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Kowa

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Livalo	Pitavastatin	2009-08-03	2024-2031	Hypercholesterolemia , Hypertriglyceridemia , Hyperlipoproteinemias
Seglentis	Celecoxib, Tramadol	2021-10-15	2029-2038	Ankylosing spondylitis , Rheumatoid arthritis , Osteoarthritis , Adenomatous polyposis coli , Dysmenorrhea , Hypertension , Coronary artery disease , Variant angina pectoris , Pain

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

metabolic syndrome

,

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

cardiovascular diseases

,

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

,

hypercholesterolemia

,

hyperlipidemias

,

healthy volunteers/patients

,

hyperlipoproteinemias

,

renal insufficiency

,

alzheimer disease

liver cirrhosis

,

,

,

non-alcoholic fatty liver disease

,

,

biliary liver cirrhosis

,

,

,

,

retinal diseases

,

diabetic retinopathy

,

type 2 diabetes mellitus

,

diabetes mellitus

,

hyperlipidemias

,

hypercholesterolemia

hepatocellular carcinoma

,

liver neoplasms

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

psoriatic arthritis

,

,

,

inborn urea cycle disorders

healthy volunteers/patients

,

diabetic nephropathies

,

kidney diseases

,

liver cirrhosis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

diabetes complications

,

,

non-alcoholic fatty liver disease

,

renal insufficiency

,

type 2 diabetes mellitus

,

diabetes mellitus

,

diabetes complications

,

coronary disease

,

coronary artery disease

,

Tofogliflozin anhydrous

healthy volunteers/patients

,

renal insufficiency

,

diabetic nephropathies

,

kidney diseases

,

liver cirrhosis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

diabetes complications

,

,

non-alcoholic fatty liver disease

,

healthy volunteers/patients

,

alzheimer disease

,

female genital neoplasms

,

,

,

chronic hepatitis b

,

,

major depressive disorder

,

depressive disorder

,

,

triple negative breast neoplasms

,

pancreatic neoplasms

,

neoplasm metastasis

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

chronic hepatitis

,

sickle cell anemia

,

,

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

parkinson disease

,

autistic disorder

,

autism spectrum disorder

,

pervasive child development disorders

,

rectal neoplasms

,

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

stomach neoplasms

,

esophageal neoplasms

,

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

breast neoplasms

,

lupus nephritis

,

,

large b-cell lymphoma diffuse

,

human influenza

,

,

,

b-cell lymphoma

,

,

non-hodgkin lymphoma

,

myeloid leukemia acute

,

multiple sclerosis

,

,

hepatocellular carcinoma

,

colonic neoplasms

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

liver cirrhosis

,

neuromyelitis optica

,

kidney diseases

,

membranous glomerulonephritis

,

chronic progressive multiple sclerosis

,

myeloid leukemia

,

nephrotic syndrome

,

,

lipoid nephrosis

,

,

ovarian neoplasms

,

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

,

,

,

,

chronic hepatitis c

,

,

rheumatoid arthritis

,

juvenile arthritis

,

follicular lymphoma

,

,

,

,

,

myelodysplastic syndromes

,

,

acquired immunodeficiency syndrome

,

kidney transplantation

,

drug-related side effects and adverse reactions

,

heart disease risk factors

,

cognitive dysfunction

thromboembolism

,

parkinson disease

,

central nervous system diseases

,

,

nervous system diseases

,

movement disorders

,

neurodegenerative diseases

,

,

,

colorectal neoplasms

,

,

non-small-cell lung carcinoma

,

head and neck neoplasms

,

esophageal neoplasms

,

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

gastrointestinal neoplasms

,

,

neuroendocrine tumors

,

carcinoid tumor

,

paraneoplastic syndromes

,

islet cell adenoma

,

malignant carcinoid syndrome

,

,

heart disease risk factors

,

vasoconstriction

,

,

,

serous cystadenocarcinoma

,

hepatic insufficiency

,

