8-hour bayer, Clopidogrel/acetylsalicylic acid teva(aspirin)
/ Aspirin / Caffeine, Aspirin /, Aspirin / Butalbital / Caffeine, Aspirin / Butalbital / Caffeine /, Axotal, Codoxy, Darvon, Darvon W/ Asa, Equagesic, Excedrin (migraine Relief), Lanorinal, Micrainin, Orphengesic, Percodan, Percodan-demi, Pravigard, Q-gesic, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vazalore, W/ Asa, Yosprala (aspirin) is a small molecule pharmaceutical. Aspirin was first approved as Codeine, aspirin, apap formula no. 4 on 1982-01-01. It is used to treat fever, gout, inflammation, osteoarthritis, and pain amongst others in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 3, transient receptor potential cation channel subfamily V member 3, and N-formyl peptide receptor 2.
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Vazalore (discontinued: Bayer aspirin for, Measurin)
CombinationsAcetaminophen, aspirin caffeine, Aspirin dipyridamole, Butalbital, aspirin caffeine, Butalbital, aspirin, caffeine, codeine, Excedrin (migraine relief), Hydrocodone aspirin, Lanorinal, Orphengesic, Oxycodone aspirin, Percodan (discontinued: Aggrenox, Aspirin dipyridamole, Axotal, Azdone, Butalbital, aspirin caffeine, Butalbital, aspirin, caffeine, codeine, Carisoprodol, Carisoprodol aspirin, Carisoprodol, aspirin codeine, Codeine, aspirin, apap no., Codoxy, Darvon, Darvon-n w/ asa, Equagesic, Fiorinal, Fiorinal w/codeine, Invagesic, Lanorinal, Mepro-aspirin, Meprobamate aspirin, Methocarbamol aspirin, Micrainin, Norgesic, Orphenadrine citrate, aspirin, caffeine, Oxycodone aspirin, Oxycodone aspirin (half-strength), Percodan, Pravigard, Propoxyphene, Propoxyphene w/ aspirin caffeine, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vicoprin, Yosprala)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
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Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AGGRENOX | Boehringer Ingelheim | N-020884 DISCN | 1999-11-22 | 1 products, RLD |
Hide discontinued
Aspirin
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Pentazocine hydrochloride
Aspirin
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Caffeine
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Orphenadrine citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NORGESIC | Bausch Health Companies | N-013416 DISCN | 1982-10-27 | 1 products, RLD |
| NORGESIC FORTE | Bausch Health Companies | N-013416 DISCN | 1982-10-27 | 1 products, RLD |
Hide discontinued
Aspirin
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Omeprazole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| YOSPRALA | Genus Lifesciences | N-205103 DISCN | 2016-09-14 | 2 products, RLD |
Hide discontinued
Aspirin
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Butalbital
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Caffeine
Aspirin
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Butalbital
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Caffeine
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Codeine phosphate
Aspirin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VAZALORE | PLx Pharma | N-203697 OTC | 2013-01-14 | 2 products, RLD, RS |
Show 3 discontinued
Aspirin
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Meprobamate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EQUAGESIC | Sun Pharmaceutical Industries | N-011702 DISCN | 1983-12-29 | 1 products |
Hide discontinued
Aspirin
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Caffeine
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Dihydrocodeine bitartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYNALGOS-DC | Sun Pharmaceutical Industries | N-011483 DISCN | 1983-09-06 | 1 products, RLD |
Hide discontinued
Aspirin
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Pravastatin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRAVIGARD PAC (COPACKAGED) | Bristol Myers Squibb | N-021387 DISCN | 2003-06-24 | 6 products |
Hide discontinued
Aspirin
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON W/ ASA | Xanodyne Pharmaceuticals | N-010996 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Aspirin
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Caffeine
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON COMPOUND | Xanodyne Pharmaceuticals | N-010996 DISCN | 1983-03-08 | 1 products |
| DARVON COMPOUND-65 | Xanodyne Pharmaceuticals | N-010996 DISCN | 1983-03-08 | 1 products |
Hide discontinued
Aspirin
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Propoxyphene napsylate
Aspirin
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Methocarbamol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ROBAXISAL | A.H. Robins Company | N-012281 DISCN | 1982-01-01 | 1 products, RLD |
