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AboutPricing
Drug ReportsEsomeprazole
Nexium iv, Nexium control(esomeprazole)
Esomeprazole, Esomeprazole Magnesium, Nexium (esomeprazole) is a small molecule pharmaceutical. Esomeprazole was first approved as Nexium on 2001-02-20. It is used to treat duodenal ulcer, esophagitis, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. It has been approved in Europe to treat gastroesophageal reflux. The pharmaceutical is active against potassium-transporting ATPase alpha chain 1.
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YTD
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Esomeprazole (discontinued: Esomeprazole, Nexium)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Esomeprazole strontium
Tradename
Company
Number
Date
Products
ESOMEPRAZOLE STRONTIUMBelcher PharmatechN-202342 DISCN2013-08-06
2 products, RLD
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Esomeprazole sodium
Tradename
Company
Number
Date
Products
NEXIUM IVAstraZenecaN-021689 DISCN2005-03-31
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
acid reducerANDA2024-11-01
acid reducer powderANDA2024-12-01
basic care esomeprazole magnesiumANDA2024-07-25
basic care omeprazole and sodium bicarbonateANDA2021-07-22
berkley and jensen heartburn treatmentANDA2024-07-31
careone esomeprazole magnesiumANDA2019-12-18
dg health esomeprazole magnesiumANDA2024-08-02
equaline esomeprazole magnesiumANDA2024-08-01
equate omeprazole and sodium bicarbonateANDA2021-05-04
esomeprazoleANDA2024-11-30
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gastroesophageal refluxEFO_0003948D005764K21
helicobacter infectionsEFO_1000961D016481—
duodenal ulcerEFO_0004607D004381K26
zollinger-ellison syndrome—D015043E16.4
esophagitisHP_0100633D004941K20
heartburn—D006356R12
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Esomeprazole Magnesium, Esomeprazole Magnesium, Dexcel
100764942036-12-08DP
108354882036-12-08DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BC: Proton pump inhibitors for peptic ulcer and gord
— A02BC05: Esomeprazole
— A02BD: Combinations for eradication of helicobacter pylori
— A02BD06: Esomeprazole, amoxicillin and clarithromycin
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE52: Naproxen and esomeprazole
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameEsomeprazole
INNesomeprazole
Description
(R)-omeprazole is a 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has R configuration at the sulfur atom. It is an enantiomer of an esomeprazole.
Classification
Small molecule
Drug classantiulcer agents (benzimidazole derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1ccc2[nH]c([S@@+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1
Identifiers
PDB—
CAS-ID119141-88-7
RxCUI—
ChEMBL IDCHEMBL1201320
ChEBI ID50275
PubChem CID9579578
DrugBankDB00736
UNII IDN3PA6559FT (ChemIDplus, GSRS)
Target
Agency Approved
ATP4A
ATP4A
Organism
Homo sapiens
Gene name
ATP4A
Gene synonyms
NCBI Gene ID
495
Protein name
potassium-transporting ATPase alpha chain 1
Protein synonyms
ATPase H+/K+ transporting alpha subunit, ATPase, H+/K+ exchanging, alpha polypeptide, ATPase, H+/K+ transporting, alpha polypeptide, epididymis secretory sperm binding protein, Gastric H(+)/K(+) ATPase subunit alpha, gastric H+/K+ ATPase alpha subunit, gastric H,K-ATPase catalytic subunit, gastric hydrogen-potassium ATPase, Proton pump
Uniprot ID
P20648
Mouse ortholog
Atp4a (11944)
potassium-transporting ATPase alpha chain 1 (Q9CV46)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Vimovo – Horizon Therapeutics Public
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Nexium – AstraZeneca
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Estimated US medical usage
Esomeprazole
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Price per prescription (USD)
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Esomeprazole
+
Naproxen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
No data
Safety
Black-box Warning
Black-box warning for: Naproxen and esomeprazole magnesium, Vimovo
Adverse Events
0 adverse events reported
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