PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsHyaluronidase
Hyaluronidase
Amphadase, Darzalex Faspro, Herceptin Hylecta, Ocrevus Zunovo, Phesgo, Tecentriq Hybreza, Vitrase, Vyvgart Hytrulo (hyaluronidase) is an enzyme pharmaceutical. Hyaluronidase was first approved as Vitrase on 2004-05-05. It is used to treat extravasation of diagnostic and therapeutic materials in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Amphadase, Vitrase (discontinued: Hydase, Vitrase)
Combinations
Darzalex faspro, Herceptin hylecta, Ocrevus zunovo, Phesgo, Tecentriq hybreza, Vyvgart hytrulo
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Hyaluronidase
Tradename
Proper name
Company
Number
Date
Products
AmphadasehyaluronidaseAmphastar PharmaceuticalsN-21665 RX2004-10-26
1 products
VitrasehyaluronidaseBausch Health CompaniesN-21640 RX2004-12-02
1 products
Show 2 discontinued
Hyaluronidase
+
Trastuzumab
Tradename
Proper name
Company
Number
Date
Products
Herceptin Hylectatrastuzumab and hyaluronidase-oyskGenentechN-761106 RX2019-02-28
1 products
Daratumumab
+
Hyaluronidase
Tradename
Proper name
Company
Number
Date
Products
Darzalex Fasprodaratumumab and hyaluronidase-fihjJohnson & JohnsonN-761145 RX2020-05-01
1 products
Hyaluronidase
+
Pertuzumab
+
Trastuzumab
Tradename
Proper name
Company
Number
Date
Products
Phesgopertuzumab, trastuzumab, and hyaluronidase-zzxfGenentechN-761170 RX2020-06-29
2 products
Efgartigimod alfa
+
Hyaluronidase
Tradename
Proper name
Company
Number
Date
Products
Vyvgart Hytruloefgartigimod alfa and hyaluronidase-qvfcArgenxN-761304 RX2023-06-20
1 products
Atezolizumab
+
Hyaluronidase
Tradename
Proper name
Company
Number
Date
Products
Tecentriq Hybrezaatezolizumab and hyaluronidase-tqjsGenentechN-761347 RX2024-09-12
1 products
Hyaluronidase
+
Ocrelizumab
Tradename
Proper name
Company
Number
Date
Products
Ocrevus Zunovoocrelizumab and hyaluronidase-ocsqGenentechN-761371 RX2024-09-13
1 products
Labels
FDA
EMA
Brand Name
Status
Last Update
amphadaseBiologic Licensing Application2024-02-01
darzalex fasproBiologic Licensing Application2024-08-08
herceptin hylectaBiologic Licensing Application2024-07-02
hyaluronidaseBiologic Licensing Application2021-06-04
hylenex recombinantBiologic Licensing Application2024-01-24
ocrevus zunovoBiologic Licensing Application2024-09-25
phesgoBiologic Licensing Application2022-11-16
rituxan hycelaBiologic Licensing Application2024-07-08
sea clearly hydrating facial spf 35 kinetinC2002632023-12-05
tecentriq hybrezaBiologic Licensing Application2024-09-25
Show 2 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
extravasation of diagnostic and therapeutic materials—D005119—
breast neoplasmsEFO_0003869D001943C50
gastrointestinal neoplasms—D005770C26.9
multiple myeloma—D009101C90.0
non-small-cell lung carcinoma—D002289—
urinary bladder neoplasms—D001749C67
multiple sclerosisEFO_0003885D009103G35
Agency Specific
FDA
EMA
Expiration
Code
efgartigimod alfa / hyaluronidase, Vyvgart Hytrulo, Argenx BV
2030-06-20Orphan excl.
daratumumab / hyaluronidase, Darzalex Faspro, Janssen Biotech, Inc.
2028-01-15Orphan excl.
