Nabiximols
Nabiximols is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
1190 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 97 | 123 | 21 | 16 | 229 | 453 |
| Cannabis | D002188 | — | — | 60 | 35 | 5 | 6 | 112 | 207 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 15 | 10 | 4 | 5 | 47 | 75 |
| Pain | D010146 | EFO_0003843 | R52 | 18 | 14 | 24 | 1 | 6 | 60 |
| Healthy volunteers/patients | — | — | — | 40 | 3 | — | 1 | 13 | 57 |
| Chronic pain | D059350 | HP_0012532 | — | 4 | 13 | 11 | 2 | 18 | 46 |
| Sclerosis | D012598 | — | — | 4 | 10 | 26 | 1 | 3 | 39 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 8 | 7 | 2 | 3 | 21 | 38 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 4 | 10 | 23 | 1 | 4 | 37 |
| Psychotic disorders | D011618 | — | F20.81 | 11 | 7 | — | 2 | 17 | 36 |
Show 42 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Marijuana use | D000074609 | — | — | 6 | 9 | 3 | — | 38 | 53 |
| Neoplasms | D009369 | — | C80 | 9 | 12 | 8 | — | 13 | 36 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 3 | 8 | 4 | — | 23 | 34 |
| Neuralgia | D009437 | EFO_0009430 | — | 4 | 9 | 16 | — | 6 | 32 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 3 | 4 | 2 | — | 18 | 26 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | 4 | 8 | 9 | — | 1 | 19 |
| Marijuana smoking | D008385 | — | — | 1 | 10 | 2 | — | 8 | 18 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 2 | 12 | — | 4 | 18 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 8 | 2 | — | 9 | 17 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 3 | 7 | 1 | — | 6 | 16 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 5 | 5 | — | — | 9 | 17 |
| Inflammation | D007249 | MP_0001845 | — | 3 | 1 | — | — | 10 | 14 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 3 | 4 | — | — | 6 | 13 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | 9 | — | — | 2 | 12 |
| Driving under the influence | D000066448 | — | — | 7 | 3 | — | — | 3 | 12 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | 5 | — | — | 7 | 12 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | 1 | — | — | 9 | 10 |
| Hiv | D006678 | — | — | 2 | 3 | — | — | 5 | 10 |
| Tobacco use | D064424 | — | — | 3 | 2 | — | — | 5 | 10 |
| Sleep | D012890 | GO_0030431 | — | 1 | 3 | — | — | 4 | 8 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adolescent behavior | D000294 | — | — | 1 | — | — | — | 11 | 12 |
| Psychomotor disorders | D011596 | — | — | 2 | — | — | — | 1 | 3 |
| Neuroimaging | D059906 | — | — | 1 | — | — | — | 2 | 3 |
| Memory | D008568 | — | — | 2 | — | — | — | 1 | 3 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | 1 | 2 |
| Psychological codependency | D017004 | — | — | 2 | — | — | — | — | 2 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 2 | — | — | — | — | 2 |
| Wasting syndrome | D019282 | — | — | 1 | — | — | — | 1 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 1 | 2 |
| Child development | D002657 | — | — | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 5 | 5 |
| Recreational drug use | D000084783 | — | — | — | — | — | — | 4 | 4 |
| Adolescent development | D041923 | — | — | — | — | — | — | 4 | 4 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | — | 4 | 4 |
| Underage drinking | D000066608 | — | — | — | — | — | — | 4 | 4 |
| Risk reduction behavior | D040242 | — | — | — | — | — | — | 3 | 3 |
| Musculoskeletal pain | D059352 | — | — | — | — | — | — | 3 | 3 |
| X-linked genetic diseases | D040181 | — | — | — | — | — | — | 2 | 2 |
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | — | — | — | 2 | 2 |
| Intractable pain | D010148 | — | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nabiximols |
| INN | — |
| Description | Nabiximols (USAN, trade name Sativex) is a specific Cannabis extract that was approved in 2010 as a botanical drug in the United Kingdom. Nabiximols is sold as a mouth spray intended to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms of multiple sclerosis; it was developed by the UK company GW Pharmaceuticals. In 2019, it was proposed that following application of the spray, nabiximols is washed away from the oral mucosa by the saliva flow and ingested into the stomach, with subsequent absorption from the gastro-intestinal tract. Nabiximols is a combination drug standardized in composition, formulation, and dose. Its principal active components are the cannabinoids: tetrahydrocannabinol (THC) and cannabidiol (CBD). Each spray delivers a dose of 2.7 mg THC and 2.5 mg CBD.
|
| Classification | Small molecule |
| Drug class | cannabinol derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O.CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 56575-23-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3833333 |
| ChEBI ID | — |
| PubChem CID | 44148067 |
| DrugBank | — |
| UNII ID | — |
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Safety
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159 adverse events reported
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