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Drug ReportsSerine
Serine
Serine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against interleukin-17A. In addition, it is known to target metabotropic glutamate receptor 4, probable G-protein coupled receptor 34, probable G-protein coupled receptor 174, metabotropic glutamate receptor 6, neutral amino acid transporter B(0), G-protein coupled receptor family C group 6 member A, sodium- and chloride-dependent glycine transporter 2, glutamate receptor ionotropic, NMDA 1, potassium voltage-gated channel subfamily A member 1, glutamate receptor ionotropic, NMDA 2D, glutamate receptor ionotropic, NMDA 2A, metabotropic glutamate receptor 8, metabotropic glutamate receptor 7, toll-like receptor 4, glutamate receptor ionotropic, NMDA 2C, and glutamate receptor ionotropic, NMDA 2B.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
aminosyn iiNew Drug Application2022-05-04
aminosyn-pfNew Drug Application2022-07-21
clinimixNew Drug Application2021-04-13
clinimix eNew Drug Application2021-04-13
clinisolANDA2018-06-01
enbrace hrunapproved drug other2025-01-02
enlyteunapproved drug other2022-07-01
kabivenNew Drug Application2023-08-02
paxlyteunapproved drug other2024-12-19
perikabivenNew Drug Application2023-08-07
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01E: Protein kinase inhibitors, antineoplastic and immunomodulating agents
L01EC: B-raf serine-threonine kinase (braf) inhibitors
HCPCS
No data
Clinical
Clinical Trials
1828 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.026834563
ThromboembolismD013923381511945
Venous thromboembolismD054556EFO_0004286I74171411841
ThrombosisD013927761011437
EmbolismD0046172731325
Pulmonary embolismD011655EFO_0003827I2643714
StrokeD020521EFO_0000712I63.9141511
HemorrhageD006470MP_0001914R58114128
Peripheral arterial diseaseD058729EFO_00042652226
Coronary artery diseaseD003324I25.111125
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Venous thrombosisD020246I82.40456924
Acute coronary syndromeD054058EFO_00056722147
NeoplasmsD009369C801315
Surgical blood lossD01606344
Renal insufficiencyD051437N191124
Postoperative hemorrhageD019106213
InfarctionD007238EFO_0009463213
Heart failureD006333EFO_0003144I50213
Heart diseasesD006331EFO_0003777I51.9112
Rheumatic diseasesD012216M79.022
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ischemic strokeD000083242123
Replacement arthroplasty kneeD019645123
IschemiaD007511EFO_0000556112
Hemophilia aD006467EFO_0007267D66112
Bariatric surgeryD050110112
Transient ischemic attackD002546EFO_0003764G45.911
Cerebral infarctionD002544I6311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients88
PharmacokineticsD01059922
Biological availabilityD00168222
Prostatic neoplasmsD011471C6111
Medical sociologyD01296211
Morbid obesityD009767EFO_000107411
ObesityD009765EFO_0001073E66.911
Drug interactionsD00434711
MalnutritionD044342EFO_0008572E40-E4611
DiseaseD004194EFO_0000408R6911
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Replacement arthroplasty hipD01964422
Intracranial hemorrhagesD020300EFO_0000551I6211
Disease progressionD01845011
Brain ischemiaD002545EFO_0003883I67.8211
BronchiectasisD001987J4711
Congenital heart defectsD006330Q24.911
Fontan procedureD01872911
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSerine
INNdexfosfoserine
Description
L-serine is the L-enantiomer of serine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a serine family amino acid, a proteinogenic amino acid, a L-alpha-amino acid and a serine. It is a conjugate base of a L-serinium. It is a conjugate acid of a L-serinate. It is an enantiomer of a D-serine. It is a tautomer of a L-serine zwitterion.
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
N[C@@H](CO)C(=O)O
Identifiers
PDB
CAS-ID56-45-1
RxCUI
ChEMBL IDCHEMBL11298
ChEBI ID17115
PubChem CID5951
DrugBankDB00133
UNII IDVI4F0K069V (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC1A5
SLC1A5
GRIN1
GRIN1
GRIN2B
GRIN2B
Organism
Homo sapiens
Gene name
SLC1A5
Gene synonyms
ASCT2, M7V1, RDR, RDRC
NCBI Gene ID
Protein name
neutral amino acid transporter B(0)
Protein synonyms
Alanine/serine/cysteine transporter 2, ASC amino acid transporter-2, ATB(0), Baboon M7 virus receptor, neutral amino acid transporter B, RD114 virus receptor, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, solute carrier family 1 (neutral amino acid transporter), member 5, Solute carrier family 1 member 5
Uniprot ID
Mouse ortholog
Slc1a5 (20514)
neutral amino acid transporter B(0) (P51912)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 464,360 documents
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Safety
Black-box Warning
Black-box warning for: Aminosyn ii, Enlyte
Adverse Events
Top Adverse Reactions
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2,922 adverse events reported
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