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Drug ReportsTropicamide
Tropicamide
Mydcombi, Mydriacyl, Paremyd, Tropicacyl, Tropicamide (tropicamide) is a small molecule pharmaceutical. Tropicamide was first approved as Mydriacyl on 1982-01-01. It is used to treat iridocyclitis, iritis, and keratitis in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M5.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Mydriacyl, Tropicacyl, Tropicamide (discontinued: Mydriacyl, Tropicamide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydroxyamphetamine hydrobromide
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Tropicamide
Tradename
Company
Number
Date
Products
PAREMYDEpic PharmaN-019261 DISCN1992-01-30
1 products, RLD
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Tropicamide
Tradename
Company
Number
Date
Products
MYDRIACYLAlcon ResearchN-012111 DISCN1982-01-01
2 products
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Phenylephrine hydrochloride
+
Tropicamide
Tradename
Company
Number
Date
Products
MYDCOMBIHyperion DeFiN-215352 DISCN2023-05-05
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
mydcombiNew Drug Application2023-05-09
mydriacylANDA2023-02-15
mydriatic-4unapproved drug other2018-05-01
paremydNew Drug Application2022-09-14
tropicacyl2008-11-25
tropicamideANDA2025-08-11
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
keratitis—D007634H16
iritisEFO_1000997D007500—
iridocyclitis—D015863H20
septic shock—D012772A48.3
hypotensionEFO_0005251D007022I95
pruritus ani—D011538L29.0
open-angle glaucomaEFO_0004190D005902H40.1
fissure in ano—D005401K60.2
hemorrhoidsEFO_0009552D006484K64
vasomotor rhinitisEFO_0007533D012223J30.0
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Agency Specific
FDA
EMA
Expiration
Code
PHENYLEPHRINE HYDROCHLORIDE / TROPICAMIDE, MYDCOMBI, EYENOVIA
2026-05-05NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Phenylephrine Hydrochloride / Tropicamide, Mydcombi, Eyenovia
108399602031-07-15U-3685
113983062031-07-15U-3685
118394872031-07-15U-3685
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01F: Mydriatics and cycloplegics
— S01FA: Anticholinergic mydriatics and cycloplegics
— S01FA06: Tropicamide
— S01FA56: Tropicamide, combinations
HCPCS
No data
Clinical
Clinical Trials
68 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MydriasisD015878—H57.04——22—4
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTropicamide
INNtropicamide
Description
Tropicamide is a member of acetamides.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1
Identifiers
PDB—
CAS-ID1508-75-4
RxCUI—
ChEMBL IDCHEMBL1200604
ChEBI ID—
PubChem CID5593
DrugBankDB00809
UNII IDN0A3Z5XTC6 (ChemIDplus, GSRS)
Target
Agency Approved
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
1131
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Q9HB60
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Alternate
CHRM2
CHRM2
CHRM4
CHRM4
CHRM5
CHRM5
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Tropicamide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 18,456 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,125 adverse events reported
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