Hide discontinued
Aspirin
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Oxycodone hydrochloride
Aspirin
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Oxycodone hydrochloride
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Oxycodone terephthalate
Aspirin
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Carisoprodol
Aspirin
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Carisoprodol
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Codeine phosphate
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 10 person ansi | OTC monograph final | 2010-06-07 |
| 25 person ansi | OTC monograph final | 2010-06-07 |
| 50 person ansi | OTC monograph final | 2010-06-07 |
| acetaminophen , aspirin and caffeine | C200263 | 2026-04-27 |
| acetaminophen 250 mg aspirin 250 mg caffeine 65 mg | C200263 | 2026-07-08 |
| acetaminophen 250mg aspirin 250mg caffeine 65mg | C200263 | 2024-12-26 |
| acetaminophen aspirin and caffeine | ANDA | 2024-03-05 |
| acetaminophen aspirin caffeine | ANDA | 2026-09-15 |
| acetaminophen, aspirin and caffeine | ANDA | 2026-10-07 |
| acetaminophen, aspirin, and caffeine | C200263 | 2025-07-02 |
Show 475 more
Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03B: Muscle relaxants, centrally acting agents
— M03BA: Carbamic acid esters, centrally acting muscle relaxants
— M03BA02: Carisoprodol
— M03BA52: Carisoprodol, combinations excl. psycholeptics
— M03BA72: Carisoprodol, combinations with psycholeptics
HCPCS
Code | Description |
|---|---|
| G2128 | Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g. history of gastrointestinal bleed, intra-cranial bleed, blood disorders, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period) |
| G8598 | Aspirin or another antiplatelet therapy used |
| G8599 | Aspirin or another antiplatelet therapy not used, reason not given |
| G9277 | Documentation that the patient is on daily aspirin or anti-platelet or has documentation of a valid contraindication or exception to aspirin/anti-platelet; contraindications/exceptions include anti-coagulant use, allergy to aspirin or anti-platelets, history of gastrointestinal bleed and bleeding disorder; additionally, the following exceptions documented by the physician as a reason for not taking daily aspirin or anti-platelet are acceptable (use of non-steroidal anti-inflammatory agents, documented risk for drug interaction, uncontrolled hypertension defined as >180 systolic or >110 diastolic or gastroesophageal reflux) |
| G9278 | Documentation that the patient is not on daily aspirin or anti-platelet regimen |
| G9793 | Patient is currently on a daily aspirin or other antiplatelet |
| G9794 | Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g., history of gastrointestinal bleed, intra-cranial bleed, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period) |
| G9795 | Patient is not currently on a daily aspirin or other antiplatelet |
| M1055 | Aspirin or another antiplatelet therapy used |
| M1056 | Prescribed anticoagulant medication during the performance period, history of gi bleeding, history of intracranial bleeding, bleeding disorder and specific provider documented reasons: allergy to aspirin or anti-platelets, use of non-steroidal anti-inflammatory agents, drug-drug interaction, uncontrolled hypertension > 180/110 mmhg or gastroesophageal reflux disease |
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Clinical
Clinical Trials
2235 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 8 | 13 | 25 | 127 | 110 | 282 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 5 | 27 | 71 | 43 | 65 | 194 |
| Ischemic stroke | D000083242 | — | — | 7 | 27 | 61 | 43 | 52 | 175 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 3 | 13 | 30 | 47 | 45 | 130 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 8 | 13 | 13 | 55 | 39 | 127 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 2 | 7 | 14 | 51 | 50 | 124 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 10 | 15 | 25 | 27 | 45 | 119 |
| Coronary disease | D003327 | — | — | 3 | 6 | 12 | 48 | 49 | 117 |
| Infarction | D007238 | EFO_0009463 | — | 3 | 11 | 26 | 39 | 42 | 115 |
| Thrombosis | D013927 | — | — | 5 | 7 | 13 | 32 | 37 | 93 |
Show 260 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 3 | 14 | 10 | — | 10 | 34 |
| Duodenal ulcer | D004381 | EFO_0004607 | K26 | 2 | 3 | 9 | — | 6 | 18 |
| Multiple myeloma | D009101 | — | C90.0 | 7 | 8 | 5 | — | 1 | 16 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 9 | 3 | — | 2 | 15 |
| Stomach ulcer | D013276 | — | K25 | — | 2 | 10 | — | 4 | 15 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 1 | 2 | 5 | — | 4 | 11 |
