Tramadol
Conzip, Seglentis, Tramadol (tramadol) is a small molecule pharmaceutical. Tramadol was first approved as Ultram on 1995-03-03. It is used to treat pain in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Conzip, Tramadol (discontinued: Conzip, Qdolo, Rybix, Ryzolt, Tramadol, Ultram)
CombinationsTramadol acetaminophen (discontinued: Seglentis, Tramadol acetaminophen, Ultracet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
+
Tramadol hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ULTRACET | Johnson & Johnson | N-021123 DISCN | 2001-08-15 | 1 products, RLD |
Hide discontinued
Tramadol hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CONZIP | Cipher Pharmaceuticals | N-022370 RX | 2010-05-07 | 3 products, RLD |
Show 6 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| banana boat kids ultramist tear free spf 30 | OTC monograph final | 2010-03-25 |
| banana boat ultramist baby tear free continuous spf 50 | OTC monograph final | 2010-03-18 |
| banana boat ultramist kids spf 50 factor de proteccion solar 50 | OTC monograph final | 2010-03-21 |
| banana boat ultramist kids tear free lotion spf 50 | OTC monograph final | 2010-03-21 |
| banana boat ultramist sport performance spf 50 | OTC monograph final | 2010-03-20 |
| conzip | New Drug Application | 2023-12-22 |
| direct rx | ANDA | 2015-09-09 |
| durela | Export only | 2024-12-06 |
| fulvicin p/g 165 | ANDA | 2025-02-10 |
| griseofulvin | ANDA | 2021-07-21 |
Show 21 more
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CELECOXIB / TRAMADOL HYDROCHLORIDE, SEGLENTIS, KOWA PHARMS | |||
| 2024-10-15 | NP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Tramadol Hydrochloride, Qdolo, Athena | |||
| 11103452 | 2040-09-01 | DP | U-3197 |
| 11752103 | 2040-09-01 | DP | U-3197 |
| Celecoxib / Tramadol Hydrochloride, Seglentis, Kowa Pharms | |||
| 8846744 | 2031-06-03 | DP | |
| 8598152 | 2030-04-19 | DS, DP | |
| 9012440 | 2030-04-19 | DS, DP | |
| 10238668 | 2030-04-19 | DS, DP | U-3244 |
| 10245276 | 2030-04-19 | DS, DP | |
| 10548909 | 2030-04-19 | U-3244 | |
| 11478488 | 2030-04-19 | U-3244 | |
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AJ: Opioids in combination with non-opioid analgesics
— N02AJ13: Tramadol and paracetamol
— N02AJ14: Tramadol and dexketoprofen
— N02AJ15: Tramadol and other non-opioid analgesics
— N02AJ16: Tramadol and celecoxib
— N02AX: Other opioids in atc
— N02AX02: Tramadol
HCPCS
No data
Clinical
Clinical Trials
592 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 2 | 8 | 10 | 43 | 98 | 159 |
| Pain | D010146 | EFO_0003843 | R52 | 10 | 8 | 17 | 19 | 19 | 73 |
| Chronic pain | D059350 | — | — | — | 5 | 11 | 4 | 13 | 32 |
| Acute pain | D059787 | — | R52 | — | 5 | 9 | 6 | 12 | 32 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | 3 | 9 | 8 | 8 | 30 |
| Healthy volunteers/patients | — | — | — | 17 | — | — | 4 | 1 | 22 |
| Low back pain | D017116 | — | M54.5 | 1 | 3 | 6 | 3 | 8 | 21 |
| Back pain | D001416 | — | M54 | 1 | 3 | 6 | 4 | 6 | 20 |
| Analgesia | D000698 | — | — | — | 1 | 2 | 7 | 11 | 20 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 3 | 6 | 1 | 10 | 20 |
Show 149 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain management | D059408 | — | — | 1 | 2 | 4 | — | 9 | 15 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 1 | — | 5 | 7 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | 1 | 1 | 2 | — | 1 | 4 |
| Spinal anesthesia | D000775 | — | — | — | — | 1 | — | 3 | 4 |
| Disease | D004194 | EFO_0000408 | R69 | 2 | — | 1 | — | — | 3 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | 1 | 2 | — | 1 | 3 |
| General anesthesia | D000768 | — | — | — | — | 1 | — | 2 | 3 |
| Procedural pain | D000073818 | — | — | — | — | 2 | — | 1 | 3 |
| Impacted tooth | D014095 | — | K01.1 | — | 2 | 1 | — | — | 3 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | 1 | 2 |
Show 15 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | 1 | — | — | 2 | 3 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 1 | — | — | 1 | 2 |
| Syndrome | D013577 | — | — | — | 1 | — | — | 1 | 2 |
| Gastrointestinal diseases | D005767 | — | — | — | 2 | — | — | — | 2 |
| Intestinal diseases | D007410 | — | K63.9 | — | 2 | — | — | — | 2 |
| Opioid-induced constipation | D000079689 | — | — | — | 2 | — | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 1 | — | — | — | 1 |
| Mucositis | D052016 | EFO_1001898 | — | — | 1 | — | — | — | 1 |
| Pruritus | D011537 | — | L29 | — | 1 | — | — | — | 1 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 2 | — | — | — | — | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Brain injuries | D001930 | — | S06.9 | 1 | — | — | — | — | 1 |
| Consciousness disorders | D003244 | — | — | 1 | — | — | — | — | 1 |
| Persistent vegetative state | D018458 | — | R40.3 | 1 | — | — | — | — | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | — | 1 |
| Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 6 | 6 |
| Bariatric surgery | D050110 | — | — | — | — | — | — | 4 | 4 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 4 | 4 |
| Joint diseases | D007592 | — | M12.9 | — | — | — | — | 3 | 3 |
| Emergencies | D004630 | — | — | — | — | — | — | 3 | 3 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 3 | 3 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 3 | 3 |
| Ultrasonography | D014463 | — | — | — | — | — | — | 2 | 2 |
| Prolapse | D011391 | — | — | — | — | — | — | 2 | 2 |
| Radiculopathy | D011843 | — | M54.1 | — | — | — | — | 2 | 2 |
Show 101 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Tramadol |
| INN | tramadol |
| Description | (R,R)-tramadol is a 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist, a serotonin uptake inhibitor and a metabolite. It is a conjugate base of a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol. |
| Classification | Small molecule |
| Drug class | analgesics (mixed opiate receptor agonists/antagonists) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cccc(C2(O)CCCCC2CN(C)C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 2914-77-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1237044 |
| ChEBI ID | 75722 |
| PubChem CID | 33741 |
| DrugBank | DB00193 |
| UNII ID | 39J1LGJ30J (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Tramadol
+
Acetaminophen
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tramadol
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 98,637 documents
View more details
Safety
Black-box Warning
Black-box warning for: Conzip, Direct rx, Tramadol acetaminophen, Tramadol hcl, Tramadol hcl and acetaminophen, Tramadol hcl er, Tramadol hcl tramadol hydrochloride, Tramadol hydrochloride, Ultracet
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
98,271 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use