Triclosan
Colgate Total (triclosan) is a small molecule pharmaceutical. Triclosan was first approved as Colgate total on 1997-07-11. It is used to treat bacterial infections and mycoses in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium fluoride
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Triclosan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLGATE TOTAL | Colgate-Palmolive | N-020231 DISCN | 1997-07-11 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aeroscent milk and honey antibacterial moisturizing | OTC monograph not final | 2015-06-23 |
| aire-master | OTC monograph not final | 2022-07-27 |
| all day freshness antibacterial body wash with moisturizer gold antibacterial hand soap with moisturizer | OTC monograph not final | 2010-06-03 |
| anti-bacterial blue raspberry hand | OTC monograph not final | 2012-10-06 |
| anti-bacterial bubble gum hand | OTC monograph not final | 2012-11-30 |
| anti-bacterial foaming | OTC monograph not final | 2011-08-12 |
| anti-bacterial fresh aloe hand | OTC monograph not final | 2013-08-20 |
| anti-bacterial lemon drop hand | OTC monograph not final | 2012-10-06 |
| anti-bacterial moisturizing hand | OTC monograph not final | 2012-04-03 |
| anti-bacterial strawberry kiss hand | OTC monograph not final | 2012-10-06 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections and mycoses | — | D001423 | — |
Agency Specific
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Clinical
Clinical Trials
84 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 1 | 5 | 8 | 8 | 22 |
| Dental plaque | D003773 | — | — | — | 2 | 11 | 3 | 2 | 18 |
| Communicable diseases | D003141 | — | — | — | — | 3 | 6 | 7 | 16 |
| Surgical wound infection | D013530 | — | — | — | — | 5 | 6 | 4 | 15 |
| Wound infection | D014946 | — | — | — | 1 | — | 5 | 6 | 12 |
| Gingivitis | D005891 | — | K05.10 | 1 | 2 | 3 | 5 | 2 | 12 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 2 | 4 | 6 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | 3 | 1 | 1 | 5 |
| Surgical wound | D000072836 | — | — | — | — | — | 4 | 1 | 5 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | 2 | 1 | — | 3 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gingival diseases | D005882 | — | K05.1 | — | — | 6 | — | — | 6 |
| Mucositis | D052016 | EFO_1001898 | — | — | — | 1 | — | 2 | 3 |
| Peri-implantitis | D057873 | EFO_1001390 | — | — | — | 1 | — | 1 | 2 |
| Emergencies | D004630 | — | — | — | — | 1 | — | 1 | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | 1 | — | — | 1 |
| Dentin sensitivity | D003807 | — | — | — | — | 1 | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrolithiasis | D053040 | — | N20.0 | — | 1 | — | — | — | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | 1 | — | — | — | 1 |
| Calculi | D002137 | — | — | — | 1 | — | — | — | 1 |
| Ureteral obstruction | D014517 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcal infections | D013203 | — | A49.01 | — | — | — | — | 3 | 3 |
| Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | — | — | 2 | 2 |
| Infectious skin diseases | D012874 | — | — | — | — | — | — | 1 | 1 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | — | — | — | 1 | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
| Dental implants | D015921 | — | — | — | — | — | — | 1 | 1 |
| Cigarette smoking | D000073865 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 1 | 1 |
| Sutures | D013537 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triclosan |
| INN | triclosan |
| Description | Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an antibacterial agent, a fungicide, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antimalarial, an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a xenobiotic, a persistent organic pollutant and a drug allergen. It is a member of phenols, an aromatic ether, a dichlorobenzene and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 3380-34-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL849 |
| ChEBI ID | 164200 |
| PubChem CID | 5564 |
| DrugBank | DB08604 |
| UNII ID | 4NM5039Y5X (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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1,040 adverse events reported
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