Therapeutic Area | MeSH |
---|---|
nutritional and metabolic diseases | D009750 |
Brand Name | Status | Last Update |
---|---|---|
acd | ANDA | 2025-01-22 |
acular | New Drug Application | 2024-09-25 |
acular ls | New Drug Application | 2024-06-21 |
acunistat-30 | ANDA | 2022-02-22 |
acunistat-60 | ANDA | 2022-02-22 |
acunivive 15 | ANDA | 2022-02-24 |
acunivive 30 | ANDA | 2022-02-25 |
acunivive 60 | ANDA | 2022-02-25 |
acunivive 90 | ANDA | 2022-02-25 |
acuvail | New Drug Application | 2024-05-31 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
acidosis | EFO_1000014 | D000138 | E87.2 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Sodium Phosphate, Dibasic, Anhydrous / Sodium Phosphate, Monobasic, Monohydrate, Osmoprep, Salix Pharms | |||
7687075 | 2028-06-22 | DS, DP |
Code | Description |
---|---|
J1885 | Injection, ketorolac tromethamine, per 15 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Postoperative pain | D010149 | — | G89.18 | 3 | 7 | 7 | 19 | 9 | 44 |
Pain | D010146 | EFO_0003843 | R52 | 1 | 5 | 6 | 10 | 5 | 26 |
Infections | D007239 | EFO_0000544 | — | 4 | 5 | 4 | 7 | 1 | 20 |
Acute pain | D059787 | — | R52 | 3 | 3 | 5 | 6 | 2 | 18 |
Cataract | D002386 | EFO_0001059 | H26.9 | 2 | 1 | 3 | 7 | 3 | 15 |
Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 3 | 5 | 6 | — | 14 |
Communicable diseases | D003141 | — | — | 4 | 3 | 3 | 3 | — | 12 |
Macular edema | D008269 | — | — | — | 3 | 2 | 4 | 2 | 10 |
Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | 2 | 5 | 1 | 9 |
Pulpitis | D011671 | EFO_1001139 | K04.0 | 1 | 5 | — | 1 | 2 | 9 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 7 | 7 | 2 | — | 1 | 15 |
Leukemia | D007938 | — | C95 | 1 | 5 | 1 | — | — | 7 |
Myelodysplastic syndromes | D009190 | — | D46 | 1 | 5 | 1 | — | — | 7 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 5 | 1 | — | — | 7 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 4 | 1 | — | — | 6 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | 3 | 1 | — | — | 5 |
Neuroblastoma | D009447 | EFO_0000621 | — | — | 2 | 3 | — | — | 5 |
Preleukemia | D011289 | — | — | 1 | 3 | 1 | — | — | 5 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 2 | 2 | — | — | 5 |
Respiratory syncytial virus infections | D018357 | EFO_1001413 | — | 2 | 2 | 1 | — | — | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 17 | 1 | — | — | 1 | 19 |
Hiv infections | D015658 | EFO_0000764 | B20 | 9 | 2 | — | — | — | 10 |
Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 9 | 3 | — | — | — | 10 |
Recurrence | D012008 | — | — | 2 | 5 | — | — | — | 7 |
Myeloid leukemia | D007951 | — | C92 | 1 | 4 | — | — | — | 5 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | — | 4 | — | — | — | 4 |
Keratoconjunctivitis sicca | D007638 | EFO_1000906 | — | — | 1 | — | — | 3 | 4 |
Dry eye syndromes | D015352 | — | H04.12 | — | 1 | — | — | 3 | 4 |
Germ cell and embryonal neoplasms | D009373 | — | — | 2 | 1 | — | — | — | 3 |
Lymphoid leukemia | D007945 | — | C91 | 1 | 2 | — | — | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Leiomyoma | D007889 | — | D25 | 1 | — | — | — | 3 | 4 |
Pneumonia | D011014 | EFO_0003106 | J18 | 3 | — | — | — | — | 3 |
Pneumococcal pneumonia | D011018 | EFO_1001474 | J13 | 3 | — | — | — | — | 3 |
Pneumococcal infections | D011008 | EFO_0000772 | J13 | 3 | — | — | — | — | 3 |
Myofibroma | D047708 | — | — | 1 | — | — | — | 2 | 3 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Ependymoma | D004806 | — | — | 1 | — | — | — | — | 1 |
Myeloid sarcoma | D023981 | — | C92.3 | 1 | — | — | — | — | 1 |
Choroid plexus neoplasms | D016545 | EFO_0007206 | — | 1 | — | — | — | — | 1 |
Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Common cold | D003139 | EFO_0007214 | J00 | — | — | — | — | 3 | 3 |
Agnosia | D000377 | EFO_0007136 | F88 | — | — | — | — | 2 | 2 |
Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 2 | 2 |
Vomiting | D014839 | — | R11.1 | — | — | — | — | 2 | 2 |
Keratoconus | D007640 | EFO_0004223 | H18.6 | — | — | — | — | 2 | 2 |
Bunion | D000071378 | — | M21.61 | — | — | — | — | 1 | 1 |
Hammer toe syndrome | D037801 | EFO_1001336 | M21.53 | — | — | — | — | 1 | 1 |
Tailor's bunion | D050489 | — | M21.62 | — | — | — | — | 1 | 1 |
Nausea | D009325 | — | R11.0 | — | — | — | — | 1 | 1 |
Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Tromethamine |
INN | trometamol |
Description | Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g. condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the "tromethamine salt" including hemabate (carboprost as trometamol salt), and "ketorolac trometamol".
... More |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | NC(CO)(CO)CO |
PDB | — |
CAS-ID | 77-86-1 |
RxCUI | — |
ChEMBL ID | CHEMBL1200391 |
ChEBI ID | 9754 |
PubChem CID | 6503 |
DrugBank | DB03754 |
UNII ID | 023C2WHX2V (ChemIDplus, GSRS) |