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Kowa

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Livalo	Pitavastatin	2009-08-03	2024-2031	Hypercholesterolemia , Hypertriglyceridemia , Hyperlipoproteinemias
Seglentis	Celecoxib, Tramadol	2021-10-15	2029-2038	Ankylosing spondylitis , Rheumatoid arthritis , Osteoarthritis , Adenomatous polyposis coli , Dysmenorrhea , Hypertension , Coronary artery disease , Variant angina pectoris , Pain

Clinical Trials

Therapeutic Areas:

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Classification:

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Approval:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

drug interactions

,

non-alcoholic fatty liver disease

,

myeloid leukemia acute

,

,

b-cell chronic lymphocytic leukemia

,

human influenza

,

,

,

,

non-small-cell lung carcinoma

,

pancreatic neoplasms

,

,

,

ischemic stroke

,

,

,

breast neoplasms

,

hyperlipoproteinemia type ii

,

,

,

,

,

hypercholesterolemia

,

hyperlipidemias

,

healthy volunteers/patients

,

,

diabetes mellitus

,

cardiovascular diseases

,

acute coronary syndrome

,

coronary disease

,

,

hyperlipoproteinemias

,

metabolic syndrome

,

myocardial infarction

,

coronary artery disease

,

myocardial ischemia

,

renal insufficiency

,

atherosclerosis

,

,

type 2 diabetes mellitus

,

kidney diseases

,

,

inferior wall myocardial infarction

,

,

,

chronic renal insufficiency

,

angina pectoris

,

oxidative stress

,

glucose intolerance

,

prediabetic state

,

heart disease risk factors

,

,

percutaneous coronary intervention

,

,

glucose metabolism disorders

,

metabolic diseases

,

liver transplantation

,

immunosuppression therapy

,

drug-related side effects and adverse reactions

,

malignant hyperthermia

,

metabolic bone diseases

,

,

postmenopausal osteoporosis

,

vascular calcification

,

,

preconception care

,

alzheimer disease

,

insulin resistance

,

,

hypersensitivity

,

,

atherosclerotic plaque

,

carotid artery diseases

,

,

benign paroxysmal positional vertigo

,

,

attention deficit disorder with hyperactivity

liver cirrhosis

,

,

,

non-alcoholic fatty liver disease

,

biliary liver cirrhosis

,

,

,

,

,

diabetic retinopathy

,

type 2 diabetes mellitus

,

hyperlipidemias

,

hypercholesterolemia

,

,

hypertriglyceridemia

,

acute coronary syndrome

,

coronary artery disease

,

,

,

healthy volunteers/patients

,

type 2 diabetes mellitus

,

diabetes complications

,

non-alcoholic fatty liver disease

,

diabetes mellitus

renal insufficiency

,

type 2 diabetes mellitus

,

diabetes mellitus

,

diabetes complications

,

coronary disease

,

coronary artery disease

,

Tofogliflozin anhydrous

healthy volunteers/patients

,

renal insufficiency

,

diabetes mellitus

,

type 2 diabetes mellitus

,

,

myeloid leukemia acute

,

deficiency diseases

,

paraproteinemias

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

breast neoplasms

,

immune system diseases

,

hematologic neoplasms

,

type 2 diabetes mellitus

,

,

metabolic diseases

,

,

glycogen storage disease

,

,

immunoglobulin g4-related disease

,

,

myeloid leukemia

,

,

falciparum malaria

,

,

,

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

,

renal insufficiency

,

hematologic diseases

,

blood protein disorders

,

neoplasms by histologic type

,

prostatic neoplasms

,

circulating neoplastic cells

,

x-linked bulbo-spinal atrophy

,

heart transplantation

,

non-small-cell lung carcinoma

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

esophageal neoplasms

,

,

neoplasm metastasis

,

aplastic anemia

,

multiple myeloma

,

hypercholesterolemia

,

