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Drug ReportsAspirin
Aspirin
/ Aspirin / Caffeine, Aspirin /, Aspirin / Butalbital / Caffeine, Aspirin / Butalbital / Caffeine /, Axotal, Codoxy, Darvon, Darvon W/ Asa, Equagesic, Excedrin (migraine Relief), Lanorinal, Micrainin, Orphengesic, Percodan, Percodan-demi, Pravigard, Q-gesic, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vazalore, W/ Asa, Yosprala (aspirin) is a small molecule pharmaceutical. Aspirin was first approved as Codeine, aspirin, apap formula no. 4 on 1982-01-01. It is used to treat fever, gout, inflammation, osteoarthritis, and pain amongst others in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 3, transient receptor potential cation channel subfamily V member 3, and N-formyl peptide receptor 2.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
nutritional and metabolic diseasesD009750
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Vazalore (discontinued: Bayer aspirin for, Measurin)
Combinations
Acetaminophen, aspirin caffeine, Aspirin dipyridamole, Butalbital, aspirin caffeine, Butalbital, aspirin, caffeine, codeine, Excedrin (migraine relief), Hydrocodone aspirin, Lanorinal, Orphengesic, Oxycodone aspirin, Percodan (discontinued: Aggrenox, Aspirin dipyridamole, Axotal, Azdone, Butalbital, aspirin caffeine, Butalbital, aspirin, caffeine, codeine, Carisoprodol, Carisoprodol aspirin, Carisoprodol, aspirin codeine, Codeine, aspirin, apap no., Codoxy, Darvon, Darvon-n w/ asa, Equagesic, Fiorinal, Fiorinal w/codeine, Invagesic, Lanorinal, Mepro-aspirin, Meprobamate aspirin, Methocarbamol aspirin, Micrainin, Norgesic, Orphenadrine citrate, aspirin, caffeine, Oxycodone aspirin, Oxycodone aspirin (half-strength), Percodan, Pravigard, Propoxyphene, Propoxyphene w/ aspirin caffeine, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vicoprin, Yosprala)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Dipyridamole
Tradename
Company
Number
Date
Products
AGGRENOXBoehringer IngelheimN-020884 DISCN1999-11-22
1 products, RLD
Hide discontinued
Aspirin
+
Pentazocine hydrochloride
Tradename
Company
Number
Date
Products
TALWIN COMPOUNDSanofiN-016891 DISCN1982-01-01
1 products, RLD
Hide discontinued
Aspirin
+
Caffeine
+
Orphenadrine citrate
Tradename
Company
Number
Date
Products
NORGESICBausch Health CompaniesN-013416 DISCN1982-10-27
1 products, RLD
NORGESIC FORTEBausch Health CompaniesN-013416 DISCN1982-10-27
1 products, RLD
Hide discontinued
Aspirin
+
Omeprazole
Tradename
Company
Number
Date
Products
YOSPRALAGenus LifesciencesN-205103 DISCN2016-09-14
2 products, RLD
Hide discontinued
Aspirin
+
Butalbital
+
Caffeine
Tradename
Company
Number
Date
Products
FIORINALAllerganN-017534 DISCN1986-04-16
2 products, RLD
Hide discontinued
Aspirin
+
Butalbital
+
Caffeine
+
Codeine phosphate
Tradename
Company
Number
Date
Products
FIORINAL W/CODEINEAllerganN-019429 DISCN1990-10-26
1 products, RLD
Hide discontinued
Aspirin
Tradename
Company
Number
Date
Products
VAZALOREPLx PharmaN-203697 OTC2013-01-14
2 products, RLD, RS
Show 3 discontinued
Aspirin
+
Meprobamate
Tradename
Company
Number
Date
Products
EQUAGESICSun Pharmaceutical IndustriesN-011702 DISCN1983-12-29
1 products
Hide discontinued
Aspirin
+
Caffeine
+
Dihydrocodeine bitartrate
Tradename
Company
Number
Date
Products
SYNALGOS-DCSun Pharmaceutical IndustriesN-011483 DISCN1983-09-06
1 products, RLD
Hide discontinued
Aspirin
+
Pravastatin sodium
Tradename
Company
Number
Date
Products
PRAVIGARD PAC (COPACKAGED)Bristol Myers SquibbN-021387 DISCN2003-06-24
6 products
Hide discontinued
Aspirin
+
Propoxyphene hydrochloride
Tradename
Company
Number
Date
Products
DARVON W/ ASAXanodyne PharmaceuticalsN-010996 DISCN1982-01-01
1 products
Hide discontinued
Aspirin
