Actemra, Roactemra(tocilizumab)
Actemra, RoActemra, Tofidence, Tyenne (tocilizumab) is an antibody pharmaceutical. Tocilizumab was first approved as Roactemra on 2009-01-15. It is used to treat cytokine release syndrome, giant cell arteritis, juvenile arthritis, and rheumatoid arthritis in the USA. It has been approved in Europe to treat arthritis, cytokine release syndrome, giant cell arteritis, and rheumatoid arthritis.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Actemra, Avtozma, Tofidence, Tyenne
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| actemra | Biologic Licensing Application | 2018-10-01 |
| actemra actemra actpen | Biologic Licensing Application | 2025-12-16 |
| avtozma | Biologic Licensing Application | 2025-02-18 |
| tocilizumab-anoh | Biologic Licensing Application | 2025-08-04 |
| tofidence | Biologic Licensing Application | 2025-09-22 |
| tyenne | Biologic Licensing Application | 2025-11-26 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
tocilizumab, Actemra, Genentech, Inc. | |||
| 2028-03-04 | Orphan excl. | ||
| 2024-08-30 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J3262 | Injection, tocilizumab, 1 mg |
| M0249 | Intravenous infusion, tocilizumab, for hospitalized adults and pediatric patients (2 years of age and older) with covid-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, includes infusion and post administration monitoring, first dose |
| M0250 | Intravenous infusion, tocilizumab, for hospitalized adults and pediatric patients (2 years of age and older) with covid-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, includes infusion and post administration monitoring, second dose |
| Q0249 | Injection, tocilizumab, for hospitalized adults and pediatric patients (2 years of age and older) with covid-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, 1 mg |
Clinical
Clinical Trials
862 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 10 | 8 | 80 | 44 | 84 | 225 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 11 | 8 | 86 | 37 | 77 | 217 |
| Covid-19 | D000086382 | — | U07.1 | 4 | 19 | 21 | 4 | 27 | 73 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 8 | 6 | 10 | 24 | 45 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 1 | 9 | 7 | 1 | 10 | 28 |
| Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | 3 | 9 | 7 | 2 | 6 | 26 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | 5 | 2 | 14 | 2 | 3 | 25 |
| Polymyalgia rheumatica | D011111 | EFO_0008518 | M35.3 | 2 | 5 | 6 | 2 | 5 | 20 |
| Healthy volunteers/patients | — | — | — | 7 | — | — | 1 | 11 | 19 |
| Cytokine release syndrome | D000080424 | — | D89.83 | 3 | 6 | 3 | 2 | 6 | 18 |
Show 50 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 4 | — | 22 | 26 |
| Lymphoma | D008223 | — | C85.9 | 9 | 9 | 1 | — | — | 15 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 6 | 1 | — | 8 | 15 |
| Ischemic stroke | D000083242 | — | — | — | 1 | 3 | — | 12 | 15 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 11 | 10 | 1 | — | — | 14 |
| Leukemia | D007938 | — | C95 | 7 | 5 | 1 | — | 1 | 13 |
| Inflammation | D007249 | MP_0001845 | — | 2 | 7 | 1 | — | 2 | 12 |
| Infections | D007239 | EFO_0000544 | — | — | 3 | 2 | — | 6 | 11 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | 3 | — | 7 | 11 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | — | 1 | — | 9 | 11 |
Show 63 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aneurysm | D000783 | — | I72.9 | — | 1 | — | — | 10 | 11 |
| B-cell lymphoma | D016393 | — | — | 9 | 5 | — | — | — | 9 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 3 | — | — | 4 | 9 |
| Virus diseases | D014777 | — | B34 | — | 4 | — | — | 3 | 7 |
| Carcinoma | D002277 | — | C80.0 | 4 | 2 | — | — | 1 | 6 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 3 | — | — | 1 | 5 |
| Kidney transplantation | D016030 | — | — | 2 | 3 | — | — | 2 | 5 |
| Graft vs host disease | D006086 | — | D89.81 | 2 | 4 | — | — | — | 5 |
| Hematologic neoplasms | D019337 | — | — | 1 | 5 | — | — | — | 5 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | 2 | — | — | — | 5 |
Show 124 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | 5 | 6 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 1 | — | — | — | 3 | 4 |
| Embolism | D004617 | — | — | 1 | — | — | — | 3 | 4 |
| Magnetic resonance imaging | D008279 | — | — | 1 | — | — | — | 3 | 4 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 1 | — | — | — | 3 | 4 |
| Colorectal neoplasms | D015179 | — | — | 2 | — | — | — | 1 | 3 |
| Musculoskeletal diseases | D009140 | — | — | 1 | — | — | — | 1 | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | 1 | 2 |
| Myositis | D009220 | EFO_0000783 | G72.49 | 2 | — | — | — | — | 2 |
Show 26 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intracranial aneurysm | D002532 | EFO_0003870 | I67.1 | — | — | — | — | 7 | 7 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | — | — | — | — | 6 | 6 |
| Critical illness | D016638 | — | — | — | — | — | — | 5 | 5 |
| Headache | D006261 | — | R51 | — | — | — | — | 5 | 5 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 4 | 4 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 4 | 4 |
| Abdominal aortic aneurysm | D017544 | EFO_0004214 | — | — | — | — | — | 4 | 4 |
| Cerebrovascular circulation | D002560 | — | — | — | — | — | — | 3 | 3 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 3 | 3 |
| Cerebral small vessel diseases | D059345 | — | — | — | — | — | — | 3 | 3 |
Show 151 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Tocilizumab |
| INN | tocilizumab |
| Description | Tocilizumab, also known as atlizumab, is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer. It was developed by Hoffmann–La Roche and Chugai.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1237022 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06273 |
| UNII ID | I031V2H011 (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 83,866 documents
View more details
Safety
Black-box Warning
Black-box warning for: Actemra, Actemra actemra actpen, Avtozma, Tocilizumab-anoh, Tofidence, Tyenne
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
118,090 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use