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Drug ReportsVACTOSERTIB
VACTOSERTIB
Vactosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against activin receptor type-1B and TGF-beta receptor type-1.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179122
NeoplasmsD009369C8011
Neoplasm metastasisD009362EFO_000970811
Stomach neoplasmsD013274EFO_0003897C16111
Esophageal neoplasmsD004938C15111
AdenocarcinomaD000230111
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVACTOSERTIB
INNvactosertib
Description
Vactosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against activin receptor type-1B and TGF-beta receptor type-1.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
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Structure (InChI/SMILES or Protein Sequence)
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1
Identifiers
PDB
CAS-ID1352608-82-2
RxCUI
ChEMBL IDCHEMBL3260567
ChEBI ID
PubChem CID
DrugBank
UNII ID6T4O391P5Y (ChemIDplus, GSRS)
Target
Agency Approved
ACVR1B
ACVR1B
TGFBR1
TGFBR1
Organism
Homo sapiens
Gene name
ACVR1B
Gene synonyms
ACVRLK4, ALK4
NCBI Gene ID
Protein name
activin receptor type-1B
Protein synonyms
activin A receptor, type IB, activin A receptor, type II-like kinase 4, Activin receptor type IB, Activin receptor-like kinase 4, ACTR-IB, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2
Uniprot ID
Mouse ortholog
Acvr1b (11479)
activin receptor type-1B (Q61271)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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