meningococcal infections

,

plasma cell neoplasms

,

hemolytic anemia autoimmune

,

,

meningococcal meningitis

,

stomach neoplasms

,

,

kidney diseases

,

gaucher disease

,

,

chronic renal insufficiency

,

hyperphosphatemia

,

multiple sclerosis

,

,

homozygous familial hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

,

healthy volunteers/patients

,

,

glycogen storage disease type ii

,

atopic dermatitis

,

diabetes mellitus

,

insulin resistance

,

,

glycogen storage disease type iii

,

,

non-hodgkin lymphoma

,

,

postmenopausal osteoporosis

,

,

lymphoproliferative disorders

healthy volunteers/patients

,

,

bcr-abl positive chronic myelogenous leukemia

,

type 2 diabetes mellitus

,

glandular and epithelial neoplasms

,

,

gata2 deficiency

,

central nervous system neoplasms

,

,

fallopian tube diseases

,

neurologic manifestations

,

,

interdigitating dendritic cell sarcoma

,

myeloproliferative disorders

,

neoplasms by histologic type

,

adenosquamous carcinoma

,

chronic hepatitis c

,

,

venous thromboembolism

,

thromboembolism

,

pharmacokinetics

,

,

behcet syndrome

,

aids-related complex

,

pleural effusion

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

malignant pleural effusion

,

pleural diseases

,

pleural neoplasms

,

immunosuppression therapy

,

small cell lung carcinoma

,

transitional cell carcinoma

,

ovarian neoplasms

,

non-hodgkin lymphoma

,

triple negative breast neoplasms

,

urologic neoplasms

,

squamous cell carcinoma

,

,

biliary tract neoplasms

,

malignant mesothelioma

,

large b-cell lymphoma diffuse

,

,

uterine cervical neoplasms

,

neoplasms by site

,

castration-resistant prostatic neoplasms

,

b-cell lymphoma

,

endometrial neoplasms

,

,

squamous cell neoplasms

,

,

uveal neoplasms

,

,

hematologic neoplasms

,

t-cell lymphoma peripheral

,

t-cell lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

neuroendocrine tumors

,

gastrointestinal neoplasms

,

adenocarcinoma of lung

,

myeloid leukemia acute

,

cholangiocarcinoma

,

graft vs host disease

,

interstitial lung diseases

,

follicular lymphoma

,

merkel cell carcinoma

,

peritoneal neoplasms

,

spinocerebellar degenerations

,

,

graft rejection

,

psychology rejection

,

clear cell adenocarcinoma

,

,

,

medulloblastoma

,

,

,

rhabdomyosarcoma

,

diffuse intrinsic pontine glioma

,

,

autoimmune diseases

,

multiple sclerosis

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

burkitt lymphoma

,

female genital neoplasms

,

endometrioid carcinoma

,

,

,

urogenital neoplasms

,

organ transplantation

,

neuroendocrine carcinoma

,

urinary bladder diseases

,

microsatellite instability

,

basal cell carcinoma

,

basal cell neoplasms

,

diffuse scleroderma

,

laryngeal diseases

,

,

heart transplantation

,

,

male breast neoplasms

,

b-cell leukemia

,

tertiary lymphoid structures

,

oropharyngeal neoplasms

,

,

prostatic diseases

,

non-muscle invasive bladder neoplasms

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

diabetic neuropathies

,

nephrotic syndrome

,

focal segmental glomerulosclerosis

,

lipoid nephrosis

,

bronchiolitis obliterans syndrome

,

diabetic nephropathies

,

kidney diseases

,

common variable immunodeficiency

,

large-cell lymphoma anaplastic

,

,

phenylketonurias

,

bile duct neoplasms

,

serous cystadenocarcinoma

,

papillary thyroid cancer

,

,

salivary gland neoplasms

,

genetic therapy

,

smoldering multiple myeloma

,

uterine neoplasms

,

large cell carcinoma

,

endometrial stromal tumors

,

small cell carcinoma

,

penile neoplasms

,

adrenocortical carcinoma

,

digestive system diseases

,

,