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B06: Other hematological agents in atc
— B06A: Other hematological agents in atc
— B06AA: Enzymes, hematological
— B06AA03: Hyaluronidase
HCPCS
Code
Description
J1575
Injection, immune globulin/hyaluronidase, (hyqvia), 100 mg immuneglobulin
J3470
Injection, hyaluronidase, up to 150 units
J3471
Injection, hyaluronidase, ovine, preservative free, per 1 usp unit (up to 999 usp units)
J3472
Injection, hyaluronidase, ovine, preservative free, per 1000 usp units
J3473
Injection, hyaluronidase, recombinant, 1 usp unit
J9144
Injection, daratumumab, 10 mg and hyaluronidase-fihj
J9311
Injection, rituximab 10 mg and hyaluronidase
J9316
Injection, pertuzumab, trastuzumab, and hyaluronidase-zzxf, per 10 mg
J9356
Injection, trastuzumab, 10 mg and hyaluronidase-oysk
Clinical
Clinical Trials
272 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———13—12—16
Immunologic deficiency syndromesD007153HP_0002721D84.91381313
Primary immunodeficiency diseasesD000081207——1381313
Diabetes mellitusD003920HP_0000819E08-E1335—2—10
DehydrationD003681—E86.01116110
Type 1 diabetes mellitusD003922EFO_0001359E1033—3—9
PainD010146EFO_0003843R52——2215
CataractD002386HP_0000518H26.9———123
Skin diseasesD012871—L00-L991——1—2
StrabismusD013285HP_0000486H50.2———1—1
Show 12 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101—C90.015118——31
Plasma cell neoplasmsD054219——14108——29
Breast neoplasmsD001943EFO_0003869C504177—127
LymphomaD008223—C85.95104——18
Non-small-cell lung carcinomaD002289——244——10
Lung neoplasmsD008175HP_0100526C34.90134—19
AdenocarcinomaD000230——462——9
B-cell lymphomaD016393——361——9
Follicular lymphomaD008224—C82251——7
AmyloidosisD000686EFO_1001875E85—21—36
Show 31 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C8088———13
Pancreatic neoplasmsD010190EFO_0003860C2566———10
Non-hodgkin lymphomaD008228—C85.932———5
SyndromeD013577———1——45
LeukemiaD007938—C9522———4
RecurrenceD012008——22———4
Large b-cell lymphoma diffuseD016403—C83.333———4
Hematologic neoplasmsD019337——33———4
Myeloid leukemia acuteD015470—C92.031———3
B-cell lymphoma marginal zoneD018442—C88.412———3
Show 42 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Carpal tunnel syndromeD002349EFO_0004143G56.01———45
Hiv infectionsD015658EFO_0000764B204————4
Chronic painD059350HP_0012532—1———23
NeuralgiaD009437EFO_0009430—2———13
Myeloid leukemiaD007951—C922————2
Systemic sclerodermaD012595EFO_0000717M34.02————2
Localized sclerodermaD012594EFO_1001361L94.02————2
MicrostomiaD008865HP_0000160Q18.52————2
Drug hypersensitivityD004342EFO_0009482T88.72————2
CholangiocarcinomaD018281—C22.11————1
Show 29 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246HP_0000789—————33
Ocular hypotensionD015814—H44.4————22
PeriodontitisD010518EFO_0000649K05.3————22
Wounds and injuriesD014947—T14.8————22
GlaucomaD005901EFO_0000516H40————11
Covid-19D000086382——————11
Failed back surgery syndromeD055111——————11
SarcopeniaD055948EFO_1000653M62.84————11
Intermittent claudicationD007383EFO_0003876I73.9————11
Pathologic constrictionD003251——————11
Show 25 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameHyaluronidase
INN—
Description
Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid. Karl Meyer classified these enzymes in 1971, into three distinct groups, a scheme based on the enzyme reaction products. The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of glycosidase.
Classification
Enzyme
Drug classenzymes
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB1FCQ, 1FCU, 1FCV, 1I8Q, 1LOH, 1LXK, 1LXM, 1N7N, 1N7O, 1N7P, 1N7Q, 1N7R, 1OJM, 1OJN, 1OJO, 1OJP, 1W3Y, 2ATM, 2BRP, 2BRV, 2BRW, 2C3F, 2CBI, 2CBJ, 2DP5, 2J1A, 2J1E, 2J62, 2J7M, 2J88, 2JNK, 2OZN, 2PE4, 2WB3, 2WDB, 2WH7, 2YVV, 2YW0, 2YX2, 3EKA, 4D0Q, 4UFQ, 5DIY, 6WV2, 6WWX, 6WXA, 6X3M, 7EYO, 8C6I, 8FNX, 8G0O
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL1201636
ChEBI ID—
PubChem CID—
DrugBankDB00070
UNII ID—
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Phesgo – Roche
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Estimated US medical usage
Hyaluronidase
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 39,517 documents
View more details
Safety
Black-box Warning
Black-box warning for: Herceptin hylecta, Phesgo, Rituxan hycela
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
9,638 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use