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rEVO Biologics

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Atryn	Antithrombin alfa	2009-02-06		Antithrombin iii deficiency

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Antithrombin alfa

congenital heart defects

,

,

postoperative hemorrhage

,

healthy volunteers/patients

,

,

,

liver cirrhosis

,

wounds and injuries

,

,

,

,

hepatic insufficiency

,

venous thromboembolism

,

thromboembolism

,

,

,

reperfusion injury

,

coronary artery bypass

,

cerebral infarction

,

,

ischemic stroke

,

respiratory distress syndrome

,

severe acute respiratory syndrome

,

acute lung injury

,

newborn respiratory distress syndrome

,

hepatic veno-occlusive disease

,

,

small cell lung carcinoma

,

,

communicable diseases

,

end stage liver disease

,

acute-on-chronic liver failure

,

blood coagulation disorders

,

hemostatic disorders

,

cardiopulmonary bypass

,

disseminated intravascular coagulation

,

,

extracorporeal membrane oxygenation

,

type 1 diabetes mellitus

,

,

non-hodgkin lymphoma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

antithrombin iii deficiency

,

,

,

venous thrombosis

,

,

myocardial infarction

,

,

cardiac surgical procedures

,

,

acute coronary syndrome

,

aortic valve stenosis

,

aortic valve insufficiency

,

mitral valve insufficiency

,

pathologic constriction

,

mitral valve stenosis

,

,

coagulation protein disorders

,

nutritional requirements

,

congenital disorders of glycosylation

,

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

sickle cell anemia

,

,

hemolytic anemia

,

,

thrombocytopenia

,

environmental biomarkers

,

,

,

,

factor xiii deficiency

,

migraine disorders

,

acute-phase reaction

,

antiphospholipid syndrome

,

,

cytokine release syndrome

,

,

upper extremity deep vein thrombosis

,

,

transfusion reaction

,

liver transplantation

,

,

heart septal defects

,

,

acute kidney injury

,

portal hypertension

,

,

budd-chiari syndrome

,

chronic renal insufficiency

,

kidney diseases

,

renal insufficiency

,

post-acute covid-19 syndrome

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

,

multi-infarct dementia

large b-cell lymphoma diffuse

,

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

,

,

,

hodgkin disease

,

mantle-cell lymphoma

,

b-cell lymphoma

,

triple negative breast neoplasms

,

renal cell carcinoma

,

,

,

,

chronic hepatitis b

,

communicable diseases

,

,

sjogren's syndrome

,

parkinson disease

,

parkinsonian disorders

,

movement disorders

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

chronic renal insufficiency

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

graft vs host disease

,

type 1 diabetes mellitus

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

brain neoplasms

,

,

oligodendroglioma

,

pancreatic neoplasms

,

,

neuroendocrine tumors

,

islet cell carcinoma

,

,

,

somatostatinoma

,

,

,

breast neoplasms

,

,

myelodysplastic syndromes

,

thrombocytopenia

,

,

,

retinal vein occlusion

,

vision disorders

,

,

macular degeneration

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

juvenile arthritis

,

,

kidney diseases

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

organ transplantation

,

wet macular degeneration

,

neoplasm metastasis

,

graft rejection

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

non-alcoholic fatty liver disease

,

,

postoperative pain

,

,

choroidal neovascularization

,

pathologic neovascularization

,

chronic kidney failure

,

renal insufficiency

,

liver transplantation

,

kidney transplantation

,

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

liver cirrhosis

,

,

atrial fibrillation

healthy volunteers/patients

,

pharmacokinetics

,

,

,

thrombocytopenia

,

patent foramen ovale

,

paradoxical embolism

,

female genital neoplasms

,

renal cell carcinoma

,

,

kidney diseases

,

,

,

cerebral infarction

,

ischemic stroke

,

coronary artery bypass

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

transient ischemic attack

,

sickle cell anemia

,

,

,

,

coronavirus infections

,

,

atrial fibrillation

,

,

thromboembolism

,

,

venous thromboembolism

,

venous thrombosis

,

pulmonary embolism

,

chronic kidney failure

,

,

,

acute coronary syndrome

,

multiple myeloma

,

plasma cell neoplasms

,

right ventricular dysfunction

,

pulmonary infarction

,

,

ventricular dysfunction

,

pulmonary heart disease

,

antiphospholipid syndrome

,

renal insufficiency

,

healthy volunteers/patients

,

,

pheochromocytoma

,

neuroendocrine tumors

,

,

meningeal carcinomatosis

,

,

laryngeal neoplasms

,

pancreatic ductal carcinoma

,

head and neck neoplasms

,

squamous cell neoplasms

,

transitional cell carcinoma

,

fallopian tube neoplasms

,

small cell carcinoma

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

dna repair-deficiency disorders

,

urinary bladder neoplasms

,

salivary gland neoplasms

,

,

,

radiation effects

,

germ cell and embryonal neoplasms

,

peritoneal neoplasms

,

,

pleural effusion

,

malignant pleural effusion

,

,

,

residual neoplasm

,

breast neoplasms

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

prostatic neoplasms

,

,

,

,

small cell lung carcinoma

,

triple negative breast neoplasms

,

,

,

,

,

rheumatoid arthritis

,

castration-resistant prostatic neoplasms

,

ovarian neoplasms

,

,

major depressive disorder

,

depressive disorder

,

,

gastroesophageal reflux

,

peptic esophagitis

,

,

colorectal neoplasms

,

,

squamous cell carcinoma

,

endometrial neoplasms

,

neoplasm metastasis

,

,

,

squamous cell carcinoma of head and neck

,

renal cell carcinoma

,

urologic neoplasms

,

ovarian epithelial carcinoma

,

neoplasms by site

,

,

,

kidney diseases

,

,

cardiovascular diseases

,

pancreatic neoplasms

,

hypersensitivity

,

stomach neoplasms

,

sickle cell anemia

,

brain neoplasms

,

,

,

opioid-induced constipation

,

hypercholesterolemia

,

hepatocellular carcinoma

,

liver neoplasms

,

hereditary breast and ovarian cancer syndrome

,

,

chronic renal insufficiency

,

,

,

kidney neoplasms

,

,

zollinger-ellison syndrome

,

,

peptic ulcer hemorrhage

,

,

,

chronic obstructive pulmonary disease

,

obstructive lung diseases

,

,

anxiety disorders

,

,

,

,

venous thrombosis

,

pulmonary embolism

,

,

plexiform neurofibroma

,

neurofibromatosis 1

,

neurofibromatoses

,

,

unknown primary neoplasms

,

respiratory insufficiency

,

myocardial infarction

,

coronary artery disease

,

biliary tract neoplasms

,

respiratory syncytial virus infections

,

non-small-cell lung carcinoma

,

,

respiratory tract diseases

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

bronchial neoplasms

,

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