Tropicamide
Mydcombi, Mydriacyl, Paremyd, Tropicacyl, Tropicamide (tropicamide) is a small molecule pharmaceutical. Tropicamide was first approved as Mydriacyl on 1982-01-01. It is used to treat iridocyclitis, iritis, and keratitis in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M5.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Mydriacyl, Tropicacyl, Tropicamide (discontinued: Mydriacyl, Tropicamide)
CombinationsMydcombi (discontinued: Paremyd)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydroxyamphetamine hydrobromide
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Tropicamide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PAREMYD | Epic Pharma | N-019261 DISCN | 1992-01-30 | 1 products, RLD |
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Tropicamide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MYDRIACYL | Alcon Research | N-012111 DISCN | 1982-01-01 | 2 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mydcombi | New Drug Application | 2023-05-09 |
| mydriacyl | ANDA | 2023-02-15 |
| mydriatic-4 | unapproved drug other | 2018-05-01 |
| paremyd | New Drug Application | 2022-09-14 |
| tropicacyl | 2008-11-25 | |
| tropicamide | ANDA | 2023-09-01 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
PHENYLEPHRINE HYDROCHLORIDE / TROPICAMIDE, MYDCOMBI, EYENOVIA | |||
| 2026-05-05 | NP | ||
HCPCS
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Clinical
Clinical Trials
63 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mydriasis | D015878 | HP_0011499 | H57.04 | 1 | — | 5 | 6 | 2 | 14 |
| Cataract | D002386 | HP_0000518 | H26.9 | — | — | 2 | 1 | 5 | 8 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | — | — | 2 | 5 | 8 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | 1 | — | — | 3 | 3 | 7 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | — | 1 | 2 | 2 | 6 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | 2 | 1 | 3 |
| Refractive errors | D012030 | EFO_0003908 | H52.7 | — | — | — | 3 | — | 3 |
| Pathologic dilatation | D004108 | — | — | — | — | 2 | 1 | — | 3 |
| Intraocular pressure | D007429 | — | — | 1 | — | — | 1 | — | 2 |
| Dilatation | D004106 | — | — | — | — | 1 | 1 | — | 2 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | 1 | — | 2 | 3 |
| Uveitis | D014605 | HP_0000554 | H20.9 | — | — | 1 | — | — | 1 |
| Anterior uveitis | D014606 | EFO_1000811 | — | — | — | 1 | — | — | 1 |
| Iridocyclitis | D015863 | HP_0001094 | H20 | — | — | 1 | — | — | 1 |
| Corneal endothelial cell loss | D055954 | — | — | — | — | 1 | — | — | 1 |
| Corneal ulcer | D003320 | — | H16.0 | — | — | 1 | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | 1 | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Presbyopia | D011305 | — | H52.4 | — | 2 | — | — | — | 2 |
| Sialorrhea | D012798 | HP_0002307 | K11.7 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | 1 | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 1 | — | — | — | 2 | 3 |
| Retinitis pigmentosa | D012174 | HP_0000580 | H35.52 | 1 | — | — | — | 1 | 2 |
| Retinitis | D012173 | — | H30.9 | 1 | — | — | — | 1 | 2 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Nervous system diseases | D009422 | — | G00-G99 | 1 | — | — | — | — | 1 |
| Primary dysautonomias | D054969 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic intolerance | D054971 | — | — | 1 | — | — | — | — | 1 |
| Penetrating keratoplasty | D015948 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 4 | 4 |
| Macular edema | D008269 | — | — | — | — | — | — | 2 | 2 |
| Syndrome | D013577 | — | — | — | — | — | — | 2 | 2 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | — | — | 2 | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 2 | 2 |
| Low vision | D015354 | — | — | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Pseudophakia | D019591 | — | — | — | — | — | — | 1 | 1 |
| Astigmatism | D001251 | EFO_0004222 | H52.2 | — | — | — | — | 1 | 1 |
| Hyperopia | D006956 | EFO_0006310 | H52.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tropicamide |
| INN | tropicamide |
| Description | Tropicamide is a member of acetamides. |
| Classification | Small molecule |
| Drug class | atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 1508-75-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200604 |
| ChEBI ID | — |
| PubChem CID | 5593 |
| DrugBank | DB00809 |
| UNII ID | N0A3Z5XTC6 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
CHRM2
CHRM2
CHRM4
CHRM4
CHRM5
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Variants
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Financial
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Estimated US medical usage
Tropicamide
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Trends
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Safety
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1,034 adverse events reported
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