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Trade Name	Drug Name	Approved	Patent Expires	Indication
Vyvgart	Efgartigimod alfa	2021-12-17		Myasthenia gravis , Extravasation of diagnostic and therapeutic materials
Vyvgart hytrulo	Efgartigimod alfa, Hyaluronidase	2023-06-20		Extravasation of diagnostic and therapeutic materials , Breast neoplasms , Gastrointestinal neoplasms , Multiple myeloma , Non-small-cell lung carcinoma , Hepatocellular carcinoma , Urinary bladder neoplasms , Melanoma , Small cell lung carcinoma , Alveolar soft part sarcoma , Multiple sclerosis

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Hyaluronidase (human recombinant)

myeloid leukemia acute

,

myeloid leukemia

,

cholangiocarcinoma

,

monocytic leukemia acute

,

castleman disease

,

burkitt lymphoma

,

multiple sclerosis

,

,

stomach neoplasms

,

hypercholesterolemia

,

,

ovarian neoplasms

,

,

ovarian epithelial carcinoma

,

myelodysplastic syndromes

,

primary myelofibrosis

,

precursor cell lymphoblastic leukemia-lymphoma

,

bcr-abl positive chronic myelogenous leukemia

,

aplastic anemia

,

,

,

pancreatic neoplasms

,

,

non-hodgkin lymphoma

,

,

,

b-cell lymphoma marginal zone

,

male breast neoplasms

,

alzheimer disease

,

type 2 diabetes mellitus

,

large b-cell lymphoma diffuse

,

b-cell chronic lymphocytic leukemia

,

hereditary angioedemas

,

,

urinary bladder neoplasms

,

hematologic neoplasms

,

prostatic neoplasms

,

hodgkin disease

,

esophageal neoplasms

,

,

cutaneous malignant melanoma

,

neoplasms by site

,

lymphoid leukemia

,

muscle spasticity

,

,

,

allergic contact dermatitis

,

,

contact dermatitis

,

triple negative breast neoplasms

,

heart transplantation

,

urologic neoplasms

,

transitional cell carcinoma

,

castration-resistant prostatic neoplasms

,

peripheral nervous system diseases

,

paraproteinemias

,

polyneuropathies

,

monoclonal gammopathy of undetermined significance

,

multiple myeloma

,

plasma cell neoplasms

,

breast neoplasms

,

,

,

b-cell lymphoma

,

non-small-cell lung carcinoma

,

,

,

follicular lymphoma

,

,

,

chronic inflammatory demyelinating polyradiculoneuropathy

,

polyradiculoneuropathy

,

pancreatic ductal carcinoma

,

mantle-cell lymphoma

,

,

immunoglobulin light-chain amyloidosis

,

,

bullous pemphigoid

,

,

dermatomyositis

,

muscular diseases

,

,

smoldering multiple myeloma

,

renal cell carcinoma

,

ductal carcinoma

,

residual neoplasm

,

,

endometrial neoplasms

,

endometrioid carcinoma

,

serous cystadenocarcinoma

,

clear cell adenocarcinoma

,

,

acinar cell carcinoma

,

mullerian mixed tumor

,

inflammatory breast neoplasms

,

healthy volunteers/patients

,

immunologic deficiency syndromes

,

primary immunodeficiency diseases

,

diabetes mellitus

,

type 1 diabetes mellitus

,

,

,

rheumatoid arthritis

,

,

,

,

stiff-person syndrome

,

neoplasm metastasis

,

,

pneumococcal pneumonia

,

invasive hydatidiform mole

,

,

pain management

,

,

,

rectal neoplasms

large b-cell lymphoma diffuse

,

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

,

,

,

hodgkin disease

,

mantle-cell lymphoma

,

b-cell lymphoma

,

triple negative breast neoplasms

,

renal cell carcinoma

,

,

,

,

chronic hepatitis b

,

communicable diseases

,

,

parkinson disease

,

parkinsonian disorders

,

movement disorders

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

chronic renal insufficiency

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

graft vs host disease

,

type 1 diabetes mellitus

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

brain neoplasms

,

,

oligodendroglioma

,

pancreatic neoplasms

