VACTOSERTIB
Vactosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against activin receptor type-1B and TGF-beta receptor type-1.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Commercial
No data
Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 1 | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VACTOSERTIB |
| INN | vactosertib |
| Description | Vactosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against activin receptor type-1B and TGF-beta receptor type-1. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 1352608-82-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3260567 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6T4O391P5Y (ChemIDplus, GSRS) |
Target
Agency Approved
ACVR1B
ACVR1B
TGFBR1
TGFBR1
Organism
Homo sapiens
Gene name
ACVR1B
Gene synonyms
ACVRLK4, ALK4
NCBI Gene ID
Protein name
activin receptor type-1B
Protein synonyms
activin A receptor, type IB, activin A receptor, type II-like kinase 4, Activin receptor type IB, Activin receptor-like kinase 4, ACTR-IB, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2
Uniprot ID
Mouse ortholog
Acvr1b (11479)
activin receptor type-1B (Q61271)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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