Aspirin - PharmaKB

8-hour bayer, Clopidogrel/acetylsalicylic acid teva(aspirin)

/ Aspirin / Caffeine, Aspirin /, Aspirin / Butalbital / Caffeine, Aspirin / Butalbital / Caffeine /, Axotal, Codoxy, Darvon, Darvon W/ Asa, Equagesic, Excedrin (migraine Relief), Lanorinal, Micrainin, Orphengesic, Percodan, Percodan-demi, Pravigard, Q-gesic, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vazalore, W/ Asa, Yosprala (aspirin) is a small molecule pharmaceutical. Aspirin was first approved as Codeine, aspirin, apap formula no. 4 on 1982-01-01. It is used to treat fever, gout, inflammation, osteoarthritis, and pain amongst others in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 3, transient receptor potential cation channel subfamily V member 3, and N-formyl peptide receptor 2.

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Commercial

Clinical

Drug

Target

Variants

Financial

Trends

Safety

Events Timeline

YTD

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

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Results first post date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
musculoskeletal diseases	D009140
hereditary congenital and neonatal diseases and abnormalities	D009358
skin and connective tissue diseases	D017437
nutritional and metabolic diseases	D009750
immune system diseases	D007154
signs and symptoms pathological conditions	D013568
psychological phenomena	D011579
musculoskeletal and neural physiological phenomena	D055687

Trade Name

FDA

EMA

Vazalore (discontinued: Bayer aspirin for, Measurin)

Combinations

Acetaminophen, aspirin caffeine, Aspirin dipyridamole, Butalbital, aspirin caffeine, Butalbital, aspirin, caffeine, codeine, Excedrin (migraine relief), Hydrocodone aspirin, Lanorinal, Orphengesic, Oxycodone aspirin, Percodan (discontinued: Aggrenox, Aspirin dipyridamole, Axotal, Azdone, Butalbital, aspirin caffeine, Butalbital, aspirin, caffeine, codeine, Carisoprodol, Carisoprodol aspirin, Carisoprodol, aspirin codeine, Codeine, aspirin, apap no., Codoxy, Darvon, Darvon-n w/ asa, Equagesic, Fiorinal, Fiorinal w/codeine, Invagesic, Lanorinal, Mepro-aspirin, Meprobamate aspirin, Methocarbamol aspirin, Micrainin, Norgesic, Orphenadrine citrate, aspirin, caffeine, Oxycodone aspirin, Oxycodone aspirin (half-strength), Percodan, Pravigard, Propoxyphene, Propoxyphene w/ aspirin caffeine, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vicoprin, Yosprala)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Aspirin

Dipyridamole

Tradename	Company	Number	Date	Products
AGGRENOX	Boehringer Ingelheim	N-020884 DISCN	1999-11-22	1 products, RLD

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Aspirin

Pentazocine hydrochloride

Tradename	Company	Number	Date	Products
TALWIN COMPOUND	Sanofi	N-016891 DISCN	1982-01-01	1 products, RLD

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Aspirin

Caffeine

Orphenadrine citrate

Tradename	Company	Number	Date	Products
NORGESIC	Bausch Health Companies	N-013416 DISCN	1982-10-27	1 products, RLD
NORGESIC FORTE	Bausch Health Companies	N-013416 DISCN	1982-10-27	1 products, RLD

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Aspirin

Omeprazole

Tradename	Company	Number	Date	Products
YOSPRALA	Genus Lifesciences	N-205103 DISCN	2016-09-14	2 products, RLD

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Aspirin

Butalbital

Caffeine

Tradename	Company	Number	Date	Products
FIORINAL	Allergan	N-017534 DISCN	1986-04-16	2 products, RLD

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Aspirin

Butalbital

Caffeine

Codeine phosphate

Tradename	Company	Number	Date	Products
FIORINAL W/CODEINE	Allergan	N-019429 DISCN	1990-10-26	1 products, RLD

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Aspirin

Tradename	Company	Number	Date	Products
VAZALORE	PLx Pharma	N-203697 OTC	2013-01-14	2 products, RLD, RS

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Aspirin

Meprobamate

Tradename	Company	Number	Date	Products
EQUAGESIC	Sun Pharmaceutical Industries	N-011702 DISCN	1983-12-29	1 products

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Aspirin

Caffeine

Dihydrocodeine bitartrate

Tradename	Company	Number	Date	Products
SYNALGOS-DC	Sun Pharmaceutical Industries	N-011483 DISCN	1983-09-06	1 products, RLD

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Aspirin

Pravastatin sodium

Tradename	Company	Number	Date	Products
PRAVIGARD PAC (COPACKAGED)	Bristol Myers Squibb	N-021387 DISCN	2003-06-24	6 products

