Aspirin
Aggrenox, Axotal, Azdone, Codoxy, Darvon, Darvon W/ Asa, Equagesic, Excedrin (migraine Relief), Fiorinal, Invagesic, Lanorinal, Micrainin, Norgesic, Percodan, Percodan-demi, Pravigard, Q-gesic, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vazalore, Vicoprin, W/ Asa, Yosprala (aspirin) is a small molecule pharmaceutical. Aspirin was first approved as Codeine, aspirin, apap formula no. 4 on 1982-01-01. It is used to treat fever, gout, inflammation, osteoarthritis, and pain amongst others in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 3, transient receptor potential cation channel subfamily V member 3, and N-formyl peptide receptor 2.
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Commercial
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Durlaza, Vazalore (discontinued: 8-hour bayer, Measurin)
CombinationsExcedrin, Percodan (generic drugs available since 1985-10-11, discontinued: , Aggrenox, Axotal, Azdone, Codoxy, Darvon, Darvon w/ asa, Darvon-n w/ asa, Equagesic, Fiorinal, Invagesic, Lanorinal, Micrainin, Norgesic, Percodan, Percodan-demi, Pravigard, Q-gesic, Robaxisal, Roxiprin, Soma, Synalgos-dc, Talwin, Vicoprin, Yosprala)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
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Aspirin
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Caffeine
Aspirin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DURLAZA | Espero BioPharma | N-200671 RX | 2015-09-04 | 1 products, RLD, RS |
| VAZALORE | PLx Pharma | N-203697 OTC | 2013-01-14 | 2 products, RLD, RS |
Show 3 discontinued
Aspirin
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Butalbital
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Caffeine
Aspirin
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Butalbital
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Caffeine
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Codeine phosphate
Aspirin
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Caffeine
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Dihydrocodeine bitartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYNALGOS-DC | Sun Pharmaceutical Industries | N-011483 DISCN | 1983-09-06 | 1 products, RLD |
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Aspirin
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Caffeine
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Orphenadrine citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NORGESIC | Bausch Health Companies | N-013416 DISCN | 1982-10-27 | 1 products, RLD |
| NORGESIC FORTE | Bausch Health Companies | N-013416 DISCN | 1982-10-27 | 1 products, RLD |
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Aspirin
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Caffeine
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON COMPOUND | Xanodyne Pharmaceuticals | N-010996 DISCN | 1983-03-08 | 1 products |
| DARVON COMPOUND-65 | Xanodyne Pharmaceuticals | N-010996 DISCN | 1983-03-08 | 1 products |
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Aspirin
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Carisoprodol
Aspirin
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Carisoprodol
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Codeine phosphate
Aspirin
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Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AGGRENOX | Boehringer Ingelheim | N-020884 DISCN | 1999-11-22 | 1 products, RLD |
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Aspirin
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Meprobamate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EQUAGESIC | Sun Pharmaceutical Industries | N-011702 DISCN | 1983-12-29 | 1 products |
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Aspirin
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Methocarbamol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ROBAXISAL | A.H. Robins Company | N-012281 DISCN | 1982-01-01 | 1 products, RLD |
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Aspirin
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Omeprazole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| YOSPRALA | Genus Lifesciences | N-205103 DISCN | 2016-09-14 | 2 products, RLD |
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Aspirin
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Oxycodone hydrochloride
Aspirin
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Oxycodone hydrochloride
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Oxycodone terephthalate
Aspirin
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Pentazocine hydrochloride
Aspirin
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Pravastatin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRAVIGARD PAC (COPACKAGED) | Bristol Myers Squibb | N-021387 DISCN | 2003-06-24 | 6 products |
