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Company ReportsBioLineRx

BioLineRx

BioLineRx (Hebrew: ביוליין אר אקס), or BioLine, is a publicly traded drug development company. Headquartered in Israel, its shares are traded on the NASDAQ Capital Market and on the Tel Aviv Stock Exchange.

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Aphexda	Motixafortide	2023-09-08		Hematopoietic stem cell mobilization

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

,

colorectal neoplasms

,

neoplasm metastasis

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

non-hodgkin lymphoma

,

multiple myeloma

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

b-cell chronic lymphocytic leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

t-cell lymphoma peripheral

,

myeloid leukemia

,

lymphoid leukemia

multiple myeloma

,

postmenopausal osteoporosis

b-cell chronic lymphocytic leukemia

,

reactive arthritis

Pegvorhyaluronidase alfa

non-small-cell lung carcinoma

,

cholangiocarcinoma

,

,

stomach neoplasms

,

pancreatic neoplasms

,

,

esophageal neoplasms

,

breast neoplasms

,

pancreatic ductal carcinoma

,

,

ductal carcinoma

,

thromboembolism

Polyglycolic acid

pancreatic neoplasms

,

esophageal neoplasms

Globulin, immune

,

,

,

neoplasm metastasis

,

,

neoplasms by histologic type

,

,

hypertrophic pyloric stenosis

,

,

,

,

cerebrovascular disorders

,

end stage liver disease

,

myasthenia gravis

,

,

,

peripheral vascular diseases

,

basal cell carcinoma

,

adenoid cystic carcinoma

,

inverted papilloma

,

verrucous carcinoma

,

mucoepidermoid carcinoma

,

neoplasms by site

,

reticulocyte count

,

,

neuroepithelial neoplasms

,

,

drug interactions

,

brain stem neoplasms

,

cerebrotendinous xanthomatosis

,

craniopharyngioma

,

subependymal glioma

,

clear cell sarcoma

,

,

muscular diseases

,

synovial sarcoma

,

autoimmune hepatitis

,

substance-related disorders

,

hidradenitis suppurativa

,

,

stem cell research

,

musculoskeletal diseases

,

muscular dystrophies

,

second primary neoplasms

,

,

neurologic manifestations

,

mental disorders

,

muscle weakness

,

adenoviridae infections

,

mycobacterium avium-intracellulare infection

,

mycobacterium infections

,

,

pancreatic ductal carcinoma

,

conjunctival neoplasms

,

medullary carcinoma

,

open-angle glaucoma

,

carpal tunnel syndrome

,

,

,

cerebral infarction

,

brain infarction

,

,

allergic rhinitis seasonal

,

nasal obstruction

,

,

hantavirus pulmonary syndrome

,

hantavirus infections

,

,

respiratory tract diseases

,

,

infectious pregnancy complications

,

pharmacokinetics

,

hemangiosarcoma

,

liver transplantation

,

fallopian tube neoplasms

,

pancreatic neoplasms

,

,

male breast neoplasms

,

,

,

,

,

,

oligodendroglioma

,

type 1 diabetes mellitus

,

ischemic stroke

,

t-cell lymphoma

,

primitive neuroectodermal tumors peripheral

,

t-cell lymphoma peripheral

,

aids-related complex

,

,

coronary artery disease

,

leukemia myeloid chronic atypical bcr-abl negative

,

hairy cell leukemia

,

colonic neoplasms

,

squamous cell carcinoma

,

rheumatoid arthritis

,

aids-related lymphoma

,

,

promyelocytic leukemia acute

,

intraocular lymphoma

,

plasma cell leukemia

,

optic nerve glioma

,

female genital neoplasms

,

systemic lupus erythematosus

,

stem cell transplantation

,

fanconi syndrome

,

peritoneal neoplasms

,

ureteral neoplasms

,

,

cystic fibrosis

,

,

t-cell leukemia

,

squamous cell neoplasms

,

salivary gland neoplasms

,

paroxysmal hemoglobinuria

,

,