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Aspirin

Propoxyphene hydrochloride

Tradename	Company	Number	Date	Products
DARVON W/ ASA	Xanodyne Pharmaceuticals	N-010996 DISCN	1982-01-01	1 products

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Aspirin

Caffeine

Propoxyphene hydrochloride

Tradename	Company	Number	Date	Products
DARVON COMPOUND	Xanodyne Pharmaceuticals	N-010996 DISCN	1983-03-08	1 products
DARVON COMPOUND-65	Xanodyne Pharmaceuticals	N-010996 DISCN	1983-03-08	1 products

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Aspirin

Propoxyphene napsylate

Tradename	Company	Number	Date	Products
DARVON-N W/ ASA	AAIPharma	N-016829 DISCN	1982-01-01	1 products
DARVON-N W/ ASA	AAIPharma	N-016863 DISCN	1982-01-01	1 products

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Aspirin

Methocarbamol

Tradename	Company	Number	Date	Products
ROBAXISAL	A.H. Robins Company	N-012281 DISCN	1982-01-01	1 products, RLD

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Aspirin

Oxycodone hydrochloride

Tradename	Company	Number	Date	Products
PERCODAN	Endo	N-007337 RX	2005-08-05	1 products, RLD, RS

Aspirin

Oxycodone hydrochloride

Oxycodone terephthalate

Tradename	Company	Number	Date	Products
PERCODAN-DEMI	Endo	N-007337 DISCN	1982-01-01	1 products
PERCODAN	Endo	N-007337 DISCN	1982-01-01	1 products

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Aspirin

Carisoprodol

Tradename	Company	Number	Date	Products
SOMA COMPOUND	Meda AB	N-012365 DISCN	1983-07-11	1 products

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Aspirin

Carisoprodol

Codeine phosphate

Tradename	Company	Number	Date	Products
SOMA COMPOUND W/ CODEINE	Meda AB	N-012366 DISCN	1983-07-11	1 products

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Acetaminophen

Aspirin

Caffeine

Tradename	Company	Number	Date	Products
EXCEDRIN (MIGRAINE RELIEF)	GSK	N-020802 OTC	1998-01-14	1 products, RLD, RS

Labels

FDA

EMA

Brand Name	Status	Last Update
10 person ansi	OTC monograph final	2010-06-07
acetaminophen 250mg aspirin 250mg caffeine 65mg	C200263	2024-12-26
acetaminophen aspirin and caffeine	ANDA	2024-03-05
acetaminophen aspirin caffeine	ANDA	2024-11-18
acetaminophen, aspirin and caffeine	C200263	2025-07-03
acetaminophen, aspirin, and caffeine	C200263	2025-07-02
acetaminophen, aspirin, caffeine	C200263	2025-02-11
acetylsalicylic acid	Export only	2025-01-15
ache and pain relief to go	OTC monograph not final	2014-10-08
acido acetilsalicilico	Export only	2023-07-06

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Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
rheumatoid arthritis	EFO_0000685	D001172	M06.9
pain	EFO_0003843	D010146	R52
headache	—	D006261	R51
fever	—	D005334	R50.9
inflammation	MP_0001845	D007249	—
osteoarthritis	EFO_0002506	D010003	M15-M19
fatigue	—	D005221	R53.83
apnea	—	D001049	R06.81
rheumatic fever	EFO_1001160	D012213	I00-I02
gout	EFO_0004274	D006073	M10

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Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	Flag	FDA Information
Aspirin / Omeprazole, Yosprala, Genus Lifesciences
9539214	2033-03-13		U-1902, U-1902
9987231	2033-01-02		U-2324, U-2324
6926907	2023-02-28	DP	U-1902, U-1902
8206741	2023-02-28	DP	U-1902, U-1902
Aspirin, Vazalore, Plx Pharma
9216150	2032-09-29	DP
9226892	2032-09-29		U-1731, U-1732, U-1733

