Triptorelin
Trelstar, Triptodur (triptorelin) is a protein pharmaceutical. Triptorelin was first approved as Trelstar on 2000-06-15. It is used to treat prostatic neoplasms in the USA. It is known to target gonadotropin-releasing hormone receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Trelstar, Triptodur
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Triptorelin pamoate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRIPTODUR KIT | Azurity | N-208956 RX | 2017-06-29 | 1 products, RLD, RS |
| TRELSTAR | Verity Pharmaceuticals | N-020715 RX | 2000-06-15 | 1 products, RLD, RS |
| TRELSTAR | Verity Pharmaceuticals | N-021288 RX | 2001-06-29 | 1 products, RLD, RS |
| TRELSTAR | Verity Pharmaceuticals | N-022437 RX | 2010-03-10 | 1 products, RLD, RS |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| prostatic neoplasms | — | D011471 | C61 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TRIPTORELIN PAMOATE, TRIPTODUR KIT, AZURITY | |||
| 2024-06-29 | ODE-149 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Triptorelin Pamoate, Trelstar, Verity | |||
| 10166181 | 2029-06-30 | DP | |
Clinical
Clinical Trials
295 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | EFO_0000545 | — | 2 | 12 | 15 | 34 | 35 | 93 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 32 | 34 | 6 | 11 | 79 |
| Female infertility | D007247 | EFO_0008560 | N97 | 2 | 6 | 4 | 6 | 12 | 26 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 2 | 5 | 3 | 5 | 14 |
| Fertilization in vitro | D005307 | — | — | — | — | 2 | 7 | 4 | 13 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | 1 | 1 | 4 | 4 | 10 |
| Syndrome | D013577 | — | — | — | — | 1 | 4 | 5 | 10 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | — | 1 | 1 | 3 | 4 | 9 |
| Precocious puberty | D011629 | — | E22.8 | — | — | 7 | 2 | — | 9 |
| Intracytoplasmic sperm injections | D020554 | — | — | — | — | — | 4 | 1 | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 12 | 7 | — | 7 | 28 |
| Adenocarcinoma | D000230 | — | — | — | 3 | 4 | — | 1 | 8 |
| Recurrence | D012008 | — | — | — | 2 | 3 | — | 1 | 6 |
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | 1 | 1 | 2 | — | 2 | 5 |
| Neoplasms | D009369 | — | C80 | — | 1 | 3 | — | 2 | 5 |
| Lymphoma | D008223 | — | C85.9 | — | 2 | 3 | — | 1 | 4 |
| Male breast neoplasms | D018567 | — | — | 1 | 1 | 1 | — | 1 | 3 |
| Fertility preservation | D059247 | — | — | — | 1 | 1 | — | 2 | 3 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | — | 3 | 1 | — | — | 3 |
| Neoadjuvant therapy | D020360 | — | — | — | 2 | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | 3 | — | — | 2 | 6 |
| Triple negative breast neoplasms | D064726 | — | — | — | 3 | — | — | — | 3 |
| Leiomyoma | D007889 | — | D25 | 1 | 1 | — | — | 1 | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | 1 | 2 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | — | 1 |
| Ectopic pregnancy | D011271 | — | O00 | 1 | 1 | — | — | — | 1 |
| Salpingitis | D012488 | — | N70.91 | 1 | 1 | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 1 | — | — | — | 1 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | — | 1 | — | — | — | 1 |
| Female urogenital diseases | D052776 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovulation induction | D010062 | — | — | — | — | — | — | 4 | 4 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 3 | 3 |
| Ovarian pregnancy | D065172 | — | O00.2 | — | — | — | — | 1 | 1 |
| Embryo implantation | D010064 | — | — | — | — | — | — | 1 | 1 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | — | — | 1 | 1 |
| Luteolysis | D003341 | — | — | — | — | — | — | 1 | 1 |
| Myofibroma | D047708 | — | — | — | — | — | — | 1 | 1 |
| Hodgkin disease | D006689 | — | C81 | — | — | — | — | 1 | 1 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triptorelin |
| INN | triptorelin |
| Description | Triptorelin is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone. It has a role as a gonadotropin releasing hormone agonist, an antineoplastic agent and a contraceptive drug. |
| Classification | Peptide |
| Drug class | prehormones or hormone-release stimulating peptides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 57773-63-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201334 |
| ChEBI ID | 63633 |
| PubChem CID | 25074470 |
| DrugBank | DB06825 |
| UNII ID | 9081Y98W2V (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GNRHR
GNRHR
Organism
Homo sapiens
Gene name
GNRHR
Gene synonyms
GRHR
NCBI Gene ID
Protein name
gonadotropin-releasing hormone receptor
Protein synonyms
gnRH receptor, gnRH-R, gonadotropin-releasing hormone (type 1) receptor 1, leutinizing hormone releasing horomone receptor, leutinizing-releasing hormone receptor, luliberin receptor, type I GnRH receptor
Uniprot ID
Mouse ortholog
Gnrhr (14715)
gonadotropin-releasing hormone receptor (Q61611)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,384 adverse events reported
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