Tegafur
Teysuno (tegafur) is a small molecule pharmaceutical. Tegafur was first approved as Teysuno on 2011-03-14. It has been approved in Europe to treat stomach neoplasms.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| digestive system diseases | D004066 |
Trade Name
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Abbreviated New Drug Application (ANDA)
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Agency Specific
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Clinical
Clinical Trials
218 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 6 | 54 | 26 | 1 | 6 | 85 |
| Colorectal neoplasms | D015179 | — | — | 5 | 10 | 10 | 1 | 1 | 24 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 10 | — | 3 | 2 | 17 |
| Neoplasms | D009369 | — | C80 | 5 | 8 | 1 | 1 | 1 | 15 |
| Colonic neoplasms | D003110 | — | C18 | 3 | 6 | 3 | 1 | 4 | 15 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 5 | — | 1 | — | 8 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 3 | 2 | 1 | — | 6 |
| Recurrence | D012008 | — | — | — | — | 1 | 1 | 1 | 3 |
| Maintenance chemotherapy | D060046 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | — | — | 3 | 15 | 3 | — | 1 | 20 |
| Rectal neoplasms | D012004 | — | — | 4 | 6 | 2 | — | 3 | 13 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 6 | 3 | — | 1 | 9 |
| Carcinoma | D002277 | — | C80.0 | — | 7 | 2 | — | — | 9 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 4 | 3 | — | 1 | 8 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | — | 7 | 1 | — | — | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | 1 | — | — | 7 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 5 | 1 | — | — | 7 |
| Neoadjuvant therapy | D020360 | — | — | — | 4 | 1 | — | 2 | 7 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 1 | 4 | 2 | — | 1 | 7 |
Show 16 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 5 | — | — | — | 7 |
| Squamous cell carcinoma | D002294 | — | — | — | 4 | — | — | — | 4 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 3 | — | — | — | 3 |
| Tongue neoplasms | D014062 | EFO_0003871 | C02.9 | — | 2 | — | — | — | 2 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 2 | — | — | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 1 | — | — | 1 | 2 |
| Unknown primary neoplasms | D009382 | — | — | — | 1 | — | — | — | 1 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | — | 1 | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | — | — | 1 | 1 | — | — | — | 1 |
| Mouth neoplasms | D009062 | EFO_0003868 | C06.9 | — | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | — | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | — | — | — | — | 1 |
| Survival rate | D015996 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tegafur |
| INN | tegafur |
| Description | Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]c(=O)n(C2CCCO2)cc1F |
Identifiers
| PDB | — |
| CAS-ID | 17902-23-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL20883 |
| ChEBI ID | 32188 |
| PubChem CID | 288216 |
| DrugBank | DB09256 |
| UNII ID | 1548R74NSZ (ChemIDplus, GSRS) |
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Safety
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6,530 adverse events reported
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