ATC Codes

M: Musculo-skeletal system drugs

— M03: Muscle relaxants

— M03B: Muscle relaxants, centrally acting agents

— M03BA: Carbamic acid esters, centrally acting muscle relaxants

— M03BA02: Carisoprodol

— M03BA52: Carisoprodol, combinations excl. psycholeptics

— M03BA72: Carisoprodol, combinations with psycholeptics

HCPCS

Code	Description
G2128	Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g. history of gastrointestinal bleed, intra-cranial bleed, blood disorders, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period)
G8598	Aspirin or another antiplatelet therapy used
G8599	Aspirin or another antiplatelet therapy not used, reason not given
G9277	Documentation that the patient is on daily aspirin or anti-platelet or has documentation of a valid contraindication or exception to aspirin/anti-platelet; contraindications/exceptions include anti-coagulant use, allergy to aspirin or anti-platelets, history of gastrointestinal bleed and bleeding disorder; additionally, the following exceptions documented by the physician as a reason for not taking daily aspirin or anti-platelet are acceptable (use of non-steroidal anti-inflammatory agents, documented risk for drug interaction, uncontrolled hypertension defined as >180 systolic or >110 diastolic or gastroesophageal reflux)
G9278	Documentation that the patient is not on daily aspirin or anti-platelet regimen
G9793	Patient is currently on a daily aspirin or other antiplatelet
G9794	Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g., history of gastrointestinal bleed, intra-cranial bleed, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period)
G9795	Patient is not currently on a daily aspirin or other antiplatelet
M1055	Aspirin or another antiplatelet therapy used
M1056	Prescribed anticoagulant medication during the performance period, history of gi bleeding, history of intracranial bleeding, bleeding disorder and specific provider documented reasons: allergy to aspirin or anti-platelets, use of non-steroidal anti-inflammatory agents, drug-drug interaction, uncontrolled hypertension > 180/110 mmhg or gastroesophageal reflux disease

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Clinical

Clinical Trials

2105 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Coronary artery disease	D003324	—	I25.1	—	—	—	2	4	6
Stroke	D020521	EFO_0000712	I63.9	—	—	1	1	3	5
Myocardial ischemia	D017202	EFO_1001375	I20-I25	—	—	—	2	2	4
Heart failure	D006333	EFO_0003144	I50	—	—	—	1	2	3
Coronary disease	D003327	—	—	—	—	—	1	2	3
Coronary restenosis	D023903	EFO_0004224	—	—	—	—	1	1	2
Atrial fibrillation	D001281	EFO_0000275	I48.0	—	—	1	1	—	2
Patent foramen ovale	D054092	—	Q21.12	—	—	1	1	—	2
Acute coronary syndrome	D054058	EFO_0005672	—	—	—	—	1	1	2
Vascular diseases	D014652	EFO_0004264	I77	—	—	—	1	—	1

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Ischemic stroke	D000083242	—	—	—	—	1	—	3	4
Dyslipidemias	D050171	—	—	—	1	2	—	—	3
Flushing	D005483	—	R23.2	—	—	2	—	1	3
Dual anti-platelet therapy	D000080903	—	—	—	—	1	—	—	1

Indications Phases 2

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Indications Phases 1

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Renal insufficiency	D051437	—	N19	—	—	—	—	2	2
Hematologic diseases	D006402	EFO_0005803	D75.9	—	—	—	—	2	2
Anemia	D000740	EFO_0004272	D64.9	—	—	—	—	2	2
Blood coagulation disorders	D001778	EFO_0009314	D68.9	—	—	—	—	2	2
Hemorrhagic stroke	D000083302	—	—	—	—	—	—	2	2
Thrombocytopenia	D013921	HP_0001873	D69.6	—	—	—	—	2	2
Hemostatic disorders	D020141	—	—	—	—	—	—	2	2
Coagulation protein disorders	D020147	—	—	—	—	—	—	2	2
Percutaneous coronary intervention	D062645	—	—	—	—	—	—	1	1
Syndrome	D013577	—	—	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Aspirin
INN	carisoprodol
Description	Acetylsalicylic acid is a member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a platelet aggregation inhibitor, an antipyretic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a prostaglandin antagonist, a teratogenic agent, an anticoagulant, a plant activator, an EC 1.1.1.188 (prostaglandin-F synthase) inhibitor, a drug allergen and a geroprotector. It is a member of benzoic acids, a member of salicylates and a member of phenyl acetates. It is functionally related to a salicylic acid. It is a conjugate acid of an acetylsalicylate.
Classification	Small molecule
Drug class	Nonsteroidal anti-inflammatory drug (NSAID)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(=O)Oc1ccccc1C(=O)O

Identifiers

PDB	—
CAS-ID	50-78-2
RxCUI	—
ChEMBL ID	CHEMBL25
ChEBI ID	15365
PubChem CID	2244
DrugBank	DB00945
UNII ID	R16CO5Y76E (ChemIDplus, GSRS)

Target

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Variants

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Financial

Revenue by drug

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Vazalore – PLx Pharma

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Estimated US medical usage

Aspirin

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Aspirin

Carisoprodol

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Aspirin

Codeine

Carisoprodol

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Aspirin

Codeine

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Aspirin

Dipyridamole

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Aspirin

Hydrocodone

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Aspirin

Meprobamate

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Aspirin

Methocarbamol

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Aspirin

Oxycodone

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Aspirin

Pravastatin

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Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 88,494 documents

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Safety

Black-box Warning

Black-box warning for: Ascomp with codeine, Butalbital, aspirin, caffeine and codeine phosphate, Clopidogrel kit, Hydrocodone bitartrate and aspirin, Oxycodone and aspirin

Adverse Events

Top Adverse Reactions

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182,895 adverse events reported

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