,

migraine disorders

,

disease progression

,

polycystic ovary syndrome

,

b-cell lymphoma marginal zone

,

,

mullerian mixed tumor

,

diffuse intrinsic pontine glioma

,

,

breast carcinoma in situ

,

lobular carcinoma

,

ductal carcinoma breast

,

ductal carcinoma

,

invasive hydatidiform mole

,

,

phenylketonurias

,

,

chronic progressive multiple sclerosis

,

noise-induced hearing loss

,

,

,

adult t-cell leukemia-lymphoma

,

t-cell leukemia

,

pharmacokinetics

,

,

sleep apnea syndromes

,

,

persian gulf syndrome

,

,

endometrioid carcinoma

,

,

shy-drager syndrome

,

multiple system atrophy

,

parkinsonian disorders

,

,

progressive supranuclear palsy

,

iron-deficiency anemia

,

iron deficiencies

,

,

frontotemporal dementia

,

primary progressive aphasia

,

pick disease of the brain

,

respiratory aspiration

,

electroencephalography

,

inhalation anesthesia

,

,

asymptomatic diseases

,

,

bacterial infections

,

atopic dermatitis

,

,

,

wound infection

,

prostheses and implants

,

prosthesis-related infections

,

,

,

,

tooth extraction

,

,

healthy volunteers/patients

,

,

pancreatic neoplasms

,

breast neoplasms

,

,

brain neoplasms

,

,

myelodysplastic syndromes

,

multiple myeloma

,

,

,

post-traumatic stress disorders

,

obsessive-compulsive disorder

,

traumatic stress disorders

,

neoplasm metastasis

,

non-hodgkin lymphoma

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

,

plasma cell neoplasms

,

esophageal neoplasms

,

cardiovascular diseases

,

,

b-cell chronic lymphocytic leukemia

,

,

triple negative breast neoplasms

,

ovarian neoplasms

,

rectal neoplasms

,

castration-resistant prostatic neoplasms

,

nervous system diseases

,

central nervous system neoplasms

,

small cell lung carcinoma

,

,

hematologic neoplasms

,

,

,

compulsive personality disorder

,

liver cirrhosis

,

squamous cell carcinoma of head and neck

,

central nervous system diseases

,

movement disorders

,

,

lymphoid leukemia

,

metabolic diseases

,

nutritional and metabolic diseases

,

small cell carcinoma

,

,

medulloblastoma

,

,

rhabdomyosarcoma

,

nervous system neoplasms

,

b-cell lymphoma

,

fallopian tube neoplasms

,

head and neck neoplasms

,

carcinoma in situ

,

,

t-cell lymphoma

,

,

sensorineural hearing loss

,

,

,

,

ovarian epithelial carcinoma

,

transitional cell carcinoma

,

myeloproliferative disorders

,

renal cell carcinoma

,

,

,

severe acute respiratory syndrome

,

hereditary breast and ovarian cancer syndrome

,

neurodegenerative diseases

,

pheochromocytoma

,

gastrointestinal neoplasms

,

,

,

germ cell and embryonal neoplasms

,

,

,

primitive neuroectodermal tumors

,

primitive neuroectodermal tumors peripheral

,

,

,

,

langerhans-cell histiocytosis

,

neuroectodermal tumors

,

follicular lymphoma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

type 1 diabetes mellitus

,

large b-cell lymphoma diffuse

,

adenocarcinoma of lung

,

neuroendocrine tumors

,

knee osteoarthritis

,

intraductal carcinoma noninfiltrating

,

,

diabetic neuropathies

,

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

t-cell lymphoma peripheral

,

,

uterine cervical neoplasms

,

liver neoplasms

,

,

uterine cervical dysplasia

,

photochemotherapy

,

,

venous insufficiency

,

,

chronic fatigue syndrome

,

,

coronavirus infections

,

bariatric surgery

,

sickle cell anemia

,

,

,

,

urologic neoplasms

,

merkel cell carcinoma

,

colonic neoplasms

,

,

hyperlipoproteinemia type i

,

hemophagocytic lymphohistiocytosis

,

dna repair-deficiency disorders

,

gastrointestinal stromal tumors

,

kidney neoplasms

,

,

endocrine system diseases

,

,

chronic hepatitis c

,

,

,

pancreatic ductal carcinoma

,

stomach neoplasms

,

digestive system neoplasms

,

biliary tract neoplasms

,

histiocytic sarcoma

,

juvenile xanthogranuloma

,

consciousness disorders

,

myelodysplastic-myeloproliferative diseases

,

graft vs host disease

,

polycythemia vera

