Surufatinib
Surufatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target fibroblast growth factor receptor 1 and vascular endothelial growth factor receptor 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
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Agency Specific
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Clinical
Clinical Trials
100 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 1 | 13 | 1 | — | 3 | 17 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 12 | 1 | — | 1 | 13 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 4 | 7 | 2 | — | 2 | 12 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 1 | 8 | 1 | — | 2 | 10 |
| Neuroendocrine carcinoma | D018278 | — | — | 1 | 3 | 1 | — | 1 | 5 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 8 | — | — | 1 | 12 |
| Small cell lung carcinoma | D055752 | — | — | 3 | 8 | — | — | — | 8 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 7 | — | — | — | 7 |
| Colorectal neoplasms | D015179 | — | — | 2 | 6 | — | — | — | 6 |
| Sarcoma | D012509 | — | — | 3 | 5 | — | — | 1 | 6 |
| Adenocarcinoma | D000230 | — | — | — | 5 | — | — | 1 | 6 |
| Cholangiocarcinoma | D018281 | — | C22.1 | — | 5 | — | — | 1 | 6 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 4 | — | — | — | 4 |
| Osteosarcoma | D012516 | — | — | 2 | 4 | — | — | — | 4 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 3 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Surufatinib |
| INN | surufatinib |
| Description | Surufatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target fibroblast growth factor receptor 1 and vascular endothelial growth factor receptor 2. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc2cc(Oc3ccnc(Nc4cccc(CS(=O)(=O)NCCN(C)C)c4)n3)ccc2[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 1308672-74-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297190 |
| ChEBI ID | — |
| PubChem CID | 52920501 |
| DrugBank | DB15106 |
| UNII ID | B2K5L1L8S9 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
FGFR1
FGFR1
KDR
KDR
Organism
Homo sapiens
Gene name
FGFR1
Gene synonyms
BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
NCBI Gene ID
Protein name
fibroblast growth factor receptor 1
Protein synonyms
Basic fibroblast growth factor receptor 1, bFGF-R-1, BFGFR, CD331, FGFR1/PLAG1 fusion, FLT-2, FMS-like tyrosine kinase 2, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, N-sam, Proto-oncogene c-Fgr
Uniprot ID
Mouse ortholog
Fgfr1 (14182)
fibroblast growth factor receptor 1 (Q9QZM7)
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 447 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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19 adverse events reported
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