Tegaserod
Zelnorm (tegaserod) is a small molecule pharmaceutical. Tegaserod was first approved as Zelnorm on 2002-07-24. It is used to treat constipation and irritable bowel syndrome in the USA. It is known to target 5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine receptor 4.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| zelnorm | New Drug Application | 2020-06-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| irritable bowel syndrome | EFO_0000555 | D043183 | K58 |
| constipation | — | D003248 | K59.0 |
Agency Specific
FDA
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Clinical
Clinical Trials
27 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Constipation | D003248 | — | K59.0 | — | 1 | 6 | 5 | 3 | 14 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 6 | 1 | — | 7 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | 1 | 2 | 1 | 4 |
| Syndrome | D013577 | — | — | — | — | 1 | 1 | 1 | 3 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | — | 1 |
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | — | — | 1 | — | 1 |
| Diarrhea | D003967 | — | R19.7 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Opioid-induced constipation | D000079689 | — | — | — | 1 | 3 | — | — | 3 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | 1 | 2 | — | — | 3 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | — | — | 2 | — | — | 2 |
| Heartburn | D006356 | — | R12 | — | — | 2 | — | — | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach diseases | D013272 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic disease | D002908 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tegaserod |
| INN | tegaserod |
| Description | Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation. Approved by the FDA in 2002, it was subsequently removed from the market in 2007 due to FDA concerns about possible adverse cardiovascular effects. Before then, it was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating, and constipation associated with irritable bowel syndrome. Its use was also approved to treat chronic idiopathic constipation.
|
| Classification | Small molecule |
| Drug class | serotonin receptor antagonists and partial agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12 |
Identifiers
| PDB | — |
| CAS-ID | 145158-71-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL76370 |
| ChEBI ID | 51043 |
| PubChem CID | 5362436 |
| DrugBank | DB01079 |
| UNII ID | 458VC51857 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
HTR2B
HTR2B
HTR4
HTR4
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
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Financial
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Estimated US medical usage
Tegaserod
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,387 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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1,188 adverse events reported
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