Xevinapant
Xevinapant is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 2 | 2 | — | 1 | 6 |
| Head and neck neoplasms | D006258 | — | — | 2 | 1 | 1 | — | — | 4 |
| Laryngeal diseases | D007818 | — | J38.7 | 1 | — | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 4 | 1 | — | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | — | 1 | — | — | — | 1 |
| Mouth neoplasms | D009062 | EFO_0003868 | C06.9 | — | 1 | — | — | — | 1 |
| Oropharyngeal neoplasms | D009959 | — | — | — | 1 | — | — | — | 1 |
| Laryngeal neoplasms | D007822 | EFO_0003817 | C32 | — | 1 | — | — | — | 1 |
| Hypopharyngeal neoplasms | D007012 | — | C13 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Xevinapant |
| INN | xevinapant |
| Description | At-406 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase SYK, tyrosine-protein kinase Lyn, and tyrosine-protein kinase ABL1. In addition, it is known to target proto-oncogene tyrosine-protein kinase receptor Ret. |
| Classification | Small molecule |
| Drug class | inhibitor of apoptosis protein (IAP); vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CC(C)C)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O |
Identifiers
| PDB | — |
| CAS-ID | 1071992-57-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2158051 |
| ChEBI ID | — |
| PubChem CID | 25022340 |
| DrugBank | DB16305 |
| UNII ID | N65WC8PXDD (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
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