Talzenna(talazoparib)
Talzenna (talazoparib) is a small molecule pharmaceutical. Talazoparib was first approved as Talzenna on 2018-10-16. It is used to treat breast neoplasms in the USA. It has been approved in Europe to treat breast neoplasms. The pharmaceutical is active against poly [ADP-ribose] polymerase 2 and poly [ADP-ribose] polymerase 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Talzenna
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| talzenna | New Drug Application | 2024-04-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| breast neoplasms | EFO_0003869 | D001943 | C50 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TALAZOPARIB TOSYLATE, TALZENNA, PFIZER | |||
| 2026-06-20 | I-920 | ||
HCPCS
No data
Clinical
Clinical Trials
115 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 26 | 17 | 1 | — | 4 | 41 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 15 | 22 | 1 | — | 3 | 36 |
| Prostatic neoplasms | D011471 | — | C61 | 9 | 10 | 2 | — | 1 | 20 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 8 | 5 | 2 | — | — | 14 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 5 | 3 | 1 | — | — | 9 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 2 | 1 | — | — | 6 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 3 | 2 | 1 | — | 1 | 6 |
| Hereditary breast and ovarian cancer syndrome | D061325 | — | — | 1 | 3 | 1 | — | — | 5 |
| Brca2 genes | D024522 | — | — | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | — | — | 7 | 10 | — | — | — | 14 |
| Carcinoma | D002277 | — | C80.0 | 5 | 7 | — | — | 1 | 12 |
| Recurrence | D012008 | — | — | 5 | 5 | — | — | — | 8 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 3 | — | — | 1 | 7 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 4 | 2 | — | — | — | 6 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 5 | 2 | — | — | 1 | 6 |
| Adenocarcinoma | D000230 | — | — | 4 | 3 | — | — | — | 6 |
| Small cell lung carcinoma | D055752 | — | — | 3 | 2 | — | — | — | 5 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 2 | — | — | — | 5 |
| Fallopian tube neoplasms | D005185 | — | — | 4 | 1 | — | — | — | 5 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Serous cystadenocarcinoma | D018284 | — | — | 3 | — | — | — | — | 3 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | 1 | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Female genital neoplasms | D005833 | — | — | 1 | — | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 1 | — | — | — | — | 1 |
| Vaginal neoplasms | D014625 | — | C52 | 1 | — | — | — | — | 1 |
| And serous mucinous cystic neoplasms | D018297 | — | — | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | — | 1 | — | — | — | — | 1 |
Show 9 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancytopenia | D010198 | HP_0001876 | D61.81 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Preleukemia | D011289 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Talazoparib |
| INN | talazoparib |
| Description | Talazoparib, sold under the brand name Talzenna, is an anti-cancer medication used for the treatment of breast cancer and prostrate cancer. It is an orally available poly ADP ribose polymerase PARP inhibitor marketed by Pfizer for the treatment of advanced breast cancer with germline BRCA mutations. Talazoparib is similar to the first in class PARP inhibitor, olaparib.
|
| Classification | Small molecule |
| Drug class | poly-ADP-ribose polymerase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1207454-56-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137320 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11760 |
| UNII ID | 9QHX048FRV (ChemIDplus, GSRS) |
Target
Agency Approved
PARP2
PARP2
PARP1
PARP1
Organism
Homo sapiens
Gene name
PARP2
Gene synonyms
ADPRT2, ADPRTL2
NCBI Gene ID
Protein name
poly [ADP-ribose] polymerase 2
Protein synonyms
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2, ADP-ribosyltransferase diphtheria toxin-like 2, ADPRT-2, ARTD2, DNA ADP-ribosyltransferase PARP2, hPARP-2, NAD(+) ADP-ribosyltransferase 2, pADPRT-2, poly (ADP-ribose) polymerase family, member 2, poly (ADP-ribosyl) transferase-like 2, Poly[ADP-ribose] synthase 2, poly[ADP-ribose] synthetase 2, Protein poly-ADP-ribosyltransferase PARP2
Uniprot ID
Mouse ortholog
Parp2 (11546)
poly [ADP-ribose] polymerase 2 (Q99N29)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,092 adverse events reported
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