D013577 | — | — | — | 2 | 1 | — | 4 | 7 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | 1 | — | 4 | 7 |
| Papillomavirus infections | D030361 | — | — | — | 4 | 3 | — | — | 7 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | 2 | — | 4 | 6 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 2 | 1 | — | 1 | 5 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 2 | — | 2 | 5 |
| Pure autonomic failure | D054970 | — | — | — | — | 3 | — | 1 | 4 |
| Depression | D003863 | — | F33.9 | — | 1 | 1 | — | 2 | 4 |
| Shy-drager syndrome | D012791 | EFO_1001050 | — | 1 | 1 | 1 | — | 1 | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 2 | — | — | 2 | 5 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 1 | — | — | 2 | 4 |
| Colonic neoplasms | D003110 | — | C18 | 3 | 1 | — | — | 1 | 4 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | — | — | 2 | 3 |
| Adenocarcinoma | D000230 | — | — | 2 | 2 | — | — | — | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | — | 1 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | 2 | 3 |
| Temporomandibular joint disorders | D013705 | — | M26.6 | 1 | 1 | — | — | 2 | 3 |
| Temporomandibular joint dysfunction syndrome | D013706 | — | — | 1 | 1 | — | — | 2 | 3 |
| Hypoxia | D000860 | — | R09.02 | — | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Frontotemporal dementia | D057180 | — | G31.0 | 1 | — | — | — | 1 | 2 |
| Primary progressive aphasia | D018888 | EFO_0009053 | G31.01 | 1 | — | — | — | 1 | 2 |
| Pick disease of the brain | D020774 | EFO_0003096 | G31.01 | 1 | — | — | — | 1 | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | 1 | 2 |
| Malabsorption syndromes | D008286 | EFO_0009554 | K90 | 1 | — | — | — | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | 1 | — | — | — | — | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | — | — | — | — | 1 |
| Mucinous adenocarcinoma | D002288 | — | — | 1 | — | — | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | 1 | — | — | — | — | 1 |
| Cystadenocarcinoma | D003536 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 6 | 6 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 5 | 5 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 4 | 4 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | — | 4 | 4 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 4 | 4 |
| Back pain | D001416 | — | M54 | — | — | — | — | 4 | 4 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 3 | 3 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 3 | 3 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 3 | 3 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hydroxyamphetamine |
| INN | hydroxyamfetamine |
| Description | 4-(2-aminopropyl)phenol is a member of amphetamines. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(N)Cc1ccc(O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 103-86-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1546 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | FQR280JW2N (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
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Adverse Events
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42 adverse events reported
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