,

primary myelofibrosis

,

aplastic anemia

,

,

loss of heterozygosity

,

carcinoid tumor

,

malignant carcinoid syndrome

,

serotonin syndrome

,

neuroendocrine carcinoma

,

thyroid neoplasms

,

anaplastic thyroid carcinoma

,

thyroid diseases

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

autonomic nervous system diseases

,

primary dysautonomias

,

familial dysautonomia

,

large-cell lymphoma anaplastic

,

optic nerve diseases

,

optic nerve injuries

,

ventilator-associated pneumonia

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

interstitial lung diseases

,

,

cryptogenic organizing pneumonia

,

idiopathic interstitial pneumonias

,

hamman-rich syndrome

,

organizing pneumonia

,

cervical intraepithelial neoplasia

,

penile prosthesis

,

phototoxic dermatitis

,

,

,

peripheral blood stem cell transplantation

,

vascular diseases

,

,

encephalomyelitis

,

biphenotypic leukemia acute

,

uveal neoplasms

,

lewy body disease

,

,

,

adolescent development

,

,

friedreich ataxia

,

cerebellar ataxia

,

,

out-of-hospital cardiac arrest

,

palliative care

,

iga glomerulonephritis

,

focal segmental glomerulosclerosis

,

myofascial pain syndromes

,

,

,

,

treatment-resistant schizophrenia

,

male breast neoplasms

,

complex partial epilepsy

,

hematopoietic stem cell transplantation

,

neurologic manifestations

,

respiratory distress syndrome

,

,

fragile x syndrome

,

vulvar neoplasms

,

squamous intraepithelial lesions

,

squamous intraepithelial lesions of the cervix

,

drug-induced dyskinesia

,

,

atherosclerosis

,

cerebrovascular disorders

,

,

alcohol drinking

,

group psychotherapy

,

,

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

hepatocellular carcinoma

,

,

,

hyperlipidemias

,

prostatic neoplasms

,

,

,

,

,

basal cell neoplasms

,

squamous cell carcinoma

,

myeloid leukemia acute

,

myeloid leukemia

,

,

alzheimer disease

,

,

,

renal insufficiency

,

diabetic nephropathies

,

,

,

autoimmune diseases of the nervous system

,

,

autistic disorder

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

squamous cell neoplasms

,

emergence delirium

,

,

bcr-abl positive chronic myelogenous leukemia

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

exfoliation syndrome

,

peripheral nervous system diseases

,

traumatic brain injuries

,

metabolic syndrome

,

anxiety disorders

,

,

,

anti-n-methyl-d-aspartate receptor encephalitis

,

acute coronary syndrome

,

hashimoto disease

,

psychomotor agitation

,

,

systemic lupus erythematosus

,

,

chikungunya fever

,

hodgkin disease

,

,

,

,

pulmonary hypertension

,

pulmonary arterial hypertension

,

,

hereditary nephritis

,

cognition disorders

,

,

cutaneous leishmaniasis

,

lupus nephritis

,

,

,

ocular hypertension

,

granulomatosis with polyangiitis

,

microscopic polyangiitis

,

precancerous conditions

,

,

sjogren's syndrome

,

drug resistant epilepsy

,

status epilepticus

,

connective tissue diseases

,

familial primary pulmonary hypertension

,

myocardial infarction

,

anterior wall myocardial infarction

,

,

partial epilepsies

,

,

tendon injuries

,

,

actinic keratosis

,

,

depressive disorder

,

,

,

major depressive disorder

,

diabetes mellitus

,

type 2 diabetes mellitus

,

kidney diseases

,

basal cell carcinoma

,

,

chronic renal insufficiency

,

,

,

parkinson disease

,

,

,

,

,

,

bowen's disease

,

,

cognitive dysfunction

,

,

psychotic disorders

,

hypersensitivity

,

,

treatment-resistant depressive disorder

,

postoperative pain

,

,

non-alcoholic fatty liver disease

,

,

mental disorders

,

,

,

suicidal ideation

,

inflammatory bowel diseases

,

ulcerative colitis

,

,

drug-related side effects and adverse reactions

,

anesthesia and analgesia

,

nutrition disorders

,

multiple sclerosis

,

,

intestinal diseases

,

wounds and injuries

,

,

,

,

coronary artery disease

,

,

,

,

allergic rhinitis

,

,

,

communicable diseases

,