extranodal nk-t-cell lymphoma

,

reperfusion injury

,

neuroendocrine tumors

,

,

bone marrow failure disorders

,

parkinson disease

,

alzheimer disease

,

peripheral arterial disease

,

respiratory distress syndrome

,

,

,

philadelphia chromosome

,

lymphomatoid granulomatosis

,

paraproteinemias

,

embryonal carcinoma

,

olfactory esthesioneuroblastoma

,

eyelid neoplasms

,

,

,

,

,

nasopharyngeal neoplasms

,

beta-thalassemia

,

,

unknown primary neoplasms

,

,

,

cholangiocarcinoma

,

diffuse intrinsic pontine glioma

,

thyroid neoplasms

,

essential thrombocythemia

,

mucinous cystadenocarcinoma

,

cystadenocarcinoma

,

dyskeratosis congenita

,

severe combined immunodeficiency

,

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

chronic disease

,

bipolar disorder

,

,

,

biliary atresia

,

,

,

ductal carcinoma breast

,

intraductal carcinoma noninfiltrating

,

vascular diseases

,

chronic granulomatous disease

,

myeloid sarcoma

,

primary effusion lymphoma

,

residual neoplasm

,

,

intestinal neoplasms

,

bone marrow transplantation

,

,

myocardial reperfusion injury

,

nasopharyngeal carcinoma

,

,

pulmonary hypertension

,

carcinoid tumor

,

anaplastic thyroid carcinoma

,

endocrine system diseases

,

chronic limb-threatening ischemia

,

myocardial ischemia

,

esophageal squamous cell carcinoma

,

,

polycythemia vera

,

b-cell leukemia

,

malignant mesothelioma

,

ovarian diseases

,

uterine diseases

,

,

x-linked combined immunodeficiency diseases

,

desmoplastic small round cell tumor

,

thrombocytopenic purpura

,

neurofibrosarcoma

,

gallbladder neoplasms

,

moyamoya disease

,

replacement arthroplasty knee

,

cognitive dysfunction

,

depressive disorder

,

congenital heart defects

,

friedreich ataxia

,

,

dilated cardiomyopathy

,

,

autoimmune diseases

,

islet cell adenoma

,

polycystic ovary syndrome

,

wiskott-aldrich syndrome

,

human herpesvirus 8

,

lymphadenopathy

,

alveolar soft part sarcoma

,

langerhans-cell histiocytosis

,

homologous transplantation

,

non-gestational choriocarcinoma

,

smoldering multiple myeloma

,

,

spinal cord ischemia

,

,

uterine neoplasms

,

chronic progressive multiple sclerosis

,

epstein-barr virus infections

,

papillomaviridae

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

neuroendocrine carcinoma

,

islet cell carcinoma

,

,

,

small cell carcinoma

,

,

reactive arthritis

,

interstitial lung diseases

,

psoriatic arthritis

,

neutrophilic leukemia chronic

,

mast-cell leukemia

,

female genital diseases

,

urogenital neoplasms

,

glandular and epithelial neoplasms

,

peritoneal diseases

,

uterine cervical diseases

,

fallopian tube diseases

,

biliary tract neoplasms

,

esophageal diseases

,

stiff-person syndrome

,

,

animal mammary neoplasms

,

progressive multifocal leukoencephalopathy

,

neurofibromatosis 1

,

neurofibromatoses

,

nerve sheath neoplasms

,

,

urethral neoplasms

,

treatment outcome

,

transient ischemic attack

,

heart valve prosthesis

,

cardiac surgical procedures

,

,

,

hemorrhagic stroke

,

nervous system diseases

,

urologic diseases

,

,

,

erectile dysfunction

,

cerebral intraventricular hemorrhage

,

transposition of great vessels

,

hypoplastic left heart syndrome

,

ventricular remodeling

,

peripheral nervous system diseases

,

,

,

,

,

,

,

epidermolysis bullosa dystrophica

,

,

gastrointestinal diseases

,

,

,

gestational trophoblastic disease

,

trophoblastic neoplasms

,

severe acute respiratory syndrome-related coronavirus

,

,

unilateral breast neoplasms