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Aspirin
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Propoxyphene hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DARVON W/ ASA | Xanodyne Pharmaceuticals | N-010996 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 10 person ansi | OTC monograph final | 2010-06-07 |
| 25 person ansi | OTC monograph final | 2010-06-07 |
| 365 everyday value aspirin | OTC monograph not final | 2021-06-15 |
| 4017 first aid kit 4022 first aid kit | unapproved drug other | 2024-01-22 |
| 4032 first aid kit | unapproved drug other | 2024-01-22 |
| 4056 first aid kit 4068 first aid kit 4081 first aid kit 4082 first aid kit 4083 first aid kit 4084 first aid kit 4085 first aid kit 4086 first aid... | unapproved drug other | 2024-01-22 |
| 4069 first aid kit | unapproved drug other | 2019-03-10 |
| 4076 first aid kit | unapproved drug other | 2019-03-17 |
| 4091 first aid kit 4092 first aid kit 4093 first aid kit 4094 first aid kit 4095 first aid kit 4096 first aid kit | unapproved drug other | 2019-01-16 |
| 4097 first aid kit 4098 first aid kit 4099 first aid kit 4100 first aid kit 4101 first aid kit 4102 first aid kit 4103 first aid kit 4104 first aid... | unapproved drug other | 2024-01-22 |
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Agency Specific
FDA
EMA
No data
Patent Expiration
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03B: Muscle relaxants, centrally acting agents
— M03BA: Carbamic acid esters, centrally acting muscle relaxants
— M03BA02: Carisoprodol
— M03BA52: Carisoprodol, combinations excl. psycholeptics
— M03BA72: Carisoprodol, combinations with psycholeptics
HCPCS
Code | Description |
|---|---|
| G2128 | Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g. history of gastrointestinal bleed, intra-cranial bleed, blood disorders, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period) |
| G8598 | Aspirin or another antiplatelet therapy used |
| G8599 | Aspirin or another antiplatelet therapy not used, reason not given |
| G9277 | Documentation that the patient is on daily aspirin or anti-platelet or has documentation of a valid contraindication or exception to aspirin/anti-platelet; contraindications/exceptions include anti-coagulant use, allergy to aspirin or anti-platelets, history of gastrointestinal bleed and bleeding disorder; additionally, the following exceptions documented by the physician as a reason for not taking daily aspirin or anti-platelet are acceptable (use of non-steroidal anti-inflammatory agents, documented risk for drug interaction, uncontrolled hypertension defined as >180 systolic or >110 diastolic or gastroesophageal reflux) |
| G9278 | Documentation that the patient is not on daily aspirin or anti-platelet regimen |
| G9793 | Patient is currently on a daily aspirin or other antiplatelet |
| G9794 | Documentation of medical reason(s) for not on a daily aspirin or other antiplatelet (e.g., history of gastrointestinal bleed, intra-cranial bleed, idiopathic thrombocytopenic purpura (itp), gastric bypass or documentation of active anticoagulant use during the measurement period) |
| G9795 | Patient is not currently on a daily aspirin or other antiplatelet |
| M1055 | Aspirin or another antiplatelet therapy used |
| M1056 | Prescribed anticoagulant medication during the performance period, history of gi bleeding, history of intracranial bleeding, bleeding disorder and specific provider documented reasons: allergy to aspirin or anti-platelets, use of non-steroidal anti-inflammatory agents, drug-drug interaction, uncontrolled hypertension > 180/110 mmhg or gastroesophageal reflux disease |
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Clinical
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 7 | 12 | 16 | 98 | 71 | 203 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 12 | 37 | 26 | 34 | 103 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 8 | 9 | 11 | 41 | 30 | 99 |
| Ischemic stroke | D000083242 | — | — | 6 | 16 | 29 | 20 | 29 | 89 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 8 | 12 | 21 | 19 | 31 | 88 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | 7 | 17 | 23 | 28 | 73 |
| Healthy volunteers/patients | — | — | — | 42 | 4 | 2 | 7 | 13 | 68 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 5 | 14 | 27 | 17 | 63 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 4 | 7 | 11 | 13 | 19 | 52 |
| Coronary disease | D003327 | — | — | 1 | 2 | 9 | 23 | 15 | 49 |
Show 174 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 2 | 10 | 10 | — | 9 | 28 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 4 | 7 | — | 6 | 17 |
| Duodenal ulcer | D004381 | EFO_0004607 | K26 | — | 3 | 8 | — | 6 | 15 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 8 | 3 | — | 2 | 14 |
| Stomach ulcer | D013276 | — | K25 | — | 1 | 8 | — | 4 | 13 |
