Triclosan
Colgate Total (triclosan) is a small molecule pharmaceutical. Triclosan was first approved as Colgate total on 1997-07-11. It is used to treat bacterial infections and mycoses in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium fluoride
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Triclosan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLGATE TOTAL | Colgate-Palmolive | N-020231 DISCN | 1997-07-11 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 1014 foaming antimicrobial | OTC monograph not final | 2013-05-01 |
| aeroscent milk and honey antibacterial moisturizing | OTC monograph not final | 2015-06-23 |
| aire-master | OTC monograph not final | 2022-07-27 |
| all day freshness antibacterial body wash with moisturizer gold antibacterial hand soap with moisturizer | OTC monograph not final | 2010-06-03 |
| anchor foaming mango | OTC monograph not final | 2010-10-28 |
| anti-bacterial blue raspberry hand | OTC monograph not final | 2012-10-06 |
| anti-bacterial bubble gum hand | OTC monograph not final | 2012-11-30 |
| anti-bacterial foaming | OTC monograph not final | 2011-08-12 |
| anti-bacterial fresh aloe hand | OTC monograph not final | 2013-08-20 |
| anti-bacterial lemon drop hand | OTC monograph not final | 2012-10-06 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections and mycoses | — | D001423 | — |
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Clinical
Clinical Trials
131 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 2 | 5 | 8 | 9 | 24 |
| Dental plaque | D003773 | — | — | 2 | 3 | 12 | 3 | 4 | 23 |
| Gingivitis | D005891 | HP_0000230 | K05.10 | 2 | 3 | 5 | 8 | 4 | 21 |
| Communicable diseases | D003141 | — | — | — | 1 | 3 | 6 | 8 | 18 |
| Surgical wound infection | D013530 | — | — | — | — | 5 | 6 | 4 | 15 |
| Dental caries | D003731 | EFO_0003819 | K02 | 2 | 1 | — | 2 | 8 | 12 |
| Wound infection | D014946 | — | — | — | 1 | — | 5 | 6 | 12 |
| Gingival diseases | D005882 | — | K05.1 | — | — | 6 | 1 | — | 7 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 2 | 4 | 6 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | 3 | 1 | 1 | 5 |
Show 19 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | 2 | — | 3 | 5 |
| Dentin sensitivity | D003807 | — | — | — | — | 2 | — | 3 | 5 |
| Mucositis | D052016 | EFO_1001898 | — | — | — | 1 | — | 3 | 4 |
| Tooth discoloration | D014075 | — | K03.6 | — | — | 1 | — | 1 | 2 |
| Peri-implantitis | D057873 | EFO_1001390 | — | — | — | 1 | — | 1 | 2 |
| Emergencies | D004630 | — | — | — | — | 1 | — | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 1 | — | — | 1 |
| Hypophosphatemia | D017674 | HP_0002148 | — | — | — | 1 | — | — | 1 |
| Familial hypophosphatemic rickets | D053098 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 1 | 2 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 1 | — | — | 1 | 2 |
| Halitosis | D006209 | — | R19.6 | 1 | 1 | — | — | — | 1 |
| Nephrolithiasis | D053040 | — | N20.0 | — | 1 | — | — | — | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | 1 | — | — | — | 1 |
| Calculi | D002137 | — | — | — | 1 | — | — | — | 1 |
| Ureteral obstruction | D014517 | HP_0006000 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fluoride poisoning | D005458 | EFO_1001328 | — | 1 | — | — | — | 1 | 2 |
| Dental fluorosis | D009050 | EFO_1000892 | K00.3 | 1 | — | — | — | 1 | 2 |
| Stomatognathic diseases | D009057 | — | K08.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcal infections | D013203 | — | A49.01 | — | — | — | — | 4 | 4 |
| Oral hygiene | D009910 | — | — | — | — | — | — | 3 | 3 |
| Hydrogen-ion concentration | D006863 | — | — | — | — | — | — | 3 | 3 |
| Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | — | — | 2 | 2 |
| Tooth demineralization | D017001 | — | — | — | — | — | — | 2 | 2 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | — | 1 | 1 |
| Infectious skin diseases | D012874 | — | — | — | — | — | — | 1 | 1 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | — | — | — | 1 | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
| Dental implants | D015921 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triclosan |
| INN | triclosan |
| Description | Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an antibacterial agent, a fungicide, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antimalarial, an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a xenobiotic, a persistent organic pollutant and a drug allergen. It is a member of phenols, an aromatic ether, a dichlorobenzene and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 3380-34-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL849 |
| ChEBI ID | 164200 |
| PubChem CID | 5564 |
| DrugBank | DB08604 |
| UNII ID | 4NM5039Y5X (ChemIDplus, GSRS) |
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Safety
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972 adverse events reported
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