Thiotepa, Tepadina(thiotepa)
Tepadina (thiotepa) is a small molecule pharmaceutical. Thiotepa was first approved as Thiotepa on 1982-01-01. It is used to treat adenocarcinoma, breast neoplasms, lymphoma, ovarian neoplasms, and sarcoma amongst others in the USA. It has been approved in Europe to treat hematopoietic stem cell transplantation and neoplasms. It is known to target cytochrome P450 2B6.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Tepadina (generic drugs available since 2001-04-02, discontinued: Thioplex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Thiotepa
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TEPADINA | ADIENNE SA | N-208264 RX | 2017-01-26 | 2 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| adenocarcinoma | — | D000230 | — |
| breast neoplasms | EFO_0003869 | D001943 | C50 |
| lymphoma | — | D008223 | C85.9 |
| ovarian neoplasms | EFO_0003893 | D010051 | C56 |
| sarcoma | — | D012509 | — |
| urinary bladder neoplasms | — | D001749 | C67 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
THIOTEPA, TEPADINA, ADIENNE SA | |||
| 2024-01-26 | ODE-129 | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9340 | Injection, thiotepa, 15 mg |
Clinical
Clinical Trials
297 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 14 | 38 | 4 | 1 | 3 | 54 |
| Leukemia | D007938 | — | C95 | 14 | 30 | 2 | 1 | 1 | 41 |
| Lymphoma | D008223 | — | C85.9 | 9 | 24 | 1 | 1 | 3 | 34 |
| Graft vs host disease | D006086 | — | D89.81 | 3 | 5 | 1 | 1 | — | 9 |
| Medulloblastoma | D008527 | — | — | 2 | 2 | 2 | 1 | 1 | 7 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 2 | — | 1 | 1 | 5 |
| Anemia | D000740 | HP_0001903 | D64.9 | 1 | 3 | — | 1 | — | 4 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 6 | 35 | 4 | — | 4 | 45 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 5 | 34 | 7 | — | 2 | 45 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 7 | 21 | 13 | — | 1 | 36 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | 24 | 2 | — | 2 | 31 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 4 | 23 | 3 | — | — | 27 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 5 | 13 | 4 | — | 1 | 22 |
| Central nervous system neoplasms | D016543 | — | — | 4 | 13 | 2 | — | 2 | 21 |
| Hematologic neoplasms | D019337 | — | — | 6 | 12 | 1 | — | 3 | 19 |
| Neoplasms | D009369 | — | C80 | 5 | 7 | 1 | — | 3 | 14 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 2 | 8 | 2 | — | 1 | 12 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin disease | D006689 | — | C81 | 3 | 11 | — | — | 1 | 14 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 6 | 10 | — | — | 1 | 14 |
| Sarcoma | D012509 | — | — | 4 | 5 | — | — | 1 | 10 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 6 | 7 | — | — | — | 10 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 2 | 6 | — | — | 1 | 9 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 5 | — | — | 2 | 8 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | — | 7 | — | — | — | 7 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 6 | — | — | 1 | 7 |
| Primitive neuroectodermal tumors | D018242 | — | — | 2 | 2 | — | — | 2 | 6 |
| Thalassemia | D013789 | EFO_1001996 | D56 | 3 | 3 | — | — | 1 | 6 |
Show 95 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ewing sarcoma | D012512 | EFO_0000173 | — | 1 | — | — | — | 1 | 2 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Choroid plexus neoplasms | D016545 | EFO_0007206 | — | 1 | — | — | — | — | 1 |
| Neuroepithelial neoplasms | D018302 | — | — | 1 | — | — | — | — | 1 |
| Lysosomal storage diseases | D016464 | — | — | 1 | — | — | — | — | 1 |
| Bone marrow transplantation | D016026 | — | — | 1 | — | — | — | — | 1 |
| Chordoma | D002817 | EFO_0000334 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | — | — | — | — | 1 | 1 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | — | — | — | — | 1 | 1 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | — | — | — | — | 1 | 1 |
| T-cell lymphoma peripheral | D016411 | — | — | — | — | — | — | 1 | 1 |
| Intraocular lymphoma | D064090 | — | — | — | — | — | — | 1 | 1 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | — | — | — | — | 1 | 1 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | — | — | — | — | 1 | 1 |
| Lymphomatoid granulomatosis | D008230 | — | C83.8 | — | — | — | — | 1 | 1 |
| Hepatoblastoma | D018197 | — | C22.2 | — | — | — | — | 1 | 1 |
| Retinal neoplasms | D019572 | — | C69.2 | — | — | — | — | 1 | 1 |
Show 2 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Thiotepa |
| INN | thiotepa |
| Description | Thiotepa is a member of aziridines. |
| Classification | Small molecule |
| Drug class | antineoplastics (thiotepa derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | S=P(N1CC1)(N1CC1)N1CC1 |
Identifiers
| PDB | — |
| CAS-ID | 52-24-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL671 |
| ChEBI ID | 9570 |
| PubChem CID | 5453 |
| DrugBank | DB04572 |
| UNII ID | 905Z5W3GKH (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CYP2B6
CYP2B6
Organism
Homo sapiens
Gene name
CYP2B6
Gene synonyms
NCBI Gene ID
Protein name
cytochrome P450 2B6
Protein synonyms
1,4-cineole 2-exo-monooxygenase, CYPIIB6, Cytochrome P450 IIB1, cytochrome P450, family 2, subfamily B, polypeptide 6, cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 5,004 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
4,623 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use