Dinoprostone
Cervidil, Prepidil (dinoprostone) is a small molecule pharmaceutical. Dinoprostone was first approved as Prostin e2 on 1982-01-01. It is used to treat fetal death, gestational trophoblastic disease, and uterine neoplasms in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Cervidil, Prepidil (discontinued: Prostin e2)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dinoprostone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CERVIDIL | Ferring Pharmaceuticals | N-020411 RX | 1995-03-30 | 1 products, RLD, RS |
| PREPIDIL | Pfizer | N-019617 RX | 1992-12-09 | 1 products, RLD, RS |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| uterine neoplasms | EFO_0003859 | D014594 | C55 |
| gestational trophoblastic disease | — | D031901 | O01.9 |
| fetal death | — | D005313 | — |
Agency Specific
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Clinical
Clinical Trials
182 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cesarean section | D002585 | — | — | — | — | — | 1 | — | 1 |
| Obstetric delivery | D036861 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cervical ripening | D020070 | — | — | — | — | 4 | — | 2 | 6 |
| Induced labor | D007751 | — | — | — | — | 2 | — | 1 | 3 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dinoprostone |
| INN | dinoprostone |
| Description | Prostaglandin E2 is prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins. It has a role as an oxytocic, a human metabolite and a mouse metabolite. It is a conjugate acid of a prostaglandin E2(1-). |
| Classification | Small molecule |
| Drug class | prostaglandins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 363-24-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL548 |
| ChEBI ID | 15551 |
| PubChem CID | 5280360 |
| DrugBank | DB00917 |
| UNII ID | K7Q1JQR04M (ChemIDplus, GSRS) |
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Safety
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1,276 adverse events reported
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