+
Caffeine
+
Propoxyphene hydrochloride
Tradename
Company
Number
Date
Products
DARVON COMPOUNDXanodyne PharmaceuticalsN-010996 DISCN1983-03-08
1 products
DARVON COMPOUND-65Xanodyne PharmaceuticalsN-010996 DISCN1983-03-08
1 products
Hide discontinued
Aspirin
+
Propoxyphene napsylate
Tradename
Company
Number
Date
Products
DARVON-N W/ ASAAAIPharmaN-016829 DISCN1982-01-01
1 products
DARVON-N W/ ASAAAIPharmaN-016863 DISCN1982-01-01
1 products
Hide discontinued
Aspirin
+
Methocarbamol
Tradename
Company
Number
Date
Products
ROBAXISALA.H. Robins CompanyN-012281 DISCN1982-01-01
1 products, RLD
Hide discontinued
Aspirin
+
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
PERCODANEndoN-007337 RX2005-08-05
1 products, RLD, RS
Aspirin
+
Oxycodone hydrochloride
+
Oxycodone terephthalate
Tradename
Company
Number
Date
Products
PERCODAN-DEMIEndoN-007337 DISCN1982-01-01
1 products
PERCODANEndoN-007337 DISCN1982-01-01
1 products
Hide discontinued
Aspirin
+
Carisoprodol
Tradename
Company
Number
Date
Products
SOMA COMPOUNDMeda ABN-012365 DISCN1983-07-11
1 products
Hide discontinued
Aspirin
+
Carisoprodol
+
Codeine phosphate
Tradename
Company
Number
Date
Products
SOMA COMPOUND W/ CODEINEMeda ABN-012366 DISCN1983-07-11
1 products
Hide discontinued
Acetaminophen
+
Aspirin
+
Caffeine
Tradename
Company
Number
Date
Products
EXCEDRIN (MIGRAINE RELIEF)GSKN-020802 OTC1998-01-14
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
10 person ansiOTC monograph final2010-06-07
25 person ansiOTC monograph final2010-06-07
50 person ansiOTC monograph final2010-06-07
acetaminophen 250mg aspirin 250mg caffeine 65mgC2002632024-12-26
acetaminophen aspirin and caffeineANDA2024-03-05
acetaminophen aspirin caffeineANDA2024-11-18
acetaminophen, aspirin and caffeineANDA2024-12-10
acetaminophen, aspirin, caffeineC2002632024-05-08
acetylsalicylic acidExport only2023-11-04
ache and pain relief to goOTC monograph not final2014-10-08
Show 468 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
rheumatoid arthritisEFO_0000685D001172M06.9
painEFO_0003843D010146R52
headacheHP_0002315D006261R51
feverHP_0001945D005334R50.9
inflammationMP_0001845D007249—
osteoarthritisEFO_0002506D010003M15-M19
fatigueHP_0012378D005221R53.83
apneaHP_0002104D001049R06.81
rheumatic feverEFO_1001160D012213I00-I02
goutEFO_0004274D006073M10
Show 21 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Aspirin / Omeprazole, Yosprala, Genus Lifesciences
95392142033-03-13U-1902, U-1902
99872312033-01-02U-2324, U-2324
69269072023-02-28DPU-1902, U-1902
82067412023-02-28DPU-1902, U-1902
Aspirin, Vazalore, Plx Pharma
92161502032-09-29DP
92268922032-09-29U-1731, U-1732, U-1733
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03B: Muscle relaxants, centrally acting agents
— M03BA: Carbamic acid esters, centrally acting muscle relaxants
— M03BA02: Carisoprodol
— M03BA52: Carisoprodol, combinations excl. psycholeptics
— M03BA72: Carisoprodol, combinations with psycholeptics
HCPCS
Code
Description
G2128
Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g. history of gastrointestinal bleed, intra-cranial bleed, blood disorders, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period)
G8598
Aspirin or another antiplatelet therapy used
G8599
Aspirin or another antiplatelet therapy not used, reason not given
G9277
Documentation that the patient is on daily aspirin or anti-platelet or has documentation of a valid contraindication or exception to aspirin/anti-platelet; contraindications/exceptions include anti-coagulant use, allergy to aspirin or anti-platelets, history of gastrointestinal bleed and bleeding disorder; additionally, the following exceptions documented by the physician as a reason for not taking daily aspirin or anti-platelet are acceptable (use of non-steroidal anti-inflammatory agents, documented risk for drug interaction, uncontrolled hypertension defined as >180 systolic or >110 diastolic or gastroesophageal reflux)