,

,

,

invasive hydatidiform mole

,

,

,

,

bronchiolo-alveolar adenocarcinoma

,

drug-related side effects and adverse reactions

,

carcinoid tumor

,

hypersensitivity

,

thyroid neoplasms

,

precancerous conditions

,

bronchopulmonary dysplasia

,

tobacco smoking

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

meningeal carcinomatosis

,

systemic scleroderma

,

patient preference

,

,

oral leukoplakia

,

churg-strauss syndrome

,

microscopic polyangiitis

,

oligodendroglioma

,

myeloid leukemia

,

,

,

ankylosing spondylitis

,

,

inflammatory breast neoplasms

,

immunoglobulin g4-related disease

,

,

,

progressive multifocal leukoencephalopathy

,

gastrointestinal stromal tumors

,

male urogenital diseases

,

female urogenital diseases

,

female urogenital diseases and pregnancy complications

,

urogenital diseases

,

reactive arthritis

,

hereditary nonpolyposis colorectal neoplasms

,

,

aplastic anemia

,

,

,

non-small-cell lung carcinoma

,

colorectal neoplasms

,

neoplasm metastasis

,

squamous cell carcinoma of head and neck

,

prostatic neoplasms

,

head and neck neoplasms

,

breast neoplasms

,

pancreatic neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

urinary bladder neoplasms

,

,

brain neoplasms

,

stomach neoplasms

,

hodgkin disease

,

multiple myeloma

,

,

colonic neoplasms

,

,

rectal neoplasms

,

esophageal neoplasms

,

,

,

,

cutaneous malignant melanoma

,

pancreatic ductal carcinoma

,

fallopian tube neoplasms

,

systemic lupus erythematosus

,

myelodysplastic syndromes

,

plasma cell neoplasms

,

,

ovarian epithelial carcinoma

,

,

,

esophageal squamous cell carcinoma

,

ulcerative colitis

,

juvenile arthritis

,

psoriatic arthritis

,

sjogren's syndrome

,

,

,

lupus nephritis

,

giant cell arteritis

,

respiratory tract diseases

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

hyperlipidemias

,

polymyalgia rheumatica

,

vascular diseases

,

,

systemic vasculitis

,

disease progression

,

pathologic complete response

,

,

rheumatoid arthritis

,

renal cell carcinoma

,

,

,

kidney transplantation

,

acquired immunodeficiency syndrome

,

,

kidney neoplasms

,

delayed graft function

,

chronic kidney failure

,

coronary artery disease

,

,

hiv-associated lipodystrophy syndrome

,

epstein-barr virus infections

,

,

transplantation

,

mitochondrial diseases

,

,

,

parkinson disease

,

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

,

alzheimer disease

,

progressive supranuclear palsy

,

,

,

diabetes mellitus

healthy volunteers/patients

,

multiple myeloma

,

,

factor xi deficiency

,

,

kidney diseases

,

atrial fibrillation

,

chronic kidney failure

,

renal insufficiency

,

,

venous thromboembolism

,

thromboembolism

healthy volunteers/patients

,

,

,

,

primary myelofibrosis

,

healthy volunteers/patients

,

uterine cervical neoplasms

,

rectal neoplasms

,

cholangiocarcinoma

,

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

colorectal neoplasms

,

stomach neoplasms

,

,

,

ovarian neoplasms

,

triple negative breast neoplasms

,

large b-cell lymphoma diffuse

,

hepatocellular carcinoma

,

liver neoplasms

,

,

,

non-hodgkin lymphoma

,

ulcerative colitis

,

b-cell chronic lymphocytic leukemia

,

small cell lung carcinoma

,

,

neoplasm metastasis

,

b-cell lymphoma

,

,

,

lupus nephritis

,

ductal carcinoma breast

,

macular degeneration

,

,

renal cell carcinoma

,

transitional cell carcinoma

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

urinary bladder neoplasms

,

colonic neoplasms

,

,

head and neck neoplasms

,

,

,

mucinous adenocarcinoma

,

inflammatory breast neoplasms