| Colonic neoplasms | D003110 | — | C18 | — | 2 | 4 | — | 4 | 10 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | 2 | — | 2 | 9 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | — | 3 | 4 | — | 1 | 8 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 5 | 1 | — | 1 | 8 |
Show 113 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasma cell neoplasms | D054219 | — | — | 6 | 6 | — | — | 1 | 10 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 7 | — | — | — | 7 |
| Hiv | D006678 | — | O98.7 | — | 3 | — | — | 3 | 6 |
| Drug resistance | D004351 | — | Z16.30 | 1 | 1 | — | — | 4 | 5 |
| Postoperative hemorrhage | D019106 | — | — | — | 1 | — | — | 3 | 4 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | 4 | — | — | — | 4 |
| Postoperative cognitive complications | D000079690 | — | — | — | 2 | — | — | 2 | 4 |
| High-risk pregnancy | D018566 | — | — | — | 2 | — | — | 2 | 4 |
| Obstructive lung diseases | D008173 | — | — | — | 4 | — | — | — | 4 |
| Rectal neoplasms | D012004 | — | — | — | 2 | — | — | 2 | 4 |
Show 89 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | 11 | 12 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | 4 | 5 |
| Blood platelet disorders | D001791 | — | — | 1 | — | — | — | 4 | 5 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | 3 | — | — | — | 1 | 4 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | — | — | — | 3 | 4 |
| Therapeutic equivalency | D013810 | — | — | 4 | — | — | — | — | 4 |
| Pharmacokinetics | D010599 | — | — | 3 | — | — | — | — | 3 |
| Heat stress disorders | D018882 | — | T67.2 | 1 | — | — | — | 1 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 1 | 2 |
| Optical coherence tomography | D041623 | — | — | 1 | — | — | — | 1 | 2 |
Show 31 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asymptomatic diseases | D058070 | — | — | — | — | — | — | 5 | 5 |
| Hemostatic disorders | D020141 | — | — | — | — | — | — | 4 | 4 |
| Coronary occlusion | D054059 | — | I21 | — | — | — | — | 3 | 3 |
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 3 | 3 |
| Thrombectomy | D017131 | — | — | — | — | — | — | 3 | 3 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | — | — | — | 3 | 3 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | — | — | — | — | 3 | 3 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 3 | 3 |
| Venous insufficiency | D014689 | — | — | — | — | — | — | 3 | 3 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 3 | 3 |
Show 187 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aspirin |
| INN | carisoprodol |
| Description | Acetylsalicylic acid is a member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a platelet aggregation inhibitor, an antipyretic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a prostaglandin antagonist, a teratogenic agent, an anticoagulant, a plant activator, an EC 1.1.1.188 (prostaglandin-F synthase) inhibitor, a drug allergen and a geroprotector. It is a member of benzoic acids, a member of salicylates and a member of phenyl acetates. It is functionally related to a salicylic acid. It is a conjugate acid of an acetylsalicylate. |
| Classification | Small molecule |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)Oc1ccccc1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 50-78-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL25 |
| ChEBI ID | 15365 |
| PubChem CID | 2244 |
| DrugBank | DB00945 |
| UNII ID | R16CO5Y76E (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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Vazalore – PLx Pharma
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Aspirin
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Codeine
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Carisoprodol
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Codeine
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Dipyridamole
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Aspirin
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Hydrocodone
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Meprobamate
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Methocarbamol
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Oxycodone
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Pravastatin
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PubMed Central
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Safety
Black-box Warning
Black-box warning for: Ascomp with codeine, Butalbital, aspirin, caffeine and codeine phosphate, Clopidogrel kit, Hydrocodone bitartrate and aspirin, Oxycodone and aspirin
Adverse Events
Top Adverse Reactions
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187,114 adverse events reported
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