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Drug ReportsCelecoxib
Celebrex, Onsenal(celecoxib)
Celebrex, Celecoxib, Consensi, Elyxyb, Onsenal, Seglentis (celecoxib) is a small molecule pharmaceutical. Celecoxib was first approved as Celebrex on 1998-12-31. It is used to treat adenomatous polyposis coli, ankylosing spondylitis, dysmenorrhea, osteoarthritis, and rheumatoid arthritis in the USA. It has been approved in Europe to treat adenomatous polyposis coli. The pharmaceutical is active against prostaglandin G/H synthase 2. In addition, it is known to target carbonic anhydrase 12 and prostaglandin G/H synthase 1.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
musculoskeletal diseasesD009140
digestive system diseasesD004066
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Celebrex, Celecoxib, Elyxyb (discontinued: Celecoxib)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Celecoxib
Tradename
Company
Number
Date
Products
ELYXYBScilex PharmaceuticalsN-212157 RX2020-05-05
1 products, RLD, RS
CELEBREXUpjohnN-020998 RX1998-12-31
4 products, RLD
Amlodipine besylate
+
Celecoxib
Tradename
Company
Number
Date
Products
CONSENSIPurple BiotechN-210045 DISCN2018-05-31
3 products, RLD
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Celecoxib
+
Tramadol hydrochloride
Tradename
Company
Number
Date
Products
SEGLENTISKowaN-213426 DISCN2021-10-15
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
celebrexNew Drug Application2024-11-22
celecoxibANDA2025-11-17
celecoxib 100 mgANDA2015-11-30
celecoxib 200 mgANDA2019-11-01
celecoxib 400 mgANDA2015-11-27
celecoxib 50 mgANDA2015-11-28
celecoxib celecoxibANDA2021-12-21
elyxybNew Drug Application2020-05-13
elyxyb - celecoxibNew Drug Application2024-11-26
generic drugANDA2022-01-17
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ankylosing spondylitisEFO_0003898D013167M45
rheumatoid arthritisEFO_0000685D001172M06.9
osteoarthritisEFO_0002506D010003M15-M19
adenomatous polyposis coli—D011125D13.91
dysmenorrhea—D004412N94.6
hypertensionEFO_0000537D006973I10
coronary artery disease—D003324I25.1
variant angina pectoris—D000788I20.1
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
Expiration
Code
CELECOXIB / TRAMADOL HYDROCHLORIDE, SEGLENTIS, KOWA PHARMS
2024-10-15NP
CELECOXIB, ELYXYB, SCILEX HLDG
2023-05-05NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Amlodipine Besylate / Celecoxib, Consensi, Purple Biotech
103501712038-06-14DP
109258352038-06-14U-2410
109459602038-06-14DP
94088372030-02-28U-2410
96623152029-05-22DPU-2410
Celecoxib, Elyxyb, Scilex Hldg
95728192036-05-27DPU-2718
97956202036-05-27DPU-2718
99499902036-05-27DPU-2718
103765272036-05-27DPU-2718
107224562036-05-27DPU-2718
107995172036-05-27DPU-2718
Celecoxib / Tramadol Hydrochloride, Seglentis, Kowa Pharms
88467442031-06-03DP
85981522030-04-19DS, DP
90124402030-04-19DS, DP
102386682030-04-19DS, DPU-3244
102452762030-04-19DS, DP
105489092030-04-19U-3244
114784882030-04-19U-3244
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA51: Amlodipine and celecoxib
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX33: Celecoxib
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AH: Coxibs
— M01AH01: Celecoxib
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AJ: Opioids in combination with non-opioid analgesics
— N02AJ16: Tramadol and celecoxib
HCPCS
No data
Clinical
Clinical Trials
669 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17—11——2
Hip osteoarthritisD015207EFO_1000786M16—11——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCelecoxib
INNcelecoxib
Description
Celecoxib is a member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis. It has a role as a cyclooxygenase 2 inhibitor, a geroprotector, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a member of toluenes, a sulfonamide, a member of pyrazoles and an organofluorine compound.
Classification
Small molecule
Drug classcyclooxygenase-2 inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1
Identifiers
PDB—
CAS-ID169590-42-5
RxCUI—
ChEMBL IDCHEMBL118
ChEBI ID41423
PubChem CID2662
DrugBankDB00482
UNII IDJCX84Q7J1L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA2
CA2
Organism
Homo sapiens
Gene name
CA2
Gene synonyms
NCBI Gene ID
760
Protein name
carbonic anhydrase 2
Protein synonyms
CA-II, CAC, Carbonate dehydratase II, carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase II, carbonic dehydratase, Cyanamide hydratase CA2, epididymis luminal protein 76, epididymis secretory protein Li 282
Uniprot ID
Q96ET9
Mouse ortholog
Car2 (12349)
carbonic anhydrase 2 (Q9DCY9)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Celebrex – Viatris
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Celebrex – Pfizer
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Elyxyb – Collegium Pharmaceutical
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Tabular view
Estimated US medical usage
Celecoxib
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 33,272 documents
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Safety
Black-box Warning
Black-box warning for: Celebrex, Celecoxib, Celecoxib 100 mg, Celecoxib 200 mg, Celecoxib 400 mg, Celecoxib 50 mg, Celecoxib celecoxib, Elyxyb, Elyxyb - celecoxib, Generic drug, Vyscoxa
Adverse Events
Top Adverse Reactions
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68,759 adverse events reported
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