Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ULTRACET | Johnson & Johnson | N-021123 DISCN | 2001-08-15 | 1 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
QDOLO | Athena Neurosciences | N-214044 RX | 2020-09-01 | 1 products, RLD, RS |
CONZIP | Cipher Pharmaceuticals | N-022370 RX | 2010-05-07 | 3 products, RLD |
Brand Name | Status | Last Update |
---|---|---|
banana boat kids ultramist tear free spf 30 | OTC monograph final | 2010-03-25 |
banana boat ultramist baby tear free continuous spf 50 | OTC monograph final | 2010-03-18 |
banana boat ultramist kids spf 50 factor de proteccion solar 50 | OTC monograph final | 2010-03-21 |
banana boat ultramist kids tear free lotion spf 50 | OTC monograph final | 2010-03-21 |
banana boat ultramist sport performance spf 50 | OTC monograph final | 2010-03-20 |
direct rx | ANDA | 2015-09-09 |
griseofulvin | ANDA | 2021-07-21 |
seglentis | New Drug Application | 2023-12-27 |
tramadol acetaminophen | ANDA | 2016-06-22 |
tramadol hcl and acetaminophen | ANDA | 2020-07-15 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
pain | EFO_0003843 | D010146 | R52 |
Expiration | Code | ||
---|---|---|---|
CELECOXIB / TRAMADOL HYDROCHLORIDE, SEGLENTIS, KOWA PHARMS | |||
2024-10-15 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Tramadol Hydrochloride, Qdolo, Athena | |||
11103452 | 2040-09-01 | DP | U-3197 |
11752103 | 2040-09-01 | DP | U-3197 |
Celecoxib / Tramadol Hydrochloride, Seglentis, Kowa Pharms | |||
8846744 | 2031-06-03 | DP | |
8598152 | 2030-04-19 | DS, DP | |
9012440 | 2030-04-19 | DS, DP | |
10238668 | 2030-04-19 | DS, DP | U-3244 |
10245276 | 2030-04-19 | DS, DP | |
10548909 | 2030-04-19 | U-3244 | |
11478488 | 2030-04-19 | U-3244 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Postoperative pain | D010149 | — | G89.18 | 2 | 3 | 3 | 31 | 51 | 90 |
Pain | D010146 | EFO_0003843 | R52 | 10 | 7 | 16 | 19 | 18 | 70 |
Acute pain | D059787 | — | R52 | — | 5 | 7 | 5 | 7 | 24 |
Chronic pain | D059350 | HP_0012532 | — | — | 4 | 10 | 2 | 8 | 23 |
Healthy volunteers/patients | — | — | — | 16 | — | — | 4 | 1 | 21 |
Low back pain | D017116 | HP_0003419 | M54.5 | 1 | 3 | 5 | 3 | 8 | 20 |
Analgesia | D000698 | — | — | — | 1 | 2 | 6 | 7 | 15 |
Anesthesia | D000758 | — | — | — | — | 1 | 5 | 7 | 13 |
Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | 2 | 1 | 7 | 1 | 13 |
Laparoscopic cholecystectomy | D017081 | — | — | — | — | — | 1 | 6 | 7 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 5 | — | 8 | 14 |
Pain management | D059408 | — | — | 1 | 1 | 4 | — | 3 | 8 |
Opioid-related disorders | D009293 | EFO_0005611 | F11 | 3 | 5 | 1 | — | 1 | 7 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 1 | — | 3 | 5 |
Spinal anesthesia | D000775 | — | — | — | — | 1 | — | 2 | 3 |
Procedural pain | D000073818 | — | — | — | — | 2 | — | 1 | 3 |
Pancreatitis | D010195 | HP_0001733 | K85 | — | 1 | 2 | — | — | 2 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | 1 | 2 |
Ebola hemorrhagic fever | D019142 | EFO_0007243 | A98.4 | — | 1 | 1 | — | — | 1 |
Spinal cord diseases | D013118 | HP_0002196 | G95.9 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | 2 | 3 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 1 | — | — | — | 1 |
Pruritus | D011537 | HP_0000989 | L29 | — | 1 | — | — | — | 1 |
Nausea | D009325 | HP_0002018 | R11.0 | — | 1 | — | — | — | 1 |
Vertigo | D014717 | — | H81.39 | — | 1 | — | — | — | 1 |
Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | 1 | — | — | — | 1 |
Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 1 |
Eye neoplasms | D005134 | EFO_0003824 | C69.9 | 1 | 1 | — | — | — | 1 |
Shoulder fractures | D012784 | — | S42.9 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
Brain injuries | D001930 | — | S06.9 | 1 | — | — | — | — | 1 |
Consciousness disorders | D003244 | — | — | 1 | — | — | — | — | 1 |
Persistent vegetative state | D018458 | — | R40.3 | 1 | — | — | — | — | 1 |
Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | — | 1 |
Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Nerve block | D009407 | — | — | — | — | — | — | 4 | 4 |
Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 3 | 3 |
Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 3 | 3 |
Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 3 | 3 |
Nephrolithiasis | D053040 | — | N20.0 | — | — | — | — | 2 | 2 |
Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | — | — | 2 | 2 |
Cholecystectomy | D002763 | — | — | — | — | — | — | 2 | 2 |
Tuberous sclerosis | D014402 | HP_0009720 | Q85.1 | — | — | — | — | 2 | 2 |
Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 2 | 2 |
Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 1 | 1 |
Drug common name | Tramadol |
INN | tramadol |
Description | (R,R)-tramadol is a 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist, a serotonin uptake inhibitor and a metabolite. It is a conjugate base of a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol. |
Classification | Small molecule |
Drug class | analgesics (mixed opiate receptor agonists/antagonists) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | COc1cccc(C2(O)CCCCC2CN(C)C)c1 |
PDB | — |
CAS-ID | 2914-77-4 |
RxCUI | — |
ChEMBL ID | CHEMBL1237044 |
ChEBI ID | 75722 |
PubChem CID | 33741 |
DrugBank | DB00193 |
UNII ID | 39J1LGJ30J (ChemIDplus, GSRS) |