,

paroxysmal hemoglobinuria

,

pancreatic neoplasms

,

,

,

,

neoplasms by site

,

breast diseases

,

urologic neoplasms

,

prostatic neoplasms

,

,

follicular lymphoma

,

lymphoid leukemia

,

systemic scleroderma

,

diffuse scleroderma

,

retinal vein occlusion

,

,

,

atypical hemolytic uremic syndrome

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

autistic disorder

,

autism spectrum disorder

,

pervasive child development disorders

,

geographic atrophy

,

,

systemic lupus erythematosus

,

nephrotic syndrome

,

ovarian epithelial carcinoma

,

brain neoplasms

,

esophageal squamous cell carcinoma

,

esophageal neoplasms

,

castration-resistant prostatic neoplasms

,

retinal diseases

,

diabetic retinopathy

,

vision disorders

,

,

,

thyroid neoplasms

,

neuroendocrine carcinoma

,

papillary thyroid cancer

,

thyroid diseases

,

disease progression

,

,

endometrioid carcinoma

,

giant cell arteritis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

membranous glomerulonephritis

,

multiple sclerosis

,

chronic progressive multiple sclerosis

,

ankylosing spondylitis

,

spondylarthritis

,

,

myeloid leukemia acute

,

myeloid leukemia

,

alzheimer disease

,

coronary disease

,

acute coronary syndrome

,

coronary artery disease

,

myocardial ischemia

,

,

relapsing-remitting multiple sclerosis

,

guillain-barre syndrome

,

autoimmune diseases of the nervous system

,

bcr-abl positive chronic myelogenous leukemia

,

circulating neoplastic cells

,

disability evaluation

,

cognition disorders

,

cytomegalovirus infections

,

,

,

hemolytic anemia autoimmune

,

,

focal segmental glomerulosclerosis

,

lipoid nephrosis

,

endometrial neoplasms

,

,

graft rejection

,

retinal neovascularization

,

human influenza

,

type 3 von willebrand disease

,

breast neoplasms

,

non-small-cell lung carcinoma

,

,

,

adenocarcinoma of lung

,

,

postmenopausal osteoporosis

open-angle glaucoma

,

,

alzheimer disease

,

,

myocardial infarction

,

,

insulin resistance

,

,

,

,

,

barrett esophagus

,

multiple sclerosis

,

chronic progressive multiple sclerosis

,

vitamin d deficiency

,

hypersensitivity

,

oral lichen planus

,

,

epidermolysis bullosa

,

,

,

,

,

sleep apnea syndromes

,

,

vestibular diseases

,

,

peripheral nervous system diseases

,

diabetic retinopathy

,

,

dry eye syndromes

,

,

,

colorectal neoplasms

,

pancreatic neoplasms

,

type 2 diabetes mellitus

,

,

,

,

retinal diseases

,

amyotrophic lateral sclerosis

,

,

bipolar disorder

,

,

post-acute covid-19 syndrome

,

neoplasm metastasis

,

cerebellar ataxia

,

autism spectrum disorder

,

type 1 diabetes mellitus

,

motor neuron disease

,

renal insufficiency

,

squamous cell carcinoma

,

squamous cell neoplasms

,

,

rectal neoplasms

,

friedreich ataxia

,

non-small-cell lung carcinoma

,

,

spinal cord injuries

,

prader-willi syndrome

,

post-cardiac arrest syndrome

,

,

pulmonary tuberculosis

,

cystic fibrosis

,

diastolic heart failure

,

sudden death cardiac

,

,

basal cell carcinoma

,

nerve compression syndromes

,

,

charcot-marie-tooth disease

,

hereditary sensory and motor neuropathy

,

,

bipolar and related disorders

,

,

,

metabolic diseases

,

,

glycogen storage disease type ii

,

lysosomal storage diseases

,

glycogen storage disease

,

systemic lupus erythematosus

,

,

uterine neoplasms

,

,

uterine cervical neoplasms

,

,

healthy volunteers/patients

,

,

mitochondrial diseases

,

parkinson disease

,

metabolic syndrome

,

chronic fatigue syndrome

,

breast neoplasms

,

,

,

coronary artery disease

,

polycystic ovary syndrome

,

,

