Triclosan
Colgate Total (triclosan) is a small molecule pharmaceutical. Triclosan was first approved as Colgate total on 1997-07-11. It is used to treat bacterial infections and mycoses in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
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Drug Products
FDA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium fluoride
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Triclosan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLGATE TOTAL | Colgate-Palmolive | N-020231 DISCN | 1997-07-11 | 1 products, RLD |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections and mycoses | — | D001423 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
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ATC Codes
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AE: Phenol and derivatives, antiseptics and disinfectants
— D08AE04: Triclosan
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA06: Triclosan
HCPCS
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Clinical
Clinical Trials
85 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental plaque | D003773 | — | — | — | 2 | 11 | 3 | — | 16 |
| Gingivitis | D005891 | — | K05.10 | — | 1 | 3 | 5 | — | 9 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | 2 | 1 | 1 | 4 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gingival diseases | D005882 | — | K05.1 | — | — | 6 | — | — | 6 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | 2 | — | — | 2 |
| Mucositis | D052016 | EFO_1001898 | — | — | — | 1 | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | 1 | — | — | 1 |
| Dentin sensitivity | D003807 | — | — | — | — | 1 | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triclosan |
| INN | triclosan |
| Description | Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an antibacterial agent, a fungicide, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antimalarial, an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a xenobiotic, a persistent organic pollutant and a drug allergen. It is a member of phenols, an aromatic ether, a dichlorobenzene and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 3380-34-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL849 |
| ChEBI ID | 164200 |
| PubChem CID | 5564 |
| DrugBank | DB08604 |
| UNII ID | 4NM5039Y5X (ChemIDplus, GSRS) |
Target
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Financial
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Trends
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Additional graphs summarizing 11,528 documents
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Safety
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Adverse Events
Top Adverse Reactions
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1,106 adverse events reported
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