Chantix, Champix(varenicline)
Champix, Tyrvaya, Varenicline (varenicline) is a small molecule pharmaceutical. Varenicline was first approved as Chantix on 2006-05-10. It has been approved in Europe to treat tobacco use cessation. The pharmaceutical is active against neuronal acetylcholine receptor subunit alpha-4. In addition, it is known to target neuronal acetylcholine receptor subunit alpha-3.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| behavior and behavior mechanisms | D001520 |
Trade Name
FDA
EMA
Chantix, Tyrvaya, Varenicline (discontinued: Varenicline)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Varenicline tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TYRVAYA | Oyster Point Pharma | N-213978 RX | 2021-10-15 | 1 products, RLD, RS |
| CHANTIX | CV Sciences | N-021928 RX | 2006-05-10 | 2 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chantix | New Drug Application | 2025-09-12 |
| tyrvaya | New Drug Application | 2024-02-12 |
| varenicline | ANDA | 2025-09-18 |
| varenicline tartrate | ANDA | 2025-09-17 |
| varenicline tartrate varenicline tartrate | ANDA | 2023-08-25 |
| varenicline varenicline | ANDA | 2024-09-27 |
| varenicline varenicline tartrate | ANDA | 2025-06-16 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
VARENICLINE TARTRATE, TYRVAYA, OYSTER POINT PHARMA | |||
| 2024-10-15 | NP | ||
HCPCS
No data
Clinical
Clinical Trials
396 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking cessation | D016540 | EFO_0004319 | — | 9 | 9 | 12 | 18 | 10 | 57 |
| Tobacco use disorder | D014029 | — | F17 | 2 | 5 | 4 | 4 | 9 | 21 |
| Smoking | D012907 | EFO_0004318 | — | 1 | 1 | — | 4 | 3 | 9 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 3 | 1 | 1 | — | 5 |
| Tobacco use cessation | D020340 | — | — | — | 1 | — | 2 | — | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | 1 | 1 | — | 2 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | 2 | — | 2 |
| Problem behavior | D000066553 | — | — | — | — | — | 2 | — | 2 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | 1 | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 1 | 1 | 2 |
Show 7 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | 1 | — | — | 2 |
| Ataxia | D001259 | — | R27.0 | — | 2 | 1 | — | — | 2 |
| Cerebellar ataxia | D002524 | — | — | — | 2 | 1 | — | — | 2 |
| Tobacco smoking | D000073869 | — | — | — | — | 1 | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | — | — | 1 | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 1 | — | — | 1 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | — | 1 | 1 | — | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 1 | — | — | 1 |
| Obstructive lung diseases | D008173 | — | — | — | — | 1 | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | — | — | — | 1 |
| Spinocerebellar degenerations | D013132 | — | G11 | — | 1 | — | — | — | 1 |
| Spinocerebellar ataxias | D020754 | — | — | — | 1 | — | — | — | 1 |
| Machado-joseph disease | D017827 | EFO_0004135 | — | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cigarette smoking | D000073865 | — | — | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Varenicline |
| INN | varenicline |
| Description | Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation and for the treatment of dry eye disease. It is a nicotinic receptor partial agonist and a cholinergic agonist. When activated, this receptor releases dopamine in the nucleus accumbens, the brain's reward center, thereby reducing cravings and withdrawal symptoms associated with smoking cessation.
|
| Classification | Small molecule |
| Drug class | nicotinic acetylcholine receptor partial agonists/agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | c1cnc2cc3c(cc2n1)C1CNCC3C1 |
Identifiers
| PDB | — |
| CAS-ID | 249296-44-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1396 |
| ChEBI ID | — |
| PubChem CID | 170361 |
| DrugBank | DB01273 |
| UNII ID | W6HS99O8ZO (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Chantix – Pfizer
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tyrvaya – Oyster Point Pharma
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
Varenicline
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 8,718 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
91,331 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use