| Multiple myeloma | D009101 | — | C90.0 | 4 | 7 | 4 | — | — | 11 |
| Polycythemia vera | D011087 | — | D45 | — | 4 | 3 | — | 1 | 8 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 1 | 1 | — | 5 | 8 |
| Inflammation | D007249 | MP_0001845 | — | 3 | 5 | 1 | — | — | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 1 | 2 | — | 3 | 7 |
Show 74 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | — | O98.7 | — | 3 | — | — | 3 | 6 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 5 | — | — | — | 5 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 4 | — | — | 1 | 5 |
| High-risk pregnancy | D018566 | — | — | — | 2 | — | — | 2 | 4 |
| Tobacco use disorder | D014029 | — | F17 | 1 | 3 | — | — | — | 4 |
| Postoperative cognitive complications | D000079690 | — | — | — | 2 | — | — | 1 | 3 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | 2 | 3 |
| Embolism and thrombosis | D016769 | — | — | — | 1 | — | — | 1 | 2 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 1 | — | — | — | 2 |
| Ischemic optic neuropathy | D018917 | EFO_1000809 | H47.01 | — | 1 | — | — | 1 | 2 |
Show 53 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ulcer | D014456 | MPATH_579 | — | 3 | — | — | — | 1 | 4 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | 2 | 3 |
| Therapeutic equivalency | D013810 | — | — | 3 | — | — | — | — | 3 |
| Pharmacokinetics | D010599 | — | — | 3 | — | — | — | — | 3 |
| Pregnancy rate | D018873 | — | — | 1 | — | — | — | 2 | 3 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | — | — | — | 1 | 2 |
| Fallopian tube neoplasms | D005185 | — | — | 2 | — | — | — | — | 2 |
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | 1 | — | — | — | — | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | — | 1 |
| Postpartum period | D049590 | — | — | 1 | — | — | — | — | 1 |
Show 22 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 3 | 3 |
| Hemorrhagic stroke | D000083302 | — | — | — | — | — | — | 3 | 3 |
| Asymptomatic diseases | D058070 | — | — | — | — | — | — | 3 | 3 |
| Drug resistance | D004351 | — | Z16.30 | — | — | — | — | 3 | 3 |
| Temporomandibular joint disorders | D013705 | — | M26.6 | — | — | — | — | 3 | 3 |
| Thrombectomy | D017131 | — | — | — | — | — | — | 2 | 2 |
| Microbiota | D064307 | — | — | — | — | — | — | 2 | 2 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | — | 2 | 2 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 2 | 2 |
| Endotoxemia | D019446 | — | — | — | — | — | — | 2 | 2 |
Show 109 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aspirin |
| INN | carisoprodol |
| Description | Acetylsalicylic acid is a member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a platelet aggregation inhibitor, an antipyretic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a prostaglandin antagonist, a teratogenic agent, an anticoagulant, a plant activator, an EC 1.1.1.188 (prostaglandin-F synthase) inhibitor, a drug allergen and a geroprotector. It is a member of benzoic acids, a member of salicylates and a member of phenyl acetates. It is functionally related to a salicylic acid. It is a conjugate acid of an acetylsalicylate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)Oc1ccccc1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 50-78-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL25 |
| ChEBI ID | 15365 |
| PubChem CID | 2244 |
| DrugBank | DB00945 |
| UNII ID | R16CO5Y76E (ChemIDplus, GSRS) |
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Financial
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Vazalore – PLx Pharma
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Carisoprodol
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Codeine
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Carisoprodol
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Codeine
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Aspirin
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Dipyridamole
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Aspirin
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Hydrocodone
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Meprobamate
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Methocarbamol
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Oxycodone
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Pravastatin
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PubMed Central
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Safety
Black-box Warning
Black-box warning for: Ascomp with codeine, Butalbital, aspirin, caffeine and codeine phosphate, Clopidogrel kit, Darvon-n, Hydrocodone bitartrate and aspirin, Oxycodone and aspirin
Adverse Events
Top Adverse Reactions
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160,079 adverse events reported
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