Silibinin
Silibinin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| skinceuticals silymarin cf acne treatment | C200263 | 2023-12-11 |
| skinceuticals silymarin cf acne treatment antioxidant | C200263 | 2024-06-24 |
Indications
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EMA
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Agency Specific
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Clinical
Clinical Trials
111 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 2 | 3 | 1 | 2 | 7 | 15 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | 1 | 3 | 5 | 10 |
| Fatty liver | D005234 | EFO_0003934 | — | 1 | 1 | — | 1 | 5 | 8 |
| Hepatitis | D006505 | — | K75.9 | 1 | 3 | 1 | 1 | — | 4 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 1 | 1 | 1 | 3 |
| Fibrosis | D005355 | — | — | — | — | — | 1 | 2 | 3 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | 1 | 2 | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | 1 | 1 | 3 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | — | — | 2 | 1 | 3 |
| Melanosis | D008548 | EFO_0003963 | L81.1 | — | 1 | — | 1 | 1 | 3 |
Show 7 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 3 | 8 | 3 | — | — | 10 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 2 | 5 | 1 | — | — | 6 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 1 | 1 | 2 | — | 3 | 6 |
| Proteinuria | D011507 | — | R80 | — | 3 | 1 | — | — | 4 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | 1 | — | 3 | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 3 | 1 | — | — | 4 |
| Liver failure | D017093 | — | K72.9 | — | 1 | 1 | — | 2 | 4 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 2 | 1 | — | — | 2 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | 1 | 1 | 1 | — | — | 2 |
| Hepatitis b | D006509 | — | — | 1 | 1 | 1 | — | — | 2 |
Show 16 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Oxidative stress | D018384 | EFO_1001905 | — | 1 | 2 | — | — | 1 | 4 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 3 | — | — | — | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 1 | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | 1 | 2 |
| Adenocarcinoma | D000230 | — | — | 1 | 2 | — | — | — | 2 |
| Recurrence | D012008 | — | — | — | 2 | — | — | — | 2 |
| Radiodermatitis | D011855 | — | L58 | 1 | 1 | — | — | 1 | 2 |
| Adenocarcinoma of lung | D000077192 | — | — | — | 1 | — | — | — | 1 |
| Hiv | D006678 | — | O98.7 | — | 1 | — | — | — | 1 |
| Alcoholic fatty liver | D005235 | — | K70.0 | — | 1 | — | — | — | 1 |
Show 17 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 3 | 5 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | 2 | 3 |
| Hiv seronegativity | D018023 | — | — | 1 | — | — | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overweight | D050177 | — | E66.3 | — | — | — | — | 3 | 3 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | — | 2 | 2 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | — | 1 | 1 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Lactation disorders | D007775 | — | O92.4 | — | — | — | — | 1 | 1 |
| Lactation | D007774 | — | — | — | — | — | — | 1 | 1 |
| Human milk | D008895 | — | — | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | — | — | 1 | 1 |
| Hypercholesterolemia | D006937 | — | — | — | — | — | — | 1 | 1 |
Show 13 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Silibinin |
| INN | silibinin |
| Description | Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(C2Oc3cc(C4Oc5cc(O)cc(O)c5C(=O)C4O)ccc3OC2CO)ccc1O |
Identifiers
| PDB | — |
| CAS-ID | 22888-70-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1401508 |
| ChEBI ID | 125451 |
| PubChem CID | 31553 |
| DrugBank | — |
| UNII ID | 33X338MNE4 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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81 adverse events reported
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