Surufatinib
Surufatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target fibroblast growth factor receptor 1 and vascular endothelial growth factor receptor 2.
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Clinical
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102 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | — | — | — | 1 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 1 | — | — | — | 1 |
| Anaplastic thyroid carcinoma | D065646 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Surufatinib |
| INN | surufatinib |
| Description | Surufatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target fibroblast growth factor receptor 1 and vascular endothelial growth factor receptor 2. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc2cc(Oc3ccnc(Nc4cccc(CS(=O)(=O)NCCN(C)C)c4)n3)ccc2[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 1308672-74-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297190 |
| ChEBI ID | — |
| PubChem CID | 52920501 |
| DrugBank | DB15106 |
| UNII ID | B2K5L1L8S9 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
FGFR1
FGFR1
KDR
KDR
Organism
Homo sapiens
Gene name
FGFR1
Gene synonyms
BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
NCBI Gene ID
Protein name
fibroblast growth factor receptor 1
Protein synonyms
Basic fibroblast growth factor receptor 1, bFGF-R-1, BFGFR, CD331, FGFR1/PLAG1 fusion, FLT-2, FMS-like tyrosine kinase 2, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, N-sam, Proto-oncogene c-Fgr
Uniprot ID
Mouse ortholog
Fgfr1 (14182)
fibroblast growth factor receptor 1 (Q9QZM7)
Variants
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Trends
PubMed Central
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Safety
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19 adverse events reported
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