,

immunosuppression therapy

,

,

severe acute respiratory syndrome

,

intermittent claudication

,

pneumococcal pneumonia

,

cytokine release syndrome

,

coronavirus infections

,

,

nerve degeneration

,

,

coronary artery bypass

,

,

lung transplantation

,

bronchiolitis obliterans

,

pathologic dilatation

,

acute lung injury

,

newborn respiratory distress syndrome

,

,

,

urologic neoplasms

,

merkel cell carcinoma

,

,

peripheral blood stem cell transplantation

,

,

,

diabetes complications

,

congenital bone marrow failure syndromes

,

eosinophilic esophagitis

,

coronary stenosis

,

coronary occlusion

,

,

autism spectrum disorder

,

acute chest syndrome

,

vaso-occlusive crises

,

alcoholic liver cirrhosis

,

adolescent development

,

hodgkin disease

,

b-cell chronic lymphocytic leukemia

,

large b-cell lymphoma diffuse

,

,

ovarian neoplasms

,

mantle-cell lymphoma

,

myeloproliferative disorders

,

bcr-abl positive chronic myelogenous leukemia

,

follicular lymphoma

,

central nervous system neoplasms

,

,

germ cell and embryonal neoplasms

,

b-cell lymphoma marginal zone

,

large-cell lymphoma immunoblastic

,

hematologic neoplasms

,

non-small-cell lung carcinoma

,

medulloblastoma

,

nervous system neoplasms

,

brain neoplasms

,

myelodysplastic-myeloproliferative diseases

,

,

kidney neoplasms

,

myelomonocytic leukemia chronic

,

,

aplastic anemia

,

neoplasm metastasis

,

ovarian epithelial carcinoma

,

,

refractory anemia with excess of blasts

,

b-cell lymphoma

,

biphenotypic leukemia acute

,

head and neck neoplasms

,

waldenstrom macroglobulinemia

,

rhabdomyosarcoma

,

,

congenital abnormalities

,

myelomonocytic leukemia acute

,

,

renal cell carcinoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

monocytic leukemia acute

,

liver neoplasms

,

hematologic diseases

,

myeloid leukemia chronic-phase

,

,

squamous cell carcinoma of head and neck

,

neuroectodermal tumors

,

t-cell lymphoma cutaneous

,

urinary bladder neoplasms

,

cutaneous malignant melanoma

,

erythroblastic leukemia acute

,

,

small cell lung carcinoma

,

,

primitive neuroectodermal tumors

,

endometrial neoplasms

,

triple negative breast neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

testicular neoplasms

,

,

megakaryoblastic leukemia acute

,

pulmonary alveolar proteinosis

,

myelomonocytic leukemia juvenile

,

primary myelofibrosis

,

sezary syndrome

,

mycosis fungoides

,

uterine cervical neoplasms

,

stomach neoplasms

,

sickle cell anemia

,

,

myeloid leukemia accelerated phase

,

,

immunoblastic lymphadenopathy

,

,

interdigitating dendritic cell sarcoma

,

lymphoproliferative disorders

,

prolymphocytic leukemia

,

precancerous conditions

,

transitional cell carcinoma

,

refractory anemia

,

hepatocellular carcinoma

,

rectal neoplasms

,

,

cardiovascular diseases

,

,

blood transfusion

,

liver cirrhosis

,

ganglioneuroblastoma

,

brain hypoxia-ischemia

,

esophageal neoplasms

,

,

orthopedic procedures

,

large granular lymphocytic leukemia

,

traumatic brain injuries

,

inflammatory breast neoplasms

,

,

st elevation myocardial infarction

,

multiple sclerosis

,

inborn genetic diseases

,

,

,

plasmablastic lymphoma

,

endometrioid carcinoma

,

atrial fibrillation

,

,

,

,

adenosquamous carcinoma

,

asphyxia neonatorum

,

choroid plexus neoplasms

,

phenylketonurias

,

serous cystadenocarcinoma

,

systemic scleroderma

,

diffuse scleroderma

,

uveal neoplasms

,

,

,

adenocarcinoma of lung

,

venous thrombosis

,

