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Disease ReportsHeadache
MeSH D006261 - headache
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Competitive Landscape
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Commercial
Clinical Trials
Competitive landscape
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D010146:Pain
308 Companies
112 Drugs
$
Success rate
D006261: 
Headache
90 Companies
16 Drugs
$
Success rate
D056124:Slit ventricle syndrome
0 Companies
0 Drugs
Success rate
Events Timeline
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Commercial
Company Name
Drug Name
Trade Name
Patent Expires
Approval Date
Revenue
Period
Able LaboratoriesAcetaminophen, Caffeine, Butalbital Butalbital, Acetaminophen Caffeine  2001-07-23   
Acetaminophen, Caffeine, Codeine, Butalbital Butalbital, Acetaminophen, Caffeine Codeine  2003-08-21   
Naproxen Naproxen  2003-08-22   
Ajanta PharmaEsomeprazole, Naproxen Naproxen Esomeprazole Magnesium  2022-10-06   
AllerganAspirin, Caffeine, Butalbital Fiorinal  1986-04-16   
Aspirin, Caffeine, Codeine, Butalbital Fiorinal W/codeine  1990-10-26   
Acetaminophen, Butalbital Butalbital Acetaminophen  1984-10-19   
Acetaminophen, Caffeine, Butalbital Butalbital, Acetaminophen Caffeine  1998-07-30   
Aspirin, Caffeine, Butalbital Butalbital, Aspirin Caffeine  1985-02-12   
Aspirin, Caffeine, Codeine, Butalbital Butalbital, Aspirin, Caffeine, Codeine  1995-08-31   
Doxylamine, Pyridoxine Doxylamine Pyridoxine  2016-08-19   
Acetaminophen, Caffeine, Codeine, Butalbital Fioricet  1992-07-30   
Naproxen Naproxen  1995-02-10   
Esomeprazole, Naproxen Naproxen Esomeprazole Magnesium  2022-08-24   
AlvogenAcetaminophen, Butalbital Butalbital Acetaminophen  2015-10-30   
Acetaminophen, Caffeine, Butalbital Butalbital, Acetaminophen Caffeine  2017-01-10   
Amneal PharmaceuticalsNaproxen Naproxen  2001-12-18   
Naproxen, Diphenhydramine Naproxen Diphenhydramine  2018-10-23   
ANDA RepositoryAcetaminophen, Butalbital Butalbital Acetaminophen  2016-11-15   
Acetaminophen, Caffeine, Butalbital Butalbital, Acetaminophen Caffeine  1987-01-21   
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Clinical Trials
Historical Success Rate
Phase 1
84%
16/19
Phase 2
69%
9/13
Phase 3
67%
34/51
Approved: 6Overall Success rate: 39%
All Clinical Trials
Therapeutic Areas:
All
Classification:
All
Approval:
All
Status:
All
Phases:
All
Company name
Phase 1
Phase 2
Phase 3
Phase 4
Drug Name
Allergan
Acetaminophen,
Aspirin,
Esomeprazole,
Codeine,
Uridine,
Bevifimod,
Azzalure
Bausch Health Companies
Caffeine
1
2
3
4
5
6
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