G9278
Documentation that the patient is not on daily aspirin or anti-platelet regimen
G9793
Patient is currently on a daily aspirin or other antiplatelet
G9794
Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g., history of gastrointestinal bleed, intra-cranial bleed, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period)
G9795
Patient is not currently on a daily aspirin or other antiplatelet
M1055
Aspirin or another antiplatelet therapy used
M1056
Prescribed anticoagulant medication during the performance period, history of gi bleeding, history of intracranial bleeding, bleeding disorder and specific provider documented reasons: allergy to aspirin or anti-platelets, use of non-steroidal anti-inflammatory agents, drug-drug interaction, uncontrolled hypertension > 180/110 mmhg or gastroesophageal reflux disease
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Clinical
Clinical Trials
2058 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17—1———1
OsteoarthritisD010003EFO_0002506M15-M19—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAspirin
INNcarisoprodol
Description
Acetylsalicylic acid is a member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a platelet aggregation inhibitor, an antipyretic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a prostaglandin antagonist, a teratogenic agent, an anticoagulant, a plant activator, an EC 1.1.1.188 (prostaglandin-F synthase) inhibitor, a drug allergen and a geroprotector. It is a member of benzoic acids, a member of salicylates and a member of phenyl acetates. It is functionally related to a salicylic acid. It is a conjugate acid of an acetylsalicylate.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(=O)Oc1ccccc1C(=O)O
Identifiers
PDB—
CAS-ID50-78-2
RxCUI—
ChEMBL IDCHEMBL25
ChEBI ID15365
PubChem CID2244
DrugBankDB00945
UNII IDR16CO5Y76E (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Vazalore – PLx Pharma
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Estimated US medical usage
Aspirin
Total medical expenditures per year (USD, in millions)
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Aspirin
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Carisoprodol
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Aspirin
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Codeine
+
Carisoprodol
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Aspirin
+
Codeine
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Aspirin
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Dipyridamole
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Aspirin
+
Hydrocodone
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Aspirin
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Meprobamate
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Aspirin
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Methocarbamol
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Aspirin
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Oxycodone
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Aspirin
+
Pravastatin
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 76,853 documents
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Safety
Black-box Warning
Black-box warning for: Ascomp with codeine, Butalbital, aspirin, caffeine and codeine phosphate, Clopidogrel kit, Darvon-n, Hydrocodone bitartrate and aspirin, Oxycodone and aspirin
Adverse Events
Top Adverse Reactions
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184,941 adverse events reported
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