prostatic neoplasms

,

,

,

,

,

progressive supranuclear palsy

,

duchenne muscular dystrophy

,

muscular dystrophies

,

coronary disease

,

myocardial ischemia

,

,

drug-related side effects and adverse reactions

,

huntington disease

,

non-alcoholic fatty liver disease

,

,

,

persian gulf syndrome

,

myelodysplastic syndromes

,

,

hyperlipidemias

,

,

,

,

,

cognitive dysfunction

,

myeloid leukemia acute

,

rem sleep behavior disorder

,

mental disorders

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

nervous system diseases

,

hepatocellular carcinoma

,

liver neoplasms

,

pathologic dilatation

,

,

corneal diseases

,

child nutrition disorders

,

deficiency diseases

,

multiple organ failure

,

,

,

hypertriglyceridemia

,

limb-girdle muscular dystrophies

,

,

,

coronary artery bypass

,

cardiac valve annuloplasty

,

,

coronary stenosis

,

,

juvenile arthritis

,

,

,

myotonic dystrophy

,

,

cardiovascular diseases

,

diabetes mellitus

,

male infertility

,

,

hypercholesterolemia

,

,

oxidative stress

,

,

kidney diseases

,

atherosclerosis

,

,

chronic kidney failure

,

,

,

,

chronic renal insufficiency

,

critical illness

,

,

opioid-related disorders

,

morphine dependence

,

,

,

,

,

,

,

muscle weakness

,

cardiomyopathies

,

dilated cardiomyopathy

,

severe acute respiratory syndrome-related coronavirus

,

severe acute respiratory syndrome

,

,

,

,

temporomandibular joint disorders

,

,

temporomandibular joint dysfunction syndrome

,

acute coronary syndrome

,

,

attitudes health knowledge practice

,

postoperative pain

,

migraine disorders

,

periodontal diseases

,

keratoconjunctivitis sicca

,

,

,

,

,

muscular diseases

,

depressive disorder

,

,

myofascial pain syndromes

,

,

,

medication adherence

,

neurobehavioral manifestations

,

autistic disorder

,

,

fetal growth retardation

,

premature birth

,

iron deficiencies

,

vitamin b 12 deficiency

,

,

dermatomyositis

,

,

female infertility

,

,

cardiovascular abnormalities

,

autonomic nervous system diseases

,

,

ovarian reserve

,

vascular remodeling

,

hyperlipoproteinemias

,

,

macular degeneration

,

wet macular degeneration

,

,

,

post-concussion syndrome

,

gestational diabetes

,

pregnancy outcome

,

gingival recession

,

acute kidney injury

,

intellectual disability

,

hepatic encephalopathy

,

psychotic disorders

,

health status indicators

,

aphthous stomatitis

,

,

,

,

attention deficit disorder with hyperactivity

,

,

mitochondrial genome

,

reproductive physiological phenomena

,

inborn genetic diseases

,

leukoencephalopathies

,

cytochrome-c oxidase deficiency

,

mitochondrial myopathies

,

lactic acidosis

,

hereditary optic atrophy leber

,

,

,

,

,

chronic progressive external ophthalmoplegia

,

kearns-sayre syndrome

,

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

spontaneous abortion

,

kidney transplantation

,

ischemic preconditioning

,

,

respiratory tract infections

,

encephalomyelitis

,

dietary supplements

,

,

,

dental implants

,

,

,

,

,

physical fitness

,

liver cirrhosis

,

,

st elevation myocardial infarction

,

,

communicable diseases

,

,

,

,

,

,

alveolar bone grafting

,

atrial fibrillation

,

asthenozoospermia

,

pharmacokinetics

,

,

community-acquired pneumonia

,

oral leukoplakia

,

muscle strength

,

body composition

,

drug resistant epilepsy

,

intermittent fasting

,

,

,

,

cardiopulmonary bypass

,

cardiac surgical procedures

,

hemodynamic monitoring

,

atopic dermatitis

,

,

sleep initiation and maintenance disorders

,

1

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