adult t-cell leukemia-lymphoma

,

pheochromocytoma

,

diamond-blackfan anemia

,

,

amyotrophic lateral sclerosis

,

radiation effects

,

neuromyelitis optica

,

,

acute-on-chronic liver failure

,

pure red-cell aplasia

,

hematopoietic stem cell mobilization

,

protein c deficiency

,

pathologic complete response

,

castration-resistant prostatic neoplasms

,

bronchiolo-alveolar adenocarcinoma

,

endodermal sinus tumor

,

monoclonal gammopathy of undetermined significance

,

,

relapsing-remitting multiple sclerosis

,

human influenza

,

radiation injuries

,

,

shwachman-diamond syndrome

,

basophilic leukemia acute

,

eosinophilic leukemia acute

,

,

,

erythropoietic protoporphyria

,

autologous blood transfusion

,

immunologic deficiency syndromes

,

coronary disease

,

,

pulmonary emphysema

,

,

thromboembolism

,

choriocarcinoma

,

hypereosinophilic syndrome

,

neuroprotection

,

cardiomyopathies

,

ventricular dysfunction

,

periventricular leukomalacia

,

,

alveolar rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

clear cell adenocarcinoma

,

acinar cell carcinoma

,

retinal neoplasms

,

,

hemoglobinopathies

,

hypersensitivity

,

multiple trauma

,

optic nerve diseases

,

neonatal anemia

,

,

cardiovascular surgical procedures

,

,

,

chagas cardiomyopathy

,

communicable diseases

,

,

,

fetal growth retardation

,

,

neurodevelopmental disorders

,

neurocognitive disorders

,

fetal erythroblastosis

,

induction chemotherapy

,

intracranial hemorrhages

,

,

cerebral malaria

,

balloon angioplasty coronary

,

pulmonary embolism

,

,

,

respiratory insufficiency

,

chronic hepatitis c

,

viral pneumonia

,

,

,

,

innate immunity

,

adrenal cortex neoplasms

,

adrenocortical carcinoma

,

nonpenetrating wounds

,

penetrating wounds

,

optic nerve injuries

,

aortic valve stenosis

,

,

spinal cord injuries

,

retinal diseases

,

drug resistance

,

,

gastrointestinal neoplasms

,

adjuvant chemotherapy

,

,

agammaglobulinemia

,

cross infection

,

sickle cell trait

,

gestational diabetes

,

cutaneous leishmaniasis

,

,

immune system diseases

,

,

pregnancy complications

,

hypercholesterolemia

,

,

hyperlipoproteinemia type ii

,

urinary tract infections

,

bacterial vaginosis

,

vaginal diseases

,

oral lichen planus

,

wasting syndrome

,

child nutrition disorders

,

postoperative pain

,

,

anesthesia and analgesia

,

,

,

,

,

myeloid leukemia acute

,

multiple myeloma

,

myelodysplastic syndromes

,

non-hodgkin lymphoma

,

breast neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

chronic renal insufficiency

,

plasma cell neoplasms

,

,

myeloid leukemia

,

,

,

,

kidney diseases

,

burkitt lymphoma

,

chronic kidney failure

,

lymphoid leukemia

,

,

,

prostatic neoplasms

,

,

,

graft vs host disease

,

healthy volunteers/patients

,

acquired immunodeficiency syndrome

,

alpha 1-antitrypsin deficiency

,

hereditary angioedemas

,

renal insufficiency

,

thrombocytopenia

,

colorectal neoplasms

,

,

,

,

large-cell lymphoma anaplastic

,

hematopoietic stem cell transplantation

,

iron-deficiency anemia

,

diabetes mellitus

,

myocardial infarction

,

,

thrombocytopenic purpura idiopathic

,

,

premature birth

,

drug-related side effects and adverse reactions

,

kidney transplantation

,

chemotherapy-induced febrile neutropenia

,

iron deficiencies

,

,

critical illness

,

,

chronic obstructive pulmonary disease

,

,

neonatal sepsis

,

acute kidney injury

,

bronchiolitis obliterans syndrome

,

,

,

inferior wall myocardial infarction