,

,

neuroendocrine tumors

,

islet cell carcinoma

,

,

,

somatostatinoma

,

,

,

breast neoplasms

,

myelodysplastic syndromes

,

thrombocytopenia

,

,

,

,

retinal vein occlusion

,

vision disorders

,

,

macular degeneration

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

juvenile arthritis

,

,

kidney diseases

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

organ transplantation

,

wet macular degeneration

,

neoplasm metastasis

,

graft rejection

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

non-alcoholic fatty liver disease

,

,

postoperative pain

,

,

choroidal neovascularization

,

pathologic neovascularization

,

chronic kidney failure

,

renal insufficiency

,

liver transplantation

,

kidney transplantation

,

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

liver cirrhosis

,

,

atrial fibrillation

,

,

Vorhyaluronidase alfa

,

neoplasms by site

,

urologic neoplasms

,

transitional cell carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

,

,

renal cell carcinoma

Sodium chloride

alzheimer disease

,

myelodysplastic syndromes

,

,

hepatic insufficiency

,

cognitive dysfunction

,

precursor cell lymphoblastic leukemia-lymphoma

,

maximum tolerated dose

,

antineoplastic protocols

,

pharmacokinetics

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

,

aplastic anemia

,

paraproteinemias

,

monoclonal gammopathy of undetermined significance

,

,

laboratory infection

,

myeloid leukemia acute

,

castration-resistant prostatic neoplasms

,

myeloid leukemia

,

,

,

acquired immunodeficiency syndrome

,

hematologic neoplasms

,

,

immunologic deficiency syndromes

,

,

hypergammaglobulinemia

,

,

chronic hepatitis b

,

,

,

prostatic neoplasms

,

neoplasm metastasis

,

multiple myeloma

,

plasma cell neoplasms

,

colorectal neoplasms

,

colonic neoplasms

,

colonic diseases

,

,

sexually transmitted diseases

,

retroviridae infections

,

viral sexually transmitted diseases

,

b-cell lymphoma marginal zone

,

burkitt lymphoma

,

,

pulmonary tuberculosis

,

healthy volunteers/patients

,

non-small-cell lung carcinoma

,

b-cell lymphoma

,

large b-cell lymphoma diffuse

,

non-hodgkin lymphoma

,

follicular lymphoma

,

,

graft vs host disease

,

bronchiolitis obliterans syndrome

,

renal insufficiency

,

respiratory syncytial viruses

,

,

ebola hemorrhagic fever

,

cerebrospinal fluid leak

,

,

soft tissue injuries

,

respiratory tract diseases

,

kidney transplantation

,

prolymphocytic leukemia t-cell

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

atrial fibrillation

,

glomerulonephritis

,

lupus nephritis

,

systemic lupus erythematosus

,

,

myeloid leukemia acute

,

myeloid leukemia

,

myelodysplastic syndromes

,

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

,

,

,

acquired immunodeficiency syndrome

myelomonocytic leukemia chronic

,

myelodysplastic syndromes

,

,

,

myeloid leukemia acute

,

myeloid leukemia

,

prostatic hyperplasia

,

,

psychological sexual dysfunctions

,

anxiety disorders

,

generalized anxiety disorder

,

,

pulmonary hypertension

,

pulmonary arterial hypertension

,

,

erectile dysfunction

,

wounds and injuries

,

spinal cord injuries

,

spinal injuries

,

type 2 diabetes mellitus

,

diabetes mellitus

prostatic hyperplasia

,

,

anxiety disorders

,

generalized anxiety disorder

,

,

pulmonary hypertension

,

pulmonary arterial hypertension

,

,

erectile dysfunction

,

wounds and injuries

,

spinal cord injuries

,

spinal injuries

,

type 2 diabetes mellitus

,

diabetes mellitus

1

2

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