surgical wound infection

,

,

postpartum hemorrhage

,

,

,

irritable bowel syndrome

,

chronic kidney failure

,

dentin sensitivity

,

,

ultrasonography

,

helicobacter infections

,

,

,

kidney transplantation

,

coronary disease

,

myocardial ischemia

,

post-dural puncture headache

,

graft rejection

,

fetal nutrition disorders

,

neurodevelopmental disorders

,

substance-induced psychoses

,

shared paranoid disorder

,

allergic rhinitis seasonal

,

postoperative complications

,

acute lung injury

,

,

extrinsic allergic alveolitis

,

multiple organ failure

,

visceral leishmaniasis

,

angina pectoris

,

,

,

,

uterine inertia

,

calcium metabolism disorders

,

,

,

renal hypertension

,

magnetic resonance imaging

,

,

,

diabetes complications

,

,

procedural pain

,

,

intra-articular injections

,

,

cystic fibrosis

,

trigger finger disorder

,

,

erectile dysfunction

,

open-angle glaucoma

,

minimally invasive surgical procedures

,

chronic obstructive pulmonary disease

,

,

bipolar disorder

,

oxidative stress

,

viral pneumonia

,

,

tobacco use disorder

,

obstetric labor complications

,

insulin resistance

,

immunosuppression therapy

,

hematologic diseases

,

epstein-barr virus infections

,

,

impulsive behavior

,

deglutition disorders

,

,

feeding and eating disorders

,

bulimia nervosa

,

,

chronic traumatic encephalopathy

,

vitamin b 12 deficiency

,

,

glucose intolerance

,

relapsing-remitting multiple sclerosis

,

bacterial vaginosis

,

vaginal diseases

,

,

,

congenital abnormalities

,

dentofacial deformities

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

,

,

escherichia coli infections

,

intestinal neoplasms

,

,

folic acid deficiency

,

,

mitral valve insufficiency

,

gastroesophageal reflux

,

peptic esophagitis

,

complete denture

,

,

,

,

soft tissue injuries

,

periodontal diseases

,

gingival diseases

,

,

cocaine-related disorders

,

,

,

,

,

,

surgical blood loss

,

,

denture stomatitis

,

learning disabilities

,

alcoholic liver diseases

,

,

,

,

intervertebral disc degeneration

,

spinal diseases

,

,

paraneoplastic syndromes

,

muscle weakness

,

,

substance-related disorders

,

,

burning mouth syndrome

,

,

wasting syndrome

,

,

endometrial neoplasms

,

cardiac surgical procedures

,

,

,

spinal fractures

,

aphthous stomatitis

,

gastrointestinal diseases

,

digestive system diseases

,

critical illness

,

somatoform disorders

,

conversion disorder

,

dissociative disorders

,

,

replacement arthroplasty knee

,

acupuncture therapy

,

periodontal pocket

,

noncommunicable diseases

,

,

platelet aggregation

,

radiodermatitis

,

local anesthesia

,

,

status asthmaticus

,

,

,

transcranial magnetic stimulation

,

autoimmune diseases

,

pelvic organ prolapse

,

inguinal hernia

,

urinary incontinence

,

stress urinary incontinence

,

,

,

,

,

neurobehavioral manifestations

,

sleep wake disorders

,

,

,

,

,

,

,

opioid-related disorders

,

,

obstructive lung diseases

,

,

aggressive periodontitis

,

,

alveolar ridge augmentation

,

edentulous mouth

healthy volunteers/patients

,

glycemic control

,

,

hypersensitivity

,

,

insulin resistance

,

,

colonic neoplasms

,

rectal neoplasms

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

hyperinsulinism

,

neuroendocrine tumors

,

,

chronic renal insufficiency

,

kidney diseases

,

glucose metabolism disorders

,

metabolic diseases

,

endocrine system diseases

,

,

cardiovascular diseases

,

chronic obstructive pulmonary disease

,

,

,

,

,

,

,

,

diabetes mellitus

,

type 2 diabetes mellitus

,

type 1 diabetes mellitus

,

,

,

metabolic syndrome

,

gestational diabetes

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

psychotic disorders

,

prediabetic state

,

disease progression

,

,

patient participation

,

peripheral nervous system diseases

,

diabetic neuropathies

,

glucose intolerance

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