VARLILUMAB
Varlilumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target CD27 antigen.
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Study first post date
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Commercial
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 4 | 3 | — | — | — | 5 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 4 | 1 | — | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | 3 | 1 | — | — | — | 4 |
| B-cell lymphoma | D016393 | — | — | 2 | 2 | — | — | — | 3 |
| Recurrence | D012008 | — | — | — | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | — | 2 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | 1 | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | 1 | 1 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | — | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 3 | — | — | — | — | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | — | — | — | — | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | 2 | — | — | — | — | 2 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | 2 | — | — | — | — | 2 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 2 | — | — | — | — | 2 |
| Urologic diseases | D014570 | — | N39.9 | 2 | — | — | — | — | 2 |
| Neoplasms by histologic type | D009370 | — | — | 2 | — | — | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | — | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VARLILUMAB |
| INN | varlilumab |
| Description | Varlilumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137347 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 0125DUV5XC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CD27
CD27
Organism
Homo sapiens
Gene name
CD27
Gene synonyms
TNFRSF7
NCBI Gene ID
Protein name
CD27 antigen
Protein synonyms
CD27, CD27L receptor, T cell activation antigen S152, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, tumor necrosis factor receptor superfamily, member 7
Uniprot ID
Mouse ortholog
Cd27 (21940)
CD27 antigen (P41272)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 407 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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43 adverse events reported
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