Benzocaine
Benzocaine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Abbreviated New Drug Application (ANDA)
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Labels
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Brand Name | Status | Last Update |
|---|---|---|
| 10 person ansi | OTC monograph final | 2010-06-07 |
| 20/20 | OTC monograph final | 2012-05-08 |
| 25 person ansi | OTC monograph final | 2010-06-07 |
| 2x med liq | OTC monograph not final | 2021-09-02 |
| 3x medicated mouth sore gel | OTC monograph not final | 2023-01-23 |
| 3x medicated toothache and gum gel | OTC monograph not final | 2023-01-23 |
| 4x medicated gum cream | OTC monograph not final | 2023-01-12 |
| 4x medicated severe toothache and gum cream | OTC monograph not final | 2023-01-11 |
| 4x medicated severe toothache and gum gel | OTC monograph not final | 2023-01-11 |
| 4x medicated toothache and gum cream | OTC monograph not final | 2023-08-18 |
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ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD03: Benzocaine
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AB: Anesthetics for topical use
— D04AB04: Benzocaine
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BA: Esters of aminobenzoic acid for local anesthesia
— N01BA05: Benzocaine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AD: Local anesthetic throat preparations
— R02AD01: Benzocaine
HCPCS
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Clinical
Clinical Trials
5358 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 6 | 4 | 6 | 11 | 152 | 178 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 13 | 7 | 14 | 17 | 124 | 171 |
| Syndrome | D013577 | — | — | 10 | 33 | 24 | 10 | 85 | 154 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 8 | 4 | 13 | 15 | 76 | 116 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 8 | 12 | 6 | 79 | 105 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 5 | 12 | 12 | 65 | 94 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 3 | 10 | 40 | 9 | 31 | 91 |
| Depression | D003863 | — | F33.9 | 6 | 2 | 8 | 2 | 75 | 91 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 3 | 9 | 4 | 6 | 69 | 88 |
| Wounds and injuries | D014947 | — | T14.8 | 6 | 12 | 3 | 4 | 66 | 86 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Exercise | D015444 | EFO_0000483 | — | — | 1 | 2 | — | 85 | 88 |
| Covid-19 | D000086382 | — | — | — | 10 | 9 | — | 46 | 64 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 7 | 2 | — | 33 | 43 |
| Infections | D007239 | EFO_0000544 | — | — | 11 | 9 | — | 21 | 40 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | 4 | 2 | — | 30 | 36 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 3 | 2 | 2 | — | 29 | 34 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 2 | — | 1 | — | 31 | 34 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 2 | 2 | 3 | — | 25 | 32 |
| Lymphoma | D008223 | — | C85.9 | 6 | 20 | 5 | — | 3 | 30 |
| Inflammation | D007249 | MP_0001845 | — | 2 | 4 | 2 | — | 22 | 28 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aging | D000375 | GO_0007568 | R41.81 | 3 | 3 | — | — | 38 | 44 |
| Neck pain | D019547 | HP_0030833 | M54.2 | — | 1 | — | — | 33 | 34 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 3 | 2 | — | — | 26 | 31 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 4 | 4 | — | — | 19 | 26 |
| Pediatric obesity | D063766 | — | — | — | 1 | — | — | 22 | 23 |
| Chronic disease | D002908 | — | — | — | 1 | — | — | 21 | 22 |
| Sleep wake disorders | D012893 | — | G47 | 3 | 1 | — | — | 12 | 16 |
| Autistic disorder | D001321 | HP_0000717 | F84.0 | 2 | 1 | — | — | 13 | 16 |
| Dyspnea | D004417 | HP_0002094 | R06.0 | — | 1 | — | — | 15 | 16 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | 1 | 1 | — | — | 12 | 14 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebral palsy | D002547 | — | G80 | 3 | — | — | — | 25 | 28 |
| Sleep | D012890 | GO_0030431 | — | 3 | — | — | — | 18 | 21 |
| Problem behavior | D000066553 | — | — | 1 | — | — | — | 9 | 10 |
| Mental health | D008603 | EFO_0003935 | — | 1 | — | — | — | 8 | 9 |
| Oxygen inhalation therapy | D010102 | — | — | 1 | — | — | — | 8 | 9 |
| Respiration disorders | D012120 | — | J00-J99 | 1 | — | — | — | 7 | 8 |
| Laparoscopic cholecystectomy | D017081 | — | — | 1 | — | — | — | 6 | 7 |
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | 1 | — | — | — | 6 | 7 |
| Sleep deprivation | D012892 | — | F51.12 | 2 | — | — | — | 4 | 6 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | 1 | — | — | — | 4 | 5 |
Show 42 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sedentary behavior | D057185 | — | — | — | — | — | — | 49 | 49 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 41 | 41 |
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | — | 25 | 25 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 22 | 22 |
| Health behavior | D015438 | — | — | — | — | — | — | 20 | 20 |
| Emergencies | D004630 | — | — | — | — | — | — | 19 | 19 |
| Weight gain | D015430 | HP_0004324 | — | — | — | — | — | 15 | 15 |
| Hypercapnia | D006935 | — | — | — | — | — | — | 15 | 15 |
| Psychological stress | D013315 | — | — | — | — | — | — | 14 | 14 |
| Disease progression | D018450 | — | — | — | — | — | — | 13 | 13 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Benzocaine |
| INN | benzocaine |
| Description | Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)c1ccc(N)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 94-09-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL278172 |
| ChEBI ID | 116735 |
| PubChem CID | 2337 |
| DrugBank | DB01086 |
| UNII ID | U3RSY48JW5 (ChemIDplus, GSRS) |
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Estimated US medical usage
Benzocaine
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Benzocaine
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Menthol
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Benzocaine
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Trimethobenzamide
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Trends
PubMed Central
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Safety
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Adverse Events
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992 adverse events reported
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