Brand Name | Status | Last Update |
---|---|---|
tukysa | New Drug Application | 2024-11-04 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
breast neoplasms | EFO_0003869 | D001943 | C50 |
Expiration | Code | ||
---|---|---|---|
TUCATINIB, TUKYSA, SEAGEN | |||
2030-01-19 | ODE-422 | ||
2027-04-17 | ODE-309 | ||
2026-01-19 | I-906 | ||
2025-04-17 | NCE |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 7 | 14 | 1 | — | 2 | 20 |
Carcinoma | D002277 | — | C80.0 | 1 | 1 | 1 | — | — | 2 |
Invasive hydatidiform mole | D002820 | — | D39.2 | 1 | 1 | 1 | — | — | 2 |
Esophageal neoplasms | D004938 | — | C15 | — | 1 | 1 | — | — | 1 |
Adenocarcinoma | D000230 | — | — | — | 1 | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 1 | 3 | — | — | — | 4 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 3 | — | — | — | 3 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 2 | — | — | — | 2 |
Multiple myeloma | D009101 | — | C90.0 | — | 2 | — | — | — | 2 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 2 | — | — | — | 2 |
Central nervous system diseases | D002493 | — | G96.9 | 1 | 1 | — | — | — | 1 |
Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | — | 1 |
Colonic neoplasms | D003110 | — | C18 | — | 1 | — | — | — | 1 |
Disease progression | D018450 | — | — | — | 1 | — | — | — | 1 |
Meningeal neoplasms | D008577 | EFO_0003851 | C70 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Drug common name | Tucatinib |
INN | tucatinib |
Description | Tucatinib, sold under the brand name Tukysa, is an anticancer medication used for the treatment of HER2-positive breast cancer. It is a small molecule inhibitor of HER2. It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics).
|
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1 |
PDB | — |
CAS-ID | 937263-43-9 |
RxCUI | — |
ChEMBL ID | CHEMBL3989868 |
ChEBI ID | — |
PubChem CID | 51039094 |
DrugBank | DB11652 |
UNII ID | 234248D0HH (ChemIDplus, GSRS) |