,

febrile neutropenia

,

alcoholic hepatitis

,

autologous transplantation

,

wounds and injuries

,

insulin resistance

,

,

graft rejection

,

,

diabetic nephropathies

,

,

chronic hepatitis b

,

atherosclerosis

,

,

multiple organ failure

,

female infertility

,

,

non-alcoholic fatty liver disease

,

,

,

type 2 diabetes mellitus

,

,

alcoholic liver diseases

,

subarachnoid hemorrhage

,

,

,

primary ovarian insufficiency

,

hereditary angioedema types i and ii

,

,

,

,

,

,

mediastinal neoplasms

,

delayed graft function

,

,

altitude sickness

,

,

,

left ventricular hypertrophy

,

stevens-johnson syndrome

,

,

,

,

pediatric obesity

,

atopic dermatitis

,

,

secondary hyperparathyroidism

,

,

,

primary immunodeficiency diseases

,

common variable immunodeficiency

,

hemolytic-uremic syndrome

,

autoimmune diseases of the nervous system

,

erythrocyte transfusion

,

,

surgical hemostasis

,

,

,

,

habitual abortion

,

,

postoperative complications

,

tooth extraction

,

,

,

,

pityriasis rubra pilaris

,

physical fitness

,

,

emergence delirium

,

,

,

inflammatory bowel diseases

,

,

chediak-higashi syndrome

,

ankylosing spondylitis

,

antiphospholipid syndrome

,

metabolic syndrome

,

anxiety disorders

,

feeding behavior

,

,

,

psychological well-being

,

continuous ambulatory peritoneal dialysis

,

iron metabolism disorders

,

autonomic nervous system diseases

,

duchenne muscular dystrophy

,

bariatric surgery

,

,

,

hemostatic disorders

,

hemophagocytic lymphohistiocytosis

,

,

,

,

juvenile arthritis

,

giant cell arteritis

,

polymyalgia rheumatica

,

churg-strauss syndrome

,

polyarteritis nodosa

,

granulomatosis with polyangiitis

,

takayasu arteritis

,

leukocytoclastic vasculitis cutaneous

,

aortic arch syndromes

,

,

hemiarthroplasty

,

retinopathy of prematurity

,

tissue adhesions

,

glycogen storage disease type ii

,

neurodegenerative diseases

,

acute liver failure

,

graft vs leukemia effect

,

blood glucose self-monitoring

,

glucose metabolism disorders

,

,

alopecia areata

,

venous thromboembolism

,

hyperlipidemias

,

,

posterior tibial tendon dysfunction

,

,

cardiac arrhythmias

,

,

subdural hematoma chronic

,

,

postpartum hemorrhage

,

gender identity

,

adolescent behavior

,

,

pelvic organ prolapse

,

blood platelet disorders

,

alcohol-related disorders

,

pregnancy-induced hypertension

,

patient compliance

,

,

adrenoleukodystrophy

,

inappropriate prescribing

,

periodontal diseases

,

neoplasm invasiveness

,

,

pleural diseases

,

sexually transmitted diseases

,

interstitial cystitis

,

premature obstetric labor

,

ulcerative colitis

,

,

leukocyte-adhesion deficiency syndrome

,

necrotizing enterocolitis

,

,

sleep deprivation

,

macular degeneration

,

infant nutrition disorders

,

preconception care

,

,

,

,

,

vaginal neoplasms

,

vulvar neoplasms

,

hereditary breast and ovarian cancer syndrome

,

,

drug monitoring

,

,

,

olfaction disorders

,

taste disorders

,

,

,

,

metabolic diseases

,

alcoholic fatty liver

,

obstructive sleep apnea

,

central sleep apnea

,

hypoventilation

,

,

,

,

,

type 3 von willebrand disease

,

von willebrand diseases

,

type 2 von willebrand disease

,

ambulatory care

,

,

alcohol drinking

,

father-child relations

,

vasovagal syncope

,

,

,

ovarian reserve

,

sleep initiation and maintenance disorders

,

ventilator-associated pneumonia

,

,

dry eye syndromes

,

marfan syndrome

,

,

1

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